HUP0401443A2 - LH- és FSH-agonista aktivitású glicinhelyettesített tieno[2,3-d]pirimidin-származékok, alkalmazásuk és az ezeket tartalmazó gyógyszerkészítmények - Google Patents
LH- és FSH-agonista aktivitású glicinhelyettesített tieno[2,3-d]pirimidin-származékok, alkalmazásuk és az ezeket tartalmazó gyógyszerkészítményekInfo
- Publication number
- HUP0401443A2 HUP0401443A2 HU0401443A HUP0401443A HUP0401443A2 HU P0401443 A2 HUP0401443 A2 HU P0401443A2 HU 0401443 A HU0401443 A HU 0401443A HU P0401443 A HUP0401443 A HU P0401443A HU P0401443 A2 HUP0401443 A2 HU P0401443A2
- Authority
- HU
- Hungary
- Prior art keywords
- compounds
- groups
- alkyl
- hydrogen atom
- pyrimidines
- Prior art date
Links
- 150000001875 compounds Chemical class 0.000 title abstract 6
- -1 Glycine-substituted thieno[2,3-d]pyrimidines Chemical class 0.000 title 1
- 230000001270 agonistic effect Effects 0.000 title 1
- 239000008194 pharmaceutical composition Substances 0.000 title 1
- 125000000217 alkyl group Chemical group 0.000 abstract 4
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 3
- 102000012673 Follicle Stimulating Hormone Human genes 0.000 abstract 2
- 108010079345 Follicle Stimulating Hormone Proteins 0.000 abstract 2
- 102000009151 Luteinizing Hormone Human genes 0.000 abstract 2
- 108010073521 Luteinizing Hormone Proteins 0.000 abstract 2
- 239000000556 agonist Substances 0.000 abstract 2
- 230000000694 effects Effects 0.000 abstract 2
- 229940028334 follicle stimulating hormone Drugs 0.000 abstract 2
- 125000001072 heteroaryl group Chemical group 0.000 abstract 2
- 229910052739 hydrogen Inorganic materials 0.000 abstract 2
- 125000002768 hydroxyalkyl group Chemical group 0.000 abstract 2
- 229940040129 luteinizing hormone Drugs 0.000 abstract 2
- 229910052760 oxygen Inorganic materials 0.000 abstract 2
- 238000002360 preparation method Methods 0.000 abstract 2
- 125000003342 alkenyl group Chemical group 0.000 abstract 1
- 125000004183 alkoxy alkyl group Chemical group 0.000 abstract 1
- 125000003277 amino group Chemical group 0.000 abstract 1
- 125000004093 cyano group Chemical group *C#N 0.000 abstract 1
- 125000004663 dialkyl amino group Chemical group 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 125000005843 halogen group Chemical group 0.000 abstract 1
- 229940088597 hormone Drugs 0.000 abstract 1
- 239000005556 hormone Substances 0.000 abstract 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 1
- 238000004519 manufacturing process Methods 0.000 abstract 1
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 abstract 1
- 229910052757 nitrogen Inorganic materials 0.000 abstract 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
- 125000001424 substituent group Chemical group 0.000 abstract 1
- 229910052717 sulfur Inorganic materials 0.000 abstract 1
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D495/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/06—Drugs for disorders of the endocrine system of the anterior pituitary hormones, e.g. TSH, ACTH, FSH, LH, PRL, GH
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/06—Drugs for disorders of the endocrine system of the anterior pituitary hormones, e.g. TSH, ACTH, FSH, LH, PRL, GH
- A61P5/08—Drugs for disorders of the endocrine system of the anterior pituitary hormones, e.g. TSH, ACTH, FSH, LH, PRL, GH for decreasing, blocking or antagonising the activity of the anterior pituitary hormones
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Veterinary Medicine (AREA)
- Engineering & Computer Science (AREA)
- Endocrinology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Reproductive Health (AREA)
- Diabetes (AREA)
- Gynecology & Obstetrics (AREA)
- Pregnancy & Childbirth (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
A találmány glükoprotein-hormon agonista aktivitású vegyületekre,közelebbről luteinizáló hormon (LH) és tüszőstimuláló hormon (FSH)agonista aktivitású vegyületekre vonatkozik. A találmány tárgyatovábbá az ilyen vegyületeket tartalmazó gyógyászati készítményekilletve az ilyen vegyületeknek a humán gyógyászatban, közelebbről aszületésszabályozásban hasznosított gyógyászati készítményekelőállítására való alkalmazása. A találmány szerinti vegyületek (I)általános képletében X jelentése O vagy H,H; A jelentése S, O, NH,N(R6) vagy egy kötés; Rl jelentése alkil-, alkenil-, fend- vagyheteroarilcsoport, és a fenil- vagy heteroarilgyűrű adott esetbenszubsztituálva lehet halogénatomok, hidroxilcsoportok, nitrocsoportok,trifluormetilcsoportok, cianocsoportok, aminocsoportok ésdialkilaminocsoportok közül megválasztott egy vagy többszubsztituenssel; R2 jelentése hidrogénatom vagy alkil-, alkoxialkil-vagy hidroxialkilcsoport; R3 <>és R4 egymástól függetlenülhidrogénatomot vagy alkil- vagy hidroxialkilcsoportot jelentenek; R5jelentése hidrogénatom vagy alkilcsoport; és R6 jelentése megegyezikRl jelentésével. Ó
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP01203328 | 2001-09-04 | ||
| PCT/EP2002/009648 WO2003020727A1 (en) | 2001-09-04 | 2002-08-29 | GLYCINE-SUBSTITUTED THIENO [2,3-d]PYRIMIDINES WITH COMBINED LH AND FSH AGONISTIC ACTIVITY |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| HUP0401443A2 true HUP0401443A2 (hu) | 2004-11-29 |
| HUP0401443A3 HUP0401443A3 (en) | 2008-05-28 |
Family
ID=8180877
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HU0401443A HUP0401443A3 (en) | 2001-09-04 | 2002-08-29 | Glycine-substituted thieno[2,3-d]pyrimidines with lh and fsh agonistic activity, use of the compounds and pharmaceutical compositions containing same |
Country Status (27)
| Country | Link |
|---|---|
| US (1) | US7375109B2 (hu) |
| EP (1) | EP1427734B1 (hu) |
| JP (1) | JP4263094B2 (hu) |
| KR (1) | KR100891630B1 (hu) |
| CN (1) | CN1261437C (hu) |
| AR (1) | AR036408A1 (hu) |
| AT (1) | ATE309251T1 (hu) |
| AU (1) | AU2002333750B2 (hu) |
| BR (1) | BR0212173A (hu) |
| CA (1) | CA2457212C (hu) |
| CY (1) | CY1106052T1 (hu) |
| DE (1) | DE60207280T2 (hu) |
| DK (1) | DK1427734T3 (hu) |
| EC (1) | ECSP044990A (hu) |
| ES (1) | ES2252540T3 (hu) |
| HR (1) | HRP20040194A2 (hu) |
| HU (1) | HUP0401443A3 (hu) |
| IL (2) | IL160194A0 (hu) |
| IS (1) | IS2419B (hu) |
| MX (1) | MXPA04002046A (hu) |
| NO (1) | NO328792B1 (hu) |
| NZ (1) | NZ531375A (hu) |
| PE (1) | PE20030467A1 (hu) |
| PL (1) | PL368388A1 (hu) |
| RU (1) | RU2294331C2 (hu) |
| WO (1) | WO2003020727A1 (hu) |
| ZA (1) | ZA200401459B (hu) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6890923B2 (en) * | 2002-12-16 | 2005-05-10 | Astrazeneca Ab | Compounds |
| KR100666484B1 (ko) * | 2005-02-04 | 2007-01-09 | 삼성전자주식회사 | 반도체 메모리 장치의 입출력 회로 및 입출력 방법 |
| US8741259B2 (en) * | 2008-10-20 | 2014-06-03 | Marvin C. Gershengorn | Low molecular weight thyroid stimulating hormone receptor (TSHR) agonists |
| CN101762915B (zh) * | 2008-12-24 | 2013-04-17 | 北京京东方光电科技有限公司 | Tft-lcd阵列基板及其驱动方法 |
| CN102791705B (zh) | 2010-04-08 | 2016-08-03 | 美国政府(由卫生和人类服务部的部长所代表) | 用于tsh受体的反向激动剂和中性拮抗剂 |
| SI2900675T1 (sl) | 2012-09-28 | 2019-06-28 | Takeda Pharmaceutical Company Limited | Postopek za pridobivanje tienopirimidin derivata |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2054784T3 (es) | 1987-08-08 | 1994-08-16 | Akzo Nv | Un metodo para la fabricacion de un implante. |
| TW564247B (en) * | 1999-04-08 | 2003-12-01 | Akzo Nobel Nv | Bicyclic heteraromatic compound |
-
2002
- 2002-08-29 ES ES02797646T patent/ES2252540T3/es not_active Expired - Lifetime
- 2002-08-29 PL PL02368388A patent/PL368388A1/xx not_active Application Discontinuation
- 2002-08-29 AU AU2002333750A patent/AU2002333750B2/en not_active Ceased
- 2002-08-29 IL IL16019402A patent/IL160194A0/xx unknown
- 2002-08-29 WO PCT/EP2002/009648 patent/WO2003020727A1/en active IP Right Grant
- 2002-08-29 NZ NZ531375A patent/NZ531375A/en not_active IP Right Cessation
- 2002-08-29 MX MXPA04002046A patent/MXPA04002046A/es active IP Right Grant
- 2002-08-29 HU HU0401443A patent/HUP0401443A3/hu unknown
- 2002-08-29 DE DE60207280T patent/DE60207280T2/de not_active Expired - Lifetime
- 2002-08-29 AT AT02797646T patent/ATE309251T1/de not_active IP Right Cessation
- 2002-08-29 DK DK02797646T patent/DK1427734T3/da active
- 2002-08-29 US US10/488,483 patent/US7375109B2/en not_active Expired - Lifetime
- 2002-08-29 RU RU2004110036/04A patent/RU2294331C2/ru not_active IP Right Cessation
- 2002-08-29 JP JP2003524997A patent/JP4263094B2/ja not_active Expired - Fee Related
- 2002-08-29 EP EP02797646A patent/EP1427734B1/en not_active Expired - Lifetime
- 2002-08-29 CN CNB02817240XA patent/CN1261437C/zh not_active Expired - Fee Related
- 2002-08-29 BR BR0212173-5A patent/BR0212173A/pt not_active IP Right Cessation
- 2002-08-29 KR KR1020047003096A patent/KR100891630B1/ko not_active IP Right Cessation
- 2002-08-29 CA CA2457212A patent/CA2457212C/en not_active Expired - Fee Related
- 2002-09-02 AR ARP020103310A patent/AR036408A1/es unknown
- 2002-09-03 PE PE2002000839A patent/PE20030467A1/es not_active Application Discontinuation
-
2004
- 2004-02-03 IL IL160194A patent/IL160194A/en not_active IP Right Cessation
- 2004-02-13 IS IS7152A patent/IS2419B/is unknown
- 2004-02-23 ZA ZA200401459A patent/ZA200401459B/en unknown
- 2004-02-26 HR HR20040194A patent/HRP20040194A2/hr not_active Application Discontinuation
- 2004-02-26 EC EC2004004990A patent/ECSP044990A/es unknown
- 2004-03-03 NO NO20040922A patent/NO328792B1/no not_active IP Right Cessation
-
2005
- 2005-12-22 CY CY20051101587T patent/CY1106052T1/el unknown
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| GB9A | Succession in title |
Owner name: N.V. ORGANON, NL Free format text: FORMER OWNER(S): AKZO NOBEL N.V., NL |
|
| FA9A | Lapse of provisional patent protection due to relinquishment or protection considered relinquished |