DE60331187D1 - Kinaseinhibitoren - Google Patents
KinaseinhibitorenInfo
- Publication number
- DE60331187D1 DE60331187D1 DE60331187T DE60331187T DE60331187D1 DE 60331187 D1 DE60331187 D1 DE 60331187D1 DE 60331187 T DE60331187 T DE 60331187T DE 60331187 T DE60331187 T DE 60331187T DE 60331187 D1 DE60331187 D1 DE 60331187D1
- Authority
- DE
- Germany
- Prior art keywords
- kinase inhibitors
- compound
- formula
- diastereomers
- solvates
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/4965—Non-condensed pyrazines
- A61K31/497—Non-condensed pyrazines containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/16—Otologicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/20—Antivirals for DNA viruses
- A61P31/22—Antivirals for DNA viruses for herpes viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/14—Drugs for disorders of the endocrine system of the thyroid hormones, e.g. T3, T4
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| AUPS2514A AUPS251402A0 (en) | 2002-05-23 | 2002-05-23 | Kinase inhibitors |
| US39899802P | 2002-07-26 | 2002-07-26 | |
| PCT/AU2003/000628 WO2003099811A1 (en) | 2002-05-23 | 2003-05-23 | Kinase inhibitors |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DE60331187D1 true DE60331187D1 (de) | 2010-03-25 |
Family
ID=29585025
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE60331187T Expired - Lifetime DE60331187D1 (de) | 2002-05-23 | 2003-05-23 | Kinaseinhibitoren |
Country Status (11)
| Country | Link |
|---|---|
| US (4) | US7259179B2 (de) |
| EP (1) | EP1511742B1 (de) |
| CN (1) | CN1671696B (de) |
| AT (1) | ATE457025T1 (de) |
| AU (1) | AU2003229370B2 (de) |
| CA (1) | CA2486187C (de) |
| DE (1) | DE60331187D1 (de) |
| GB (1) | GB2398781B (de) |
| IL (2) | IL165262A0 (de) |
| NZ (1) | NZ537156A (de) |
| WO (1) | WO2003099811A1 (de) |
Families Citing this family (43)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2005021531A1 (en) * | 2003-08-21 | 2005-03-10 | Osi Pharmaceuticals, Inc. | N-substituted benzimidazolyl c-kit inhibitors |
| EP1670794A2 (de) | 2003-09-30 | 2006-06-21 | Amgen Inc. | Vanilloidrezeptorliganden und deren verwendung bei behandlungen |
| AU2004294355B2 (en) * | 2003-12-03 | 2011-12-22 | Ym Biosciences Australia Pty Ltd | Azole-based kinase inhibitors |
| ES2578254T3 (es) | 2003-12-03 | 2016-07-22 | Ym Biosciences Australia Pty Ltd | Inhibidores de cinasas basados en azol |
| AU2005203919B2 (en) * | 2004-01-12 | 2011-07-21 | Ym Biosciences Australia Pty Ltd | Selective kinase inhibitors |
| EP1704145B1 (de) * | 2004-01-12 | 2012-06-13 | YM BioSciences Australia Pty Ltd | Selektive kinaseinhibitoren |
| CN1976709A (zh) * | 2004-06-04 | 2007-06-06 | 比奥尼斯生命科学公司 | 伊马替尼在治疗肝脏疾病和病毒感染中的用途 |
| CA2589770A1 (en) * | 2004-12-01 | 2006-06-08 | Osi Pharmaceuticals, Inc. | N-substituted benzimidazolyl c-kit inhibitors and combinatorial benzimidazole library |
| NZ562468A (en) * | 2005-04-05 | 2009-10-30 | Pharmacopeia Inc | Purine and imidazopyridine derivatives for immunosuppression |
| ES2351357T3 (es) * | 2005-07-26 | 2011-02-03 | Vertex Pharmaceuticals Incorporated | Bencimidazoles útiles como inhibidores de proteínas cinasas. |
| EP1988776B1 (de) * | 2006-03-02 | 2012-08-08 | Siga Technologies, Inc. | Antivirale mittel zur behandlung von arenavirus-infektionen |
| US8871746B2 (en) | 2006-03-02 | 2014-10-28 | Kineta Four, LLC | Antiviral drugs for treatment of arenavirus infection |
| US7977365B2 (en) | 2006-03-02 | 2011-07-12 | Siga Technologies, Inc. | Antiviral drugs for treatment of arenavirus infection |
| WO2007109362A2 (en) | 2006-03-20 | 2007-09-27 | Synta Pharmaceuticals Corp. | Benzoimidazolyl-parazine compounds for inflammation and immune-related uses |
| AU2007254179B2 (en) * | 2006-05-18 | 2013-03-21 | Pharmacyclics Llc | Intracellular kinase inhibitors |
| US8461161B2 (en) | 2006-11-15 | 2013-06-11 | Ym Biosciences Australia Pty Ltd | Substituted pyrazines as inhibitors of kinase activity |
| US8895745B2 (en) | 2006-12-22 | 2014-11-25 | Astex Therapeutics Limited | Bicyclic heterocyclic compounds as FGFR inhibitors |
| AU2007337895C1 (en) * | 2006-12-22 | 2014-07-31 | Astex Therapeutics Limited | Tricyclic amine derivatives as protein tyrosine kinase inhibitors |
| US8131527B1 (en) | 2006-12-22 | 2012-03-06 | Astex Therapeutics Ltd. | FGFR pharmacophore compounds |
| TWI415609B (zh) * | 2006-12-22 | 2013-11-21 | Astex Therapeutics Ltd | 新化合物 |
| US8415358B2 (en) | 2007-09-17 | 2013-04-09 | Neurosearch A/S | Pyrazine derivatives and their use as potassium channel modulators |
| GB0720041D0 (en) | 2007-10-12 | 2007-11-21 | Astex Therapeutics Ltd | New Compounds |
| GB0720038D0 (en) | 2007-10-12 | 2007-11-21 | Astex Therapeutics Ltd | New compounds |
| US8008013B2 (en) * | 2007-11-16 | 2011-08-30 | Oklahoma Medical Research Foundation | Predicting and diagnosing patients with autoimmune disease |
| WO2009119776A1 (ja) * | 2008-03-27 | 2009-10-01 | 武田薬品工業株式会社 | 縮合複素環誘導体およびその用途 |
| CA2723358A1 (en) * | 2008-05-05 | 2009-11-12 | Allison B. Reiss | Method for improving cardiovascular risk profile of cox inhibitors |
| GB0810902D0 (en) | 2008-06-13 | 2008-07-23 | Astex Therapeutics Ltd | New compounds |
| WO2010012745A2 (en) * | 2008-07-29 | 2010-02-04 | Boehringer Ingelheim International Gmbh | Benzimidazoles |
| GB0906472D0 (en) | 2009-04-15 | 2009-05-20 | Astex Therapeutics Ltd | New compounds |
| GB0906470D0 (en) | 2009-04-15 | 2009-05-20 | Astex Therapeutics Ltd | New compounds |
| JP2013525438A (ja) | 2010-04-29 | 2013-06-20 | アメリカ合衆国 | ヒトピルビン酸キナーゼ活性剤 |
| EP2651939B1 (de) | 2010-12-13 | 2015-04-08 | Array Biopharma, Inc. | Substituierte n- (1h-indazol-4-yl) imidazo [1,2-a] pyridin-3-carboxamidverbindungen als typ-iii-rezeptor-tyrosinkinasenhibitoren |
| WO2012112567A1 (en) * | 2011-02-15 | 2012-08-23 | Georgetown University | Small molecule inhibitors of agbl2 |
| EP2799537B1 (de) | 2011-12-28 | 2021-09-22 | Kyoto Prefectural Public University Corporation | Normalisierung der züchtung von hornhautendothelzellen |
| SG10201600149VA (en) | 2012-11-21 | 2016-02-26 | Ptc Therapeutics Inc | Substituted reverse pyrimidine bmi-1 inhibitors |
| EP3007689B1 (de) | 2013-01-10 | 2018-03-07 | Pulmokine, Inc. | Nicht-selektive kinasehemmer |
| EP2967046A4 (de) * | 2013-03-15 | 2016-12-21 | Whitehead Inst Biomedical Res | Benzimidazolderivate und verwendungen davon |
| ES2959419T3 (es) | 2013-10-11 | 2024-02-26 | Pulmokine Inc | Formulaciones secas por aspersión |
| US10813920B2 (en) | 2013-11-14 | 2020-10-27 | The Doshisha | Drug for treating corneal endothelium by promoting cell proliferation or inhibiting cell damage |
| WO2015076800A1 (en) | 2013-11-21 | 2015-05-28 | Ptc Therapeutics, Inc. | Substituted pyridine and pyrazine bmi-1 inhibitors |
| US11352328B2 (en) | 2016-07-12 | 2022-06-07 | Arisan Therapeutics Inc. | Heterocyclic compounds for the treatment of arenavirus |
| CN110087653A (zh) | 2016-10-27 | 2019-08-02 | 普尔莫凯恩股份有限公司 | 用于治疗肺高血压的组合疗法 |
| WO2023220046A1 (en) * | 2022-05-10 | 2023-11-16 | Biogen Ma Inc. | Tyk2 inhibitors |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7125875B2 (en) | 1999-04-15 | 2006-10-24 | Bristol-Myers Squibb Company | Cyclic protein tyrosine kinase inhibitors |
| KR100710100B1 (ko) * | 1999-04-15 | 2007-04-23 | 브리스톨-마이어스스퀴브컴파니 | 환형 단백질 티로신 키나제 억제제 |
| WO2002060492A1 (en) * | 2001-01-30 | 2002-08-08 | Cytopia Pty Ltd | Methods of inhibiting kinases |
| GB0215775D0 (en) * | 2002-07-06 | 2002-08-14 | Astex Technology Ltd | Pharmaceutical compounds |
-
2003
- 2003-05-23 NZ NZ537156A patent/NZ537156A/en not_active IP Right Cessation
- 2003-05-23 DE DE60331187T patent/DE60331187D1/de not_active Expired - Lifetime
- 2003-05-23 EP EP03722065A patent/EP1511742B1/de not_active Expired - Lifetime
- 2003-05-23 CA CA2486187A patent/CA2486187C/en not_active Expired - Fee Related
- 2003-05-23 AT AT03722065T patent/ATE457025T1/de not_active IP Right Cessation
- 2003-05-23 US US10/472,156 patent/US7259179B2/en active Active
- 2003-05-23 WO PCT/AU2003/000628 patent/WO2003099811A1/en active Application Filing
- 2003-05-23 AU AU2003229370A patent/AU2003229370B2/en not_active Ceased
- 2003-05-23 GB GB0318343A patent/GB2398781B/en not_active Expired - Lifetime
- 2003-05-23 CN CN038174529A patent/CN1671696B/zh not_active Expired - Fee Related
- 2003-05-23 IL IL16526203A patent/IL165262A0/xx active IP Right Grant
-
2004
- 2004-11-16 IL IL165262A patent/IL165262A/en unknown
-
2006
- 2006-04-04 US US11/397,982 patent/US7511047B2/en active Active
- 2006-04-04 US US11/397,973 patent/US7598272B2/en not_active Expired - Lifetime
-
2007
- 2007-02-27 US US11/711,957 patent/US20070161635A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| CA2486187A1 (en) | 2003-12-04 |
| IL165262A0 (en) | 2005-12-18 |
| EP1511742B1 (de) | 2010-02-03 |
| WO2003099811A1 (en) | 2003-12-04 |
| CN1671696A (zh) | 2005-09-21 |
| NZ537156A (en) | 2007-06-29 |
| US20050004140A1 (en) | 2005-01-06 |
| CA2486187C (en) | 2013-02-19 |
| GB2398781A (en) | 2004-09-01 |
| CN1671696B (zh) | 2010-12-08 |
| AU2003229370A1 (en) | 2003-12-12 |
| US20060241112A1 (en) | 2006-10-26 |
| EP1511742A4 (de) | 2006-07-05 |
| ATE457025T1 (de) | 2010-02-15 |
| EP1511742A1 (de) | 2005-03-09 |
| US7259179B2 (en) | 2007-08-21 |
| US7598272B2 (en) | 2009-10-06 |
| IL165262A (en) | 2011-10-31 |
| US20070161635A1 (en) | 2007-07-12 |
| GB0318343D0 (en) | 2003-09-10 |
| US7511047B2 (en) | 2009-03-31 |
| GB2398781B (en) | 2005-02-02 |
| AU2003229370B2 (en) | 2009-02-26 |
| US20060270687A1 (en) | 2006-11-30 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| 8327 | Change in the person/name/address of the patent owner |
Owner name: YM BIOSCIENCES AUSTRALIA PTY LTD., MELBOURNE, , AU |
|
| 8364 | No opposition during term of opposition |