NO20011936D0 - Fremgangsmåte for fremstilling av Citalopram - Google Patents

Fremgangsmåte for fremstilling av Citalopram

Info

Publication number
NO20011936D0
NO20011936D0 NO20011936A NO20011936A NO20011936D0 NO 20011936 D0 NO20011936 D0 NO 20011936D0 NO 20011936 A NO20011936 A NO 20011936A NO 20011936 A NO20011936 A NO 20011936A NO 20011936 D0 NO20011936 D0 NO 20011936D0
Authority
NO
Norway
Prior art keywords
citalopram
preparation
Prior art date
Application number
NO20011936A
Other languages
English (en)
Other versions
NO327038B1 (no
NO20011936L (no
Inventor
Asta Leone Dall
Umberto Casazza
Hans Petersen
Original Assignee
Lundbeck & Co As H
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from IT002242 external-priority patent/IT1302700B1/it
Priority claimed from IT1999MI001152 external-priority patent/IT1312319B1/it
Priority claimed from IT99MI001724 external-priority patent/IT1313587B1/it
Application filed by Lundbeck & Co As H filed Critical Lundbeck & Co As H
Publication of NO20011936D0 publication Critical patent/NO20011936D0/no
Publication of NO20011936L publication Critical patent/NO20011936L/no
Publication of NO327038B1 publication Critical patent/NO327038B1/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/87—Benzo [c] furans; Hydrogenated benzo [c] furans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
    • C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
    • C07D263/08—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D263/10—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C07D263/14—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms with radicals substituted by oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
NO20011936A 1998-10-20 2001-04-19 Fremgangsmate for fremstilling av citalopram NO327038B1 (no)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
IT002242 IT1302700B1 (it) 1998-10-20 1998-10-20 Procedimento per la preparazione di un derivato dell'isobenzofurano
IT1999MI001152 IT1312319B1 (it) 1999-05-25 1999-05-25 Procedimento per la preparazione del citalopram.
IT99MI001724 IT1313587B1 (it) 1999-08-02 1999-08-02 Procedimento per la preparazione di un derivato del5-cianoisobenzofurano.
PCT/DK1999/000576 WO2000023431A1 (en) 1998-10-20 1999-10-19 Method for the preparation of citalopram

Publications (3)

Publication Number Publication Date
NO20011936D0 true NO20011936D0 (no) 2001-04-19
NO20011936L NO20011936L (no) 2001-06-01
NO327038B1 NO327038B1 (no) 2009-04-06

Family

ID=27274104

Family Applications (1)

Application Number Title Priority Date Filing Date
NO20011936A NO327038B1 (no) 1998-10-20 2001-04-19 Fremgangsmate for fremstilling av citalopram

Country Status (25)

Country Link
US (1) US6365747B1 (no)
EP (1) EP1123284B1 (no)
JP (1) JP3892667B2 (no)
KR (1) KR100411505B1 (no)
CN (1) CN1129592C (no)
AR (1) AR018693A1 (no)
AT (1) ATE230738T1 (no)
AU (1) AU746665B2 (no)
BG (1) BG64704B1 (no)
BR (1) BR9915158B1 (no)
CA (1) CA2291134C (no)
CZ (1) CZ299920B6 (no)
DE (1) DE69904853T2 (no)
DK (1) DK1123284T3 (no)
EA (1) EA002977B1 (no)
ES (1) ES2189502T3 (no)
HK (1) HK1042297B (no)
HU (1) HU228576B1 (no)
IL (1) IL142346A0 (no)
IS (1) IS2256B (no)
NO (1) NO327038B1 (no)
NZ (1) NZ510858A (no)
PL (1) PL199423B1 (no)
SK (1) SK285719B6 (no)
WO (1) WO2000023431A1 (no)

Families Citing this family (50)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PT1140886E (pt) 1998-12-23 2003-08-29 Lundbeck & Co As H Metodo para a preparacao de 5- cianoftalida
AR022329A1 (es) 1999-01-29 2002-09-04 Lundbeck & Co As H Metodo para la preparacion de 5-cianoftalida
ES2195554T5 (es) * 1999-04-14 2010-02-02 H. Lundbeck A/S Metodo para la preparacion de citalopram.
ITMI991581A1 (it) * 1999-06-25 2001-01-15 Lundbeck & Co As H Metodo per la preparazione di citalopram
ITMI991579A1 (it) 1999-06-25 2001-01-15 Lundbeck & Co As H Metodo per la preparazione di citalopram
AR021155A1 (es) * 1999-07-08 2002-06-12 Lundbeck & Co As H Tratamiento de desordenes neuroticos
TR200401456T1 (tr) 1999-10-25 2005-04-21 H. Lundbeck A/S Sitalopram hazırlanması için yöntem.
ES2169709A1 (es) 1999-10-25 2002-07-01 Lundbeck & Co As H Metodo para la preparacion de citalopram
AR026063A1 (es) 1999-11-01 2002-12-26 Lundbeck & Co As H Metodo para la preparacion de 5-carboxiftalida.
AU778751B2 (en) 1999-12-28 2004-12-16 H. Lundbeck A/S Method for the preparation of citalopram
ATE253568T1 (de) 1999-12-30 2003-11-15 Lundbeck & Co As H Verfahren zur herstellung von citalopram
WO2001051477A1 (en) 2000-01-14 2001-07-19 H. Lundbeck A/S Method for the preparation of 5-cyanophthalide
IT1317729B1 (it) 2000-01-18 2003-07-15 Norpharma S P A Procedimento per la preparazione della 5-carbossiftalide.
FR2805812A1 (fr) 2000-02-24 2001-09-07 Lundbeck & Co As H Procede de preparation du citalopram
NL1017417C1 (nl) 2000-03-03 2001-03-16 Lundbeck & Co As H Werkwijze voor de bereiding van Citalopram.
GB0005477D0 (en) * 2000-03-07 2000-04-26 Resolution Chemicals Limited Process for the preparation of citalopram
PL360110A1 (en) * 2000-03-13 2004-09-06 H.Lundbeck A/S Method for the preparation of citalopram
GB2357762B (en) 2000-03-13 2002-01-30 Lundbeck & Co As H Crystalline base of citalopram
NL1017500C1 (nl) 2000-03-13 2001-04-26 Lundbeck & Co As H Werkwijze voor de bereiding van Citalopram.
JP2003527385A (ja) * 2000-03-13 2003-09-16 ハー・ルンドベック・アクチエゼルスカベット ５−置換された１−（４−フルオロフェニル）−１，３−ジヒドロイソベンゾフランの段階的アルキル化法
PL360107A1 (en) 2000-03-14 2004-09-06 H.Lundbeck A/S Method for the preparation of citalopram
CZ20023406A3 (cs) * 2000-03-16 2003-01-15 H. Lundbeck A/S Způsob výroby 5-kyano-1-(4-fluorfenyl)-1,3-dihydroisobenzofuranu
US6977306B2 (en) 2000-05-02 2005-12-20 Sumitomo Chemical Company, Limited Citalopram hydrobromide crystal and method for crystallization thereof
AR032455A1 (es) 2000-05-12 2003-11-12 Lundbeck & Co As H Metodo para la preparacion de citalopram, un intermediario empleado en el metodo, un metodo para la preparacion del intermediario empleado en el metodo y composicion farmaceutica antidepresiva
IL144817A0 (en) 2000-08-18 2002-06-30 Lundbeck & Co As H Method for the preparation of citalopram
CA2360303C (en) * 2000-12-22 2003-08-12 Marco Villa Process for the preparation of pure citalopram
EP1181272B1 (en) * 2000-12-28 2002-08-28 H. Lundbeck A/S Process for the preparation of pure citalopram
CA2435925A1 (en) 2001-01-30 2002-08-08 Orion Corporation Fermion Process for the preparation of 1-(3-dimethylaminopropyl)-1-(4-fluorophenyl)-1,3-dihydroisobenzofuran-5-carbonitrile
US20040198809A1 (en) * 2001-05-01 2004-10-07 Connie Sanchez Use of enantiomeric pure escitalopram
TR200400189T2 (tr) 2001-07-31 2004-12-21 H.Lundbeck A/S Esitalopram içeren kristal yapılı bileşim.
IS7239A (is) * 2001-12-14 2004-04-29 H. Lundbeck A/S Aðferð til framleiðslu á essítalóprami
WO2003057132A2 (en) 2002-01-07 2003-07-17 Sun Pharmaceutical Industries Limited Process for the preparation of 1-[3-(dimethylamino)propyl]-1-(4-fluorophenyl)- 1,3-dihydro-5-isobenzofuran carbonitrile
WO2003064617A2 (en) * 2002-01-30 2003-08-07 Montana State University Pestalotiopsis microsporia isolates and compounds derived therefrom
CA2381341A1 (en) * 2002-04-09 2003-10-09 Torcan Chemical Ltd. Process and intermediates for preparing escitalopram
PE20040991A1 (es) 2002-08-12 2004-12-27 Lundbeck & Co As H Separacion de intermediarios para la preparacion de escitalopram
US6812355B2 (en) 2002-10-22 2004-11-02 Sekhsaria Chemicals Limited Process for the manufacture of citalopram hydrobromide from 5-bromophthalide
PT1578738E (pt) * 2002-12-23 2008-04-11 Lundbeck & Co As H Bromidrato de escitalopram e um método para a sua preparação
EP1486492A3 (en) 2003-06-10 2005-02-23 Sun Pharmaceuticals Industries Ltd. A process for hydrogenolysis of [1-(3-dimethylamino)propyl)]-1-(4-fluorophenyl)-1,3-dihydro-5-halo-isobenzofuran.
CN100569765C (zh) * 2003-12-19 2009-12-16 杭州民生药业集团有限公司 西酞普兰中间体晶体碱
TWI339651B (en) 2004-02-12 2011-04-01 Lundbeck & Co As H Method for the separation of intermediates which may be used for the preparation of escitalopram
ITMI20040717A1 (it) * 2004-04-09 2004-07-09 Adorkem Technology Spa Procedimento chemo-enzimatico per la preparazione dell'escitalopram
JP2006008603A (ja) * 2004-06-25 2006-01-12 Sumitomo Chemical Co Ltd 光学活性シタロプラムの製造方法、その中間体およびその製造方法
DE05815687T1 (de) 2004-08-23 2007-10-18 Sun Pharmaceutical Industries Ltd. Verfahren zur herstellung von citalopram und enantiomeren
WO2006090409A1 (en) * 2005-02-28 2006-08-31 Kekule Pharma Ltd., An improved process for the preparation of 5 - carboxyphthalide
KR20080004575A (ko) * 2005-05-04 2008-01-09 팜드 메디케어 프리베이트 리미티드 염소화 반응을 위한 디(트리클로로메틸)카보네이트 유래의빌스마이어 헥크 시약의 합성
CN101157674B (zh) * 2005-07-12 2010-04-14 西陇化工股份有限公司 西酞普兰盐的提纯方法
US8258291B2 (en) * 2006-10-25 2012-09-04 Mamtek International Limited Process for the preparation of sucralose by the chlorination of sugar with triphosgene (BTC)
US9339500B2 (en) * 2008-03-04 2016-05-17 Intra-Cellular Therapies, Inc. Methods of treating vasomotor symptoms
US9346777B2 (en) * 2012-09-06 2016-05-24 MediSynergics, LLC Antiprotozoal compounds
US9284291B2 (en) * 2014-07-29 2016-03-15 MediSynergies, LLC Kappa opioid receptor compounds

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1143702A (no) 1965-03-18
GB1526331A (en) 1976-01-14 1978-09-27 Kefalas As Phthalanes
GB8419963D0 (en) 1984-08-06 1984-09-12 Lundbeck & Co As H Intermediate compound and method
GB8814057D0 (en) * 1988-06-14 1988-07-20 Lundbeck & Co As H New enantiomers & their isolation
DK213290D0 (da) * 1990-09-06 1990-09-06 Lundbeck & Co As H Treatment of cerebrovascular disorders
DE19626659A1 (de) 1996-07-03 1998-01-08 Basf Ag Verfahren zur Herstellung von Phthaliden
DE19627697A1 (de) 1996-07-10 1998-01-15 Basf Ag Verfahren zur Herstellung von Phthaliden
DK1015416T3 (da) * 1997-07-08 2001-11-05 Lundbeck & Co As H Fremgangsmåde til fremstilling af citalopram
UA62985C2 (en) * 1997-11-10 2004-01-15 Lunnbeck As H A method for the preparation of citalopram
JP3813820B2 (ja) * 1997-11-11 2006-08-23 ハー・ルンドベック・アクチエゼルスカベット シタロプラムの製造方法
PT1140886E (pt) 1998-12-23 2003-08-29 Lundbeck & Co As H Metodo para a preparacao de 5- cianoftalida
AR022329A1 (es) 1999-01-29 2002-09-04 Lundbeck & Co As H Metodo para la preparacion de 5-cianoftalida
ES2195554T5 (es) 1999-04-14 2010-02-02 H. Lundbeck A/S Metodo para la preparacion de citalopram.
ES2169709A1 (es) 1999-10-25 2002-07-01 Lundbeck & Co As H Metodo para la preparacion de citalopram
US6310222B1 (en) 1999-11-01 2001-10-30 Sumika Fine Chemicals Co., Ltd. Production method of 5-phthalancarbonitrile compound, intermediate therefor and production method of the intermediate

Also Published As

Publication number Publication date
EA200100457A1 (ru) 2001-10-22
CZ299920B6 (cs) 2008-12-29
KR20010080236A (ko) 2001-08-22
CN1324351A (zh) 2001-11-28
NO327038B1 (no) 2009-04-06
DK1123284T3 (da) 2003-04-28
JP2002527511A (ja) 2002-08-27
CZ20011418A3 (cs) 2001-10-17
BR9915158B1 (pt) 2012-02-22
IS5911A (is) 2001-03-30
AU746665B2 (en) 2002-05-02
NZ510858A (en) 2003-11-28
BG105457A (en) 2001-12-29
DE69904853T2 (de) 2003-09-04
ES2189502T3 (es) 2003-07-01
EP1123284B1 (en) 2003-01-08
HU228576B1 (en) 2013-04-29
IL142346A0 (en) 2002-03-10
CN1129592C (zh) 2003-12-03
EA002977B1 (ru) 2002-12-26
CA2291134C (en) 2006-05-23
JP3892667B2 (ja) 2007-03-14
AR018693A1 (es) 2001-11-28
HK1042297B (zh) 2004-09-10
PL199423B1 (pl) 2008-09-30
CA2291134A1 (en) 2000-04-20
BR9915158A (pt) 2001-08-07
SK285719B6 (sk) 2007-07-06
SK5352001A3 (en) 2002-02-05
BG64704B1 (bg) 2005-12-30
AU6326099A (en) 2000-05-08
US6365747B1 (en) 2002-04-02
DE69904853D1 (de) 2003-02-13
HK1042297A1 (en) 2002-08-09
HUP0104128A3 (en) 2003-01-28
HUP0104128A2 (hu) 2002-04-29
IS2256B (is) 2007-06-15
EP1123284A1 (en) 2001-08-16
WO2000023431A1 (en) 2000-04-27
KR100411505B1 (ko) 2003-12-18
PL347189A1 (en) 2002-03-25
NO20011936L (no) 2001-06-01
ATE230738T1 (de) 2003-01-15

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Representative=s name: PLOUGMANN & VINGTOFT, POSTBOKS 1003 SENTRUM, 0104

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