NL8801516A - Werkwijze voor de fermentatieve bereiding van organische zuren. - Google Patents

Werkwijze voor de fermentatieve bereiding van organische zuren. Download PDF

Info

Publication number: NL8801516A
Authority: NL; Netherlands
Prior art keywords: acid; lactic acid; permeate; organic; membrane
Prior art date: 1988-06-14

Application number

NL8801516A

Other languages

English (en)

Dutch (nl)

Original Assignee

Suiker Unie

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1988-06-14

Filing date

1988-06-14

Publication date

1990-01-02

Family has litigation

First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=19852458&utm_source=***_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=NL8801516(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.

1988-06-14 Application filed by Suiker Unie filed Critical Suiker Unie

1988-06-14 Priority to NL8801516A priority Critical patent/NL8801516A/nl

1989-06-08 Priority to AT89201495T priority patent/ATE102653T1/de

1989-06-08 Priority to ES89201495T priority patent/ES2061940T3/es

1989-06-08 Priority to EP89201495A priority patent/EP0346983B1/fr

1989-06-08 Priority to DE68913595T priority patent/DE68913595T2/de

1989-06-13 Priority to US07/365,842 priority patent/US5002881A/en

1989-06-14 Priority to JP1152026A priority patent/JPH0327291A/ja

1990-01-02 Publication of NL8801516A publication Critical patent/NL8801516A/nl

Links

238000000034 method Methods 0.000 title claims abstract description 13
238000002360 preparation method Methods 0.000 title claims abstract description 10
150000007524 organic acids Chemical class 0.000 title claims description 16
235000005985 organic acids Nutrition 0.000 title claims description 7
JVTAAEKCZFNVCJ-UHFFFAOYSA-N lactic acid Chemical compound CC(O)C(O)=O JVTAAEKCZFNVCJ-UHFFFAOYSA-N 0.000 claims abstract description 46
239000012528 membrane Substances 0.000 claims abstract description 33
239000004310 lactic acid Substances 0.000 claims abstract description 24
235000014655 lactic acid Nutrition 0.000 claims abstract description 24
238000000909 electrodialysis Methods 0.000 claims abstract description 15
150000003839 salts Chemical class 0.000 claims abstract description 15
239000012466 permeate Substances 0.000 claims abstract description 13
238000006243 chemical reaction Methods 0.000 claims abstract description 12
238000000108 ultra-filtration Methods 0.000 claims abstract description 9
239000011541 reaction mixture Substances 0.000 claims abstract description 6
239000012465 retentate Substances 0.000 claims abstract description 6
JVTAAEKCZFNVCJ-UHFFFAOYSA-M Lactate Chemical compound CC(O)C([O-])=O JVTAAEKCZFNVCJ-UHFFFAOYSA-M 0.000 claims abstract description 3
239000001963 growth medium Substances 0.000 claims abstract description 3
XLYOFNOQVPJJNP-UHFFFAOYSA-M hydroxide Chemical compound [OH-] XLYOFNOQVPJJNP-UHFFFAOYSA-M 0.000 claims abstract description 3
229910052751 metal Chemical group 0.000 claims abstract description 3
239000002184 metal Chemical group 0.000 claims abstract description 3
XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 10
239000002253 acid Substances 0.000 claims description 9
-1 lactic acid acetic acid citric acid propionic acid pyruvic acid Chemical compound 0.000 claims description 9
150000001450 anions Chemical class 0.000 claims description 5
150000001768 cations Chemical class 0.000 claims description 5
VBUYCZFBVCCYFD-JJYYJPOSSA-N 2-dehydro-D-gluconic acid Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)C(=O)C(O)=O VBUYCZFBVCCYFD-JJYYJPOSSA-N 0.000 claims description 4
241000894006 Bacteria Species 0.000 claims description 4
FERIUCNNQQJTOY-UHFFFAOYSA-N Butyric acid Chemical compound CCCC(O)=O FERIUCNNQQJTOY-UHFFFAOYSA-N 0.000 claims description 4
RGHNJXZEOKUKBD-SQOUGZDYSA-N Gluconic acid Natural products OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C(O)=O RGHNJXZEOKUKBD-SQOUGZDYSA-N 0.000 claims description 4
241000193749 Bacillus coagulans Species 0.000 claims description 3
IAJILQKETJEXLJ-UHFFFAOYSA-N Galacturonsaeure Natural products O=CC(O)C(O)C(O)C(O)C(O)=O IAJILQKETJEXLJ-UHFFFAOYSA-N 0.000 claims description 3
229940054340 bacillus coagulans Drugs 0.000 claims description 3
RXMWXENJQAINCC-DMTCNVIQSA-N 2,5-didehydro-D-gluconic acid Chemical compound OCC(=O)[C@@H](O)[C@H](O)C(=O)C(O)=O RXMWXENJQAINCC-DMTCNVIQSA-N 0.000 claims description 2
RXMWXENJQAINCC-UHFFFAOYSA-N 2,5-diketo-D-gluconic acid Natural products OCC(=O)C(O)C(O)C(=O)C(O)=O RXMWXENJQAINCC-UHFFFAOYSA-N 0.000 claims description 2
JAHNSTQSQJOJLO-UHFFFAOYSA-N 2-(3-fluorophenyl)-1h-imidazole Chemical compound FC1=CC=CC(C=2NC=CN=2)=C1 JAHNSTQSQJOJLO-UHFFFAOYSA-N 0.000 claims description 2
RGHNJXZEOKUKBD-MGCNEYSASA-N D-galactonic acid Chemical compound OC[C@@H](O)[C@H](O)[C@H](O)[C@@H](O)C(O)=O RGHNJXZEOKUKBD-MGCNEYSASA-N 0.000 claims description 2
RGHNJXZEOKUKBD-UHFFFAOYSA-N D-gluconic acid Natural products OCC(O)C(O)C(O)C(O)C(O)=O RGHNJXZEOKUKBD-UHFFFAOYSA-N 0.000 claims description 2
AEMOLEFTQBMNLQ-AQKNRBDQSA-N D-glucopyranuronic acid Chemical compound OC1O[C@H](C(O)=O)[C@@H](O)[C@H](O)[C@H]1O AEMOLEFTQBMNLQ-AQKNRBDQSA-N 0.000 claims description 2
RGHNJXZEOKUKBD-MBMOQRBOSA-N D-mannonic acid Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@H](O)C(O)=O RGHNJXZEOKUKBD-MBMOQRBOSA-N 0.000 claims description 2
239000000174 gluconic acid Substances 0.000 claims description 2
235000012208 gluconic acid Nutrition 0.000 claims description 2
229950006191 gluconic acid Drugs 0.000 claims description 2
229940097043 glucuronic acid Drugs 0.000 claims description 2
LVHBHZANLOWSRM-UHFFFAOYSA-N methylenebutanedioic acid Natural products OC(=O)CC(=C)C(O)=O LVHBHZANLOWSRM-UHFFFAOYSA-N 0.000 claims description 2
VZCYOOQTPOCHFL-OWOJBTEDSA-N Fumaric acid Chemical compound OC(=O)\C=C\C(O)=O VZCYOOQTPOCHFL-OWOJBTEDSA-N 0.000 claims 2
LNTHITQWFMADLM-UHFFFAOYSA-N gallic acid Chemical compound OC(=O)C1=CC(O)=C(O)C(O)=C1 LNTHITQWFMADLM-UHFFFAOYSA-N 0.000 claims 2
KJTLQQUUPVSXIM-ZCFIWIBFSA-N (R)-mevalonic acid Chemical compound OCC[C@](O)(C)CC(O)=O KJTLQQUUPVSXIM-ZCFIWIBFSA-N 0.000 claims 1
BJEPYKJPYRNKOW-REOHCLBHSA-N (S)-malic acid Chemical compound OC(=O)[C@@H](O)CC(O)=O BJEPYKJPYRNKOW-REOHCLBHSA-N 0.000 claims 1
NTDFJPCHHGBHCO-UHFFFAOYSA-N 7,9-dihydro-3H-purine-2,6,8-trione Chemical compound OC1=NC(O)=C2NC(O)=NC2=N1.N1C(=O)NC(=O)C2=C1NC(=O)N2 NTDFJPCHHGBHCO-UHFFFAOYSA-N 0.000 claims 1
KJTLQQUUPVSXIM-UHFFFAOYSA-N DL-mevalonic acid Natural products OCCC(O)(C)CC(O)=O KJTLQQUUPVSXIM-UHFFFAOYSA-N 0.000 claims 1
BJEPYKJPYRNKOW-UHFFFAOYSA-N alpha-hydroxysuccinic acid Natural products OC(=O)C(O)CC(O)=O BJEPYKJPYRNKOW-UHFFFAOYSA-N 0.000 claims 1
239000001530 fumaric acid Substances 0.000 claims 1
235000004515 gallic acid Nutrition 0.000 claims 1
229940074391 gallic acid Drugs 0.000 claims 1
239000001630 malic acid Substances 0.000 claims 1
235000011090 malic acid Nutrition 0.000 claims 1
VZCYOOQTPOCHFL-UHFFFAOYSA-N trans-butenedioic acid Natural products OC(=O)C=CC(O)=O VZCYOOQTPOCHFL-UHFFFAOYSA-N 0.000 claims 1
241000193830 Bacillus <bacterium> Species 0.000 abstract description 3
238000004064 recycling Methods 0.000 abstract description 3
241000304886 Bacilli Species 0.000 abstract description 2
239000007864 aqueous solution Substances 0.000 abstract 1
238000000855 fermentation Methods 0.000 description 11
WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 10
230000004151 fermentation Effects 0.000 description 10
239000008103 glucose Substances 0.000 description 10
239000002609 medium Substances 0.000 description 9
LCTONWCANYUPML-UHFFFAOYSA-N Pyruvic acid Chemical compound CC(=O)C(O)=O LCTONWCANYUPML-UHFFFAOYSA-N 0.000 description 6
HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 description 6
239000000243 solution Substances 0.000 description 6
239000002028 Biomass Substances 0.000 description 5
229940041514 candida albicans extract Drugs 0.000 description 5
150000002500 ions Chemical class 0.000 description 5
244000005700 microbiome Species 0.000 description 5
239000000203 mixture Substances 0.000 description 5
239000012138 yeast extract Substances 0.000 description 5
238000004519 manufacturing process Methods 0.000 description 4
239000000047 product Substances 0.000 description 4
239000003518 caustics Substances 0.000 description 3
ZPWVASYFFYYZEW-UHFFFAOYSA-L dipotassium hydrogen phosphate Chemical compound [K+].[K+].OP([O-])([O-])=O ZPWVASYFFYYZEW-UHFFFAOYSA-L 0.000 description 3
229910000396 dipotassium phosphate Inorganic materials 0.000 description 3
235000019797 dipotassium phosphate Nutrition 0.000 description 3
230000012010 growth Effects 0.000 description 3
229910052739 hydrogen Inorganic materials 0.000 description 3
239000001257 hydrogen Substances 0.000 description 3
239000013587 production medium Substances 0.000 description 3
229940107700 pyruvic acid Drugs 0.000 description 3
YBJHBAHKTGYVGT-ZKWXMUAHSA-N (+)-Biotin Chemical compound N1C(=O)N[C@@H]2[C@H](CCCCC(=O)O)SC[C@@H]21 YBJHBAHKTGYVGT-ZKWXMUAHSA-N 0.000 description 2
VHUUQVKOLVNVRT-UHFFFAOYSA-N Ammonium hydroxide Chemical compound [NH4+].[OH-] VHUUQVKOLVNVRT-UHFFFAOYSA-N 0.000 description 2
239000004251 Ammonium lactate Substances 0.000 description 2
239000005696 Diammonium phosphate Substances 0.000 description 2
239000007836 KH2PO4 Substances 0.000 description 2
241000186660 Lactobacillus Species 0.000 description 2
QAOWNCQODCNURD-UHFFFAOYSA-N Sulfuric acid Chemical compound OS(O)(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-N 0.000 description 2
150000007513 acids Chemical class 0.000 description 2
235000011114 ammonium hydroxide Nutrition 0.000 description 2
229940059265 ammonium lactate Drugs 0.000 description 2
235000019286 ammonium lactate Nutrition 0.000 description 2
RZOBLYBZQXQGFY-HSHFZTNMSA-N azanium;(2r)-2-hydroxypropanoate Chemical compound [NH4+].C[C@@H](O)C([O-])=O RZOBLYBZQXQGFY-HSHFZTNMSA-N 0.000 description 2
MNNHAPBLZZVQHP-UHFFFAOYSA-N diammonium hydrogen phosphate Chemical compound [NH4+].[NH4+].OP([O-])([O-])=O MNNHAPBLZZVQHP-UHFFFAOYSA-N 0.000 description 2
229910000388 diammonium phosphate Inorganic materials 0.000 description 2
235000019838 diammonium phosphate Nutrition 0.000 description 2
238000010790 dilution Methods 0.000 description 2
239000012895 dilution Substances 0.000 description 2
OVBPIULPVIDEAO-LBPRGKRZSA-N folic acid Chemical compound C=1N=C2NC(N)=NC(=O)C2=NC=1CNC1=CC=C(C(=O)N[C@@H](CCC(O)=O)C(O)=O)C=C1 OVBPIULPVIDEAO-LBPRGKRZSA-N 0.000 description 2
229910052943 magnesium sulfate Inorganic materials 0.000 description 2
229910000402 monopotassium phosphate Inorganic materials 0.000 description 2
235000019796 monopotassium phosphate Nutrition 0.000 description 2
TXXHDPDFNKHHGW-UHFFFAOYSA-N muconic acid Chemical compound OC(=O)C=CC=CC(O)=O TXXHDPDFNKHHGW-UHFFFAOYSA-N 0.000 description 2
235000015097 nutrients Nutrition 0.000 description 2
GNSKLFRGEWLPPA-UHFFFAOYSA-M potassium dihydrogen phosphate Chemical compound [K+].OP(O)([O-])=O GNSKLFRGEWLPPA-UHFFFAOYSA-M 0.000 description 2
239000002904 solvent Substances 0.000 description 2
RIZUCYSQUWMQLX-UHFFFAOYSA-N 2,3-dimethylbenzoic acid Chemical compound CC1=CC=CC(C(O)=O)=C1C RIZUCYSQUWMQLX-UHFFFAOYSA-N 0.000 description 1
102100026400 ADP/ATP translocase 4 Human genes 0.000 description 1
239000004475 Arginine Substances 0.000 description 1
DCXYFEDJOCDNAF-UHFFFAOYSA-N Asparagine Natural products OC(=O)C(N)CC(N)=O DCXYFEDJOCDNAF-UHFFFAOYSA-N 0.000 description 1
RGHNJXZEOKUKBD-SQOUGZDYSA-M D-gluconate Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C([O-])=O RGHNJXZEOKUKBD-SQOUGZDYSA-M 0.000 description 1
101100108280 Homo sapiens SLC25A31 gene Proteins 0.000 description 1
DCXYFEDJOCDNAF-REOHCLBHSA-N L-asparagine Chemical compound OC(=O)[C@@H](N)CC(N)=O DCXYFEDJOCDNAF-REOHCLBHSA-N 0.000 description 1
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235000013958 Lactobacillus casei Nutrition 0.000 description 1
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OVBPIULPVIDEAO-UHFFFAOYSA-N N-Pteroyl-L-glutaminsaeure Natural products C=1N=C2NC(N)=NC(=O)C2=NC=1CNC1=CC=C(C(=O)NC(CCC(O)=O)C(O)=O)C=C1 OVBPIULPVIDEAO-UHFFFAOYSA-N 0.000 description 1
PVNIIMVLHYAWGP-UHFFFAOYSA-N Niacin Chemical compound OC(=O)C1=CC=CN=C1 PVNIIMVLHYAWGP-UHFFFAOYSA-N 0.000 description 1
239000004952 Polyamide Substances 0.000 description 1
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240000004808 Saccharomyces cerevisiae Species 0.000 description 1
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JZRWCGZRTZMZEH-UHFFFAOYSA-N Thiamine Natural products CC1=C(CCO)SC=[N+]1CC1=CN=C(C)N=C1N JZRWCGZRTZMZEH-UHFFFAOYSA-N 0.000 description 1
240000008042 Zea mays Species 0.000 description 1
235000005824 Zea mays ssp. parviglumis Nutrition 0.000 description 1
235000002017 Zea mays subsp mays Nutrition 0.000 description 1
230000002378 acidificating effect Effects 0.000 description 1
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239000000908 ammonium hydroxide Substances 0.000 description 1
ODKSFYDXXFIFQN-UHFFFAOYSA-N arginine Natural products OC(=O)C(N)CCCNC(N)=N ODKSFYDXXFIFQN-UHFFFAOYSA-N 0.000 description 1
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235000020958 biotin Nutrition 0.000 description 1
239000011616 biotin Substances 0.000 description 1
239000006227 byproduct Substances 0.000 description 1
238000005341 cation exchange Methods 0.000 description 1
229920002301 cellulose acetate Polymers 0.000 description 1
239000012141 concentrate Substances 0.000 description 1
238000010924 continuous production Methods 0.000 description 1
235000005822 corn Nutrition 0.000 description 1
XUJNEKJLAYXESH-UHFFFAOYSA-N cysteine Natural products SCC(N)C(O)=O XUJNEKJLAYXESH-UHFFFAOYSA-N 0.000 description 1
235000018417 cysteine Nutrition 0.000 description 1
238000010612 desalination reaction Methods 0.000 description 1
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238000009792 diffusion process Methods 0.000 description 1
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230000005593 dissociations Effects 0.000 description 1
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239000003102 growth factor Substances 0.000 description 1
HNDVDQJCIGZPNO-UHFFFAOYSA-N histidine Natural products OC(=O)C(N)CC1=CN=CN1 HNDVDQJCIGZPNO-UHFFFAOYSA-N 0.000 description 1
125000002887 hydroxy group Chemical group [H]O* 0.000 description 1
BEJNERDRQOWKJM-UHFFFAOYSA-N kojic acid Chemical compound OCC1=CC(=O)C(O)=CO1 BEJNERDRQOWKJM-UHFFFAOYSA-N 0.000 description 1
229960004705 kojic acid Drugs 0.000 description 1
WZNJWVWKTVETCG-UHFFFAOYSA-N kojic acid Natural products OC(=O)C(N)CN1C=CC(=O)C(O)=C1 WZNJWVWKTVETCG-UHFFFAOYSA-N 0.000 description 1
229940001447 lactate Drugs 0.000 description 1
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239000007788 liquid Substances 0.000 description 1
238000001471 micro-filtration Methods 0.000 description 1
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238000007254 oxidation reaction Methods 0.000 description 1
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PHZLMBHDXVLRIX-UHFFFAOYSA-M potassium lactate Chemical compound [K+].CC(O)C([O-])=O PHZLMBHDXVLRIX-UHFFFAOYSA-M 0.000 description 1
239000001521 potassium lactate Substances 0.000 description 1
235000011085 potassium lactate Nutrition 0.000 description 1
229960001304 potassium lactate Drugs 0.000 description 1
238000011112 process operation Methods 0.000 description 1
239000002994 raw material Substances 0.000 description 1
239000012429 reaction media Substances 0.000 description 1
238000011084 recovery Methods 0.000 description 1
239000013535 sea water Substances 0.000 description 1
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JXOHGGNKMLTUBP-HSUXUTPPSA-N shikimic acid Chemical compound O[C@@H]1CC(C(O)=O)=C[C@@H](O)[C@H]1O JXOHGGNKMLTUBP-HSUXUTPPSA-N 0.000 description 1
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229910001415 sodium ion Inorganic materials 0.000 description 1
235000019157 thiamine Nutrition 0.000 description 1
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Classifications

- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D61/00—Processes of separation using semi-permeable membranes, e.g. dialysis, osmosis or ultrafiltration; Apparatus, accessories or auxiliary operations specially adapted therefor
- B01D61/58—Multistep processes
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D61/00—Processes of separation using semi-permeable membranes, e.g. dialysis, osmosis or ultrafiltration; Apparatus, accessories or auxiliary operations specially adapted therefor
- B01D61/42—Electrodialysis; Electro-osmosis ; Electro-ultrafiltration; Membrane capacitive deionization
- B01D61/422—Electrodialysis
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D61/00—Processes of separation using semi-permeable membranes, e.g. dialysis, osmosis or ultrafiltration; Apparatus, accessories or auxiliary operations specially adapted therefor
- B01D61/42—Electrodialysis; Electro-osmosis ; Electro-ultrafiltration; Membrane capacitive deionization
- B01D61/44—Ion-selective electrodialysis
- B01D61/445—Ion-selective electrodialysis with bipolar membranes; Water splitting
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
- C12M47/00—Means for after-treatment of the produced biomass or of the fermentation or metabolic products, e.g. storage of biomass
- C12M47/10—Separation or concentration of fermentation products
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
- C12N1/20—Bacteria; Culture media therefor
- C12N1/205—Bacterial isolates
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P7/00—Preparation of oxygen-containing organic compounds
- C12P7/40—Preparation of oxygen-containing organic compounds containing a carboxyl group including Peroxycarboxylic acids
- C12P7/56—Lactic acid
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D61/00—Processes of separation using semi-permeable membranes, e.g. dialysis, osmosis or ultrafiltration; Apparatus, accessories or auxiliary operations specially adapted therefor
- B01D61/14—Ultrafiltration; Microfiltration
- B01D61/145—Ultrafiltration
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12R—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES C12C - C12Q, RELATING TO MICROORGANISMS
- C12R2001/00—Microorganisms ; Processes using microorganisms
- C12R2001/01—Bacteria or Actinomycetales ; using bacteria or Actinomycetales
- C12R2001/07—Bacillus
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S435/00—Chemistry: molecular biology and microbiology
- Y10S435/8215—Microorganisms
- Y10S435/822—Microorganisms using bacteria or actinomycetales
- Y10S435/832—Bacillus
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S435/00—Chemistry: molecular biology and microbiology
- Y10S435/8215—Microorganisms
- Y10S435/822—Microorganisms using bacteria or actinomycetales
- Y10S435/853—Lactobacillus
- Y10S435/856—Lactobacillus casei

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Tropical Medicine & Parasitology (AREA)
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Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
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NL8801516A 1988-06-14 1988-06-14 Werkwijze voor de fermentatieve bereiding van organische zuren. NL8801516A (nl)

Priority Applications (7)

Application Number	Priority Date	Filing Date	Title
NL8801516A NL8801516A (nl)	1988-06-14	1988-06-14	Werkwijze voor de fermentatieve bereiding van organische zuren.
AT89201495T ATE102653T1 (de)	1988-06-14	1989-06-08	Herstellung von organischen saeuren durch fermentation.
ES89201495T ES2061940T3 (es)	1988-06-14	1989-06-08	Un procedimiento para la preparacion fermentativa de acidos organicos.
EP89201495A EP0346983B1 (fr)	1988-06-14	1989-06-08	Procédé de préparation d'acides organiques par fermentation
DE68913595T DE68913595T2 (de)	1988-06-14	1989-06-08	Herstellung von organischen Säuren durch Fermentation.
US07/365,842 US5002881A (en)	1988-06-14	1989-06-13	Process for the fermentative preparation of organic acids
JP1152026A JPH0327291A (ja)	1988-06-14	1989-06-14	有機酸の発酵調整方法

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
NL8801516A NL8801516A (nl)	1988-06-14	1988-06-14	Werkwijze voor de fermentatieve bereiding van organische zuren.
NL8801516		1988-06-14

Publications (1)

Publication Number	Publication Date
NL8801516A true NL8801516A (nl)	1990-01-02

Family

ID=19852458

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
NL8801516A NL8801516A (nl)	1988-06-14	1988-06-14	Werkwijze voor de fermentatieve bereiding van organische zuren.

Country Status (7)

Country	Link
US (1)	US5002881A (fr)
EP (1)	EP0346983B1 (fr)
JP (1)	JPH0327291A (fr)
AT (1)	ATE102653T1 (fr)
DE (1)	DE68913595T2 (fr)
ES (1)	ES2061940T3 (fr)
NL (1)	NL8801516A (fr)

Families Citing this family (34)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5464760A (en) *	1990-04-04	1995-11-07	University Of Chicago	Fermentation and recovery process for lactic acid production
FR2686897B1 (fr) *	1992-02-05	1995-07-13	Sonertec	Procede en continu de fabrication d'acides organiques.
JPH07155191A (ja) *	1993-12-08	1995-06-20	Musashino Kagaku Kenkyusho:Kk	乳酸の発酵方法
DE4420033C2 (de) *	1994-06-08	1997-04-10	Fraunhofer Ges Forschung	Verfahren zum Reinigen von Molkereiabwasser
US5746920A (en) *	1994-06-08	1998-05-05	Fraunhofer-Gesellschaft Zur Foerder Der Angewandten Forschung E.V.	Process for purifying dairy wastewater
US5681728A (en) *	1995-06-07	1997-10-28	Chronopol, Inc.	Method and apparatus for the recovery and purification of organic acids
BR9605262A (pt)	1995-10-27	1998-07-21	Shimadzu Corp	Método para a produçao de ácido lático com alta pureza óptica usando cepas de bacillus
DE19604700C1 (de) *	1996-02-09	1997-05-07	Geesthacht Gkss Forschung	Verfahren zur Separierung organischer Säuren aus einem Fermentationsmedium
DE19700044C1 (de) *	1996-09-17	1998-02-05	Fraunhofer Ges Forschung	Verfahren zum Elektrodialysieren von Flüssigkeiten
CN1097635C (zh)	1996-12-23	2003-01-01	拉克塔斯坎有限公司	乳酸的发酵生产和分离
US6716435B1 (en) *	1997-04-18	2004-04-06	Ganeden Biotech, Inc.	Absorbent product containing absorbent structure and Bacillus coagulans
JP3144354B2 (ja)	1997-08-26	2001-03-12	株式会社デンソー	エアバッグ
US6187570B1 (en)	1998-05-26	2001-02-13	The Electrosynthesis Company, Inc.	Electrodialysis methods for purification and recovery of gluconic acid derivatives
US6902917B1 (en)	1999-08-03	2005-06-07	Archer-Daniels-Midland Company	Process for recovery of organic acids from fermentration broths
FR2799754A1 (fr) *	1999-10-18	2001-04-20	Roquette Freres	Procede de separation et de purification d'acide lactique a partir d'un milieu de fermentation
DE19952961A1 (de)	1999-11-03	2001-05-10	Basf Ag	Verfahren zur Aufreinigung von aminosäurehaltigen Lösungen durch Elektrodialyse
CA2414012A1 (fr) *	2000-05-30	2001-12-06	Birgir Norddahl	Procede de production d'acide lactique
US6509179B1 (en)	2000-10-12	2003-01-21	Barbara I. Veldhuis-Stribos	Continuous process for preparing lactic acid
US20030161815A1 (en) *	2002-02-12	2003-08-28	Intercytex Limited	Cell delivery system
US8119376B2 (en)	2002-05-14	2012-02-21	Purac Biochem B.V.	Method for the production of lactic acid or a salt thereof by simultaneous saccharification and fermentation of starch
DK1563061T3 (da) *	2002-11-14	2012-10-01	Aderans Res Inst Inc	Dyrkning af hårinducerende celler
US7083955B2 (en) *	2003-01-13	2006-08-01	Purac Biochem Bv	Preparation of lactic acid from a pentose-containing substrate
AT504206B8 (de) *	2006-12-19	2008-09-15	Gruene Bioraffinerie At Gmbh	Verfahren zur behandlung eines stoffstromes
EP1953234A1 (fr) *	2007-01-31	2008-08-06	Galactic S.A.	Procédé de production d'acide lactique par fermentation d'un milieu autosuffisant à base de jus vert de canne
US20090142459A1 (en) *	2007-12-03	2009-06-04	Batchelder Bruce T	Process for demineralizing whey and product therefrom
CN101407350B (zh) *	2008-10-13	2010-09-15	中国科学院过程工程研究所	发酵法生产赖氨酸中离交废液的处理方法
CN101392273B (zh) *	2008-11-10	2013-02-06	南京工业大学	一种乳酸的清洁生产工艺
CN101492409A (zh) *	2009-02-26	2009-07-29	江苏赛奥生化有限公司	一种色氨酸发酵法清洁生产新工艺
CN101914465B (zh)	2010-05-20	2012-10-03	上海交通大学	用于制备l-乳酸的凝结芽孢杆菌及其应用方法
EP2609989A1 (fr) *	2010-08-19	2013-07-03	Companhia Refinadora da Amazônia	Procédé d'obtention d'acide lactique à haut degré de pureté à partir d'une liqueur fermentative
WO2013022334A1 (fr) *	2011-08-08	2013-02-14	Soo Keng Lee	Procédé pour la production d'acides organiques à partir d'une intégration de photopile ou de pile à combustible doté d'un système d'électrodialyse
DE102015208690A1 (de)	2015-05-11	2016-11-17	Technische Universität Bergakademie Freiberg	Elektrodialytische Herstellung von Phosphorsäure und Vorrichtung
JP6778918B2 (ja)	2015-06-29	2020-11-04	ピーティーティーグローバルケミカルパブリックカンパニーリミテッド	耐熱性のＢａｃｉｌｌｕｓ（バチルス）細菌を用いた、発酵による乳酸またはその塩を製造するためのプロセス
DE102016212242B4 (de)	2016-07-05	2019-02-07	Technische Universität Bergakademie Freiberg	Verfahren zur Herstellung von Phosphorsäure aus phosphorhaltigen Primär- und Sekundärrohstoffen

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
FR2555200B1 (fr) *	1983-11-23	1986-07-25	Centre Nat Rech Scient	Procede de preparation d'acide lactique par fermentation de lactoserum et installation pour la mise en oeuvre en continu de ce procede

1988
- 1988-06-14 NL NL8801516A patent/NL8801516A/nl not_active Application Discontinuation
1989
- 1989-06-08 DE DE68913595T patent/DE68913595T2/de not_active Expired - Fee Related
- 1989-06-08 ES ES89201495T patent/ES2061940T3/es not_active Expired - Lifetime
- 1989-06-08 EP EP89201495A patent/EP0346983B1/fr not_active Expired - Lifetime
- 1989-06-08 AT AT89201495T patent/ATE102653T1/de not_active IP Right Cessation
- 1989-06-13 US US07/365,842 patent/US5002881A/en not_active Expired - Fee Related
- 1989-06-14 JP JP1152026A patent/JPH0327291A/ja active Pending

Also Published As

Publication number	Publication date
DE68913595D1 (de)	1994-04-14
EP0346983B1 (fr)	1994-03-09
ES2061940T3 (es)	1994-12-16
EP0346983A3 (en)	1990-01-03
DE68913595T2 (de)	1994-06-16
US5002881A (en)	1991-03-26
ATE102653T1 (de)	1994-03-15
JPH0327291A (ja)	1991-02-05
EP0346983A2 (fr)	1989-12-20

Legal Events

Date	Code	Title	Description
1990-01-02	A1B	A search report has been drawn up
1990-05-01	AK	Correction of former applications already laid open	Free format text: IN PAT.BUL.01/90,PAGES 7 AND 10:B01D 13/02 CORR. B01D 61/00
1991-02-01	BV	The patent application has lapsed

Publication	Publication Date	Title
NL8801516A (nl)	1990-01-02	Werkwijze voor de fermentatieve bereiding van organische zuren.
Pal et al.	2016	Manufacture of gluconic acid: A review towards process intensification for green production
US5746920A (en)	1998-05-05	Process for purifying dairy wastewater
Kumar et al.	2014	Production and purification of glutamic acid: A critical review towards process intensification
Boyaval et al.	1993	Concentrated propionic acid production by electrodialysis
JP2872723B2 (ja)	1999-03-24	コハク酸の製造及び精製方法
US4882277A (en)	1989-11-21	Continuous process for preparing organic acids by fermentation
JPH0213386A (ja)	1990-01-17	電気透析による全発酵液からの乳酸塩の回収と精製
CA2275758A1 (fr)	1998-07-02	Production et isolement d'acide lactique par fermentation
WO2010051676A1 (fr)	2010-05-14	Procédé de nettoyage pour la production d’acide lactique
YAO et al.	1990	Lactic acid production in electrodialysis culture
EP0393818A1 (fr)	1990-10-24	Procédé de préparation et de purification de l'acide lactique
NZ523459A (en)	2004-08-27	Method for producing lactic acid
AU696254B2 (en)	1998-09-03	Process for purifying dairy wastewater
Börgardts et al.	1998	Integrated bioprocess for the simultaneous production of lactic acid and dairy sewage treatment
US6187570B1 (en)	2001-02-13	Electrodialysis methods for purification and recovery of gluconic acid derivatives
Lech et al.	2018	Batch electrodialysis of lactic acid obtained from LAB fermentation
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Persson et al.	2001	Conversion of sodium lactate to lactic acid with water-splitting electrodialysis
Jiang et al.	2016	Membranes for the recovery of organic acids from fermentation broths
Pöhland et al.	1993	Optimization of gluconic acid synthesis by removing limitations and inhibitions
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