NO143063B - Analogifremgangsmaate ved fremstilling av farmakologisk aktive hetrocyklisk substituerte urea, tiourea og guanidinforbindelser - Google Patents
Analogifremgangsmaate ved fremstilling av farmakologisk aktive hetrocyklisk substituerte urea, tiourea og guanidinforbindelser Download PDFInfo
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- NO143063B NO143063B NO742563A NO742563A NO143063B NO 143063 B NO143063 B NO 143063B NO 742563 A NO742563 A NO 742563A NO 742563 A NO742563 A NO 742563A NO 143063 B NO143063 B NO 143063B
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- cylinder
- cage
- traverse
- ring
- tiourea
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- XSQUKJJJFZCRTK-UHFFFAOYSA-N Urea Chemical class NC(N)=O XSQUKJJJFZCRTK-UHFFFAOYSA-N 0.000 title 1
- 239000004202 carbamide Substances 0.000 title 1
- 150000001875 compounds Chemical class 0.000 title 1
- 210000000056 organ Anatomy 0.000 claims description 2
- 238000006073 displacement reaction Methods 0.000 claims 1
- 238000009434 installation Methods 0.000 description 3
- 238000010276 construction Methods 0.000 description 2
- 230000010355 oscillation Effects 0.000 description 2
- 238000005096 rolling process Methods 0.000 description 2
- 229910000831 Steel Inorganic materials 0.000 description 1
- 238000012423 maintenance Methods 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 238000009958 sewing Methods 0.000 description 1
- 239000010959 steel Substances 0.000 description 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/64—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms, e.g. histidine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D213/28—Radicals substituted by singly-bound oxygen or sulphur atoms
- C07D213/32—Sulfur atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/62—Oxygen or sulfur atoms
- C07D213/63—One oxygen atom
- C07D213/65—One oxygen atom attached in position 3 or 5
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D233/68—Halogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
- C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
- C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D261/00—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings
- C07D261/02—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings
- C07D261/06—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings having two or more double bonds between ring members or between ring members and non-ring members
- C07D261/08—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings having two or more double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
- C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
- C07D263/30—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D263/34—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D263/46—Sulfur atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D275/00—Heterocyclic compounds containing 1,2-thiazole or hydrogenated 1,2-thiazole rings
- C07D275/02—Heterocyclic compounds containing 1,2-thiazole or hydrogenated 1,2-thiazole rings not condensed with other rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
- C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D277/22—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
- C07D277/26—Radicals substituted by sulfur atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D285/00—Heterocyclic compounds containing rings having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by groups C07D275/00 - C07D283/00
- C07D285/01—Five-membered rings
- C07D285/02—Thiadiazoles; Hydrogenated thiadiazoles
- C07D285/04—Thiadiazoles; Hydrogenated thiadiazoles not condensed with other rings
- C07D285/12—1,3,4-Thiadiazoles; Hydrogenated 1,3,4-thiadiazoles
- C07D285/125—1,3,4-Thiadiazoles; Hydrogenated 1,3,4-thiadiazoles with oxygen, sulfur or nitrogen atoms, directly attached to ring carbon atoms, the nitrogen atoms not forming part of a nitro radical
- C07D285/135—Nitrogen atoms
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- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Thiazole And Isothizaole Compounds (AREA)
- Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
- Pyridine Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Description
Innretning for håndtering av roterende ovner av kaldotypen.
Foreliggende oppfinnelse angår en innretning til- håndtering, spesielt montering og demontering, av roterende ovner av Kaldo-ty.pen som ligger roterbart opplag-ret i et bur som danner en vugge. Spesielt angår den innretninger for håndtering av eventuelt opphetede roterovner som an-vendes ved stålfremstilling.
Disse sylindere eller roterovner — som
i det følgende for enkelhets skyld kalles «sylindere» — må kunne demonteres med jevne mellomrom for vedlikehold, spesielt for reparasjon av deres foring.
En tidligere anvendt løsning av dette
problem består i at to eller flere sylindere anbringes i en eneste, faststående installasjon på en slik måte at anlegget kan ar-beide kontinuerlig, idet de sylindere som behøver å utskiftes kan tas ut og erstattes med nye sylindere.
I dette tilfelle kan man for å fjerne
sylindere fra den faststående installasjon anvende de betj enings-innretninger som normalt er tilstede i fabrikklokalet, men hvis sylindrenes store vekt krever en rulle-bro, blir håndteringen meget vanskelig og krever i et hvert tilfelle rullebroer av spe-sialfconstruksjon, som er så kostbare at deres amortisering oppveier de økonomiske fordeler som kan oppnås ved suksessiv an-vendelse av to eller flere sylindere.
En mere fordelaktig løsning av proble-met består i at man demonterer sylindrene utenfor det faststående bur. For dette for-mål er en av det faststående anleggs vug-getraverser utført bevegbar og svingbar om en akse. Denne travers på den rullende bro løftes etter at en vogn, som bærer en hy-draulisk donkraft, er blitt skjøvet inn under den sylinder som skal repareres. Vognen tar imot sylinderen, senker denne litt og kjører den til et reparasjonsverksted, hvor sylinderen avlastes. Den samme vogn kan føre den reparerte sylinder tilbake på sylinderens plass i apparatets vugge. Deretter stenges traversen og installasjonen kan straks settes i arbeidsvirksomhet igjen.
Oppfinnelsen skaffer en ny innretning for betjening av selv meget tunge sylindere hvor man unngår å måtte anvende en ar-beidende travers, mens sylindrene likevel kan utskiftes like lett, samtidig som appa-raturens bur den hele tid holdes lukket.
For å oppnå dette foreslår oppfinnerne at sylinderen fra en stilling som hensiktsmessig ligger ovenfor den vanlige arbeidsstilling skal kunne senkes til et nivå hvor den kan passere under de lavest beliggende organer i buret. Det vil med andre ord si, at innretningen i henhold til oppfinnelsen utmerker seg ved at sylindrene senkes fra sin normale posisjon til et nivå hvor de kan passere under de lavest beliggende elementer i buret, og at sylindrene deretter, ved hvilke som helst egnede midler, kan forflyttes til et ønsket punkt. Senk-ningen skier ved anlegg mot de burorganer som er beregnet på normalt å understøtte sylinderen.
Hovedhensikten med anordningen i henhold til oppfinnelsen er å kunne hånd-tere (montere og demontere) ovnen uten å behøve é åpne.' «buret», selv; når- ovnen veier så mye som f. eks. 600 tonn, og dette er oppnådd ved å benytte ovnssylinderens faste oppbygninger, som støtteramme, under håndteringen og ikke rullebroer ellen lignende, som eventuelt da måtte gjøres; uforholdsmessig, kraftige., og., dyre..
Det er fordelaktig attden understøttelse:: som er nødvendig under sylinderens senk-ning skjer ved støtte mot svingeringene: for at understellet ikke skal bli utsatt for-for store belastninger.
En. foretrukket, innretning- ifølge= opp,-? finnelsen..omfatter for., det. ene .en travers som er fbrskyvbar ved lijelp av en rullébro, og~som~ ved- sine ender~er-utstyrt- med" om-vendte vugger som. støtter seg på svingeringene, og for det annet avtraversentøårne' innretninger, fon understøttelse o,g; manøvr-rering av sylinderen,- .samt- låseorganer.-som-sørger for fast forbindelse mellom støtter vuggene og -ringene.
Traversen dannes av bjelker i et antall som er tilstrekkelig-Æbr-å bære* sylinderen og hver endevugge er montert på traversen ved en-KvUKen^somsltelstiegnet} i^og-.for-seg kjent' anordning, som- gir- travers-vugger enheten fullstendig-- stivhet! Underflaten som danner-Mver;vugges-.støtteflMe-mot:dén; tilsvarende- svingering er? mask-ihotehandlet så nøyaktig.- som- mulig- til<1> svingeringens-ytre radius; Dimensjonene1-av «de'Sirkulære støtteflater-' for vuggene - velges -størst' nra-lig-^ for - å: oppnå', déni best mulige fordeling, av de-- vertikale.- påkjenninger' på- ringene?
Fast'- forbindelse" mellom- vuggene og ringene1 kam ff eks., oppnås ved<f> at hver vugge er r utstyrt :• med: et; visst' antall* fingre; som s — ved1" itaren å?i forskyves* vertikalt-: gripen innimellom ringenes medføringstap-perr.Den sentrale? finger kan fr eks- være utformet - med-1- ihngrepstenner- og sidéten-nene'kan'- være•• utformet': slik' at" dej går vertikalt' inn- mellom to andre-' elementer av den' tllsvarende-spindél' eller - pihne: Anordningene" som*, understøtter og vertikalt: forskyver.-sylinderen- beståt-r for-trinnsviS'av 'Vihsjer.'med'sn!or.trekk. som-kan arbeide'samlet :eMier f enkel tvisj hvon en av endene • av> hveivenkelt :snor er; f estet tir en tilsvarende'fdrankrin;g-på i sylinderen.
Ved! Mj elfp av oppfinnelsens' - apparatur kan' man.isåiLedeis>:på .en enkel måte-ved'en liten hevning." ay>' arbeidsplåtåeU og uten noen-annen'endring':avTammeverket'Skifte ut en sylinder uansetfcdennes' vekt-. Ein-nør.-maU rullebro-.ellér.-løpekatt' er?tilstrekkelig til forflytning av traversen og å føre^dénne hem overi de.' f ast'Ståiende,: apparater.' i fa-brikknallen.
De-- vedf øyde-1 tegninger viser. • som eks-
empel en utførelsesform:av.4 emapparatun i henhold til oppfinnelsen.
Fig. 1 viser et vertikalsnitt gjennom apparaturen, og I fig. 2 viser et vertikalsnitt vinkelrett pårsnittet i fig. 1.
[ Henvisningstallet 1 betegner touret i etr anlegg/som har. svingeringer 2, 3 med støtteruller 2' og den dreibare sylinder 4. Videre ser man på tegningen det øvre ar-beidsplatå 5. I henhold til den f oreliggende oppfinnelse er festekrokene 6 anbragt på sylinderen. 4... Ennvidere er. en. betjeningsr-travers 7, som her dannes av tre bjelker 7',', 7o og-7|, opphengt-ved4 en-anordning-8 på- en- (ikke- vist) - ruilebro? Ved" sine-ender er bjelkene 7,, 72 og 73 fast forbundet ved hj'elp£av«;en."deli81 som 'er.-fåst;forenet med en.vugge„9;..den nedre..bue 10.av.hver vugge 9,".er, maskinibeaxbeidét,.nøyaktig til radien av syingeringene 2. Vuggen 9 er ennvidere forsynt med en sentral finger 11, som har ét<f> symmetrisk^Hodé'-11' som- skal: gripe- inn m'ellomfito*elementerr3-ji—32 i svingeringen 3. På hver side av fingeren 11 er ennvidere
vuggen,. 9,«.i„deti viste utførelseseksempel, forsynt., med; to.- andre,- fingre, 12: resp: 13>-hvisrhode. I2l'1(l31)..,har,.en ver.tifcal-JIate på. den-side som vender, mot den .midtre, f inger.-Hi,men hellen i, forhold itlL vertikalen på den„ motsatte ,sider
På':traver$en-<7ier detimontert;firermed. snorskiver 14,, l&,i,.,16j,. 17^,utstyrte?vinsjer 14; 15, 16?,17y. hvisremdeihaker.--kan .festes til hver.-av(-festekrokene;^ påv sylinderen 4>.En lednings 18:> føren sfcrømn til: vinsj enei f raa en (ikke-vist)!, kontaktisom- er.~antora;gt'.på<ar^ beidsplatået.
Påv i f abrikkhallen- anordnede-' skinner 19"- kan-- en> vogn-. 20'; av hvilken- som'-. Helst kjent-, egnet type; føres-- inn. under1' buret' fon åtta opp i sy lin der en • og forflytt,e:-'denne horisontalt: Utskifting aw sylindere--foregår..'pa den følgende måte: Ved^hjelpiavånnretningen- 8°.fører man betj eningsanordhlhgen: i henhold til' opp.r-finnelsen i undén-buret! i'f rivilfceti en sylinder skal' utskiftes;, For.'å bringe • vuggene- 9^på plass! på* svingeringene • 2? beveges innretningen Sislik at! den .føres1 nedi til travers-7£vugge-9:-anordhiragen: Når' anléggsflå-tene: påv.vuggene?leggen seg>an-mot< ringene 2? vHrfingrene"ll 'med^sine symmetriske Ho-der IT; gripe^nn mellormto- elémenteTt-3:/, og 32. Fingrene11'21'ogrl'Sivil:gripe ihmmellom elementene:'.31/, 3'^ resp.' 35",, 3?2" i*akslene, utelukkendé?Hvistdisse ^fingre-befinner -seg i: vertikal) stilling!.' Nar..-fingrene-' 11^—128-13 er.rslik.plassert;, får'traversen',17 "vertikalt an-leggj moti,svifj;geringene'!2r Vinsjene: 14? 15";
16 og 17 styres hver for seg, slik at de ha-kes inn ved 6 og at snoren 14,, 15,, 16, settes
under strekk. Deretter manøvreres alle vinsjene samtidig så de innvirker på de fire
snorer etter å ha utløst alle holdeinnret-ninger som må utløses for å frigjøre sylinderen 4, som man så senker ned på vognen 20 (den med prikkstrekede linjer viste
stilling).
Hakene 6 utløses og vognen 20 forflyttes på skinnene 19 til reparasjonsverkste-det, hvor sylinderen avsettes. Deretter anbringes ved egnede anordninger en ny sylinder på vognen 20, som føres tilbake til
buret 1. Hakene 6 hektes inn på sorene 14,
—17, og sylinderen løftes til sin arbeidsstilling hvor den fastlåses; hakene 6 utløses
og ved hjelp av broen 8 heves traversen 7
og vuggen 9. Broen 8 kan deretter forflytte
traversen og vuggen til et annet bur i bat-teriet.
Claims (3)
1. Innretning for håndtering av roterende ovner av Kaldo-typen, roterbart opp-lagret i et bur (1) ved hjelp av ringmeier (2), karakterisert ved en travers (7) som er forskyvbar ved hjelp av en rullébro og som utgjøres av bjelker (7,, 72, 7.,)
som bærer sylinderen (4) ved hjelp av vin-sjer medl snorskiver (14, 15, 16, 17) som til-later, uten å åpne buret (1), å forskyve sylinderen (4) vertikalt, og spesielt fra en arbeidsstilling (5) som hensiktsmessig er gjort høyere i forhold til vanlig arbeidsstilling ved disse ovner, ned til et nivå som muliggjør sylinderens passering under bu-rets nederste organer, idet traversen dess-uten ved sine ender er utstyrt med støtte-vugger (9) som på .grunn av utformingen av den nedre del (10) samvirker med ring-meiene (2) og kan fastlåses på ringen ved hjelp av låseorganer (11, 12, 13).
2. Innretning ifølge påstand 1, karakterisert ved at hver vugge (9) bærer et antall fingre (11, 12, 13) som bare ved vertikale forskyvninger kan gripe inn mellom ringmeienes (2) drivelementer (3).
3. Innretning ifølge påstand 2, karakterisert ved at den midtre finger (11) har form som en inngripende tann, og ved at de sideliggende fingre (12, 13) har en slik form at de kan gripe vertikalt inn mellom to andre elementer (3',, 3'2) eller (3",, 3"2) på tilsvarende aksel.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB3342873A GB1431589A (en) | 1973-07-13 | 1973-07-13 | Ureas, thioureas and guanidines n,n-disubstituted by heterocyclo- alkylene and/or heterocycloalkylenethioalkylene groups |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| NO742563L NO742563L (no) | 1975-02-10 |
| NO143063B true NO143063B (no) | 1980-09-01 |
| NO143063C NO143063C (no) | 1980-12-10 |
Family
ID=10352834
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO742563A NO143063C (no) | 1973-07-13 | 1974-07-12 | Analogifremgangsmaate ved fremstilling av farmakologisk aktive hetrocyklisk substituerte urea, tiourea og guanidinforbindelser |
Country Status (31)
| Country | Link |
|---|---|
| US (1) | US4499101A (no) |
| JP (1) | JPS5830314B2 (no) |
| AR (3) | AR204928A1 (no) |
| AT (1) | AT346855B (no) |
| BE (1) | BE816850A (no) |
| BG (1) | BG25792A3 (no) |
| CA (1) | CA1049524A (no) |
| CH (1) | CH601252A5 (no) |
| CS (1) | CS199255B2 (no) |
| DD (1) | DD112449A5 (no) |
| DE (1) | DE2433625A1 (no) |
| DK (1) | DK334674A (no) |
| EG (1) | EG11259A (no) |
| ES (3) | ES428246A1 (no) |
| FI (1) | FI213274A (no) |
| FR (1) | FR2274298A1 (no) |
| GB (1) | GB1431589A (no) |
| HU (1) | HU169394B (no) |
| IE (1) | IE39607B1 (no) |
| IL (1) | IL45006A (no) |
| IN (1) | IN140943B (no) |
| LU (1) | LU70507A1 (no) |
| MW (1) | MW2674A1 (no) |
| NL (1) | NL7408942A (no) |
| NO (1) | NO143063C (no) |
| OA (1) | OA04814A (no) |
| PH (1) | PH11618A (no) |
| PL (3) | PL96460B1 (no) |
| SE (1) | SE416202B (no) |
| SU (3) | SU559647A3 (no) |
| ZM (1) | ZM10374A1 (no) |
Families Citing this family (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4215125A (en) | 1973-07-13 | 1980-07-29 | Smith Kline & French Laboratories Limited | Pyridyl ureas, thioureas and guanidines |
| US4062967A (en) * | 1974-02-07 | 1977-12-13 | Smith Kline & French Laboratories Limited | Bis-guanidino-alkane compounds |
| US4151289A (en) | 1975-01-22 | 1979-04-24 | Smith Kline & French Laboratories Limited | Nitromethylene amidino derivatives containing imidazole groups |
| US4120972A (en) | 1975-02-03 | 1978-10-17 | Smith Kline & French Laboratories Limited | Imidazolylmethylthio-ethyl isothiourea compounds |
| GB1542840A (en) * | 1975-02-03 | 1979-03-28 | Smith Kline French Lab | Heterocyclic dithiocarbamates and isothioureas |
| IL49528A (en) | 1975-05-21 | 1980-11-30 | Smith Kline French Lab | Imidazolyl(or thiazolyl)methylthio(or butyl)guanidine or thiourea derivatives,their preparation and pharmaceutical compositions comprising them |
| US4165378A (en) | 1977-04-20 | 1979-08-21 | Ici Americas Inc. | Guanidine derivatives of imidazoles and thiazoles |
| NZ186965A (en) | 1977-04-20 | 1980-02-21 | Ici Ltd | Guanidino derivatives and pharmaceutical compositions |
| US4233302A (en) | 1977-12-23 | 1980-11-11 | Glaxo Group Limited | Amine derivatives and pharmaceutical compositions containing them |
| US4309435A (en) | 1978-10-16 | 1982-01-05 | Imperial Chemical Industries Ltd. | Antisecretory guanidine derivatives and pharmaceutical compositions containing them |
| JPS5610175A (en) * | 1979-07-06 | 1981-02-02 | Fujisawa Pharmaceut Co Ltd | Preparation of imidazole derivative |
| EP0050407A1 (en) * | 1980-08-27 | 1982-04-28 | Glaxo Group Limited | 3,5-Disubstituted-1,2,4-triazole compounds, processes for their preparation and pharmaceutical compositions containing them |
| EP0089765A3 (en) * | 1982-03-17 | 1984-05-23 | Smith Kline & French Laboratories Limited | Pyridine derivatives |
| DE3512084A1 (de) * | 1985-04-02 | 1986-10-09 | Ludwig Heumann & Co GmbH, 8500 Nürnberg | Guanidinderivate, verfahren zu ihrer herstellung und diese verbindungen enthaltende arzneimittel |
| EP0199845B1 (de) | 1985-04-02 | 1990-08-01 | HEUMANN PHARMA GMBH & CO | Imidazolylalkylguanidinderivate, Verfahren zu ihrer Herstellung und diese Verbindungen enthaltende Arzneimittel |
| DE3631334A1 (de) * | 1986-09-15 | 1988-03-17 | Heumann Pharma Gmbh & Co | Neue imidazolylguanidinderivate, verfahren zu ihrer herstellung und diese verbindungen enthaltende arzneimittel |
| WO1992015567A1 (en) * | 1991-02-27 | 1992-09-17 | Seed Capital Investment (Sci) B.V. | Imidazole-derivatives having agonistic or antagonistic activity on the histamine h3-receptor |
| NL9100365A (nl) * | 1991-02-27 | 1992-09-16 | Seed Capital Investments | Imidazoolderivaten met agonistische of antagonistische activiteit op de histamine h3-receptor. |
| CA2307597A1 (en) * | 1997-10-21 | 1999-04-29 | Cambridge Neuroscience, Inc. | Pharmaceutically active compounds and methods of use |
| US7041702B1 (en) | 1997-10-21 | 2006-05-09 | Scion Pharmaceuticals, Inc. | Pharmaceutically active compounds and methods of use |
| EP4196793A1 (en) | 2020-08-11 | 2023-06-21 | Université de Strasbourg | H2 blockers targeting liver macrophages for the prevention and treatment of liver disease and cancer |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NL292485A (no) * | 1962-05-09 | |||
| CH484918A (de) * | 1965-10-28 | 1970-01-31 | Ciba Geigy | Verfahren zur Herstellung heterocyclischer, Aethylendoppelbindungen enthaltender Verbindungen |
| US3770755A (en) * | 1967-09-26 | 1973-11-06 | Ici Ltd | 4-(4-bromophenyl)-2-(2-hydroxysopropyl) thiazole |
| US3868457A (en) * | 1969-10-29 | 1975-02-25 | Smith Kline French Lab | Method of inhibiting histamine activity with guanidine compounds |
| BE758146A (fr) * | 1969-10-29 | 1971-04-28 | Smith Kline French Lab | Derives de l'amidine |
| US3749728A (en) * | 1972-02-15 | 1973-07-31 | Smith Kline French Lab | N-cycloalkyl and n-cycloalkane-alkylthioamides |
| US3821229A (en) * | 1972-12-07 | 1974-06-28 | American Cyanamid Co | Diquaternary salts of di-4-pyridyl ketone |
| US4013659A (en) * | 1973-07-13 | 1977-03-22 | Smith Kline & French Laboratories Limited | Certain n,n'-disubstituted guanidine compounds and their use |
| US4156727A (en) * | 1975-07-31 | 1979-05-29 | Smith Kline & French Laboratories Limited | Alkoxy pyridine compounds |
-
1973
- 1973-07-13 GB GB3342873A patent/GB1431589A/en not_active Expired
-
1974
- 1974-01-01 AR AR254698A patent/AR204928A1/es active
- 1974-06-11 IL IL45006A patent/IL45006A/xx unknown
- 1974-06-19 MW MW26/74*UA patent/MW2674A1/xx unknown
- 1974-06-21 DK DK334674A patent/DK334674A/da not_active Application Discontinuation
- 1974-06-21 PH PH15964A patent/PH11618A/en unknown
- 1974-06-25 ZM ZM103/74A patent/ZM10374A1/xx unknown
- 1974-06-25 BE BE145878A patent/BE816850A/xx not_active IP Right Cessation
- 1974-06-28 FR FR7422670A patent/FR2274298A1/fr active Granted
- 1974-07-02 NL NL7408942A patent/NL7408942A/xx not_active Application Discontinuation
- 1974-07-04 AT AT552674A patent/AT346855B/de not_active IP Right Cessation
- 1974-07-05 JP JP49077751A patent/JPS5830314B2/ja not_active Expired
- 1974-07-06 EG EG260/74A patent/EG11259A/xx active
- 1974-07-09 CH CH943074A patent/CH601252A5/xx not_active IP Right Cessation
- 1974-07-11 CA CA204,550A patent/CA1049524A/en not_active Expired
- 1974-07-11 FI FI2132/74A patent/FI213274A/fi unknown
- 1974-07-11 LU LU70507A patent/LU70507A1/xx unknown
- 1974-07-12 SU SU2043788A patent/SU559647A3/ru active
- 1974-07-12 DD DD179888A patent/DD112449A5/xx unknown
- 1974-07-12 SE SE7409188A patent/SE416202B/xx not_active IP Right Cessation
- 1974-07-12 DE DE2433625A patent/DE2433625A1/de not_active Withdrawn
- 1974-07-12 IE IE1480/74A patent/IE39607B1/xx unknown
- 1974-07-12 PL PL1974172671A patent/PL96460B1/pl unknown
- 1974-07-12 NO NO742563A patent/NO143063C/no unknown
- 1974-07-12 PL PL1974183273A patent/PL98609B1/pl unknown
- 1974-07-12 HU HUSI1421A patent/HU169394B/hu unknown
- 1974-07-12 OA OA55247A patent/OA04814A/xx unknown
- 1974-07-12 CS CS744991A patent/CS199255B2/cs unknown
- 1974-07-12 PL PL1974183272A patent/PL98705B1/pl unknown
- 1974-07-13 BG BG7400027239A patent/BG25792A3/xx unknown
- 1974-07-13 ES ES428246A patent/ES428246A1/es not_active Expired
- 1974-07-18 IN IN1600/CAL/1974A patent/IN140943B/en unknown
-
1975
- 1975-05-13 AR AR258761A patent/AR202617A1/es active
- 1975-05-13 AR AR258762A patent/AR202618A1/es active
- 1975-05-19 ES ES437770A patent/ES437770A1/es not_active Expired
- 1975-05-19 ES ES437769A patent/ES437769A1/es not_active Expired
- 1975-09-04 SU SU7502168215A patent/SU571193A3/ru active
- 1975-09-05 SU SU7502169007A patent/SU567405A3/ru active
-
1983
- 1983-02-04 US US06/463,768 patent/US4499101A/en not_active Expired - Lifetime
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