ATE440603T1 - 8-hydroxychinolinderivate - Google Patents

8-hydroxychinolinderivate

Info

Publication number
ATE440603T1
ATE440603T1 AT03763516T AT03763516T ATE440603T1 AT E440603 T1 ATE440603 T1 AT E440603T1 AT 03763516 T AT03763516 T AT 03763516T AT 03763516 T AT03763516 T AT 03763516T AT E440603 T1 ATE440603 T1 AT E440603T1
Authority
AT
Austria
Prior art keywords
subject
hydroxyquinoline derivatives
solvates
hydrates
compound
Prior art date
Application number
AT03763516T
Other languages
English (en)
Inventor
Kevin Barnham
Elisabeth GAUTIER
Gaik Kok
Guy Krippner
Original Assignee
Prana Biotechnology Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Prana Biotechnology Ltd filed Critical Prana Biotechnology Ltd
Application granted granted Critical
Publication of ATE440603T1 publication Critical patent/ATE440603T1/de

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    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/20—Oxygen atoms
    • C07D215/24—Oxygen atoms attached in position 8
    • C—CHEMISTRY; METALLURGY
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    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/48—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
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    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
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AT03763516T 2002-07-16 2003-07-16 8-hydroxychinolinderivate ATE440603T1 (de)

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Families Citing this family (78)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7781396B2 (en) * 2002-01-31 2010-08-24 Tel Aviv University Future Technology Development L.P. Peptides directed for diagnosis and treatment of amyloid-associated disease
AU2002950217A0 (en) * 2002-07-16 2002-09-12 Prana Biotechnology Limited 8- Hydroxy Quinoline Derivatives
US8058442B2 (en) 2002-11-07 2011-11-15 Technion Research And Development Foundation Ltd. Neuroprotective iron chelators and pharmaceutical compositions comprising them
US7491699B2 (en) 2002-12-09 2009-02-17 Ramot At Tel Aviv University Ltd. Peptide nanostructures and methods of generating and using the same
WO2004060791A1 (en) 2003-01-07 2004-07-22 Ramot At Tel Aviv University Ltd. Peptide nanostructures encapsulating a foreign material and method of manufacturing same
CA2540407A1 (en) 2003-09-25 2005-03-31 Tel Aviv University Future Technology Development L.P. Compositions and methods using same for treating amyloid-associated diseases
FR2864535B1 (fr) 2003-12-24 2006-12-22 Merck Sante Sas Derives acides de quinoline et leurs applications en therapeutique
DK1737831T3 (da) * 2004-04-02 2013-08-19 Prana Biotechnology Ltd Neurologisk aktive forbindelser
WO2006006172A2 (en) * 2004-07-15 2006-01-19 Ramot At Tel Aviv University Ltd. Use of anti-amyloid agents for treating and typing pathogen infections
WO2006013552A2 (en) 2004-08-02 2006-02-09 Ramot At Tel Aviv University Ltd. Articles of peptide nanostructures and method of forming the same
US7732479B2 (en) 2004-08-19 2010-06-08 Tel Aviv University Future Technology Development L.P. Compositions for treating amyloid associated diseases
US7786086B2 (en) 2004-09-08 2010-08-31 Ramot At Tel-Aviv University Ltd. Peptide nanostructures containing end-capping modified peptides and methods of generating and using the same
US8697674B2 (en) * 2004-12-29 2014-04-15 Naturon, Inc. Xanthurenic acid derivative pharmaceutical compositions and methods related thereto
FR2889525A1 (fr) 2005-08-04 2007-02-09 Palumed Sa Nouveaux derives de polyquinoleines et leur utilisation therapeutique.
US10004828B2 (en) * 2005-10-11 2018-06-26 Romat at Tel-Aviv University Ltd. Self-assembled Fmoc-ff hydrogels
US7879212B2 (en) * 2005-11-03 2011-02-01 Ramot At Tel-Aviv University Ltd. Peptide nanostructure-coated electrodes
WO2007056580A2 (en) * 2005-11-08 2007-05-18 Pharmadyn, Inc. Methods and compositions for treating diseases associated with pathogenic proteins
KR100821649B1 (ko) * 2006-01-24 2008-04-11 서울시립대학교 산학협력단 클리오퀴놀을 유효성분으로 포함하는 ＨＩＦ-1α 활성제
EP2514824A3 (de) 2006-03-03 2013-01-23 Amorfix Life Sciences Ltd. Verfahren und Zusammensetzungen zum Behandeln und Erkennen von missgefaltetem SOD 1-herbeigeführte Erkrankungen
DK2012789T3 (da) * 2006-04-14 2013-12-16 Prana Biotechnology Ltd Fremgangsmåde til behandling af aldersrelateret makulær degeneration (AMD)
JP2009544631A (ja) * 2006-07-25 2009-12-17 エンビボ ファーマシューティカルズ インコーポレイテッド キノリン誘導体
AU2007286659A1 (en) * 2006-08-23 2008-02-28 Wyeth 8-Hydroxyquinoline Compounds and methods thereof
US7964729B2 (en) * 2006-08-28 2011-06-21 Massachusetts Institute Of Technology Sox-based kinase sensor
US20080173652A1 (en) * 2007-01-23 2008-07-24 Bob Chou Integral heat-resisting structure of a disposable drinking cup
US8440835B2 (en) 2007-02-26 2013-05-14 Massachusetts Institute Of Technology Environmentally sensitive fluorophores
DE102007017654A1 (de) * 2007-04-12 2008-10-16 Henkel Ag & Co. Kgaa Bis(hydroxychinolin)-Metallkomplexe als Bleichkatalysatoren
KR100875493B1 (ko) 2007-05-14 2008-12-22 서울시립대학교 산학협력단 클리오퀴놀 및 그의 유도체를 유효성분으로 함유하는지방형성 억제용 조성물
TWI366565B (en) 2007-06-06 2012-06-21 Otsuka Pharma Co Ltd Quinolone compound and pharmaceutical composition
US9321730B2 (en) * 2007-08-21 2016-04-26 The Hong Kong Polytechnic University Method of making and administering quinoline derivatives as anti-cancer agents
JP2009079037A (ja) * 2007-09-06 2009-04-16 Sumitomo Chemical Co Ltd アミロイドβタンパク質の蓄積を抑制するための医薬組成物
US8268849B2 (en) * 2007-09-25 2012-09-18 Board Of Regents Of The University Of Nebraska Multifunctional Antioxidants and methods of use thereof
EP2222689B1 (de) * 2007-12-07 2017-03-29 Prana Biotechnology Ltd Verbindungen zur therapie und diagnose
TWI472525B (zh) 2008-12-05 2015-02-11 Otsuka Pharma Co Ltd 喹啉酮化合物及藥學組成物
WO2010068767A1 (en) 2008-12-10 2010-06-17 The Trustees Of The University Of Pennsylvania Small molecule activators of mitochondrial function
WO2010144102A1 (en) * 2009-06-09 2010-12-16 The United States Of America, As Represented By The Secretary Of The Army, On Behalf Of U.S. Army Medical Research And Material Command Pentafluorosulfanyl analogs of mefloquine
MX2019008390A (es) * 2009-06-12 2019-09-09 Abivax Compuestos utiles para tratar cancer.
EP2261214A1 (de) 2009-06-12 2010-12-15 Splicos Sas Zusammensetzungen, die zur Behandlung von vorzeitiger Alterung und insbesondere Hutchinson-Gilford-Syndrom von Nutzen sind
DK2440545T3 (da) * 2009-06-12 2019-07-22 Abivax Forbindelser, der er anvendelige til behandling af cancer
US10253020B2 (en) 2009-06-12 2019-04-09 Abivax Compounds for preventing, inhibiting, or treating cancer, AIDS and/or premature aging
US8680077B2 (en) 2009-07-24 2014-03-25 Duke University Prochelators useful for inhibiting metal-associated toxicity
WO2011022216A1 (en) * 2009-08-17 2011-02-24 High Point Pharmaceuticals, Llc Substituted pyridine derivatives, pharmaceutical compositions, and methods of use to treat oxidative stress
US8409820B2 (en) 2009-08-31 2013-04-02 Massachusetts Institute Of Technology Kinase sensors
EP2353599A1 (de) * 2010-01-28 2011-08-10 University of Ljubljana 8-Hydroxychinoline als Inhibitoren von Cathepsin B
US11701374B1 (en) 2010-05-18 2023-07-18 Sierra Sciences, Inc. 8-hydroxy quinoline derivatives for enhancing telomerase reverse transcriptase (TERT) expression
WO2012066330A1 (en) 2010-11-17 2012-05-24 Heptares Therapeutics Limited Compounds useful as a2a receptor inhibitors
EP2465502A1 (de) 2010-12-15 2012-06-20 Société Splicos Nützliche Verbindungen zur Behandlung von AIDS
CN102584698B (zh) * 2012-01-19 2013-10-09 华南师范大学 一类2-取代-3-喹啉酸乙酯化合物及其制备方法和应用
BR112015007095A8 (pt) 2012-09-28 2019-08-20 Warner Babcock Inst For Green Chemistry Llc derivados de di-hidro-6-azafenaleno para o tratamento de doenças do snc, oncológicas e distúrbios relacionados, composição farmacêutica compreendendoos e uso dos referidos derivados
EP2757161A1 (de) 2013-01-17 2014-07-23 Splicos miRNA-124 als ein Biomarker für virale Infektion
CN103965105A (zh) * 2013-01-29 2014-08-06 中山大学 苯乙烯基喹啉衍生物及其在治疗阿尔茨海默病症中的应用
CN105452224B (zh) * 2013-04-02 2017-12-26 安基生技新药股份有限公司 作为抗神经退化剂的多官能性喹啉衍生物
US9302992B2 (en) 2013-04-02 2016-04-05 Annji Pharmaceutical Co., Ltd. Multifunctional quinoline derivatives as anti-neurodegenerative agents
WO2014194407A1 (en) 2013-06-05 2014-12-11 The University Of British Columbia Anti-fibrogenic compounds, methods and uses thereof
CA2916623C (en) 2013-07-05 2021-09-14 Abivax Bicyclic compounds useful for treating diseases caused by retroviruses
CN103349742B (zh) * 2013-07-08 2015-03-25 张雅静 附子萸肉中药冲剂
GB201403595D0 (en) * 2014-02-28 2014-04-16 Isis Innovation Quinoline compounds
CN103980194B (zh) * 2014-05-15 2016-09-07 浙江省医学科学院 6,8-双取代喹啉化合物或其药学上可接受的盐及其制备方法和应用
EP2974729A1 (de) 2014-07-17 2016-01-20 Abivax Chinolinderivate zur Verwendung bei der Behandlung von Entzündungskrankheiten
EP2975034A1 (de) * 2014-07-17 2016-01-20 Abivax Chinolinderivat zur Behandlung von Entzündungskrankheiten und AIDS
WO2016095205A1 (en) * 2014-12-19 2016-06-23 Merck Sharp & Dohme Corp. Heteroaryl orexin receptor antagonists
US9951057B2 (en) 2015-01-30 2018-04-24 Lieber Institute For Brain Development COMT inhibiting methods and compositions
US10035799B2 (en) 2015-01-30 2018-07-31 Lieber Institute For Brain Development COMT inhibiting methods and compositions
HUP1500098A2 (hu) 2015-03-09 2016-09-28 Avidin Kft 8-hidroxikinolin származékok új enantiomerjei és szintézisük
US10781178B2 (en) 2015-08-12 2020-09-22 The General Hospital Corporation 8-hydroxyquinoline derivatives as diagnostic and therapeutic agents
ES2893613T3 (es) 2015-11-25 2022-02-09 Lieber Inst Inc Dba Lieber Inst For Brain Development Tetrahidro-8H-pirido[1,2-a]pirazin-8-onas como inhibidores de COMT para el tratamiento de trastornos neurodegenerativos
CN105367553A (zh) * 2015-12-04 2016-03-02 广东工业大学 一种他克林-8-羟（胺）基喹啉衍生物及其应用
US11357770B2 (en) 2016-07-01 2022-06-14 Alterity Therapeutics Limited Method of treating immunoglobulin light chain amyloidosis
EP3694515A4 (de) * 2017-10-13 2021-04-21 The University of Queensland Zinkionophore und deren verwendung
EP3866802A1 (de) * 2018-10-17 2021-08-25 Duke University Chinon-reduktase-2-inhibitoren zur verwendung als neuroprotektiva
AU2019404061A1 (en) 2018-12-19 2021-07-22 The Board Of Trustees Of The Leland Stanford Junior University Bifunctional molecules for lysosomal targeting and related compositions and methods
WO2020242157A1 (ko) * 2019-05-31 2020-12-03 건국대학교 글로컬산학협력단 Iox1의 항생제, 항염증제 및 항패혈증제 용도
EP4089083A1 (de) * 2019-09-23 2022-11-16 Accutar Biotechnology Inc. Piperidin-2,6-dion substituierte isoindole in der herstellung von chinolin-8-carbonitril abkömmlingen mit androgen-rezeptor-abbauaktivität und deren verwendung
CN111307957A (zh) * 2019-11-25 2020-06-19 澳美制药(苏州)有限公司 药物制剂中吐温80含量的检测方法
US20230158155A1 (en) * 2020-01-10 2023-05-25 Lycia Therapeutics, Inc. Cell Surface Receptor Binding Compounds and Conjugates
CN112362797B (zh) * 2020-10-26 2022-05-27 浙江国正检测技术有限公司 一种饲料中喹诺酮类药物的检测方法
CN112315963B (zh) * 2020-11-05 2022-02-11 中国科学院包头稀土研发中心 一种8-羟基喹啉稀土金属有机配合物在制备抗SARS-CoV-2试剂中的应用及其制备方法
CN112940075B (zh) * 2021-01-07 2023-03-31 渤海大学 一种乙酰胆碱酯酶抑制肽及其应用
CN112666088B (zh) * 2021-01-21 2023-03-28 上海菁一科技有限公司 一种分光光度测试法样品处理测试胶囊

Family Cites Families (33)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3682927A (en) * 1968-06-15 1972-08-08 Massimo Carissimi 5,7-bichloro-8-hydroxy-2-acetylamino quinoline
JPS58189165A (ja) * 1982-04-22 1983-11-04 ナシヨナル・リサ−チ・デイベロツプメント・コ−ポレイシヨン 抗菌剤
US5021567A (en) * 1987-09-24 1991-06-04 Abbott Laboratories 8-hydroxyquinoline chelating agents
DE3932338A1 (de) 1989-09-28 1991-04-11 Nmi Naturwissenschaftl U Mediz Verfahren zur praeventiven therapie von morbus alzheimer
JPH0597674A (ja) * 1991-10-01 1993-04-20 Nikko Kyodo Co Ltd コラーゲナーゼ阻害剤
IS4164A (is) 1993-06-11 1994-12-12 Ab Astra Efnasambönd sem hindra flæði magasýru
US6231833B1 (en) 1999-08-05 2001-05-15 Pfizer Inc 2,7-substituted octahydro-1H-pyrido[1,2-A]pyrazine derivatives as ligands for serotonin receptors
WO1997009976A2 (en) * 1995-09-01 1997-03-20 Washington University Method of reducing neurotoxic injury with zinc chelators
CZ296163B6 (cs) 1996-05-20 2006-01-11 Karboxyamidy chinolinu jako inhibitory TNF a inhibitory PDE-IV
IL128416A (en) * 1996-08-13 2004-06-01 Gerolymatos P N Sa Use of Clioquinol for the preparation of a pharmaceutical preparation for the treatment of Alzheimer's disease and pharmaceutical preparations containing it
JP3609907B2 (ja) * 1996-09-11 2005-01-12 株式会社クラレ 光学活性テトラヒドロキノリン誘導体の製造方法
EP0835659B1 (de) * 1996-10-14 2004-12-15 Aventis Pharma Deutschland GmbH Verwendung von nicht-peptidischen Bradykinin-Antagonisten zur Herstellung von Arzneimitteln zur Behandlung und Prävention der Alzheimerischen Krankheit
WO1999009981A1 (en) 1997-08-21 1999-03-04 P.N. Gerolymatos S.A. Use of phanquinone for the treatment of alzheimer's disease
US5980914A (en) 1997-08-22 1999-11-09 P.N. Gerolymatos S.A. Clioquinol for the treatment of Parkinson's disease
US6323218B1 (en) * 1998-03-11 2001-11-27 The General Hospital Corporation Agents for use in the treatment of Alzheimer's disease
JP3546715B2 (ja) * 1998-06-16 2004-07-28 三菱マテリアル株式会社 ８−キノリノール誘導体とその金属錯体の製造方法
US6242422B1 (en) * 1998-10-22 2001-06-05 Idun Pharmacueticals, Inc. (Substituted)Acyl dipeptidyl inhibitors of the ice/ced-3 family of cysteine proteases
US6379666B1 (en) * 1999-02-24 2002-04-30 Edward L. Tobinick TNF inhibitors for the treatment of neurological, retinal and muscular disorders
FR2791263B1 (fr) * 1999-03-26 2001-04-27 Halina Zofia Malina Preparations des medicaments bases sur une reponse immunitaire contre l'accumulation de proteines modifiees par l'acide xanthurenique
US6362339B1 (en) * 1999-10-06 2002-03-26 3M Innovative Properties Company Method of making metal 8-quinolinolato complexes
US20040176324A1 (en) * 2000-09-19 2004-09-09 Salvati Mark E. Fused heterocyclic succinimide compounds and analogs thereof, modulators of nuclear hormone receptor function
JP2004509893A (ja) 2000-09-20 2004-04-02 ファルマシア・アンド・アップジョン・カンパニー 置換型アゼピノ［４，５ｂ］インドリン誘導体
JP2002138081A (ja) * 2000-10-30 2002-05-14 Toyo Ink Mfg Co Ltd キノリン系化合物およびその製造方法
US20040087548A1 (en) * 2001-02-27 2004-05-06 Salvati Mark E. Fused cyclic succinimide compounds and analogs thereof, modulators of nuclear hormone receptor function
DE10132725A1 (de) 2001-07-05 2006-08-03 Grünenthal GmbH Substituierte γ-Lactonverbindungen
DE10132726A1 (de) 2001-07-05 2003-02-27 Gruenenthal Gmbh Verwendung von substituierten gamma-Lactonverbindungen als Arzneimittel
FR2827045B1 (fr) 2001-07-05 2007-08-10 Univ Pasteur Methodes et compositions pour la selection et le developpement de nouveaux agents pharmacologiques ou de nouveaux medicaments
FR2827599A1 (fr) * 2001-07-20 2003-01-24 Neuro3D Composes derives de quinoleine et quinoxaline,preparation et utilisations
AP2004003049A0 (en) 2001-11-08 2004-06-30 Elan Pharm Inc N,N' -substituted-1,3-diamino -2-hydroxypropane derivatives.
DE10159453A1 (de) 2001-12-04 2003-06-18 Merck Patent Gmbh Verwendung von 1-Phenyl-oxazolidin-2-on-Verbindungen als Protease
AU2002950217A0 (en) * 2002-07-16 2002-09-12 Prana Biotechnology Limited 8- Hydroxy Quinoline Derivatives
DK2012789T3 (da) 2006-04-14 2013-12-16 Prana Biotechnology Ltd Fremgangsmåde til behandling af aldersrelateret makulær degeneration (AMD)
WO2007147217A1 (en) 2006-06-22 2007-12-27 Prana Biotechnology Limited Method of treatment of glioma brain tumour

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JP2006504646A (ja) 2006-02-09
AU2003243836B2 (en) 2009-06-18
AU2003243836A1 (en) 2004-02-02
JP4694834B2 (ja) 2011-06-08
RU2348618C2 (ru) 2009-03-10
US9169211B2 (en) 2015-10-27
MXPA05000708A (es) 2005-08-16
US20060089380A1 (en) 2006-04-27
BR0312934A (pt) 2005-06-21
KR101149323B1 (ko) 2012-05-30
CN1681791A (zh) 2005-10-12
NZ537677A (en) 2007-10-26
US7619091B2 (en) 2009-11-17
EP1539700B1 (de) 2009-08-26
ES2332715T3 (es) 2010-02-11
EP1539700A1 (de) 2005-06-15
CA2493536A1 (en) 2004-01-22
KR20050036954A (ko) 2005-04-20
AU2002950217A0 (en) 2002-09-12
EP1539700A4 (de) 2006-06-28
ZA200501253B (en) 2006-11-29
CA2493536C (en) 2011-09-06
HK1072940A1 (en) 2005-09-16
WO2004007461A1 (en) 2004-01-22
US8975278B2 (en) 2015-03-10
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DE60329001D1 (en) 2009-10-08
IL166298A (en) 2013-03-24
US20150025108A1 (en) 2015-01-22
US20080161353A1 (en) 2008-07-03
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US20150335635A1 (en) 2015-11-26
CN1681791B (zh) 2013-03-27
IN2006KO01346A (de) 2015-09-04
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