NO20060408L - Fremgangsmate for a modulere kalsium ione-frigjorings- aktivert kalsium ionekanaler - Google Patents

Fremgangsmate for a modulere kalsium ione-frigjorings- aktivert kalsium ionekanaler

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Publication number
NO20060408L
NO20060408L NO20060408A NO20060408A NO20060408L NO 20060408 L NO20060408 L NO 20060408L NO 20060408 A NO20060408 A NO 20060408A NO 20060408 A NO20060408 A NO 20060408A NO 20060408 L NO20060408 L NO 20060408L
Authority
NO
Norway
Prior art keywords
calcium ion
modulating
release activated
ion channels
channels
Prior art date
Application number
NO20060408A
Other languages
English (en)
Norwegian (no)
Inventor
Mitsunori Ono
Lijun Sun
Yu Xie
Mats Holmqvist
Jerome Mahiou
Shoujun Chen
Shijie Zhang
Jun Jiang
Dinesh Chimmanamada
Andrea Fleig
Chih-Yi Yu
Original Assignee
Synta Pharmaceuticals Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Synta Pharmaceuticals Corp filed Critical Synta Pharmaceuticals Corp
Publication of NO20060408L publication Critical patent/NO20060408L/no

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    • C07C233/66—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by halogen atoms or by nitro or nitroso groups
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Families Citing this family (77)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2005538697A (ja) * 2002-04-19 2005-12-22 シエーリング アクチエンゲゼルシャフト 新規前立腺腫瘍特異的プロモーター
TWI376370B (en) * 2003-07-23 2012-11-11 Synta Pharmaceuticals Corp Compounds for inflammation and immune-related uses
AU2004261589B2 (en) * 2003-07-25 2008-05-22 Novartis Ag p-38 kinase inhibitors
TWI359017B (en) * 2003-11-10 2012-03-01 Synta Pharmaceuticals Corp Heteroaryl-hydrazone compounds
KR20070107022A (ko) * 2005-01-07 2007-11-06 신타 파마슈티칼스 코프. 염증 및 면역 관련 용도를 위한 화합물
US8802721B2 (en) 2005-01-25 2014-08-12 Synta Pharmaceuticals Corp. Thiophene compounds for inflammation and immune-related uses
BRPI0607308A2 (pt) 2005-01-25 2009-08-25 Synta Pharmaceuticals Corp compostos, composições farmacêuticas e usos dos referidos compostos
US20070155738A1 (en) * 2005-05-20 2007-07-05 Alantos Pharmaceuticals, Inc. Heterobicyclic metalloprotease inhibitors
KR20080087070A (ko) * 2005-05-20 2008-09-30 알란토스 파마슈티컬즈 홀딩, 인코포레이티드 피리미딘 또는 트리아진 융합된 비시클릭 메탈로프로테아제억제제
DE602006016313D1 (de) * 2005-09-16 2010-09-30 Arrow Therapeutics Ltd Biphenylderivate und ihre verwendung bei der behandlung von hepatitis c
EP1968968A1 (fr) * 2005-12-21 2008-09-17 PainCeptor Pharma Corp. Compositions et procedes de modulation de canaux ioniques commandes par porte
US8623871B2 (en) * 2006-01-25 2014-01-07 Synta Pharmaceuticals Corp. Substituted biaryl compounds for inflammation and immune-related uses
AU2007208239B2 (en) * 2006-01-25 2013-04-18 Synta Pharmaceuticals Corp. Substituted aromatic compounds for inflammation and immune-related uses
AU2007208151B2 (en) 2006-01-25 2013-04-18 Synta Pharmaceuticals Corp. Vinyl-phenyl derivatives for inflammation and immune-related uses
US8455658B2 (en) * 2006-01-25 2013-06-04 Synta Pharmaceuticals Corp. Thiazole and thiadiazole compounds for inflammation and immune-related uses
TWI417096B (zh) * 2006-01-25 2013-12-01 Synta Pharmaceuticals Corp 用於發炎及免疫相關用途之苯基及吡啶基化合物
ES2403368T3 (es) * 2006-01-31 2013-05-17 Synta Pharmaceuticals Corporation Compuestos de piridilfenilo para la inflamación y usos inmunorrelacionados
WO2007109362A2 (fr) 2006-03-20 2007-09-27 Synta Pharmaceuticals Corp. Composés à base de benzoimidazolyl-parazine pour utilisations contre l'inflammation et des troubles immunitaires
JP2009531385A (ja) 2006-03-31 2009-09-03 グラクソ グループ リミテッド 成長ホルモン分泌促進物質（ｇｈｓ）受容体アゴニストとしてのピペラジン誘導体
US20080096227A1 (en) * 2006-04-10 2008-04-24 Reinhold Penner CRAC modulators and use of same for drug discovery
WO2007147794A1 (fr) * 2006-06-19 2007-12-27 Smithkline Beecham Corporation Dérivés du furanne et leur utilisation comme agents antiviraux
US8779154B2 (en) * 2006-09-26 2014-07-15 Qinglin Che Fused ring compounds for inflammation and immune-related uses
CA2669311C (fr) 2006-11-13 2011-09-20 Pfizer Products Inc. Derives diaryle, dipyridinyle et aryl-pyridinyle et leurs utilisations
NZ598345A (en) * 2006-11-21 2013-09-27 Kalobios Pharmaceuticals Inc Methods of treating chronic inflammatory diseases using a gm-csf antagonist
EP2129660A2 (fr) 2006-12-19 2009-12-09 Pfizer Products Inc. Dérivés de nicotinamide en tant qu'inhibiteurs de h-pgds et leur utilisation pour le traitement de maladies liées aux prostaglandines d2
UY30892A1 (es) 2007-02-07 2008-09-02 Smithkline Beckman Corp Inhibidores de la actividad akt
CN103450077B (zh) 2007-06-08 2016-07-06 满康德股份有限公司 IRE-1α抑制剂
US20120064121A1 (en) * 2007-08-01 2012-03-15 Synta Pharmaceuticals Corp. Pyridine compounds for inflammation and immune-related uses
TW200914440A (en) * 2007-08-01 2009-04-01 Synta Pharmaceuticals Corp Vinyl-aryl derivatives for inflammation and immune-related uses
CA2699157A1 (fr) 2007-09-10 2009-03-19 Calcimedica, Inc. Composes modulant le calcium intracellulaire
ES2647504T3 (es) 2007-09-10 2017-12-21 Janssen Pharmaceutica N.V. Proceso para la preparación de compuestos útiles como inhibidores de SGLT
US8389567B2 (en) 2007-12-12 2013-03-05 Calcimedica, Inc. Compounds that modulate intracellular calcium
TWI392673B (zh) 2008-08-27 2013-04-11 Calcimedica Inc 調控細胞內鈣離子濃度之化合物
US8524763B2 (en) 2008-09-22 2013-09-03 Calcimedica, Inc. Inhibitors of store operated calcium release
US8143269B2 (en) 2008-10-03 2012-03-27 Calcimedica, Inc. Inhibitors of store operated calcium release
US9056850B2 (en) 2008-10-17 2015-06-16 Janssen Pharmaceutica N.V. Process for the preparation of compounds useful as inhibitors of SGLT
PE20120003A1 (es) * 2009-01-30 2012-02-12 Glaxosmithkline Llc Hidrocloruro de n-{(1s)-2-amino-1-[(3-fluorofenil)metil)etil}-5-cloro-4-(4-cloro-1-metil-1h-pirazol-5-il)-2-tiofenocarboxamida cristalino
US20110009347A1 (en) 2009-07-08 2011-01-13 Yin Liang Combination therapy for the treatment of diabetes
CN102482250B (zh) 2009-07-10 2014-11-19 詹森药业有限公司 1-(β-D-吡喃葡糖基)-4-甲基-3-[5-(4-氟苯基)-2-噻吩基甲基]苯的结晶方法
WO2011034962A2 (fr) 2009-09-16 2011-03-24 Calcimedica Inc. Composés qui modulent le calcium intracellulaire
US8993612B2 (en) 2009-10-08 2015-03-31 Rhizen Pharmaceuticals Sa Modulators of calcium release-activated calcium channel and methods for treatment of non-small cell lung cancer
US8377970B2 (en) 2009-10-08 2013-02-19 Rhizen Pharmaceuticals Sa Modulators of calcium release-activated calcium channel
CN102648196B (zh) 2009-10-14 2016-04-27 詹森药业有限公司 可用作sglt2的抑制剂的化合物的制备方法
TW201129379A (en) 2009-11-20 2011-09-01 Amgen Inc Anti-Orai1 antigen binding proteins and uses thereof
HUE029570T2 (en) 2010-04-27 2017-03-28 Calcimedica Inc Intracellular calcium modifying compounds
US10703722B2 (en) 2010-04-27 2020-07-07 Calcimedica, Inc. Compounds that modulate intracellular calcium
EP2563759B1 (fr) 2010-04-27 2022-04-06 Calcimedica, Inc. Composés qui modulent le calcium intracellulaire
CN108354930A (zh) 2010-05-11 2018-08-03 詹森药业有限公司 包含1-(β-D-吡喃葡萄糖基)-2-噻吩基-甲基苯衍生物的药物制剂
MX337711B (es) 2010-08-27 2016-03-15 Calcimedica Inc Compuestos que modulan el calcio intracelular.
GEP20156315B (en) 2010-10-30 2015-07-10 Lupin Ltd Oxazoline and isoxazoline derivatives as crac modulators
US10544135B2 (en) 2011-04-13 2020-01-28 Janssen Pharmaceutica Nv Process for the preparation of compounds useful as inhibitors of SGLT2
CA2834928C (fr) 2011-05-03 2017-10-17 Synta Pharmaceuticals Corp. Composes pour une inflammation et des utilisations apparentees au systeme immunitaire
TWI542596B (zh) 2011-05-09 2016-07-21 健生藥品公司 （２ｓ,３ｒ,４ｒ,５ｓ,６ｒ）－２－（３－（（５－（４－氟苯基）噻吩－２－基）甲基）－４－甲基苯基）－６－（羥甲基）四氫－２ｈ－哌喃－３,４,５－三醇之ｌ－脯胺酸及檸檬酸共晶體
US20120316182A1 (en) 2011-06-10 2012-12-13 Calcimedica, Inc. Compounds that modulate intracellular calcium
KR101373705B1 (ko) * 2011-08-05 2014-03-14 동국대학교 산학협력단 신규한 바이페닐 유도체 또는 이의 약학적으로 허용가능한 염, 및 이를 유효성분으로 포함하는 염증성 질환 또는 자가면역질환의 예방 또는 치료용 약학적 조성물
BR112014005935A2 (pt) 2011-09-16 2017-03-28 Fovea Pharmaceuticals derivados de anilina, sua preparação e sua aplicação terapêutica
WO2013059677A1 (fr) 2011-10-19 2013-04-25 Calcimedica, Inc. Composés qui modulent le calcium intracellulaire
CA2871270A1 (fr) 2012-05-02 2013-11-07 Lupin Limited Composes substitues de pyridine en tant que modulateurs de crac
AU2013255441B2 (en) 2012-05-02 2017-11-09 Lupin Limited Substituted pyrazole compounds as CRAC modulators
UA117913C2 (uk) 2012-05-31 2018-10-25 Фінекс Фармас'Ютікалс Аг КАРБОКСАМІД- АБО СУЛЬФОНАМІДЗАМІЩЕНІ ТІАЗОЛИ ТА СПОРІДНЕНІ ПОХІДНІ ЯК МОДУЛЯТОРИ ОРФАНОВОГО ЯДЕРНОГО РЕЦЕПТОРА RORγ
WO2014043715A1 (fr) * 2012-09-17 2014-03-20 Calcimedica, Inc. Composés modulateurs de calcium intracellulaire
US9512116B2 (en) 2012-10-12 2016-12-06 Calcimedica, Inc. Compounds that modulate intracellular calcium
EP2738172A1 (fr) 2012-11-28 2014-06-04 Almirall, S.A. Nouveaux composés bicycliques utilisés comme modulateurs du canal crac
BR112015016391A2 (pt) 2013-01-10 2017-07-11 Gruenenthal Gmbh carboxamidas i baseadas em pirazolil como inibidoras do canal crac
EP2943197A1 (fr) 2013-01-10 2015-11-18 Grünenthal GmbH Carboxamides ii à base de pyrazolyle servant d'inhibiteurs de crac
CA2914132A1 (fr) 2013-06-21 2014-12-24 Lupin Limited Composes heterocycliques substitues utiles en tant que modulateurs de crac
US9790231B2 (en) 2013-06-24 2017-10-17 Lupin Limited Chromane and chromene derivatives and their use as CRAC modulators
EP2848615A1 (fr) 2013-07-03 2015-03-18 Almirall, S.A. Nouveaux dérivés de pyrazole utilisés comme modulateurs du canal CRAC
US20170114060A1 (en) * 2014-06-03 2017-04-27 The Trustees Of The University Of Pennsylvania Novel effective antiviral compounds and methods using same
WO2015197187A1 (fr) 2014-06-24 2015-12-30 Grünenthal GmbH Carboxamides à base de pyrazolyle v
PT3778595T (pt) 2015-02-27 2021-11-09 Calcimedica Inc Tratamento de pancreatite
CN107847548B (zh) 2015-05-18 2022-06-14 贝思以色列女会吏医学中心公司 P物质、肥大细胞脱颗粒抑制剂和周围神经病
AU2016306301B2 (en) 2015-08-07 2021-02-11 Calcimedica, Inc. Use of CRAC channel inhibitors for the treatment of stroke and traumatic brain injury
US20170071970A1 (en) 2015-09-15 2017-03-16 Janssen Pharmaceutica Nv Co-therapy comprising canagliflozin and phentermine for the treatment of obesity and obesity related disorders
EA202190556A1 (ru) 2018-09-14 2021-08-24 Ризен Фармасьютикалс А Г Композиции, содержащие ингибитор crac и кортикостероид, и способы их применения
IT202000003692A1 (it) 2020-02-21 2021-08-21 Univ Degli Studi Del Piemonte Orientale Amedeo Avogadro Composti bifenilici come modulatori di soce, loro composizioni e usi
JP2024519215A (ja) * 2021-05-07 2024-05-09 カイメラ セラピューティクス， インコーポレイテッド Ｃｄｋ２分解剤およびそれらの使用

Family Cites Families (53)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3536809A (en) 1969-02-17 1970-10-27 Alza Corp Medication method
US3598123A (en) * 1969-04-01 1971-08-10 Alza Corp Bandage for administering drugs
US3845770A (en) * 1972-06-05 1974-11-05 Alza Corp Osmatic dispensing device for releasing beneficial agent
US3916899A (en) 1973-04-25 1975-11-04 Alza Corp Osmotic dispensing device with maximum and minimum sizes for the passageway
US4008719A (en) 1976-02-02 1977-02-22 Alza Corporation Osmotic system having laminar arrangement for programming delivery of active agent
IE58110B1 (en) * 1984-10-30 1993-07-14 Elan Corp Plc Controlled release powder and process for its preparation
US4710515A (en) * 1987-03-17 1987-12-01 Riker Laboratories, Inc. Substituted biphenyl derivatives
US5073543A (en) 1988-07-21 1991-12-17 G. D. Searle & Co. Controlled release formulations of trophic factors in ganglioside-lipsome vehicle
IT1229203B (it) 1989-03-22 1991-07-25 Bioresearch Spa Impiego di acido 5 metiltetraidrofolico, di acido 5 formiltetraidrofolico e dei loro sali farmaceuticamente accettabili per la preparazione di composizioni farmaceutiche in forma a rilascio controllato attive nella terapia dei disturbi mentali organici e composizioni farmaceutiche relative.
US5120548A (en) 1989-11-07 1992-06-09 Merck & Co., Inc. Swelling modulated polymeric drug delivery device
US5733566A (en) 1990-05-15 1998-03-31 Alkermes Controlled Therapeutics Inc. Ii Controlled release of antiparasitic agents in animals
US5580578A (en) 1992-01-27 1996-12-03 Euro-Celtique, S.A. Controlled release formulations coated with aqueous dispersions of acrylic polymers
US5591767A (en) * 1993-01-25 1997-01-07 Pharmetrix Corporation Liquid reservoir transdermal patch for the administration of ketorolac
FR2701026B1 (fr) * 1993-02-02 1995-03-31 Adir Nouveaux dérivés de l'indole, de l'indazole et du benzisoxazole, leur procédé de préparation et les compositions pharmaceutiques qui les contiennent.
GB2276161A (en) * 1993-03-17 1994-09-21 Glaxo Group Ltd Aniline and benzanilide derivatives
US5348948A (en) 1993-05-07 1994-09-20 American Cyanamid Company 2,2-diaryl-1-(oxa and thia)-2a-azonia-2-borataacenaphthene fungicidal
IT1270594B (it) * 1994-07-07 1997-05-07 Recordati Chem Pharm Composizione farmaceutica a rilascio controllato di moguisteina in sospensione liquida
WO1996040640A1 (fr) * 1995-06-07 1996-12-19 Pfizer Inc. DERIVES DE BIPHENYL-2-ACIDE CARBOXYLIQUE-TETRAHYDRO-ISOQUINOLEINE-6-YL AMIDES, PREPARATION DE CES AMIDES ET UTILISATION EN TANT QU'INHIBITEURS DE LA PROTEINE DE TRANSFERT DE TRIGLYCERIDE MICROSOMAL ET/OU DE LA SECRETION D'APOLIPOPROTEINES B (Apo B)
JPH11511442A (ja) 1995-08-30 1999-10-05 バイエル・アクチエンゲゼルシヤフト アシルアミノサリチル酸アミドおよびそれらの有害生物防除剤としての使用
US6274171B1 (en) 1996-03-25 2001-08-14 American Home Products Corporation Extended release formulation of venlafaxine hydrochloride
US6187797B1 (en) * 1996-12-23 2001-02-13 Dupont Pharmaceuticals Company Phenyl-isoxazoles as factor XA Inhibitors
US6020357A (en) * 1996-12-23 2000-02-01 Dupont Pharmaceuticals Company Nitrogen containing heteroaromatics as factor Xa inhibitors
ATE236890T1 (de) * 1996-12-23 2003-04-15 Bristol Myers Squibb Pharma Co Sauerstoff oder schwefel enthaltende 5-gliedrige heteroaromatishe derivative als factor xa hemmer
CA2293824A1 (fr) * 1997-06-19 1998-12-23 Mimi Lifen Quan Agents aromatiques a six membres amidino utiles en tant qu'inhibiteurs du facteur xa
US6060491A (en) * 1997-06-19 2000-05-09 Dupont Pharmaceuticals 6-membered aromatics as factor Xa inhibitors
EE9900584A (et) * 1997-06-19 2000-08-15 Dupont Pharmaceuticals Company Neutraalse P1 spetsiifilisusrühmaga faktori Xa inhibiitorid
US6339099B1 (en) * 1997-06-20 2002-01-15 Dupont Pharmaceuticals Company Guanidine mimics as factor Xa inhibitors
ZA985542B (en) 1997-07-03 1999-04-07 Smithkline Beecham Corp Substituted benzanilides as CCR5 receptor ligands antiinflammatory agents and antiviral agents
AU751139B2 (en) * 1997-10-13 2002-08-08 Astellas Pharma Inc. Amide derivative
US6022884A (en) * 1997-11-07 2000-02-08 Amgen Inc. Substituted pyridine compounds and methods of use
IL136637A0 (en) * 1997-12-22 2001-06-14 Du Pont Pharm Co Nitrogen containing heteroaromatics with ortho-substituted pi's as factor xa inhibitors
HUP0102782A3 (en) * 1998-06-19 2002-12-28 Smithkline Beecham Corp Salycilanilide as inhibitors of transcription factor nf-kb
CN1376150A (zh) * 1999-07-26 2002-10-23 盐野义制药株式会社 具有血栓形成素受体拮抗作用的药物组合物
US6844367B1 (en) * 1999-09-17 2005-01-18 Millennium Pharmaceuticals, Inc. Benzamides and related inhibitors of factor Xa
US6632815B2 (en) * 1999-09-17 2003-10-14 Millennium Pharmaceuticals, Inc. Inhibitors of factor Xa
US6720317B1 (en) * 1999-09-17 2004-04-13 Millennium Pharmaceuticals, Inc. Inhibitors of factor Xa
CA2325358C (fr) * 1999-11-10 2005-08-02 Pfizer Products Inc. Amides de l'acide 7-¬(4'-trifluoromethylbiphenyl-2-carbonyl)amino|-quinoleine-3-carboxylique et methodes pour inhiber la secretion d'apolipoproteine b
FR2803592A1 (fr) * 2000-01-06 2001-07-13 Aventis Cropscience Sa Nouveaux derives de l'acide 3-hydroxypicolinique, leur procede de preparation et compositions fongicides les contenant.
WO2001055146A1 (fr) * 2000-01-29 2001-08-02 Lg Chem Investment Ltd. INHIBITEURS DU FACTEUR Xa CONTENANT DES ARYLAMIDINES ET DES DERIVES, ET PROMEDICAMENTS OBTENUS A PARTIR DESDITS INHIBITEURS
FR2805223B1 (fr) 2000-02-22 2002-06-21 Ecia Equip Composants Ind Auto Agencement de planche de bord de vehicule automobile
MY138097A (en) * 2000-03-22 2009-04-30 Du Pont Insecticidal anthranilamides
CA2407587A1 (fr) * 2000-04-28 2001-11-08 Sankyo Company, Limited Modulateurs de ppar.gamma.
WO2002000647A1 (fr) * 2000-06-23 2002-01-03 Bristol-Myers Squibb Pharma Company Inhibiteurs du facteur xa a substitution heteroaryl-phenyle
CN1289072C (zh) * 2000-12-22 2006-12-13 石原产业株式会社 苯胺衍生物或其盐以及含有它们的细胞因子产生抑制剂
JP4083422B2 (ja) * 2000-12-22 2008-04-30 石原産業株式会社 アニリン誘導体またはその塩ならびにそれらを含有するサイトカイン産生抑制剤
US6995162B2 (en) * 2001-01-12 2006-02-07 Amgen Inc. Substituted alkylamine derivatives and methods of use
US6878714B2 (en) * 2001-01-12 2005-04-12 Amgen Inc. Substituted alkylamine derivatives and methods of use
US6620811B2 (en) * 2001-11-19 2003-09-16 Hoffmann-La Roche Inc. Isonicotin- and nicotinamide derivatives of benzothiazoles
TW200403223A (en) * 2002-02-15 2004-03-01 Glaxo Group Ltd Novel compounds
AU2003257541A1 (en) * 2002-08-27 2004-03-19 Yamanouchi Pharmaceutical Co., Ltd. Novel crystals
WO2004056774A2 (fr) * 2002-12-19 2004-07-08 Neurogen Corporation Analogues d'arylamide d'acide biphenyl-4-carboxylique substitues
TWI376370B (en) * 2003-07-23 2012-11-11 Synta Pharmaceuticals Corp Compounds for inflammation and immune-related uses
US20050165015A1 (en) * 2004-01-23 2005-07-28 Ncube Mghele V. Vanilloid receptor ligands and their use in treatments

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US20050107436A1 (en) 2005-05-19
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CN1826121A (zh) 2006-08-30
EP1651232A4 (fr) 2007-06-06
CA2533594A1 (fr) 2005-02-03
CN1826121B (zh) 2013-05-29
JP2007501186A (ja) 2007-01-25
AU2004259024A1 (en) 2005-02-03
EP1651232A2 (fr) 2006-05-03
DK1651232T3 (da) 2011-02-28
NZ545447A (en) 2010-03-26
AU2011200458A1 (en) 2011-02-24
NO20060409L (no) 2006-04-04
SI1651232T1 (sl) 2011-06-30
CN101947218A (zh) 2011-01-19
DE602004030689D1 (de) 2011-02-03
KR101245062B1 (ko) 2013-03-19
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ES2358426T3 (es) 2011-05-10
MXPA06000837A (es) 2006-05-04
KR20060058092A (ko) 2006-05-29
CA2533598A1 (fr) 2005-02-03
TWI332832B (en) 2010-11-11
AU2004259024B2 (en) 2011-06-23
EP1653968A2 (fr) 2006-05-10
EP2319516A1 (fr) 2011-05-11
WO2005009539A2 (fr) 2005-02-03
JP4979378B2 (ja) 2012-07-18
IL173270A0 (en) 2006-06-11
CN102793692A (zh) 2012-11-28
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EP1651232B1 (fr) 2010-12-22
TW200523250A (en) 2005-07-16
BRPI0412805A (pt) 2006-09-26
WO2005009539A3 (fr) 2005-09-09
BRPI0412257A (pt) 2006-10-03
IL173269A0 (en) 2006-06-11
US20050148633A1 (en) 2005-07-07
WO2005009954A2 (fr) 2005-02-03
KR20060066711A (ko) 2006-06-16
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NZ587056A (en) 2012-03-30
PT1651232E (pt) 2011-02-16
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US20140107134A1 (en) 2014-04-17
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EP1653968A4 (fr) 2006-09-06
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