MXPA04002046A - Tieno [2,3-d]pirimidinas sustituidas por glicina con actividad agonistica de fsh y lh combinada. - Google Patents
Tieno [2,3-d]pirimidinas sustituidas por glicina con actividad agonistica de fsh y lh combinada.Info
- Publication number
- MXPA04002046A MXPA04002046A MXPA04002046A MXPA04002046A MXPA04002046A MX PA04002046 A MXPA04002046 A MX PA04002046A MX PA04002046 A MXPA04002046 A MX PA04002046A MX PA04002046 A MXPA04002046 A MX PA04002046A MX PA04002046 A MXPA04002046 A MX PA04002046A
- Authority
- MX
- Mexico
- Prior art keywords
- alkyl
- glycine
- hydroxy
- pyrimidines
- combined
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D495/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/06—Drugs for disorders of the endocrine system of the anterior pituitary hormones, e.g. TSH, ACTH, FSH, LH, PRL, GH
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/06—Drugs for disorders of the endocrine system of the anterior pituitary hormones, e.g. TSH, ACTH, FSH, LH, PRL, GH
- A61P5/08—Drugs for disorders of the endocrine system of the anterior pituitary hormones, e.g. TSH, ACTH, FSH, LH, PRL, GH for decreasing, blocking or antagonising the activity of the anterior pituitary hormones
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Veterinary Medicine (AREA)
- Engineering & Computer Science (AREA)
- Endocrinology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Reproductive Health (AREA)
- Diabetes (AREA)
- Gynecology & Obstetrics (AREA)
- Pregnancy & Childbirth (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
La presente invencion reside en derivados de tieno[2,3- d]pirimidina sustituida por glicina de acuerdo a la Formula general I, (I) o una sal farmaceuticamente aceptable de la misma, en donde X es O o H,H A es S, NH, N(R6), O es un enlace; R1 es (1-4C)alquilo, (2-4C)alquenilo, fenilo o (2-5C)heteroarilo, el anillo heteroarilo o fenilo sustituyendose opcionalmente con uno o mas de los grupos de sustituyentes: hidroxi, halogeno, nitro, trifluorometilo, ciano, amino o (1-4C)(di)alquilarnino y R2 es H, (1 -4C)alquilo, (1-4C)alcoxi(2-4C)alquilo o hidroxi(2-4C)alquilo; R3 y R4 pueden seleccionarse independientemente de H e hidroxi(1-4C)alquilo; R5 es H o (1-4C)alquilo. R6 puede seleccionarse de los mismos grupos segun se describe para R1. Los compuestos de la invencion tienen actividad de activacion receptora LH asi como tambien FSH y pueden utilizarse en terapias reguladoras de la fertilidad.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP01203328 | 2001-09-04 | ||
| PCT/EP2002/009648 WO2003020727A1 (en) | 2001-09-04 | 2002-08-29 | GLYCINE-SUBSTITUTED THIENO [2,3-d]PYRIMIDINES WITH COMBINED LH AND FSH AGONISTIC ACTIVITY |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| MXPA04002046A true MXPA04002046A (es) | 2004-07-16 |
Family
ID=8180877
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MXPA04002046A MXPA04002046A (es) | 2001-09-04 | 2002-08-29 | Tieno [2,3-d]pirimidinas sustituidas por glicina con actividad agonistica de fsh y lh combinada. |
Country Status (27)
| Country | Link |
|---|---|
| US (1) | US7375109B2 (es) |
| EP (1) | EP1427734B1 (es) |
| JP (1) | JP4263094B2 (es) |
| KR (1) | KR100891630B1 (es) |
| CN (1) | CN1261437C (es) |
| AR (1) | AR036408A1 (es) |
| AT (1) | ATE309251T1 (es) |
| AU (1) | AU2002333750B2 (es) |
| BR (1) | BR0212173A (es) |
| CA (1) | CA2457212C (es) |
| CY (1) | CY1106052T1 (es) |
| DE (1) | DE60207280T2 (es) |
| DK (1) | DK1427734T3 (es) |
| EC (1) | ECSP044990A (es) |
| ES (1) | ES2252540T3 (es) |
| HR (1) | HRP20040194A2 (es) |
| HU (1) | HUP0401443A3 (es) |
| IL (2) | IL160194A0 (es) |
| IS (1) | IS2419B (es) |
| MX (1) | MXPA04002046A (es) |
| NO (1) | NO328792B1 (es) |
| NZ (1) | NZ531375A (es) |
| PE (1) | PE20030467A1 (es) |
| PL (1) | PL368388A1 (es) |
| RU (1) | RU2294331C2 (es) |
| WO (1) | WO2003020727A1 (es) |
| ZA (1) | ZA200401459B (es) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6890923B2 (en) * | 2002-12-16 | 2005-05-10 | Astrazeneca Ab | Compounds |
| KR100666484B1 (ko) * | 2005-02-04 | 2007-01-09 | 삼성전자주식회사 | 반도체 메모리 장치의 입출력 회로 및 입출력 방법 |
| US8741259B2 (en) * | 2008-10-20 | 2014-06-03 | Marvin C. Gershengorn | Low molecular weight thyroid stimulating hormone receptor (TSHR) agonists |
| CN101762915B (zh) * | 2008-12-24 | 2013-04-17 | 北京京东方光电科技有限公司 | Tft-lcd阵列基板及其驱动方法 |
| CN102791705B (zh) | 2010-04-08 | 2016-08-03 | 美国政府(由卫生和人类服务部的部长所代表) | 用于tsh受体的反向激动剂和中性拮抗剂 |
| SI2900675T1 (sl) | 2012-09-28 | 2019-06-28 | Takeda Pharmaceutical Company Limited | Postopek za pridobivanje tienopirimidin derivata |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2054784T3 (es) | 1987-08-08 | 1994-08-16 | Akzo Nv | Un metodo para la fabricacion de un implante. |
| TW564247B (en) * | 1999-04-08 | 2003-12-01 | Akzo Nobel Nv | Bicyclic heteraromatic compound |
-
2002
- 2002-08-29 ES ES02797646T patent/ES2252540T3/es not_active Expired - Lifetime
- 2002-08-29 PL PL02368388A patent/PL368388A1/xx not_active Application Discontinuation
- 2002-08-29 AU AU2002333750A patent/AU2002333750B2/en not_active Ceased
- 2002-08-29 IL IL16019402A patent/IL160194A0/xx unknown
- 2002-08-29 WO PCT/EP2002/009648 patent/WO2003020727A1/en active IP Right Grant
- 2002-08-29 NZ NZ531375A patent/NZ531375A/en not_active IP Right Cessation
- 2002-08-29 MX MXPA04002046A patent/MXPA04002046A/es active IP Right Grant
- 2002-08-29 HU HU0401443A patent/HUP0401443A3/hu unknown
- 2002-08-29 DE DE60207280T patent/DE60207280T2/de not_active Expired - Lifetime
- 2002-08-29 AT AT02797646T patent/ATE309251T1/de not_active IP Right Cessation
- 2002-08-29 DK DK02797646T patent/DK1427734T3/da active
- 2002-08-29 US US10/488,483 patent/US7375109B2/en not_active Expired - Lifetime
- 2002-08-29 RU RU2004110036/04A patent/RU2294331C2/ru not_active IP Right Cessation
- 2002-08-29 JP JP2003524997A patent/JP4263094B2/ja not_active Expired - Fee Related
- 2002-08-29 EP EP02797646A patent/EP1427734B1/en not_active Expired - Lifetime
- 2002-08-29 CN CNB02817240XA patent/CN1261437C/zh not_active Expired - Fee Related
- 2002-08-29 BR BR0212173-5A patent/BR0212173A/pt not_active IP Right Cessation
- 2002-08-29 KR KR1020047003096A patent/KR100891630B1/ko not_active IP Right Cessation
- 2002-08-29 CA CA2457212A patent/CA2457212C/en not_active Expired - Fee Related
- 2002-09-02 AR ARP020103310A patent/AR036408A1/es unknown
- 2002-09-03 PE PE2002000839A patent/PE20030467A1/es not_active Application Discontinuation
-
2004
- 2004-02-03 IL IL160194A patent/IL160194A/en not_active IP Right Cessation
- 2004-02-13 IS IS7152A patent/IS2419B/is unknown
- 2004-02-23 ZA ZA200401459A patent/ZA200401459B/en unknown
- 2004-02-26 HR HR20040194A patent/HRP20040194A2/hr not_active Application Discontinuation
- 2004-02-26 EC EC2004004990A patent/ECSP044990A/es unknown
- 2004-03-03 NO NO20040922A patent/NO328792B1/no not_active IP Right Cessation
-
2005
- 2005-12-22 CY CY20051101587T patent/CY1106052T1/el unknown
Also Published As
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| GB | Transfer or rights | ||
| FG | Grant or registration | ||
| GB | Transfer or rights | ||
| GB | Transfer or rights |