NI201600051A - Combinaciones de inhibidores de histona desacetilasa y farmacos inmunomoduladores - Google Patents

Combinaciones de inhibidores de histona desacetilasa y farmacos inmunomoduladores

Info

Publication number
NI201600051A
NI201600051A NI201600051A NI201600051A NI201600051A NI 201600051 A NI201600051 A NI 201600051A NI 201600051 A NI201600051 A NI 201600051A NI 201600051 A NI201600051 A NI 201600051A NI 201600051 A NI201600051 A NI 201600051A
Authority
NI
Nicaragua
Prior art keywords
combinations
desacetilase
histone
inhibitors
subject
Prior art date
Application number
NI201600051A
Other languages
English (en)
Inventor
Norman QUAYLE Steven
Stewart Jones Simon
c anderson Kenneth
Hideshima Teru
Original Assignee
Acetylon Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Acetylon Pharmaceuticals Inc filed Critical Acetylon Pharmaceuticals Inc
Publication of NI201600051A publication Critical patent/NI201600051A/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/454—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. pimozide, domperidone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/57—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone
    • A61K31/573—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone substituted in position 21, e.g. cortisone, dexamethasone, prednisone or aldosterone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/32—One oxygen, sulfur or nitrogen atom
    • C07D239/42—One nitrogen atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond

Abstract

La presente invención se refiere a combinaciones que comprenden un inhibidor de HDAC y un fármaco inmunomodulador para el tratamiento de mieloma múltiple en un sujeto en necesidad del mismo. Las combinaciones, opcionalmente, pueden comprender además un agente antiinflamatorio, tal como dexametasona. También en la presente se proporcionan métodos para tratar el mieloma múltiple en un sujeto en necesidad del mismo que comprenden administrar al sujeto una cantidad efectiva de una de las combinaciones anteriores.
NI201600051A 2013-10-11 2016-04-11 Combinaciones de inhibidores de histona desacetilasa y farmacos inmunomoduladores NI201600051A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201361889640P 2013-10-11 2013-10-11
US201361911089P 2013-12-03 2013-12-03

Publications (1)

Publication Number Publication Date
NI201600051A true NI201600051A (es) 2017-07-11

Family

ID=52810182

Family Applications (1)

Application Number Title Priority Date Filing Date
NI201600051A NI201600051A (es) 2013-10-11 2016-04-11 Combinaciones de inhibidores de histona desacetilasa y farmacos inmunomoduladores

Country Status (17)

Country Link
US (2) US20150105358A1 (es)
EP (1) EP3054939A4 (es)
JP (4) JP2016532667A (es)
KR (1) KR20160060143A (es)
CN (1) CN105722507A (es)
AU (1) AU2014332147A1 (es)
CA (1) CA2926808A1 (es)
CL (1) CL2016000838A1 (es)
CR (1) CR20160200A (es)
EA (1) EA201690753A1 (es)
IL (1) IL244923A0 (es)
MX (1) MX2016004604A (es)
NI (1) NI201600051A (es)
PE (1) PE20161342A1 (es)
PH (1) PH12016500649A1 (es)
SG (1) SG11201602791RA (es)
WO (1) WO2015054175A1 (es)

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SG182646A1 (en) 2010-01-22 2012-08-30 Acetylon Pharmaceuticals Inc Reverse amide compounds as protein deacetylase inhibitors and methods of use thereof
PL2640709T3 (pl) 2010-11-16 2016-10-31 Związki pirymidynohydroksyamidowe jako inhibitory deacetylazy białkowej oraz sposoby ich stosowania”
EP2839037B1 (en) 2012-04-19 2018-12-26 Acetylon Pharmaceuticals, Inc. Biomarkers to identify patients that will respond to treatment and treating such patients
US9145412B2 (en) 2012-11-02 2015-09-29 Acetylon Pharmaceuticals, Inc. Selective HDAC1 and HDAC2 inhibitors
JP6626437B2 (ja) * 2013-10-08 2019-12-25 アセチロン ファーマシューティカルズ インコーポレイテッドＡｃｅｔｙｌｏｎ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ，Ｉｎｃ． ヒストンデアセチラーゼ阻害剤とＨｅｒ２阻害剤またはＰＩ３Ｋ阻害剤のいずれかの組み合わせ
US9278963B2 (en) * 2013-10-10 2016-03-08 Acetylon Pharmaceuticals, Inc. Pyrimidine hydroxy amide compounds as histone deacetylase inhibitors
SG11201602791RA (en) * 2013-10-11 2016-05-30 Acetylon Pharmaceuticals Inc Combinations of histone deactylase inhibitors and immunomodulatory drugs
ES2918673T3 (es) 2013-10-24 2022-07-19 Mayo Found Medical Education & Res Tratamiento de enfermedades poliquísticas con un inhibidor de HDAC6
AU2014360544A1 (en) 2013-12-03 2016-07-21 Acetylon Pharmaceuticals, Inc. Combinations of histone deacetylase inhibitors and immunomodulatory drugs
US9464073B2 (en) 2014-02-26 2016-10-11 Acetylon Pharmaceuticals, Inc. Pyrimidine hydroxy amide compounds as HDAC6 selective inhibitors
AU2015288060A1 (en) 2014-07-07 2017-02-09 Acetylon Pharmaceuticals, Inc. Treatment of leukemia with histone deacetylase inhibitors
CN107438436A (zh) 2014-12-05 2017-12-05 摩德纳和雷焦艾米利亚大学 用于治疗淋巴瘤的组蛋白脱乙酰酶抑制剂和苯达莫司汀的组合
AU2015360270B9 (en) 2014-12-12 2019-12-05 Regenacy Pharmaceuticals, Llc Piperidine derivatives as HDAC1/2 inhibitors
CN107922352B (zh) 2015-06-08 2021-08-06 埃斯泰隆制药公司 制备蛋白质脱乙酰酶抑制剂的方法
JP6816036B2 (ja) 2015-06-08 2021-01-20 アセチロン ファーマシューティカルズ インコーポレイテッドＡｃｅｔｙｌｏｎ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ，Ｉｎｃ． ヒストン脱アセチル化阻害剤の結晶形態
WO2017143237A1 (en) * 2016-02-17 2017-08-24 Acetylon Pharmaceuticals, Inc. Increasing expression of interferon regulated genes with combinatons of histone deacetylase inhibitors and immunomodulatory drugs
JP2019515909A (ja) 2016-04-19 2019-06-13 アセチロン ファーマシューティカルズ インコーポレイテッドＡｃｅｔｙｌｏｎ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ，Ｉｎｃ． 慢性リンパ性白血病の治療を目的とするｈｄａｃ阻害剤単独またはｂｔｋ阻害剤との配合物
US11298354B2 (en) 2016-06-09 2022-04-12 Dana-Farber Cancer Institute, Inc. Methods of use and pharmaceutical combinations of HDAC inhibitors with BET inhibitors
EP3496751B1 (en) 2016-08-08 2022-10-19 Acetylon Pharmaceuticals Inc. Pharmaceutical combinations of histone deacetylase 6 inhibitors and cd20 inhibitory antibodies and uses thereof
KR102002581B1 (ko) * 2016-10-04 2019-07-22 주식회사 종근당 혈액암 치료를 위한 hdac 저해제 및 프로테아좀 억제제 또는 면역조절성 약물을 포함하는 약학적 조합물
WO2018098348A1 (en) * 2016-11-23 2018-05-31 Acetylon Pharmaceuticals, Inc. Pharmaceutical combinations comprising a histone deacetylase inhibitor and a cd38 inhibitor and methods of use thereof
JP7090611B2 (ja) * 2016-11-23 2022-06-24 アセチロン ファーマシューティカルズ インコーポレイテッド ヒストン脱アセチル化酵素阻害剤とプログラム細胞死リガンド１（ｐｄ－ｌ１）阻害剤とを含む医薬組み合わせ物及びその使用方法
CN117561059A (zh) 2021-04-23 2024-02-13 特纳亚治疗股份有限公司 用于治疗扩张型心肌病的hdac6抑制剂
IL308152A (en) 2021-05-04 2024-01-01 Tenaya Therapeutics Inc 2-fluoroalkyl-4,3,1-oxadiazol-5-yl-thiazole, HDAC6 inhibitors for use in the treatment of metabolic disease and HFPEF

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5635517B1 (en) 1996-07-24 1999-06-29 Celgene Corp Method of reducing TNFalpha levels with amino substituted 2-(2,6-dioxopiperidin-3-YL)-1-oxo-and 1,3-dioxoisoindolines
US6281230B1 (en) 1996-07-24 2001-08-28 Celgene Corporation Isoindolines, method of use, and pharmaceutical compositions
US7323479B2 (en) * 2002-05-17 2008-01-29 Celgene Corporation Methods for treatment and management of brain cancer using 1-oxo-2-(2,6-dioxopiperidin-3-yl)-4-methylisoindoline
US7968569B2 (en) * 2002-05-17 2011-06-28 Celgene Corporation Methods for treatment of multiple myeloma using 3-(4-amino-1-oxo-1,3-dihydro-isoindol-2-yl)-piperidine-2,6-dione
AU2006313517B2 (en) 2005-11-10 2013-06-27 Topotarget Uk Limited Histone deacetylase (HDAC) inhibitors (PXD101) for the treatment of cancer alone or in combination with chemotherapeutic agent
SG182646A1 (en) * 2010-01-22 2012-08-30 Acetylon Pharmaceuticals Inc Reverse amide compounds as protein deacetylase inhibitors and methods of use thereof
PL2640709T3 (pl) * 2010-11-16 2016-10-31 Związki pirymidynohydroksyamidowe jako inhibitory deacetylazy białkowej oraz sposoby ich stosowania”
JP6169076B2 (ja) * 2011-07-20 2017-07-26 ザ ジェネラル ホスピタル コーポレイション 骨疾患の処置のためのヒストン脱アセチル化酵素６選択的阻害剤
SG11201602791RA (en) 2013-10-11 2016-05-30 Acetylon Pharmaceuticals Inc Combinations of histone deactylase inhibitors and immunomodulatory drugs

Also Published As

Publication number Publication date
SG11201602791RA (en) 2016-05-30
PH12016500649A1 (en) 2016-05-30
JP2019052171A (ja) 2019-04-04
US20200323849A1 (en) 2020-10-15
JP2016532667A (ja) 2016-10-20
CL2016000838A1 (es) 2016-11-25
WO2015054175A1 (en) 2015-04-16
KR20160060143A (ko) 2016-05-27
EP3054939A4 (en) 2017-12-13
PE20161342A1 (es) 2016-12-31
IL244923A0 (en) 2016-05-31
JP7403950B2 (ja) 2023-12-25
CN105722507A (zh) 2016-06-29
US20150105358A1 (en) 2015-04-16
EA201690753A1 (ru) 2016-07-29
JP2021073314A (ja) 2021-05-13
CA2926808A1 (en) 2015-04-16
MX2016004604A (es) 2016-08-01
EP3054939A1 (en) 2016-08-17
JP2024010118A (ja) 2024-01-23
CR20160200A (es) 2016-08-29
AU2014332147A1 (en) 2016-05-05

Similar Documents

Publication Publication Date Title
NI201600051A (es) Combinaciones de inhibidores de histona desacetilasa y farmacos inmunomoduladores
CR20160308A (es) Combinaciones de inhibidores de histona deacetilasa y farmacos inmunomoduladores
NI201600071A (es) Compuestos de inhibidor de autotaxina
ECSP18040250A (es) Composiciones y métodos para inhibir la actividad arginasa
CO2017004525A2 (es) Dihidropirrolopiridinas inhibidoras de ror-gamma
CL2015002658A1 (es) Derivados de 2, 3 - disustituto 1- acil -4 amino - 1,2,3,4 tetrahidroquinilina y su uso como inhibidores de bromodominio
MX2017000307A (es) Tratamiento de leucemia con inhibidores de histona deacetilasa.
CR20140108A (es) Compuesto de ciclopropanoamina
BR112016003201A2 (pt) inibidores de grp94 seletivos e usos dos mesmos
HN2012000023A (es) Compuestos y composiciones para el tratamiento de enfermedades parasitarias
MX2015016100A (es) Inhibidores de criopirina para prevenir y tratar la inflamacion.
EA201691808A1 (ru) Кортикостероидные композиции для местного применения
EA201792496A1 (ru) Способы лечения воспаления или нейропатической боли
MX2015010791A (es) Metodos para tratar el cancer y prevenir la resistencia a farmacos.
NI201600070A (es) Inhibidores tetracíclicos de autotaxina
BR112017000730B8 (pt) Derivados de pirrolidinona como inibidores de metap-2, e medicamentos
EA201690039A1 (ru) Ингибиторы rorc2 и способы их применения
BR112018003836A2 (pt) combinações de inibidor de btk para tratar mieloma múltiplo
UY35328A (es) Tratamiento de formas progresivas de esclerosis múltiple con laquinimod
AR102871A1 (es) Métodos de tratamiento de fibrosis
CL2017002229A1 (es) Inhibidores de bace1.
SV2016005308A (es) Composiciã“n farmacã‰utica para el tratamiento de alopatã�as relacionadas con el dolor, usando como agente activo al ketorolaco trometamina y clorhidrato de tramadol
AR103636A1 (es) Métodos de tratamiento de neuralgia postherpética con una formulación tópica de un compuesto de espiro-oxindol
PH12020500472A1 (en) Autotaxin inhibitor compounds
AR099681A1 (es) Composiciones de grapiprant y métodos para su utilización