WO2001002383A8 - Process for the synthesis of citalopram - Google Patents
Process for the synthesis of citalopramInfo
- Publication number
- WO2001002383A8 WO2001002383A8 PCT/EP2000/006426 EP0006426W WO0102383A8 WO 2001002383 A8 WO2001002383 A8 WO 2001002383A8 EP 0006426 W EP0006426 W EP 0006426W WO 0102383 A8 WO0102383 A8 WO 0102383A8
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- citalopram
- synthesis
- converted
- halophthalane
- hydrazone
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D307/87—Benzo [c] furans; Hydrogenated benzo [c] furans
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Transition And Organic Metals Composition Catalysts For Addition Polymerization (AREA)
- Catalysts (AREA)
Abstract
Priority Applications (12)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
AU64328/00A AU6432800A (en) | 1999-07-06 | 2000-07-06 | Process for the synthesis of citalopram |
SK336-2002A SK3362002A3 (en) | 2000-07-06 | 2001-07-06 | Method for the preparation of citalopram |
CA002383963A CA2383963A1 (en) | 2000-07-06 | 2001-07-06 | Method for the preparation of citalopram |
IL14852501A IL148525A0 (en) | 2000-07-06 | 2001-07-06 | Method for the preparation of citalopram |
CZ2002832A CZ2002832A3 (en) | 2000-07-06 | 2001-07-06 | Process for preparing citalopram |
AU2001272368A AU2001272368A1 (en) | 2000-07-06 | 2001-07-06 | Method for the preparation of citalopram |
BR0106976-4A BR0106976A (en) | 2000-07-06 | 2001-07-06 | Method for the preparation of citalopram |
EA200200332A EA200200332A1 (en) | 2000-07-06 | 2001-07-06 | METHOD OF OBTAINING CYTALOPRAMA |
PCT/DK2001/000481 WO2002004435A1 (en) | 2000-07-06 | 2001-07-06 | Method for the preparation of citalopram |
IS6293A IS6293A (en) | 2000-07-06 | 2002-03-05 | Method for producing citalopram |
US10/096,149 US20020128497A1 (en) | 2000-07-06 | 2002-03-06 | Method for the preparation of citalopram |
NO20021118A NO20021118L (en) | 2000-07-06 | 2002-03-06 | Process for the preparation of citalopram |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
IT1999MI001486A ITMI991486A1 (en) | 1999-07-06 | 1999-07-06 | PROCESS FOR THE SYNTHESIS OF CITALOPRAM |
Publications (3)
Publication Number | Publication Date |
---|---|
WO2001002383A2 WO2001002383A2 (en) | 2001-01-11 |
WO2001002383A3 WO2001002383A3 (en) | 2001-05-03 |
WO2001002383A8 true WO2001002383A8 (en) | 2001-10-18 |
Family
ID=11383286
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/EP2000/006426 WO2001002383A2 (en) | 1999-07-06 | 2000-07-06 | Process for the synthesis of citalopram |
Country Status (3)
Country | Link |
---|---|
AU (1) | AU6432800A (en) |
IT (1) | ITMI991486A1 (en) |
WO (1) | WO2001002383A2 (en) |
Families Citing this family (15)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
ATE237604T1 (en) | 1999-04-14 | 2003-05-15 | Lundbeck & Co As H | METHOD FOR PRODUCING CITALOPRAM |
NL1017417C1 (en) | 2000-03-03 | 2001-03-16 | Lundbeck & Co As H | Process for the preparation of Citalopram. |
GB0005477D0 (en) | 2000-03-07 | 2000-04-26 | Resolution Chemicals Limited | Process for the preparation of citalopram |
AR032455A1 (en) | 2000-05-12 | 2003-11-12 | Lundbeck & Co As H | METHOD FOR THE PREPARATION OF CITALOPRAM, AN INTERMEDIARY EMPLOYED IN THE METHOD, A METHOD FOR THE PREPARATION OF THE INTERMEDIARY EMPLOYED IN THE METHOD AND PHARMACEUTICAL COMPOSITION ANTIDEPRESSIVE |
BR0106976A (en) * | 2000-07-06 | 2002-07-23 | Lundbeck & Co As H | Method for the preparation of citalopram |
SG167655A1 (en) * | 2000-12-22 | 2011-01-28 | Lundbeck & Co As H | Method for the preparation of pure citalopram |
CA2435925A1 (en) | 2001-01-30 | 2002-08-08 | Orion Corporation Fermion | Process for the preparation of 1-(3-dimethylaminopropyl)-1-(4-fluorophenyl)-1,3-dihydroisobenzofuran-5-carbonitrile |
DK1281707T3 (en) * | 2001-08-02 | 2005-05-02 | Infosint Sa | Process for the preparation of 5-substituted isobenzene furans |
WO2003057132A2 (en) | 2002-01-07 | 2003-07-17 | Sun Pharmaceutical Industries Limited | Process for the preparation of 1-[3-(dimethylamino)propyl]-1-(4-fluorophenyl)- 1,3-dihydro-5-isobenzofuran carbonitrile |
AR040970A1 (en) | 2002-08-12 | 2005-04-27 | Lundbeck & Co As H | METHOD FOR THE SEPARATION OF INTERMEDIARIES THAT CAN BE USED FOR THE PREPARATION OF SCITALOPRAM |
TWI339651B (en) | 2004-02-12 | 2011-04-01 | Lundbeck & Co As H | Method for the separation of intermediates which may be used for the preparation of escitalopram |
EP2141156A1 (en) | 2004-08-23 | 2010-01-06 | Sun Pharma Global FZE | Process for Preparation of Citalopram and Enantiomers |
CN102503759B (en) * | 2011-10-27 | 2013-10-09 | 天津大学 | Method and device for simultaneously recycling methylbenzene and dimethyl formamide in industrial waste gas by using solvent |
CN111533662B (en) * | 2020-04-07 | 2022-08-23 | 福建海西新药创制有限公司 | Synthesis method of citalopram intermediate |
CN114763343A (en) * | 2021-01-14 | 2022-07-19 | 浙江华海药业股份有限公司 | Method for purifying citalopram or S-citalopram |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB1526331A (en) * | 1976-01-14 | 1978-09-27 | Kefalas As | Phthalanes |
GB8419963D0 (en) * | 1984-08-06 | 1984-09-12 | Lundbeck & Co As H | Intermediate compound and method |
ES2148120T3 (en) * | 1997-07-08 | 2002-01-16 | Lundbeck & Co As H | METHOD FOR THE PREPARATION OF CITALOPRAM. |
ES2149734T3 (en) * | 1997-11-11 | 2003-02-16 | Lundbeck & Co As H | METHOD FOR THE PREPARATION OF CITALOPRAM. |
-
1999
- 1999-07-06 IT IT1999MI001486A patent/ITMI991486A1/en unknown
-
2000
- 2000-07-06 WO PCT/EP2000/006426 patent/WO2001002383A2/en active Search and Examination
- 2000-07-06 AU AU64328/00A patent/AU6432800A/en not_active Withdrawn
Also Published As
Publication number | Publication date |
---|---|
WO2001002383A3 (en) | 2001-05-03 |
ITMI991486A0 (en) | 1999-07-06 |
AU6432800A (en) | 2001-01-22 |
ITMI991486A1 (en) | 2001-01-06 |
WO2001002383A2 (en) | 2001-01-11 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
WO2001002383A8 (en) | Process for the synthesis of citalopram | |
Corey et al. | Highly enantioselective borane reduction of ketones catalyzed by chiral oxazaborolidines. Mechanism and synthetic implications | |
CA2291068A1 (en) | Method for the preparation of citalopram | |
Tamaru et al. | Stereoselective generation of Z-enolates of thioamides: its application to diastereoselective aldol condensations and thio-Claisen rearrangements | |
ATE259344T1 (en) | CHEMICAL COMPOUND USABLE AS EXPLOSIVE, INTERMEDIATE AND PROCESS FOR PRODUCING THE COMPOUND | |
WO2001074741A3 (en) | Catalytic asymmetric desymmetrization of meso compounds | |
NO993162L (en) | Oxygen atom formation using non-zeolite small pore molecular sieve catalysts | |
Ezoe et al. | Remarkably High 1, 5‐Diastereoselectivity in a Nickel‐Catalyzed Conjugate Addition of Me2Zn and Carbonyl Compounds to 1, ω‐Dienynes with Through‐Space Coupling | |
Rajagopal et al. | Asymmetric synthesis without solvent | |
Sahu et al. | Selective oxidation of arylaldoximes by cetyltrimethylammonium dichromate to arylaldehydes and arylnitriles | |
HUP0000313A3 (en) | Process for the solid phase synthesis of aldehydes ,ketones, oximes, amines and hidroxamic acid compounds | |
Hegedüs et al. | Zeolite-catalyzed simple synthesis of isochromans via the oxa-Pictet–Spengler reaction | |
NZ505897A (en) | Method for producing (-)cis-3-hydroxy-1-methyl-4-(2,4,6- trimethoxyphenyl)-piperidine | |
CA2130915A1 (en) | Purification of 6-aminocapronitrile | |
EP1193251A3 (en) | Method for producing E-caprolactam and reactor for the method | |
Ito et al. | Practical method for synthesis of optically pure propargylic alcohols | |
Kleinman et al. | Total synthesis of (±)-Lycodine | |
Domon et al. | Highly efficient method for coriolin synthesis | |
DE69930940D1 (en) | SYNTHESIS OF COMPOUNDS FOR THE PREPARATION OF KETOROLAC | |
Chavan et al. | An efficient synthesis of α-Cuparenone | |
Labeeuw et al. | An efficient ruthenium‐catalyzed formal synthesis of (−)‐isoavenaciolide | |
Au | Cyano-Carbonates (I) Efficient Latent Acyl Carbanions | |
Jacobi et al. | A novel synthesis of pyrromethenones | |
Sasidharan et al. | Titanium silicate molecular sieves (TS-1 and TS-2) catalyzed Michael reaction of silyl enol ethers with α, β unsaturated carbonyl compounds | |
Baker et al. | Spiroacetal synthesis from a key lactone intermediate leading to novel C24 and C25-substituted milbemycins |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
AK | Designated states |
Kind code of ref document: A2 Designated state(s): AE AG AL AM AT AU AZ BA BB BG BR BY BZ CA CH CN CR CU CZ DE DK DM DZ EE ES FI GB GD GE GH GM HR HU ID IL IN IS JP KE KG KP KR KZ LC LK LR LS LT LU LV MA MD MG MK MN MW MX MZ NO NZ PL PT RO RU SD SE SG SI SK SL TJ TM TR TT TZ UA UG US UZ VN YU ZA ZW |
|
AL | Designated countries for regional patents |
Kind code of ref document: A2 Designated state(s): GH GM KE LS MW MZ SD SL SZ TZ UG ZW AM AZ BY KG KZ MD RU TJ TM AT BE CH CY DE DK ES FI FR GB GR IE IT LU MC NL PT SE BF BJ CF CG CI CM GA GN GW ML MR NE SN TD TG |
|
121 | Ep: the epo has been informed by wipo that ep was designated in this application | ||
DFPE | Request for preliminary examination filed prior to expiration of 19th month from priority date (pct application filed before 20040101) | ||
AK | Designated states |
Kind code of ref document: A3 Designated state(s): AE AG AL AM AT AU AZ BA BB BG BR BY BZ CA CH CN CR CU CZ DE DK DM DZ EE ES FI GB GD GE GH GM HR HU ID IL IN IS JP KE KG KP KR KZ LC LK LR LS LT LU LV MA MD MG MK MN MW MX MZ NO NZ PL PT RO RU SD SE SG SI SK SL TJ TM TR TT TZ UA UG US UZ VN YU ZA ZW |
|
AL | Designated countries for regional patents |
Kind code of ref document: A3 Designated state(s): GH GM KE LS MW MZ SD SL SZ TZ UG ZW AM AZ BY KG KZ MD RU TJ TM AT BE CH CY DE DK ES FI FR GB GR IE IT LU MC NL PT SE BF BJ CF CG CI CM GA GN GW ML MR NE SN TD TG |
|
AK | Designated states |
Kind code of ref document: C1 Designated state(s): AE AG AL AM AT AU AZ BA BB BG BR BY BZ CA CH CN CR CU CZ DE DK DM DZ EE ES FI GB GD GE GH GM HR HU ID IL IN IS JP KE KG KP KR KZ LC LK LR LS LT LU LV MA MD MG MK MN MW MX MZ NO NZ PL PT RO RU SD SE SG SI SK SL TJ TM TR TT TZ UA UG US UZ VN YU ZA ZW |
|
AL | Designated countries for regional patents |
Kind code of ref document: C1 Designated state(s): GH GM KE LS MW MZ SD SL SZ TZ UG ZW AM AZ BY KG KZ MD RU TJ TM AT BE CH CY DE DK ES FI FR GB GR IE IT LU MC NL PT SE BF BJ CF CG CI CM GA GN GW ML MR NE SN TD TG |
|
CFP | Corrected version of a pamphlet front page | ||
CR1 | Correction of entry in section i |
Free format text: PAT. BUL. 02/2001 UNDER (30) DELETE "MI99A001486, 06.07.99, IT" |
|
REG | Reference to national code |
Ref country code: DE Ref legal event code: 8642 |