MXPA04005433A - Proceso para la medicion de la potencia de acetato de glatiramero. - Google Patents
Proceso para la medicion de la potencia de acetato de glatiramero.Info
- Publication number
- MXPA04005433A MXPA04005433A MXPA04005433A MXPA04005433A MXPA04005433A MX PA04005433 A MXPA04005433 A MX PA04005433A MX PA04005433 A MXPA04005433 A MX PA04005433A MX PA04005433 A MXPA04005433 A MX PA04005433A MX PA04005433 A MXPA04005433 A MX PA04005433A
- Authority
- MX
- Mexico
- Prior art keywords
- glatiramer acetate
- potency
- measurement
- processes
- provides
- Prior art date
Links
- 108010072051 Glatiramer Acetate Proteins 0.000 title abstract 3
- FHEAIOHRHQGZPC-KIWGSFCNSA-N acetic acid;(2s)-2-amino-3-(4-hydroxyphenyl)propanoic acid;(2s)-2-aminopentanedioic acid;(2s)-2-aminopropanoic acid;(2s)-2,6-diaminohexanoic acid Chemical compound CC(O)=O.C[C@H](N)C(O)=O.NCCCC[C@H](N)C(O)=O.OC(=O)[C@@H](N)CCC(O)=O.OC(=O)[C@@H](N)CC1=CC=C(O)C=C1 FHEAIOHRHQGZPC-KIWGSFCNSA-N 0.000 title abstract 3
- 229960003776 glatiramer acetate Drugs 0.000 title abstract 3
- 238000000034 method Methods 0.000 title abstract 2
- 238000005259 measurement Methods 0.000 title 1
- 238000004519 manufacturing process Methods 0.000 abstract 1
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
- G01N33/6863—Cytokines, i.e. immune system proteins modifying a biological response such as cell growth proliferation or differentiation, e.g. TNF, CNF, GM-CSF, lymphotoxin, MIF or their receptors
- G01N33/6869—Interleukin
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
- G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
- G01N33/502—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics for testing non-proliferative effects
- G01N33/5038—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics for testing non-proliferative effects involving detection of metabolites per se
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
- A61K31/197—Carboxylic acids, e.g. valproic acid having an amino group the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid or pantothenic acid
- A61K31/198—Alpha-amino acids, e.g. alanine or edetic acid [EDTA]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/02—Peptides of undefined number of amino acids; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
- G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
- G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
- G01N33/502—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics for testing non-proliferative effects
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
- G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
- G01N33/5044—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics involving specific cell types
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
- G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
- G01N33/5044—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics involving specific cell types
- G01N33/5047—Cells of the immune system
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
- G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
- G01N33/5044—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics involving specific cell types
- G01N33/5047—Cells of the immune system
- G01N33/505—Cells of the immune system involving T-cells
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
- G01N33/6863—Cytokines, i.e. immune system proteins modifying a biological response such as cell growth proliferation or differentiation, e.g. TNF, CNF, GM-CSF, lymphotoxin, MIF or their receptors
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
- G01N33/6863—Cytokines, i.e. immune system proteins modifying a biological response such as cell growth proliferation or differentiation, e.g. TNF, CNF, GM-CSF, lymphotoxin, MIF or their receptors
- G01N33/6866—Interferon
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
- G01N2333/52—Assays involving cytokines
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
- G01N2333/52—Assays involving cytokines
- G01N2333/54—Interleukins [IL]
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
- G01N2333/52—Assays involving cytokines
- G01N2333/54—Interleukins [IL]
- G01N2333/5412—IL-6
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
- G01N2333/52—Assays involving cytokines
- G01N2333/54—Interleukins [IL]
- G01N2333/5428—IL-10
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
- G01N2333/52—Assays involving cytokines
- G01N2333/54—Interleukins [IL]
- G01N2333/55—IL-2
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
- G01N2333/52—Assays involving cytokines
- G01N2333/555—Interferons [IFN]
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
- G01N2333/52—Assays involving cytokines
- G01N2333/555—Interferons [IFN]
- G01N2333/57—IFN-gamma
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Immunology (AREA)
- Biomedical Technology (AREA)
- Chemical & Material Sciences (AREA)
- Molecular Biology (AREA)
- Urology & Nephrology (AREA)
- Hematology (AREA)
- Cell Biology (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Biotechnology (AREA)
- Microbiology (AREA)
- Pathology (AREA)
- General Physics & Mathematics (AREA)
- Biochemistry (AREA)
- Analytical Chemistry (AREA)
- Physics & Mathematics (AREA)
- Food Science & Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Tropical Medicine & Parasitology (AREA)
- Toxicology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Epidemiology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
El tema de la invencion proporciona un proceso para medir la potencia relativa de un lote de prueba de acetato de glatiramero. Ademas, el tema de la invencion proporciona un proceso para preparar un lote de acetato de glatiramero como aceptable para uso farmaceutico.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US33876701P | 2001-12-04 | 2001-12-04 | |
PCT/US2002/038859 WO2003048735A2 (en) | 2001-12-04 | 2002-12-04 | Processes for the measurement of the potency of glatiramer acetate |
Publications (1)
Publication Number | Publication Date |
---|---|
MXPA04005433A true MXPA04005433A (es) | 2004-10-11 |
Family
ID=23326090
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MXPA04005433A MXPA04005433A (es) | 2001-12-04 | 2002-12-04 | Proceso para la medicion de la potencia de acetato de glatiramero. |
Country Status (22)
Country | Link |
---|---|
US (6) | US7429374B2 (es) |
EP (1) | EP1459065B1 (es) |
JP (1) | JP4369234B2 (es) |
KR (1) | KR100657048B1 (es) |
CN (1) | CN1308683C (es) |
AT (1) | ATE475883T1 (es) |
AU (1) | AU2002353059B2 (es) |
CA (1) | CA2469393C (es) |
CY (1) | CY1110878T1 (es) |
DE (1) | DE60237170D1 (es) |
DK (1) | DK1459065T3 (es) |
ES (1) | ES2349033T3 (es) |
HK (1) | HK1070421A1 (es) |
IL (3) | IL162127A0 (es) |
IS (1) | IS7286A (es) |
MX (1) | MXPA04005433A (es) |
NO (1) | NO338247B1 (es) |
NZ (1) | NZ533327A (es) |
PT (1) | PT1459065E (es) |
SI (1) | SI1459065T1 (es) |
WO (1) | WO2003048735A2 (es) |
ZA (1) | ZA200404472B (es) |
Families Citing this family (38)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
ES2527760T3 (es) * | 1998-07-23 | 2015-01-29 | Yeda Research And Development Co., Ltd. | Tratamiento de enfermedad de Crohn con copolímero 1 y polipéptidos |
EP1098902A4 (en) | 1998-07-23 | 2002-07-24 | Yeda Res & Dev | TREATMENT OF AUTOIMMUNE DISEASES BY COPOLYMER 1 AND SIMILAR COPOLYMERS AND PEPTIDES |
US6800287B2 (en) | 1998-09-25 | 2004-10-05 | Yeda Research And Development Co., Ltd. | Copolymer 1 related polypeptides for use as molecular weight markers and for therapeutic use |
US7022663B2 (en) * | 2000-02-18 | 2006-04-04 | Yeda Research And Development Co., Ltd. | Oral, nasal and pulmonary dosage formulations of copolymer 1 |
US20020077278A1 (en) | 2000-06-05 | 2002-06-20 | Yong V. Wee | Use of glatiramer acetate (copolymer 1) in the treatment of central nervous system disorders |
WO2002076503A1 (en) * | 2000-06-20 | 2002-10-03 | Mayo Foundation For Medical Education And Research | Treatment of central nervous system diseases by antibodies against glatiramer acetate |
MXPA04005433A (es) | 2001-12-04 | 2004-10-11 | Teva Pharma | Proceso para la medicion de la potencia de acetato de glatiramero. |
US20070244056A1 (en) * | 2004-03-03 | 2007-10-18 | Liat Hayardeny | Combination Therapy With Glatiramer Acetate and Riluzole |
ATE536363T1 (de) * | 2004-09-09 | 2011-12-15 | Teva Pharma | Verfahren zur herstellung von mischungen von trifluoroacetyl-glatirameracetat bei verwendung von hydrobromsäure |
WO2006029411A2 (en) * | 2004-09-09 | 2006-03-16 | Yeda Research And Development Co. Ltd. | Mixtures of polypeptides, compositions containing and processes for preparing same, and uses thereof |
US8324641B2 (en) * | 2007-06-29 | 2012-12-04 | Ledengin, Inc. | Matrix material including an embedded dispersion of beads for a light-emitting device |
CA2588908C (en) * | 2004-11-29 | 2014-09-23 | Yeda Research And Development Co. Ltd | Induction of neurogenesis and stem cell therapy in combination with copolymer 1 |
EP1838326A4 (en) * | 2005-02-02 | 2009-09-30 | Teva Pharma | PROCESS FOR PREPARING POLYPEPTIDE MIXTURES BY HYDROGENOLYSIS |
PT1848415E (pt) * | 2005-02-17 | 2013-06-27 | Teva Pharma | Terapia de combinação com acetato de glatirâmero e rasagilina para o tratamento da esclerose múltipla |
US20060240463A1 (en) * | 2005-04-25 | 2006-10-26 | Rappaport Family Institute For Research In The Medical Sciences | Markers associated with the therapeutic efficacy of glatiramer acetate |
ES2477232T5 (es) * | 2007-06-21 | 2017-11-23 | Momenta Pharmaceuticals, Inc. | Análisis de copolímeros |
AU2008330093A1 (en) * | 2007-11-28 | 2009-06-04 | Yeda Research And Development Co., Ltd. | Method of delaying the onset of clinically definite multiple sclerosis |
RU2010146489A (ru) | 2008-04-16 | 2012-05-27 | Момента Фармасьютикалз, Инк. (Us) | Анализ композиций сополимера аминокислот |
RS52885B (en) | 2009-08-20 | 2014-02-28 | Yeda Research And Development Co. Ltd. | LOW-FREQUENCY GLATIRAMER ACETATOM THERAPY |
CN102869990A (zh) * | 2009-11-17 | 2013-01-09 | 阿雷斯贸易股份有限公司 | 通过对定向序列聚合物的组合物进行基于血清蛋白的检测,改进含定向序列聚合物的组合物的设计、生物利用度和效能的方法 |
USRE49251E1 (en) | 2010-01-04 | 2022-10-18 | Mapi Pharma Ltd. | Depot systems comprising glatiramer or pharmacologically acceptable salt thereof |
US8759302B2 (en) * | 2010-03-16 | 2014-06-24 | Teva Pharmaceutical Industries, Ltd. | Methods of treating a subject afflicted with an autoimmune disease using predictive biomarkers of clinical response to glatiramer acetate therapy in multiple sclerosis |
EA025780B1 (ru) | 2010-10-11 | 2017-01-30 | Тева Фармасьютикал Индастриз Лтд. | Цитокиновые биомаркеры в качестве биомаркеров, прогнозирующих клинический ответ на глатирамер ацетат |
WO2013009885A2 (en) | 2011-07-11 | 2013-01-17 | Momenta Pharmaceuticals, Inc. | Evaluation of copolymer diethylamide |
US8575198B1 (en) | 2011-09-07 | 2013-11-05 | Momenta Pharmaceuticals, Inc. | In-process control for the manufacture of glatiramer acetate |
TW201326399A (zh) | 2011-10-10 | 2013-07-01 | Teva Pharma | 用於預測對格拉替雷(glatiramer)醋酸鹽之臨床反應之單核苷酸多型性之判定 |
US20130210054A1 (en) * | 2012-02-09 | 2013-08-15 | Momenta Pharmaceuticals, Inc. | Amino Acid Copolymer Assay |
EP2642290A1 (en) | 2012-03-19 | 2013-09-25 | Synthon BV | Glatiramer acetate human monocytic cell line-based potency assay |
WO2013139728A1 (en) | 2012-03-19 | 2013-09-26 | Synthon Bv | Glatiramer acetate human monocyte cell-based potency assay |
MX2015004563A (es) | 2012-10-10 | 2015-07-14 | Teva Pharma | Biomarcadores predictivos para respuesta clinica para acetato de glatiramero. |
KR20150111945A (ko) * | 2013-01-04 | 2015-10-06 | 테바 파마슈티컬 인더스트리즈 리미티드 | 글라티라머 아세테이트 관련 완제의 특성조사 |
AU2014244550B2 (en) * | 2013-03-14 | 2018-11-01 | Mylan Inc. | Glatiramer acetate response biomarker mRNA potency assay |
WO2014173463A1 (en) | 2013-04-26 | 2014-10-30 | Synthon Bv | Glatiramer acetate human monocytic cell line-based potency assay |
UY35790A (es) | 2013-10-21 | 2015-05-29 | Teva Pharma | Marcadores genéticos que predicen la respuesta al acetato de glatiramer |
TWI717314B (zh) | 2013-10-24 | 2021-02-01 | 美商麥蘭股份有限公司 | 供評估格拉默醋酸鹽製備物之免疫同一性用的人類t細胞株分析方法 |
US9155775B1 (en) | 2015-01-28 | 2015-10-13 | Teva Pharmaceutical Industries, Ltd. | Process for manufacturing glatiramer acetate product |
US20190025285A1 (en) * | 2015-02-12 | 2019-01-24 | Insight Biopharmaceutical Ltd. | Methods of determining relative potency of glatiramer acetate and use thereof in preparing a batch of glatiramer acetate as acceptable for pharmaceutical use |
EP3600553A4 (en) | 2017-03-26 | 2020-09-02 | Mapi Pharma Ltd. | GLATIRAMER DEPOT SYSTEMS FOR TREATMENT OF PROGRESSIVE FORMS OF MULTIPLE SCLEROSIS |
Family Cites Families (72)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
IL36670A (en) * | 1971-04-21 | 1974-09-10 | Sela M | Therapeutic basic copolymers of amino acids |
US3991210A (en) * | 1974-03-11 | 1976-11-09 | The Dow Chemical Company | Acetamidine urinary antiseptics |
US4129666A (en) * | 1977-04-29 | 1978-12-12 | Walter Wizerkaniuk | Method of providing pellets with a water insoluble coating using a melt |
US4339431A (en) * | 1980-12-31 | 1982-07-13 | Colgate-Palmolive Company | Anticalculus oral composition |
JPS6053535A (ja) | 1983-09-02 | 1985-03-27 | Nitto Boseki Co Ltd | 規則性ポリアミノ酸樹脂の製造方法 |
SU1182051A1 (ru) | 1984-04-28 | 1985-09-30 | Таджикский государственный университет им.В.И.Ленина | Политрипептиды,обладающие энантовой селективностью в реакци х гидролиза @ -нитрофениловых эфиров карбобензокси - @ - и @ -аланина |
IE59233B1 (en) | 1985-06-18 | 1994-01-26 | Univ Emory | Use of biologically active copolymers for the manufacture of a medicament for stimulating the growth of an animal |
DD257174A3 (de) | 1985-12-20 | 1988-06-08 | Ve Forschungszentrum Biotechno | Verfahren zur herstellung der peptide z-ala-ala-lon-p-nitranilid oder z-asp-phe-ome mit metalloprotease |
SU1469826A1 (ru) | 1986-05-30 | 1995-11-20 | Институт Высокомолекулярных Соединений Ан Ссср | Сополимер l-лизина с l-глутаминовой кислотой, содержащий дофаминовые боковые группы, обладающий пролонгированной гипотензивной активностью и компенсаторным эффектом при геморрагическом шоке, и способ его получения |
US5554372A (en) * | 1986-09-22 | 1996-09-10 | Emory University | Methods and vaccines comprising surface-active copolymers |
CA1336954C (en) | 1987-06-24 | 1995-09-12 | Howard L. Weiner | Treatment of autoimmune diseases by oral administration of autoantigens |
CA2009996A1 (en) | 1989-02-17 | 1990-08-17 | Kathleen S. Cook | Process for making genes encoding random polymers of amino acids |
SU1690368A1 (ru) | 1989-07-20 | 1995-08-20 | Институт Высокомолекулярных Соединений Ан Ссср | Статистические сополимеры в качестве низкотоксичных веществ, обладающих пролонгированным гипотензивным действием, и способ их получения |
DE3930733A1 (de) | 1989-09-14 | 1991-03-28 | Roehm Gmbh | Verfahren zur herstellung eines komplexierten arzneimittels |
FR2658076B1 (fr) * | 1990-02-12 | 1992-06-12 | Sanofi Sa | Composition cosmetique contenant des copolymeres d'aminoacides, utile comme agent hydratant. |
AU8305491A (en) | 1990-08-01 | 1992-03-02 | Cytel Corporation | Novel immunosuppressant peptides |
US5668117A (en) * | 1991-02-22 | 1997-09-16 | Shapiro; Howard K. | Methods of treating neurological diseases and etiologically related symptomology using carbonyl trapping agents in combination with previously known medicaments |
US5734023A (en) * | 1991-11-19 | 1998-03-31 | Anergen Inc. | MHC class II β chain/peptide complexes useful in ameliorating deleterious immune responses |
US5583031A (en) * | 1992-02-06 | 1996-12-10 | President And Fellows Of Harvard College | Empty major histocompatibility class II heterodimers |
ES2107048T3 (es) | 1992-07-31 | 1997-11-16 | Merrell Pharma Inc | Tensioactivos pulmonares peptidicos sinteticos con antioxidantes covalentemente unidos. |
WO1994026774A1 (en) | 1993-05-19 | 1994-11-24 | Cytel Corporation | Novel treatments for allergic diseases |
ES2210289T3 (es) * | 1994-03-31 | 2004-07-01 | Vertex Pharmaceuticals Incorporated | Derivados de pirimidinilo como inhibidores de interleuquinas. |
CA2186873A1 (en) | 1994-04-01 | 1995-10-12 | Charles J. Hackett | Haptenated peptides and uses thereof |
US5591629A (en) * | 1994-04-29 | 1997-01-07 | Mayo Foundation For Medical Education & Research | Monoclonal antibodies which promote central nervous system remyelination |
US5502022A (en) * | 1994-05-16 | 1996-03-26 | Biosepra, Inc. | Chromatography adsorbents utilizing mercapto heterocyclic ligands |
WO1995031997A1 (en) | 1994-05-20 | 1995-11-30 | UNITED STATES OF AMERICA, represented by THE SECRETARY OF THE ARMY | Model for testing immunogenicity of peptides |
US5800808A (en) | 1994-05-24 | 1998-09-01 | Veda Research And Development Co., Ltd. | Copolymer-1 improvements in compositions of copolymers |
GB9411292D0 (en) | 1994-06-06 | 1994-07-27 | Teva Pharma | Pharmaceuticals compositions |
US5858964A (en) * | 1995-04-14 | 1999-01-12 | Yeda Research And Development Co. Ltd. | Pharmaceutical compositions comprising synthetic peptide copolymer for prevention of GVHD |
US5627206A (en) * | 1995-06-02 | 1997-05-06 | Warner-Lambert Company | Tricyclic inhibitor of matrix metalloproteinases |
US5665764A (en) * | 1995-06-02 | 1997-09-09 | Warner-Lambert Company | Tricyclic inhibitors of matrix metalloproteinases |
US5719296A (en) | 1995-10-30 | 1998-02-17 | Merck & Co., Inc. | Pseudopeptide lactam inhibitors of peptide binding to MHC class II proteins |
US5965600A (en) | 1996-01-17 | 1999-10-12 | Taiho Pharmaceutical Co., Ltd. | 3-(bis-substituted phenylmethylene) oxindole derivatives |
US5716946A (en) * | 1996-02-13 | 1998-02-10 | Wisconsin Alumni Research Foundation | Multiple sclerosis treatment |
US6214791B1 (en) * | 1997-01-10 | 2001-04-10 | Yeda Research And Development Co. Ltd. | Treatment of multiple sclerosis through ingestion or inhalation of copolymer-1 |
IL119989A0 (en) | 1997-01-10 | 1997-04-15 | Yeda Res & Dev | Pharmaceutical compositions for oral treatment of multiple sclerosis |
US6024981A (en) * | 1997-04-16 | 2000-02-15 | Cima Labs Inc. | Rapidly dissolving robust dosage form |
US6114317A (en) * | 1998-05-21 | 2000-09-05 | Wisconsin Alumni Research Foundation | Method of locking 1α-OH of vitamin D compounds in axial orientation |
ES2527760T3 (es) * | 1998-07-23 | 2015-01-29 | Yeda Research And Development Co., Ltd. | Tratamiento de enfermedad de Crohn con copolímero 1 y polipéptidos |
EP1098902A4 (en) | 1998-07-23 | 2002-07-24 | Yeda Res & Dev | TREATMENT OF AUTOIMMUNE DISEASES BY COPOLYMER 1 AND SIMILAR COPOLYMERS AND PEPTIDES |
WO2000005249A2 (en) | 1998-07-23 | 2000-02-03 | The President And Fellows Of Harvard College | Synthetic peptides and methods of use for autoimmune disease therapies |
US6514938B1 (en) * | 1998-09-25 | 2003-02-04 | Yeda Research And Development Co. Ltd. At The Weizmann Institute Of Science | Copolymer 1 related polypeptides for use as molecular weight markers and for therapeutic use |
US6800287B2 (en) * | 1998-09-25 | 2004-10-05 | Yeda Research And Development Co., Ltd. | Copolymer 1 related polypeptides for use as molecular weight markers and for therapeutic use |
EP2090583B1 (en) | 1998-09-25 | 2011-07-13 | Yeda Research And Development Co., Ltd. | Copolymer 1 related polypeptides for use as molecular weight markers and for therapeutic use |
WO2000020010A1 (en) | 1998-10-02 | 2000-04-13 | Yeda Research And Development Co., Ltd. | Alternate day administration of copolymer 1 for treating autoimmune diseases |
CA2355400A1 (en) | 1998-11-12 | 2000-05-18 | Yeda Research And Development Co., Ltd. | Pharmaceutical compositions comprising synthetic peptide copolymers and methods for preventing and treating gvhd and hvgd |
US6844314B2 (en) | 2000-01-20 | 2005-01-18 | Yeda Research Development Co., Ltd. | Use of copolymer 1 and related peptides and polypeptides and T cells treated therewith for neuroprotective therapy |
JP2003522799A (ja) | 2000-02-18 | 2003-07-29 | イエダ・リサーチ・アンド・ディベロップメント・カンパニー・リミテッド・アット・ザ・ウェイズマン・インスティテュート・オブ・サイエンス | コポリマー1の経口、経鼻および経肺投与製剤 |
US7022663B2 (en) * | 2000-02-18 | 2006-04-04 | Yeda Research And Development Co., Ltd. | Oral, nasal and pulmonary dosage formulations of copolymer 1 |
AU2000261978B2 (en) | 2000-05-10 | 2006-07-06 | Mayo Foundation For Medical Education And Research | Human igm antibodies with the capability of inducing remyelination, and diagnostic and therapeutic uses thereof particularly in the central nervous system |
US20020107388A1 (en) * | 2000-05-12 | 2002-08-08 | Vandenbark Arthur A. | Methods of identifying and monitoring disease-associated T cells |
US20020077278A1 (en) * | 2000-06-05 | 2002-06-20 | Yong V. Wee | Use of glatiramer acetate (copolymer 1) in the treatment of central nervous system disorders |
AU7528001A (en) | 2000-06-05 | 2001-12-17 | Teva Pharma | The use of glatiramer acetate (copolymer 1) in the treatment of central nervous system disorders |
DK1294390T3 (da) | 2000-06-07 | 2006-04-03 | Yeda Res & Dev | Anvendelse af copolymer 1 og beslægtede peptider og polypeptider og T-celelr behandlet dermed til neurobeskyttelse mod glutamattoksicitet |
WO2002076503A1 (en) | 2000-06-20 | 2002-10-03 | Mayo Foundation For Medical Education And Research | Treatment of central nervous system diseases by antibodies against glatiramer acetate |
CN2469393Y (zh) | 2001-03-08 | 2002-01-02 | 祁新 | 暖气热水器 |
CN1152258C (zh) * | 2001-03-19 | 2004-06-02 | 上海肿瘤特殊项目检测中心 | 一种检测化学药物在体内抗癌功效的方法 |
CA2456275A1 (en) * | 2001-06-07 | 2002-12-12 | University Of Kentucky Research Foundation | Nanoscintillation systems for aqueous-based liquid scintillation counting |
MXPA04005433A (es) * | 2001-12-04 | 2004-10-11 | Teva Pharma | Proceso para la medicion de la potencia de acetato de glatiramero. |
EP1565486A2 (en) | 2002-11-13 | 2005-08-24 | Apotex Pharmachem Inc. | Process for the preparation of glatiramer acetate by polymerisation of n-carboxy anhydrides of l-alanine, l-tyrosine, benzyl l-glutamate and benzyloxycarbonyl l-lysine |
US8008258B2 (en) * | 2003-01-21 | 2011-08-30 | Yeda Research And Development Co. Ltd. | Cop 1 for treatment of inflammatory bowel diseases |
US7968511B2 (en) | 2003-05-14 | 2011-06-28 | Teva Pharmaceutical Industries, Ltd. | Combination therapy with glatiramer acetate and mitoxantrone for the treatment of multiple sclerosis |
AU2004274957B2 (en) * | 2003-09-19 | 2009-02-05 | Sangamo Therapeutics, Inc. | Engineered zinc finger proteins for regulation of gene expression |
CA2541445A1 (en) | 2003-10-31 | 2005-05-12 | Teva Pharmaceutical Industries Ltd. | Nanoparticles for drug delivery |
ATE536363T1 (de) * | 2004-09-09 | 2011-12-15 | Teva Pharma | Verfahren zur herstellung von mischungen von trifluoroacetyl-glatirameracetat bei verwendung von hydrobromsäure |
WO2006029411A2 (en) * | 2004-09-09 | 2006-03-16 | Yeda Research And Development Co. Ltd. | Mixtures of polypeptides, compositions containing and processes for preparing same, and uses thereof |
AU2005302500B2 (en) | 2004-10-29 | 2008-11-27 | Sandoz Ag | Processes for preparing glatiramer |
EP1838326A4 (en) * | 2005-02-02 | 2009-09-30 | Teva Pharma | PROCESS FOR PREPARING POLYPEPTIDE MIXTURES BY HYDROGENOLYSIS |
US20060240463A1 (en) | 2005-04-25 | 2006-10-26 | Rappaport Family Institute For Research In The Medical Sciences | Markers associated with the therapeutic efficacy of glatiramer acetate |
US20070059798A1 (en) | 2005-09-09 | 2007-03-15 | Alexander Gad | Polypeptides useful for molecular weight determinations |
ES2338488T3 (es) | 2006-07-05 | 2010-05-07 | Momenta Pharmaceuticals, Inc. | Proceso mejorado para la preparacion de copolimero-1. |
ITRM20070552A1 (it) | 2007-10-23 | 2009-04-24 | Acqua Minerale S Benedetto S P | Contenitore in materiale plastico |
-
2002
- 2002-12-04 MX MXPA04005433A patent/MXPA04005433A/es active IP Right Grant
- 2002-12-04 US US10/313,726 patent/US7429374B2/en not_active Expired - Fee Related
- 2002-12-04 ES ES02790028T patent/ES2349033T3/es not_active Expired - Lifetime
- 2002-12-04 AT AT02790028T patent/ATE475883T1/de active
- 2002-12-04 AU AU2002353059A patent/AU2002353059B2/en not_active Ceased
- 2002-12-04 NZ NZ533327A patent/NZ533327A/en not_active IP Right Cessation
- 2002-12-04 JP JP2003549881A patent/JP4369234B2/ja not_active Expired - Fee Related
- 2002-12-04 EP EP02790028A patent/EP1459065B1/en not_active Expired - Lifetime
- 2002-12-04 SI SI200230921T patent/SI1459065T1/sl unknown
- 2002-12-04 DE DE60237170T patent/DE60237170D1/de not_active Expired - Lifetime
- 2002-12-04 CA CA2469393A patent/CA2469393C/en not_active Expired - Lifetime
- 2002-12-04 IL IL16212702A patent/IL162127A0/xx unknown
- 2002-12-04 CN CNB028277732A patent/CN1308683C/zh not_active Expired - Fee Related
- 2002-12-04 WO PCT/US2002/038859 patent/WO2003048735A2/en active Application Filing
- 2002-12-04 KR KR1020047008518A patent/KR100657048B1/ko active IP Right Grant
- 2002-12-04 PT PT02790028T patent/PT1459065E/pt unknown
- 2002-12-04 DK DK02790028.1T patent/DK1459065T3/da active
-
2004
- 2004-05-23 IL IL162127A patent/IL162127A/en not_active IP Right Cessation
- 2004-05-26 IS IS7286A patent/IS7286A/is unknown
- 2004-06-07 ZA ZA2004/04472A patent/ZA200404472B/en unknown
- 2004-07-02 NO NO20042816A patent/NO338247B1/no not_active IP Right Cessation
-
2005
- 2005-03-19 HK HK05102405.0A patent/HK1070421A1/xx not_active IP Right Cessation
-
2008
- 2008-08-28 US US12/231,081 patent/US7923215B2/en not_active Expired - Fee Related
-
2009
- 2009-04-22 IL IL198285A patent/IL198285A/en not_active IP Right Cessation
-
2010
- 2010-10-25 CY CY20101100963T patent/CY1110878T1/el unknown
-
2011
- 2011-04-08 US US13/083,112 patent/US8389228B2/en not_active Expired - Fee Related
-
2012
- 2012-08-13 US US13/584,631 patent/US20120309671A1/en not_active Abandoned
-
2014
- 2014-08-25 US US14/467,576 patent/US20150094488A1/en not_active Abandoned
-
2015
- 2015-07-22 US US14/806,467 patent/US20160025707A1/en not_active Abandoned
Also Published As
Similar Documents
Publication | Publication Date | Title |
---|---|---|
HK1070421A1 (en) | Processes for the measurement of the potency of glatiramer acetate | |
MY125978A (en) | Admantane derivatives | |
WO2001026693A3 (en) | Manufacture of polyglutamate-therapeutic agent conjugates | |
HUP0402264A3 (en) | Substituted 2-thio-3,5-dicyano-4-phenyl-6-aminopyridines process for preparing them, pharmaceutical compositions containing them and use thereof | |
TW200508214A (en) | Novel compounds | |
HK1042710A1 (en) | Covalently bridged insulin dymers | |
HUP0401005A3 (en) | Oxazolidinone and/or isoxazoline antibacterials, process for their preparation, their use and pharmaceutical compositions containing them | |
YU7804A (sh) | Stabilni polimorf flibanserina,postupak za njegovo dobijanje u industrijskim razmerama i njegova primena za pripremanje lekova | |
HUP0300701A2 (hu) | Zolpidem hemitartarát, eljárás az előállítására és ezt tartalmazó gyógyszerkészítmények | |
AU2003297199A8 (en) | Human chondroitinase glycoprotein (chasegp), process for preparing the same, and pharmaceutical compositions comprising thereof | |
HUP0202233A3 (en) | Derivatives and analogues of galanthamin, their use, pharmaceutical compositions containing them and process for the preparation of them | |
GR20020100478A (el) | Ανυδρη κρυσταλλικη μορφη της βαλακyκλοβιρης υδροχλωρικης | |
HUP0400317A3 (en) | Beta-carboline derivatives, process for their preparation, their use and pharmaceutical compositions containing them | |
HUP0401369A3 (en) | Pharmaceutical formulation comprising (r)-bicalutamide, process for its preparation and use thereof | |
HK1060558A1 (en) | 2H-1-benzopyran derivatives, processes for their preparation and pharmaceutical compositions thereof. | |
HUP0400262A2 (hu) | Glikopeptidek, előállításuk és alkalmazásuk szklerózis multiplex kezelésében | |
DE60237994D1 (de) | 3.beta.,28-diacetoxy-18-oxo-19,20,21,29,30-pentanorlupan-22-säure solvate, verfahren zu ihrer herstellung und pharmazeutische präparate daraus | |
IL160160A0 (en) | SUBSTITUTED 5,6,6a, 11b-TETRAHYDRO-7-OXA-5-AZA-BENZO[c]FLUORENE-6-CARBOXYLIC ACID DERIVATIVES SERVING AS NMDA ANTAGONISTS | |
HUP0303482A3 (en) | Mercaptoacetylamide derivatives, process for their preparation and their use and pharmaceutical compositions containing them | |
HUP0202011A3 (en) | Novel cyclic alpha-amino-gamma-hydroxyamide derivatives, process for their preparation and pharmaceutical compositions containing them | |
HUP0202284A3 (en) | Novel benzenesulphonamide derivatives, process for their preparation and pharmaceutical compositions containing them | |
HUP0402424A3 (en) | Imidazoquinoline derivatives, process for their preparation and pharmaceutical compositions containing the same | |
PL354270A1 (en) | Interferometer system, particularly for measuring linear and angular displacements | |
ECSP992947A (es) | Procedimiento para la preparacion de (s,s) bencil - 2.8 diazabiciclo (4,3,0) nonano (caso lea 32965) |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
FG | Grant or registration |