MXPA04001399A - Derivados de tiazolilo 2-amino-4,5-trisustituidos. - Google Patents

Derivados de tiazolilo 2-amino-4,5-trisustituidos.

Info

Publication number
MXPA04001399A
MXPA04001399A MXPA04001399A MXPA04001399A MXPA04001399A MX PA04001399 A MXPA04001399 A MX PA04001399A MX PA04001399 A MXPA04001399 A MX PA04001399A MX PA04001399 A MXPA04001399 A MX PA04001399A MX PA04001399 A MXPA04001399 A MX PA04001399A
Authority
MX
Mexico
Prior art keywords
amino
6alkyl
aminocarbonyl
mono
optionally substituted
Prior art date
Application number
MXPA04001399A
Other languages
English (en)
Inventor
Paul Cooymans Ludwig
Original Assignee
Janssen Pharmaceutica Nv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Janssen Pharmaceutica Nv filed Critical Janssen Pharmaceutica Nv
Publication of MXPA04001399A publication Critical patent/MXPA04001399A/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425—Thiazoles
    • A61K31/426—1,3-Thiazoles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D277/38—Nitrogen atoms
    • C07D277/42—Amino or imino radicals substituted by hydrocarbon or substituted hydrocarbon radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems

Abstract

Esta invencion se relaciona con el uso de un compuesto de formula (l'°), un N-oxido, una sal de adicion farmaceuticamente aceptable, una amina cuaternaria y una forma estereoquimicamente isomerica del mismo, en donde Z es halo; alquilo de C1-6; alquilcarbonilo de C1-6; alquiloxicarbonilo de C1-6; aminocarbonilo; alquilo de C1-6 sustituido con hidroxi, carboxilo, ciano, amino, amino sustituido con piperidinilo, amino sustituido con piperidinilo sustituido con alquilo de C1-4, mono o di(alquil de C1-6)amino, aminocarbonilo, mono o di(alquil de C1-6)aminocarbonilo, alquiloxicarbonilo d e C1-6, alquiloxi de C1-6, piperidinilo, piperacinilo, motfoIinilo, tiomorioIinilo; polihaloalquilo de C1-4; ciano; amino; mono o di(alquil de C1-6)aminocarbonilo; alquiloxicarbonilo de C1-6; alquilcarboniloxi de C1-6; amino-S(=O)2-; mono o di(alquil de C1-6)amino- S(=O)2; -C(=N-Rx)NRyRZ; Q es cicloalquilo de C3-6, fenilo, piridilo, pirimidinilo, piracinilo, piridacinilo, benztiazolilo, benzoxazolilo, bencimidazolilo, indazolilo, o imidazopiridilo sustituido opcionalmente, o Q es un radical de la formula (b- 1), (b-2), o (b-3), L es fenilo sustituido opcionalmente o un heterociclo monociclico de 5 o 6 miembros parcialmente saturado o aromatico, o un heterociclo biciclico parcialmente saturado o aromatico, sustituido opcionalmente; arilo es fenilo sustituido opcionalmente; para la fabricacion de un medicamento para la prevencion o el tratamiento de enfermedades inflamatorias y/o autoinmunes, mediadas a traves del TNF-a y/o la IL-12.
MXPA04001399A 2001-08-13 2002-08-09 Derivados de tiazolilo 2-amino-4,5-trisustituidos. MXPA04001399A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP01203087 2001-08-13
PCT/EP2002/008955 WO2003015773A2 (en) 2001-08-13 2002-08-09 2-amino-4,5-trisubstituted thiazolyl derivatives and their use against autoimmune diseases

Publications (1)

Publication Number Publication Date
MXPA04001399A true MXPA04001399A (es) 2004-05-27

Family

ID=8180790

Family Applications (1)

Application Number Title Priority Date Filing Date
MXPA04001399A MXPA04001399A (es) 2001-08-13 2002-08-09 Derivados de tiazolilo 2-amino-4,5-trisustituidos.

Country Status (21)

Country Link
US (2) US7232838B2 (es)
EP (1) EP1418909B1 (es)
JP (1) JP4388805B2 (es)
KR (2) KR101034489B1 (es)
CN (1) CN100496493C (es)
AU (1) AU2002324045C1 (es)
BR (1) BR0211887A (es)
CA (1) CA2451980C (es)
EA (1) EA007717B1 (es)
ES (1) ES2407807T3 (es)
HK (1) HK1069997A1 (es)
HR (1) HRP20040097B1 (es)
HU (1) HUP0401748A3 (es)
IL (2) IL160329A0 (es)
MX (1) MXPA04001399A (es)
NO (1) NO327409B1 (es)
NZ (1) NZ530950A (es)
PL (1) PL368130A1 (es)
UA (1) UA82176C2 (es)
WO (1) WO2003015773A2 (es)
ZA (1) ZA200401162B (es)

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WO2005073225A1 (en) * 2004-01-30 2005-08-11 Ab Science 2-(3-substituted-aryl)amino-4-aryl-thiazoles as tyrosine kinase inhibitors
UA92746C2 (en) * 2005-05-09 2010-12-10 Акилайон Фармасьютикалз, Инк. Thiazole compounds and methods of use
US20070032493A1 (en) * 2005-05-26 2007-02-08 Synta Pharmaceuticals Corp. Method for treating B cell regulated autoimmune disorders
EA015034B1 (ru) * 2005-09-13 2011-04-29 Янссен Фармацевтика Н.В. 2-анилин-4-арилзамещенные тиазольные производные
EP1999119A2 (en) 2006-02-15 2008-12-10 Abbott Laboratories Novel acetyl-coa carboxylase (acc) inhibitors and their use in diabetes, obesity and metabolic syndrome
CN101384568B (zh) * 2006-02-15 2012-12-12 雅培制药有限公司 乙酰辅酶a羧化酶(acc)抑制剂及其在糖尿病、肥胖症和代谢综合征中的应用
JP2009529059A (ja) * 2006-03-08 2009-08-13 アキリオン ファーマシューティカルズ，インコーポレーテッド 抗ｃ型肝炎ウイルス活性を有する置換アミノチアゾール誘導体
CA2647819C (en) 2006-03-31 2012-12-11 Novartis Ag Phenylcyclohexyl derivatives as dgat1 inhibitors
EA200901573A1 (ru) * 2007-05-22 2010-04-30 Ачиллион Фармасьютикалз, Инк. Гетероарилзамещенные тиазолы
ES2617305T3 (es) * 2007-07-17 2017-06-16 Acea Biosciences, Inc. Compuestos heterocíclicos y usos como agentes anticancerosos
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JP5486591B2 (ja) 2008-05-09 2014-05-07 ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ アセチルコリン受容体モジュレーターとしての三置換ピラゾール
US8106209B2 (en) * 2008-06-06 2012-01-31 Achillion Pharmaceuticals, Inc. Substituted aminothiazole prodrugs of compounds with anti-HCV activity
EP2306836B1 (en) * 2008-07-01 2016-09-07 PTC Therapeutics, Inc. Bmi-1 protein expression modulators
UA104147C2 (uk) 2008-09-10 2014-01-10 Новартис Аг Похідна піролідиндикарбонової кислоти та її застосування у лікуванні проліферативних захворювань
EP2350064A1 (en) * 2008-10-01 2011-08-03 Synta Pharmaceuticals Corp. Compounds for inflammation and immune-related uses
US8293753B2 (en) * 2009-07-02 2012-10-23 Novartis Ag Substituted 2-carboxamide cycloamino ureas
JP6240078B2 (ja) 2011-10-04 2017-11-29 バルーク エス．ブルームバーグ インスティテュート 肝細胞癌を含む癌の阻害剤、および肝炎ウイルス複製の阻害剤としての置換アミノチアゾール
CN103159695B (zh) * 2011-12-08 2015-08-12 首都师范大学 可抑制hiv复制并对耐药hiv病毒株有效的噻唑类化合物及其制备方法和用途
CN102863435B (zh) * 2012-09-25 2015-02-18 盐城工学院 一种2-[[4-氟-3-(三氟甲基)苯基]氨基]-4-吡啶基-5-噻唑甲醛及其还原产物的制备方法
US9453002B2 (en) 2013-08-16 2016-09-27 Janssen Pharmaceutica Nv Substituted imidazoles as N-type calcium channel blockers
US11072592B2 (en) 2015-02-27 2021-07-27 The Regents Of The University Of California Small molecules that enable cartilage rejuvenation
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CN105524056A (zh) * 2016-01-05 2016-04-27 中山大学肿瘤防治中心 一种氨基噻唑化合物及其制备方法和应用

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Also Published As

Publication number Publication date
EA200400306A1 (ru) 2004-08-26
CN1541097A (zh) 2004-10-27
JP2005501099A (ja) 2005-01-13
JP4388805B2 (ja) 2009-12-24
CA2451980A1 (en) 2003-02-27
KR100979988B1 (ko) 2010-09-03
AU2002324045C1 (en) 2008-05-29
IL160329A (en) 2010-05-31
EP1418909A2 (en) 2004-05-19
AU2002324045B2 (en) 2007-10-04
HRP20040097A2 (en) 2004-06-30
EP1418909B1 (en) 2013-02-20
KR20040031712A (ko) 2004-04-13
NO20040632L (no) 2004-03-11
HUP0401748A3 (en) 2011-03-28
HRP20040097B1 (hr) 2013-10-11
WO2003015773A3 (en) 2003-12-18
EA007717B1 (ru) 2006-12-29
NO327409B1 (no) 2009-06-22
CN100496493C (zh) 2009-06-10
UA82176C2 (en) 2008-03-25
US20070203189A1 (en) 2007-08-30
ZA200401162B (en) 2005-07-27
IL160329A0 (en) 2004-07-25
KR20100076043A (ko) 2010-07-05
BR0211887A (pt) 2004-09-21
US7803823B2 (en) 2010-09-28
HK1069997A1 (en) 2005-06-10
CA2451980C (en) 2012-12-11
ES2407807T3 (es) 2013-06-14
PL368130A1 (en) 2005-03-21
US20040254191A1 (en) 2004-12-16
HUP0401748A2 (hu) 2004-12-28
NZ530950A (en) 2006-03-31
KR101034489B1 (ko) 2011-05-17
WO2003015773A2 (en) 2003-02-27
US7232838B2 (en) 2007-06-19

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