FR2274298A1 - Derives de l'uree, procede pour les preparer et leurs applications - Google Patents

Derives de l'uree, procede pour les preparer et leurs applications

Info

Publication number: FR2274298A1
Authority: FR; France
Prior art keywords: urea; derivatives; preparing; applications
Prior art date: 1973-07-13
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Granted

Application number

FR7422670A

Other languages

English (en)

Other versions

FR2274298B1 (fr

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Smith Kline and French Laboratories Ltd

Original Assignee

Smith Kline and French Laboratories Ltd

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1973-07-13

Filing date

1974-06-28

Publication date

1976-01-09

1974-06-28 Application filed by Smith Kline and French Laboratories Ltd filed Critical Smith Kline and French Laboratories Ltd

1976-01-09 Publication of FR2274298A1 publication Critical patent/FR2274298A1/fr

1978-07-21 Application granted granted Critical

1978-07-21 Publication of FR2274298B1 publication Critical patent/FR2274298B1/fr

Status Granted legal-status Critical Current

Links

XSQUKJJJFZCRTK-UHFFFAOYSA-N Urea Chemical class NC(N)=O XSQUKJJJFZCRTK-UHFFFAOYSA-N 0.000 title 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/64—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms, e.g. histidine
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D213/28—Radicals substituted by singly-bound oxygen or sulphur atoms
- C07D213/32—Sulfur atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/62—Oxygen or sulfur atoms
- C07D213/63—One oxygen atom
- C07D213/65—One oxygen atom attached in position 3 or 5
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D233/68—Halogen atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
- C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
- C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D261/00—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings
- C07D261/02—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings
- C07D261/06—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings having two or more double bonds between ring members or between ring members and non-ring members
- C07D261/08—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings having two or more double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
- C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
- C07D263/30—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D263/34—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D263/46—Sulfur atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D275/00—Heterocyclic compounds containing 1,2-thiazole or hydrogenated 1,2-thiazole rings
- C07D275/02—Heterocyclic compounds containing 1,2-thiazole or hydrogenated 1,2-thiazole rings not condensed with other rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
- C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D277/22—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
- C07D277/26—Radicals substituted by sulfur atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D285/00—Heterocyclic compounds containing rings having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by groups C07D275/00 - C07D283/00
- C07D285/01—Five-membered rings
- C07D285/02—Thiadiazoles; Hydrogenated thiadiazoles
- C07D285/04—Thiadiazoles; Hydrogenated thiadiazoles not condensed with other rings
- C07D285/12—1,3,4-Thiadiazoles; Hydrogenated 1,3,4-thiadiazoles
- C07D285/125—1,3,4-Thiadiazoles; Hydrogenated 1,3,4-thiadiazoles with oxygen, sulfur or nitrogen atoms, directly attached to ring carbon atoms, the nitrogen atoms not forming part of a nitro radical
- C07D285/135—Nitrogen atoms

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Bioinformatics & Cheminformatics (AREA)
Pharmacology & Pharmacy (AREA)
Engineering & Computer Science (AREA)
Animal Behavior & Ethology (AREA)
Chemical Kinetics & Catalysis (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Thiazole And Isothizaole Compounds (AREA)
Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
Pyridine Compounds (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

FR7422670A 1973-07-13 1974-06-28 Derives de l'uree, procede pour les preparer et leurs applications Granted FR2274298A1 (fr)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
GB3342873A GB1431589A (en)	1973-07-13	1973-07-13	Ureas, thioureas and guanidines n,n-disubstituted by heterocyclo- alkylene and/or heterocycloalkylenethioalkylene groups

Publications (2)

Publication Number	Publication Date
FR2274298A1 true FR2274298A1 (fr)	1976-01-09
FR2274298B1 FR2274298B1 (fr)	1978-07-21

Family

ID=10352834

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
FR7422670A Granted FR2274298A1 (fr)	1973-07-13	1974-06-28	Derives de l'uree, procede pour les preparer et leurs applications

Country Status (31)

Country	Link
US (1)	US4499101A (fr)
JP (1)	JPS5830314B2 (fr)
AR (3)	AR204928A1 (fr)
AT (1)	AT346855B (fr)
BE (1)	BE816850A (fr)
BG (1)	BG25792A3 (fr)
CA (1)	CA1049524A (fr)
CH (1)	CH601252A5 (fr)
CS (1)	CS199255B2 (fr)
DD (1)	DD112449A5 (fr)
DE (1)	DE2433625A1 (fr)
DK (1)	DK334674A (fr)
EG (1)	EG11259A (fr)
ES (3)	ES428246A1 (fr)
FI (1)	FI213274A (fr)
FR (1)	FR2274298A1 (fr)
GB (1)	GB1431589A (fr)
HU (1)	HU169394B (fr)
IE (1)	IE39607B1 (fr)
IL (1)	IL45006A (fr)
IN (1)	IN140943B (fr)
LU (1)	LU70507A1 (fr)
MW (1)	MW2674A1 (fr)
NL (1)	NL7408942A (fr)
NO (1)	NO143063C (fr)
OA (1)	OA04814A (fr)
PH (1)	PH11618A (fr)
PL (3)	PL96460B1 (fr)
SE (1)	SE416202B (fr)
SU (3)	SU559647A3 (fr)
ZM (1)	ZM10374A1 (fr)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4215125A (en)	1973-07-13	1980-07-29	Smith Kline & French Laboratories Limited	Pyridyl ureas, thioureas and guanidines
US4062967A (en) *	1974-02-07	1977-12-13	Smith Kline & French Laboratories Limited	Bis-guanidino-alkane compounds
US4151289A (en)	1975-01-22	1979-04-24	Smith Kline & French Laboratories Limited	Nitromethylene amidino derivatives containing imidazole groups
US4120972A (en)	1975-02-03	1978-10-17	Smith Kline & French Laboratories Limited	Imidazolylmethylthio-ethyl isothiourea compounds
GB1542840A (en) *	1975-02-03	1979-03-28	Smith Kline French Lab	Heterocyclic dithiocarbamates and isothioureas
IL49528A (en)	1975-05-21	1980-11-30	Smith Kline French Lab	Imidazolyl(or thiazolyl)methylthio(or butyl)guanidine or thiourea derivatives,their preparation and pharmaceutical compositions comprising them
US4165378A (en)	1977-04-20	1979-08-21	Ici Americas Inc.	Guanidine derivatives of imidazoles and thiazoles
NZ186965A (en)	1977-04-20	1980-02-21	Ici Ltd	Guanidino derivatives and pharmaceutical compositions
US4233302A (en)	1977-12-23	1980-11-11	Glaxo Group Limited	Amine derivatives and pharmaceutical compositions containing them
US4309435A (en)	1978-10-16	1982-01-05	Imperial Chemical Industries Ltd.	Antisecretory guanidine derivatives and pharmaceutical compositions containing them
JPS5610175A (en) *	1979-07-06	1981-02-02	Fujisawa Pharmaceut Co Ltd	Preparation of imidazole derivative
EP0050407A1 (fr) *	1980-08-27	1982-04-28	Glaxo Group Limited	Dérivés du 1,2,4-triazole, 3,5-disubstitués, leurs procédés de préparation et compositions pharmaceutiques les contenant
EP0089765A3 (fr) *	1982-03-17	1984-05-23	Smith Kline & French Laboratories Limited	Dérivés de pyridine
DE3512084A1 (de) *	1985-04-02	1986-10-09	Ludwig Heumann & Co GmbH, 8500 Nürnberg	Guanidinderivate, verfahren zu ihrer herstellung und diese verbindungen enthaltende arzneimittel
EP0199845B1 (fr)	1985-04-02	1990-08-01	HEUMANN PHARMA GMBH & CO	Dérivés d'imidazolylalkylguanidine, leur procédé de préparation et compositions les contenant
DE3631334A1 (de) *	1986-09-15	1988-03-17	Heumann Pharma Gmbh & Co	Neue imidazolylguanidinderivate, verfahren zu ihrer herstellung und diese verbindungen enthaltende arzneimittel
WO1992015567A1 (fr) *	1991-02-27	1992-09-17	Seed Capital Investment (Sci) B.V.	Derives d'imidazoles possedant une activite agoniste ou antagoniste sur le recepteur de l'histamine h3
NL9100365A (nl) *	1991-02-27	1992-09-16	Seed Capital Investments	Imidazoolderivaten met agonistische of antagonistische activiteit op de histamine h3-receptor.
CA2307597A1 (fr) *	1997-10-21	1999-04-29	Cambridge Neuroscience, Inc.	Composes pharmaceutiquement actifs et procedes d'utilisation
US7041702B1 (en)	1997-10-21	2006-05-09	Scion Pharmaceuticals, Inc.	Pharmaceutically active compounds and methods of use
EP4196793A1 (fr)	2020-08-11	2023-06-21	Université de Strasbourg	Bloqueurs de h2 ciblant des macrophages du foie pour la prévention et le traitement d'une maladie du foie et du cancer

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
NL292485A (fr) *	1962-05-09
CH484918A (de) *	1965-10-28	1970-01-31	Ciba Geigy	Verfahren zur Herstellung heterocyclischer, Aethylendoppelbindungen enthaltender Verbindungen
US3770755A (en) *	1967-09-26	1973-11-06	Ici Ltd	4-(4-bromophenyl)-2-(2-hydroxysopropyl) thiazole
US3868457A (en) *	1969-10-29	1975-02-25	Smith Kline French Lab	Method of inhibiting histamine activity with guanidine compounds
BE758146A (fr) *	1969-10-29	1971-04-28	Smith Kline French Lab	Derives de l'amidine
US3749728A (en) *	1972-02-15	1973-07-31	Smith Kline French Lab	N-cycloalkyl and n-cycloalkane-alkylthioamides
US3821229A (en) *	1972-12-07	1974-06-28	American Cyanamid Co	Diquaternary salts of di-4-pyridyl ketone
US4013659A (en) *	1973-07-13	1977-03-22	Smith Kline & French Laboratories Limited	Certain n,n'-disubstituted guanidine compounds and their use
US4156727A (en) *	1975-07-31	1979-05-29	Smith Kline & French Laboratories Limited	Alkoxy pyridine compounds

1973
- 1973-07-13 GB GB3342873A patent/GB1431589A/en not_active Expired
1974
- 1974-01-01 AR AR254698A patent/AR204928A1/es active
- 1974-06-11 IL IL45006A patent/IL45006A/xx unknown
- 1974-06-19 MW MW26/74*UA patent/MW2674A1/xx unknown
- 1974-06-21 DK DK334674A patent/DK334674A/da not_active Application Discontinuation
- 1974-06-21 PH PH15964A patent/PH11618A/en unknown
- 1974-06-25 ZM ZM103/74A patent/ZM10374A1/xx unknown
- 1974-06-25 BE BE145878A patent/BE816850A/fr not_active IP Right Cessation
- 1974-06-28 FR FR7422670A patent/FR2274298A1/fr active Granted
- 1974-07-02 NL NL7408942A patent/NL7408942A/xx not_active Application Discontinuation
- 1974-07-04 AT AT552674A patent/AT346855B/de not_active IP Right Cessation
- 1974-07-05 JP JP49077751A patent/JPS5830314B2/ja not_active Expired
- 1974-07-06 EG EG260/74A patent/EG11259A/xx active
- 1974-07-09 CH CH943074A patent/CH601252A5/xx not_active IP Right Cessation
- 1974-07-11 CA CA204,550A patent/CA1049524A/fr not_active Expired
- 1974-07-11 FI FI2132/74A patent/FI213274A/fi unknown
- 1974-07-11 LU LU70507A patent/LU70507A1/xx unknown
- 1974-07-12 SU SU2043788A patent/SU559647A3/ru active
- 1974-07-12 DD DD179888A patent/DD112449A5/xx unknown
- 1974-07-12 SE SE7409188A patent/SE416202B/xx not_active IP Right Cessation
- 1974-07-12 DE DE2433625A patent/DE2433625A1/de not_active Withdrawn
- 1974-07-12 IE IE1480/74A patent/IE39607B1/xx unknown
- 1974-07-12 PL PL1974172671A patent/PL96460B1/pl unknown
- 1974-07-12 NO NO742563A patent/NO143063C/no unknown
- 1974-07-12 PL PL1974183273A patent/PL98609B1/pl unknown
- 1974-07-12 HU HUSI1421A patent/HU169394B/hu unknown
- 1974-07-12 OA OA55247A patent/OA04814A/fr unknown
- 1974-07-12 CS CS744991A patent/CS199255B2/cs unknown
- 1974-07-12 PL PL1974183272A patent/PL98705B1/pl unknown
- 1974-07-13 BG BG7400027239A patent/BG25792A3/xx unknown
- 1974-07-13 ES ES428246A patent/ES428246A1/es not_active Expired
- 1974-07-18 IN IN1600/CAL/1974A patent/IN140943B/en unknown
1975
- 1975-05-13 AR AR258761A patent/AR202617A1/es active
- 1975-05-13 AR AR258762A patent/AR202618A1/es active
- 1975-05-19 ES ES437770A patent/ES437770A1/es not_active Expired
- 1975-05-19 ES ES437769A patent/ES437769A1/es not_active Expired
- 1975-09-04 SU SU7502168215A patent/SU571193A3/ru active
- 1975-09-05 SU SU7502169007A patent/SU567405A3/ru active
1983
- 1983-02-04 US US06/463,768 patent/US4499101A/en not_active Expired - Lifetime

Also Published As

Publication number	Publication date
PL98705B1 (pl)	1978-05-31
EG11259A (en)	1977-01-31
NO742563L (fr)	1975-02-10
ZM10374A1 (en)	1975-04-21
JPS5830314B2 (ja)	1983-06-28
SE7409188L (sv)	1975-01-14
AT346855B (de)	1978-11-27
LU70507A1 (fr)	1974-11-28
ATA552674A (de)	1978-04-15
HU169394B (fr)	1976-11-28
IL45006A (en)	1978-07-31
ES437769A1 (es)	1977-02-01
IN140943B (fr)	1977-01-01
SU571193A3 (ru)	1977-08-30
BE816850A (fr)	1974-12-27
ES428246A1 (es)	1976-07-16
NO143063B (no)	1980-09-01
SU559647A3 (ru)	1977-05-25
CS199255B2 (en)	1980-07-31
SE416202B (sv)	1980-12-08
JPS5032174A (fr)	1975-03-28
OA04814A (fr)	1980-10-31
PL98609B1 (pl)	1978-05-31
CH601252A5 (fr)	1978-06-30
AR204928A1 (es)	1976-03-19
DE2433625A1 (de)	1975-01-30
NL7408942A (nl)	1975-01-15
AU6984574A (en)	1975-12-11
IL45006A0 (en)	1974-09-10
US4499101A (en)	1985-02-12
BG25792A3 (en)	1978-12-12
FI213274A (fr)	1975-01-14
ES437770A1 (es)	1977-01-16
DD112449A5 (fr)	1975-04-12
NO143063C (no)	1980-12-10
MW2674A1 (en)	1975-05-13
AR202618A1 (es)	1975-06-24
AR202617A1 (es)	1975-06-24
GB1431589A (en)	1976-04-07
IE39607B1 (en)	1978-11-22
SU567405A3 (ru)	1977-07-30
CA1049524A (fr)	1979-02-27
PL96460B1 (pl)	1977-12-31
FR2274298B1 (fr)	1978-07-21
PH11618A (en)	1978-04-12
DK334674A (fr)	1975-03-03
IE39607L (en)	1975-01-13

Legal Events

Date	Code	Title	Description
1986-04-25	ST	Notification of lapse

Publication	Publication Date	Title
FR2274298A1 (fr)	1976-01-09	Derives de l'uree, procede pour les preparer et leurs applications
BE779203A (fr)	1972-05-30	2-hydrocarbyldithio-5-mercapto-1, 3, 4, -thiadiazoles et procede pour les preparer,
RO70660A (fr)	1983-09-26	Procede pour la preparation des derives de 3-arylo0y-3-phenylpro®ylamine
RO65655A (fr)	1980-06-15	Procede pour la preparation des n-(methoxymethyl-fprocede pour la preparation des n-(methoxymethylfurylmethyle)-6,7-benzomorphanes et morphinanes urylmethyle)-6,7-benzomorphanes et morphinanes
BE823887A (fr)	1975-06-27	N,n'-bis-amino-alkyl-amides des acides polyoxaperfluoroalcandioiques, leurs derives et procede pour les preparer
BE813144A (fr)	1974-10-01	Procede pour la preparation de derives de 2-arylamino-2-imidazoline et de leurs sels
BE804550A (fr)	1974-03-06	Derives du benzofuranne et procede pour les preparer
FR2274628A1 (fr)	1976-01-09	Derives de la paromomycine et procede pour les preparer
BE849003A (fr)	1977-06-02	Nouveaux derives de la cephalosporine, leurs intermediaires et procede pour les preparer
BE788415A (fr)	1973-03-05	Derives de l'acide 15-oxoprostanoique et procede pour les preparer
BE811467A (fr)	1974-08-22	Tripeptides et procede pour les preparer
BE808599A (fr)	1974-03-29	Nouvelles pyrazolodiazepines et procede pour les preparer
BE805047A (fr)	1974-03-19	Agents anti-arythmiques et procede pour les preparer
BE799139A (fr)	1973-11-05	Derives antibiotiques et procede pour les preparer
RO65069A (fr)	1978-10-15	Procede pour la preparation des derives de pyrimidine et quinoline
PT65164B (fr)	1977-11-17	Procede pour la preparation de nouveaux benzamides substitues et leurs derives
FR2281366A1 (fr)	1976-03-05	Ureylene-thiophanes et leurs derives, et procede pour leur preparation
BE799098A (fr)	1973-11-05	Derives de pyrazole et procede pour les preparer
BE796895A (fr)	1973-07-16	Derives de l'acide thiocarbamique et procede pour les preparer
BE848349A (fr)	1977-05-16	Antibiotiques et procede pour les preparer,
CH553207A (fr)	1974-08-30	Procede pour la preparation de derives azotes.
BE766710A (fr)	1971-10-01	Derives monoacetyles des antibiotiques sf-837 et sf-837-a2 et procede pour les preparer
BE816452A (fr)	1974-12-17	Nouveaux agents de contraste radiographique et procede pour les preparer
BE814661A (fr)	1974-09-02	Derives benzimidazoliques et procede pour leur preparation
BE799099A (fr)	1973-11-05	Derives de pyrazine et procede pour les preparer