IL58849A
(en)
*
|
1978-12-11 |
1983-03-31 |
Merck & Co Inc |
Carboxyalkyl dipeptides and derivatives thereof,their preparation and pharmaceutical compositions containing them
|
US4595675A
(en)
*
|
1979-09-19 |
1986-06-17 |
Hoechst Aktiengesellschaft |
Bicyclic α-iminocarboxylic acid compounds having hypotensive activity
|
US4616031A
(en)
*
|
1979-12-07 |
1986-10-07 |
Adir |
Perhydroindole-2-carboxylic acids as antihypertensives
|
US4508729A
(en)
*
|
1979-12-07 |
1985-04-02 |
Adir |
Substituted iminodiacids, their preparation and pharmaceutical compositions containing them
|
FR2503155A2
(fr)
*
|
1980-10-02 |
1982-10-08 |
Science Union & Cie |
Nouveaux imino diacides substitues, leurs procedes de preparation et leur emploi comme inhibiteur d'enzyme
|
US4616030A
(en)
*
|
1979-12-07 |
1986-10-07 |
Adir |
Perhydroindole-2-carboxylic acids as antihypertensives
|
US4644008A
(en)
*
|
1979-12-07 |
1987-02-17 |
Adir |
Perhydroindole-2-carboxylic acids as antihypertensives
|
US4616029A
(en)
*
|
1979-12-07 |
1986-10-07 |
Adir |
Perhydromdole-2-carboxylic acids as antihypertensives
|
JPS5683483A
(en)
*
|
1979-12-13 |
1981-07-08 |
Santen Pharmaceut Co Ltd |
Thiazolidine compound
|
IE52663B1
(en)
*
|
1980-04-02 |
1988-01-20 |
Warner Lambert Co |
Substituted acyl derivatives of octahydro-1h-indole-2-carboxylic acids
|
US4350704A
(en)
*
|
1980-10-06 |
1982-09-21 |
Warner-Lambert Company |
Substituted acyl derivatives of octahydro-1H-indole-2-carboxylic acids
|
FR2480747A1
(fr)
*
|
1980-04-17 |
1981-10-23 |
Roques Bernard |
Derives d'acides amines et leur application therapeutique
|
GR74625B
(no)
*
|
1980-08-18 |
1984-06-29 |
Merck & Co Inc |
|
IL63540A0
(en)
*
|
1980-08-18 |
1981-11-30 |
Merck & Co Inc |
Substituted enantholactam derivatives as antihypertensives
|
GR74635B
(no)
*
|
1980-08-18 |
1984-06-29 |
Merck & Co Inc |
|
EP0048159A3
(en)
*
|
1980-09-17 |
1982-05-12 |
University Of Miami |
Novel carboxyalkyl peptides and thioethers and ethers of peptides as antihypertensive agents
|
US4344949A
(en)
*
|
1980-10-03 |
1982-08-17 |
Warner-Lambert Company |
Substituted acyl derivatives of 1,2,3,4-tetrahydroisoquinoline-3-carboxylic acids
|
GR75775B
(no)
*
|
1980-10-06 |
1984-08-02 |
Merck & Co Inc |
|
EP0050800B2
(en)
*
|
1980-10-23 |
1995-06-07 |
Schering Corporation |
Carboxyalkyl dipeptides, processes for their production and pharmaceutical compositions containing them
|
ZA817261B
(en)
*
|
1980-10-23 |
1982-09-29 |
Schering Corp |
Carboxyalkyl dipeptides,processes for their production and pharmaceutical compositions containing them
|
US4296110A
(en)
*
|
1980-10-28 |
1981-10-20 |
E. I. Du Pont De Nemours And Company |
Antihypertensive I-substituted cyclic lactam-2-carboxylic acids
|
AU543804B2
(en)
*
|
1980-10-31 |
1985-05-02 |
Takeda Chemical Industries Ltd. |
Amides having bicyclic substituents on nitrogen
|
GB2086390B
(en)
*
|
1980-11-03 |
1984-06-06 |
Ciba Geigy Ag |
1-carboxy-azaalkanoylindoline-2-carboxylic acids process for their manufacture pharmaceutical preparations containing these compounds and their therapeutic application
|
US4462943A
(en)
*
|
1980-11-24 |
1984-07-31 |
E. R. Squibb & Sons, Inc. |
Carboxyalkyl amino acid derivatives of various substituted prolines
|
IE53315B1
(en)
*
|
1980-12-18 |
1988-10-12 |
Schering Corp |
Substituted dipeptides,processes for their preparation and pharmaceutical compositions containing them and their use in the inhibition of enkephalinase
|
CY1406A
(en)
*
|
1980-12-18 |
1988-04-22 |
Schering Corp |
Substituted dipeptides, processes for their preparation and pharmaceutical compositions containing them and their use in the inhibition of enkephalinase
|
US4906615A
(en)
*
|
1980-12-18 |
1990-03-06 |
Schering Corporation |
Substituted dipeptides as inhibitors of enkephalinases
|
EP0057998B1
(en)
*
|
1981-01-23 |
1984-08-08 |
Takeda Chemical Industries, Ltd. |
Alicyclic compounds, their production and use
|
US4532342A
(en)
*
|
1981-02-20 |
1985-07-30 |
Warner-Lambert Company |
N-substituted amino acids as intermediates in the preparation of acyl derivatives of 1,2,3,4-tetrahydroisoquinoline-3-carboxylic acids
|
EP0059966B1
(en)
*
|
1981-03-09 |
1986-08-13 |
Merck & Co. Inc. |
Substituted thiazolidine carboxylic acid analogs and derivatives as antihypertensives
|
US4512979A
(en)
|
1981-03-23 |
1985-04-23 |
Merck & Co., Inc. |
Dipeptides containing thialysine and related amino acids as antihypertensives
|
US4820729A
(en)
*
|
1981-03-30 |
1989-04-11 |
Rorer Pharmaceutical Corporation |
N-substituted-amido-amino acids
|
AU556932B2
(en)
*
|
1981-03-30 |
1986-11-27 |
Usv Pharmaceutical Corp. |
Dipetide with heterocyclic groiup
|
US4510322A
(en)
*
|
1981-07-13 |
1985-04-09 |
Merck & Co., Inc. |
Indacrinone having enhanced uricosuric
|
US4454291A
(en)
*
|
1981-07-20 |
1984-06-12 |
American Home Products Corporation |
N-(2-Substituted-1-oxoalkyl)-2,3-dihydro-1H-indole-2-carboxylic acid derivatives
|
US4454292A
(en)
*
|
1981-07-20 |
1984-06-12 |
American Home Products Corporation |
N-[2-Substituted-1-oxoalkyl]-2,3-dihydro-1H-indole-2-carboxylic acid derivatives
|
CS226907B1
(en)
*
|
1981-08-07 |
1984-04-16 |
Kasafirek Evzen |
Alkylamides of carboxyalkanoylpeptides
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US4766110A
(en)
*
|
1981-08-21 |
1988-08-23 |
Ryan James W |
Novel complex amido and imido derivatives of carboxyalkyl peptides
|
ZA826022B
(en)
*
|
1981-08-21 |
1983-08-31 |
Univ Miami |
Novel complex amido and imido derivatives of carboxyalkyl peptides and thioethers and ethers of peptides
|
DE3226768A1
(de)
*
|
1981-11-05 |
1983-05-26 |
Hoechst Ag, 6230 Frankfurt |
Derivate der cis, endo-2-azabicyclo-(3.3.0)-octan-3-carbonsaeure, verfahren zu ihrer herstellung, diese enthaltende mittel und deren verwendung
|
EP0079521A1
(en)
*
|
1981-11-09 |
1983-05-25 |
Merck & Co. Inc. |
Process for preparation of carboxyalkyldipeptide derivatives
|
US4410520A
(en)
*
|
1981-11-09 |
1983-10-18 |
Ciba-Geigy Corporation |
3-Amino-[1]-benzazepin-2-one-1-alkanoic acids
|
EP0079522B1
(en)
*
|
1981-11-09 |
1986-05-07 |
Merck & Co. Inc. |
N-carboxymethyl(amidino)lysyl-proline antihypertensive agents
|
EP0081094A1
(en)
*
|
1981-11-12 |
1983-06-15 |
Merck & Co. Inc. |
Substituted omega-amino-carboxymethyldipeptide antihypertensive agents
|
EP0080822A1
(en)
*
|
1981-11-27 |
1983-06-08 |
Beecham Group Plc |
Anti-hypertensive prolinol-based peptides
|
US4503043A
(en)
*
|
1981-12-07 |
1985-03-05 |
Warner-Lambert Company |
Substituted acyl derivatives of octahydro-1H-isoindole-1-carboxylic acids
|
GR78413B
(no)
*
|
1981-12-29 |
1984-09-27 |
Hoechst Ag |
|
US4555502A
(en)
*
|
1982-09-30 |
1985-11-26 |
Merck & Co., Inc. |
Aminoacyl-containing dipeptide derivatives useful as antihypertensives
|
JPS58126851A
(ja)
*
|
1982-01-11 |
1983-07-28 |
メルク エンド カムパニー インコーポレーテッド |
抗高血圧剤として有用なアミノアシル含有ジペプチド誘導体
|
DE3378266D1
(en)
*
|
1982-01-11 |
1988-11-24 |
Merck & Co Inc |
Aminoacyl-containing dipeptide derivatives useful as antihypertensives
|
IE54551B1
(en)
*
|
1982-01-22 |
1989-11-22 |
Ici Plc |
Amide derivatives
|
US4665087A
(en)
*
|
1982-02-22 |
1987-05-12 |
Ciba-Geigy Corporation |
1-(carbamyl, thiocarbamyl, and iminocarbamyl)-indoline derivatives
|
EP0088350B1
(en)
*
|
1982-03-08 |
1985-02-20 |
Schering Corporation |
Carboxyalkyl dipeptides, processes for their production and pharmaceutical compositions containing them
|
US4410807A
(en)
*
|
1982-03-26 |
1983-10-18 |
Kay Industries, Inc. |
Regulating device for polyphase electrical circuits
|
DE3211397A1
(de)
*
|
1982-03-27 |
1983-11-10 |
Hoechst Ag, 6230 Frankfurt |
Spiro (4.(3+n))-2-aza-3-carbonsaeure-derivate, verfahren zu ihrer herstellung, diese enthaltende mittel und ihre verwendung
|
DE3211676A1
(de)
*
|
1982-03-30 |
1983-10-06 |
Hoechst Ag |
Neue derivate von cycloalka (c) pyrrol-carbonsaeuren, verfahren zu ihrer herstellung, diese enthaltende mittel und deren verwendung sowie neue cycloalka (c) pyrrol-carbonsaeuren als zwischenstufen und verfahren zu deren herstellung
|
JPS58188847A
(ja)
*
|
1982-04-26 |
1983-11-04 |
Takeda Chem Ind Ltd |
ペプチド誘導体
|
US4681886A
(en)
*
|
1982-04-30 |
1987-07-21 |
E. R. Squibb & Sons, Inc. |
Substituted 4-phenoxy or 4-phenylthio prolines
|
US4555503A
(en)
*
|
1982-05-05 |
1985-11-26 |
Merck & Co., Inc. |
N2 -(Substituted)carboxymethyl-N6 -(substituted)-lysyl-and αε-aminoalkyl)glycyl amino acid antihypertensive agents
|
US4483850A
(en)
*
|
1982-05-10 |
1984-11-20 |
Merck & Co., Inc. |
N-Terminal substituted oligopeptide converting enzyme inhibitors
|
GB2128984B
(en)
*
|
1982-05-12 |
1985-05-22 |
Hoffmann La Roche |
Diaza-bicyclic compounds
|
ZA833214B
(en)
*
|
1982-05-12 |
1983-12-28 |
Hoffmann La Roche |
Bicyclic compounds
|
AU563196B2
(en)
*
|
1982-05-18 |
1987-07-02 |
Smithkline Beckman Corporation |
Peptide prodrug transport system
|
JPS6058233B2
(ja)
*
|
1982-05-24 |
1985-12-19 |
田辺製薬株式会社 |
2−オキソイミダゾリジン誘導体及びその製法
|
US4442030A
(en)
*
|
1982-06-07 |
1984-04-10 |
Merck & Co., Inc. |
Process for preparing carboxyalkyl dipeptides
|
DE3376649D1
(en)
*
|
1982-06-17 |
1988-06-23 |
Schering Corp |
Substituted dipeptides, methods for their production, pharmaceutical compositions containing them, method for making such pharmaceutical compositions
|
US4442089A
(en)
*
|
1982-07-06 |
1984-04-10 |
E. R. Squibb & Sons, Inc. |
Method for treating glaucoma with topical or systemic ACE inhibitor compositions
|
AU560285B2
(en)
*
|
1982-07-19 |
1987-04-02 |
Imperial Chemical Industries Plc |
Heterocyclyl carbonyl sulphonamides
|
US4473575A
(en)
*
|
1982-07-19 |
1984-09-25 |
Ciba-Geigy Corporation |
3-Amino-(1)-benzazepin-2-one-1-alkanoic acids
|
US4736066A
(en)
*
|
1982-07-19 |
1988-04-05 |
E. R. Squibb & Sons, Inc. |
Intermediate for substituted peptide compounds
|
US4470973A
(en)
*
|
1982-07-19 |
1984-09-11 |
E. R. Squibb & Sons, Inc. |
Substituted peptide compounds
|
IL69136A0
(en)
*
|
1982-07-19 |
1983-10-31 |
Squibb & Sons Inc |
Substituted peptide compounds
|
US4661515A
(en)
*
|
1982-07-21 |
1987-04-28 |
Usv Pharmaceutical Corporation |
Compounds having angiotensin converting enzyme inhibitory activity and diuretic activity
|
US4621092A
(en)
*
|
1982-07-22 |
1986-11-04 |
E. R. Squibb & Sons, Inc. |
Substituted proline compounds, composition and method of use
|
US4742067A
(en)
*
|
1982-07-22 |
1988-05-03 |
E. R. Squibb & Sons, Inc. |
Acylalkylaminocarbonyl substituted amino and imino acid compounds
|
US4487716A
(en)
*
|
1982-08-23 |
1984-12-11 |
American Home Products Corporation |
N-(1-Carboxy-3-phenylpropyl)-dipeptides
|
US4439364A
(en)
*
|
1982-09-01 |
1984-03-27 |
E. I. Du Pont De Nemours & Company |
Process for preparing antihypertensive 1-substituted cyclic lactam-2-carboxylic acids and their derivatives
|
US4866173A
(en)
*
|
1982-09-22 |
1989-09-12 |
Rorer Pharmaceutical Corporation |
Therapeutic substituted semicarbazides
|
US4500713A
(en)
*
|
1982-09-23 |
1985-02-19 |
Usv Pharmaceutical Corporation |
Therapeutic dipeptides
|
US4634716A
(en)
*
|
1982-09-30 |
1987-01-06 |
Merck & Co., Inc. |
Substituted N-carboxymethyl-aminoacylaminoalkanoic acids useful as antihypertensive agents
|
US4642315A
(en)
*
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1982-11-18 |
1987-02-10 |
E. R. Squibb & Sons, Inc. |
Carboxy and substituted carboxy alkanoyl and cycloalkanoyl peptides
|
US4587234A
(en)
*
|
1982-11-18 |
1986-05-06 |
E. R. Squibb & Sons, Inc. |
Carboxy and substituted carboxy alkanoyl and cycloalkanoyl peptides
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US4499079A
(en)
*
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1982-11-18 |
1985-02-12 |
E. R. Squibb & Sons, Inc. |
Carboxy and substituted carboxy alkanoyl and cycloalkanoyl peptides
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US4482544A
(en)
*
|
1982-11-29 |
1984-11-13 |
Usv Pharmaceutical Corporation |
Compounds for treating hypertension
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US4456595A
(en)
*
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1982-12-06 |
1984-06-26 |
E. R. Squibb & Sons, Inc. |
Carboxy and substituted carboxy aroly peptides
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US4826812A
(en)
*
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1982-12-27 |
1989-05-02 |
Schering Corporation |
Antiglaucoma agent
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US4496541A
(en)
*
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1983-01-12 |
1985-01-29 |
Usv Pharmaceutical Corporation |
Compounds for treating hypertension
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DE3300774A1
(de)
*
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1983-01-12 |
1984-07-12 |
Hoechst Ag, 6230 Frankfurt |
Neue spirocyclische aminosaeuren, verfahren zu ihrer herstellung, diese enthaltende mittel und deren verwendung sowie neue spirocyclische aminosaeuren als zwischenprodukte und verfahren zu deren herstellung
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DE3302125A1
(de)
*
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1983-01-22 |
1984-07-26 |
Boehringer Ingelheim KG, 6507 Ingelheim |
Aminosaeure-derivate, verfahren zu ihrer herstellung und verwendung
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EP0115091A1
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1983-01-27 |
1984-08-08 |
ENI-Ente Nazionale Idrocarburi |
N-carboxyacyl derivatives of cyclic amino acids, useful as antihypertensives
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US4659711A
(en)
*
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1983-01-31 |
1987-04-21 |
Usv Pharmaceutical Corporation |
1,2,3,4-Tetrahydrophthalazine and hexahydropyridazine compounds for treating hypertension
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US5175306A
(en)
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1983-01-31 |
1992-12-29 |
Hoechst Aktiengesellschaft |
Process for the resolution of racemates of optically active bicyclic imino-α-carboxylic esters
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US4711884A
(en)
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1983-02-28 |
1987-12-08 |
E. R. Squibb & Sons, Inc. |
Thiazine and thiazepine containing compounds
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US4666906A
(en)
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|
1983-03-16 |
1987-05-19 |
Usv Pharmaceutical Corporation |
Compounds for treating hypertension
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US4596791A
(en)
*
|
1983-03-16 |
1986-06-24 |
Usv Pharmaceutical Corp. |
Compounds for treating hypertension
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US4481191A
(en)
*
|
1983-03-30 |
1984-11-06 |
The Regents Of The University Of California |
Method for controlling blood pressure
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GB8311286D0
(en)
*
|
1983-04-26 |
1983-06-02 |
Searle & Co |
Carboxyalkyl peptide derivatives
|
US4585758A
(en)
*
|
1983-05-20 |
1986-04-29 |
Usv Pharmaceutical Corp. |
Angiotensin-converting enzyme inhibitors
|
EP0127124A3
(en)
*
|
1983-05-23 |
1987-04-08 |
Usv Pharmaceutical Corporation |
Compounds for treating hypertension
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US4574079A
(en)
*
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1983-05-27 |
1986-03-04 |
Gavras Haralambos P |
Radiolabeled angiotensin converting enzyme inhibitors for radiolabeling mammalian organ sites
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US4584285A
(en)
*
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1983-06-02 |
1986-04-22 |
Schering Corporation |
Antihypertensive agents
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US4840772A
(en)
*
|
1983-06-02 |
1989-06-20 |
Schering Corporation |
Antiglaucoma compositions and methods
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US4783444A
(en)
*
|
1984-09-17 |
1988-11-08 |
Schering Corporation |
Antiglaucoma compositions and methods
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US4472384A
(en)
*
|
1983-06-15 |
1984-09-18 |
Merck & Co., Inc. |
Antihypertensive composition
|
US4514391A
(en)
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1983-07-21 |
1985-04-30 |
E. R. Squibb & Sons, Inc. |
Hydroxy substituted peptide compounds
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DE3333454A1
(de)
*
|
1983-09-16 |
1985-04-11 |
Hoechst Ag, 6230 Frankfurt |
Verfahren zur herstellung von n-alkylierten dipeptiden und deren estern
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DE3333455A1
(de)
*
|
1983-09-16 |
1985-04-11 |
Hoechst Ag, 6230 Frankfurt |
Verfahren zur herstellung n-alkylierter dipeptide und deren estern
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EP0137746A3
(en)
*
|
1983-09-22 |
1986-01-08 |
FISONS plc |
Nitrogen substituted angiotensin converting enzyme inhibitors
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US4642355A
(en)
*
|
1984-02-24 |
1987-02-10 |
Otsuka Pharmaceutical Factory, Inc. |
Proline derivatives
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AU578456B2
(en)
*
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1984-03-01 |
1988-10-27 |
Vernon Erk |
Tryptophans & manganese treats hypertension and toxemia of pregancy
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DK110285A
(da)
*
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1984-03-12 |
1985-09-13 |
Pfizer |
Polypeptider og polypeptidderivater indeholdende statin eller derivater deraf og farmaceutiske praeparater
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US4536501A
(en)
*
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1984-03-30 |
1985-08-20 |
E. R. Squibb & Sons, Inc. |
Substituted 4-phenoxy or 4-phenylthio prolines
|
DE3413710A1
(de)
*
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1984-04-12 |
1985-10-24 |
Hoechst Ag, 6230 Frankfurt |
Verfahren zur behandlung der herzinsuffizienz
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US4568666A
(en)
*
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1984-10-18 |
1986-02-04 |
G. D. Searle & Co. |
Carboxylalkyl peptide derivatives
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US5684016A
(en)
*
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1984-04-12 |
1997-11-04 |
Hoechst Aktiengesellschaft |
Method of treating cardiac insufficiency
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EP0159396B1
(en)
|
1984-04-12 |
1990-06-27 |
G.D. Searle & Co. |
Carboxyalkyl peptide derivatives
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US4558150A
(en)
*
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1984-04-19 |
1985-12-10 |
E. R. Squibb & Sons, Inc. |
Intermediates for preparing amino thiol dipeptides
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US4500518A
(en)
*
|
1984-04-19 |
1985-02-19 |
E. R. Squibb & Sons, Inc. |
Amino thiol dipeptides
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AU569789B2
(en)
*
|
1984-05-03 |
1988-02-18 |
Brigham And Women's Hospital |
A.c.e. inhibitors to treat renal diseases
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US4558037A
(en)
*
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1984-06-04 |
1985-12-10 |
Merck & Co., Inc. |
Cardiovascular composition
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EP0168769A3
(en)
*
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1984-07-16 |
1989-02-08 |
Merck & Co. Inc. |
Process for preparing carboxyalkyl dipeptides
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US4801721A
(en)
*
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1984-08-16 |
1989-01-31 |
Ryan James W |
Stereospecific synthesis of carboxyalkyl peptides
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USH642H
(en)
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1984-08-20 |
1989-06-06 |
E. R. Squibb & Sons, Inc. |
Substituted urido amino and imino acids and esters
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US4626545A
(en)
*
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1984-08-27 |
1986-12-02 |
Merck & Co., Inc. |
Amino acid derivatives as enzyme inhibitors
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DE3431541A1
(de)
*
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1984-08-28 |
1986-03-06 |
Hoechst Ag, 6230 Frankfurt |
Cis,endo-2-azabicycloalkan-3-carbonsaeure-derivate, verfahren zu deren herstellung, deren verwendung sowie zwischenprodukte bei deren herstellung
|
GB8422165D0
(en)
*
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1984-09-01 |
1984-10-03 |
Wellcome Found |
Compounds
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US4746676A
(en)
*
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1984-09-12 |
1988-05-24 |
Rorer Pharmaceutical Corporation |
Carboxyalkyl dipeptide compounds
|
IT1176983B
(it)
*
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1984-10-16 |
1987-08-26 |
Zambon Spa |
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