EA200970372A1 - Ингибитор развития болезни альцгеймера, содержащий гетероциклическое соединение - Google Patents

Ингибитор развития болезни альцгеймера, содержащий гетероциклическое соединение

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Publication number
EA200970372A1
EA200970372A1 EA200970372A EA200970372A EA200970372A1 EA 200970372 A1 EA200970372 A1 EA 200970372A1 EA 200970372 A EA200970372 A EA 200970372A EA 200970372 A EA200970372 A EA 200970372A EA 200970372 A1 EA200970372 A1 EA 200970372A1
Authority
EA
Eurasian Patent Office
Prior art keywords
heterocyclic compound
algheimer
containing heterocyclic
inhibitor containing
disease inhibitor
Prior art date
Application number
EA200970372A
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English (en)
Other versions
EA018592B1 (ru
Inventor
Йосимаса Ямагути
Рёго Юи
Тосиюки Мацуно
Кенити Сайтох
Хитоси Миясита
Такеси Нагата
Original Assignee
Зеняку Когио Кабусикикайся
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Publication date
Application filed by Зеняку Когио Кабусикикайся filed Critical Зеняку Когио Кабусикикайся
Publication of EA200970372A1 publication Critical patent/EA200970372A1/ru
Publication of EA018592B1 publication Critical patent/EA018592B1/ru

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
    • A—HUMAN NECESSITIES
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A—HUMAN NECESSITIES
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    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/4015—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil having oxo groups directly attached to the heterocyclic ring, e.g. piracetam, ethosuximide
    • A—HUMAN NECESSITIES
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    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425—Thiazoles
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    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425—Thiazoles
    • A61K31/426—1,3-Thiazoles
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    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/444—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring heteroatom, e.g. amrinone
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    • A61K31/4738—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems
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    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
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    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
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    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
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    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
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    • C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
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    • C07D513/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains three hetero rings
    • C07D513/20—Spiro-condensed systems

Abstract

Ингибитор развития болезни Альцгеймера, содержащий гетероциклическое соединение, имеющее общую формулу (I)
EA200970372A 2006-10-13 2007-10-15 Ингибитор развития болезни альцгеймера, содержащий гетероциклическое соединение EA018592B1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2006280768A JP5160764B2 (ja) 2006-10-13 2006-10-13 特定の構造の複素環化合物を含む抗鬱剤、脳保護剤、アミロイドβ沈着抑制剤または老化抑制剤
PCT/JP2007/070962 WO2008047951A2 (en) 2006-10-13 2007-10-15 An alzheimer' s disease progression inhibitor containing heterocyclic compound

Publications (2)

Publication Number Publication Date
EA200970372A1 true EA200970372A1 (ru) 2009-10-30
EA018592B1 EA018592B1 (ru) 2013-09-30

Family

ID=39069373

Family Applications (2)

Application Number Title Priority Date Filing Date
EA200970372A EA018592B1 (ru) 2006-10-13 2007-10-15 Ингибитор развития болезни альцгеймера, содержащий гетероциклическое соединение
EA200970373A EA017751B1 (ru) 2006-10-13 2007-10-15 Применение гетероциклического соединения конкретной структуры для ингибирования отложения beta-амилоида и способ ингибирования отложения beta-амилоида с использованием этого соединения

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EA200970373A EA017751B1 (ru) 2006-10-13 2007-10-15 Применение гетероциклического соединения конкретной структуры для ингибирования отложения beta-амилоида и способ ингибирования отложения beta-амилоида с использованием этого соединения

Country Status (16)

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US (3) US20080103158A1 (ru)
EP (5) EP2077835A2 (ru)
JP (1) JP5160764B2 (ru)
KR (2) KR101156412B1 (ru)
CN (2) CN101547693A (ru)
AU (2) AU2007311984B2 (ru)
BR (2) BRPI0719201A2 (ru)
CA (5) CA2666258C (ru)
EA (2) EA018592B1 (ru)
HK (1) HK1164114A1 (ru)
IL (2) IL198088A (ru)
MX (2) MX2009003713A (ru)
NZ (3) NZ576164A (ru)
TW (2) TWI441635B (ru)
WO (2) WO2008047952A2 (ru)
ZA (2) ZA200902809B (ru)

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JP5160764B2 (ja) * 2006-10-13 2013-03-13 全薬工業株式会社 特定の構造の複素環化合物を含む抗鬱剤、脳保護剤、アミロイドβ沈着抑制剤または老化抑制剤
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US20100256173A1 (en) * 2009-04-02 2010-10-07 Eckard Weber Method of Treating Cognitive Impairment
WO2010120872A2 (en) * 2009-04-14 2010-10-21 Kim Nicholas Green Method of decreasing pro-adam10 secretase and/or beta secretase levels
EP2429522A4 (en) * 2009-05-11 2013-01-09 Univ California METHOD FOR REDUCING THE CONCENTRATION OF UBIQUITINATED PROTEINS
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