MXPA01006742A - Compuestos 3-heteroarilidenil-2-indolinona para modular la actividad de la quinasa de proteina y para utilizarse en la quimioterapia de cancer. - Google Patents

Compuestos 3-heteroarilidenil-2-indolinona para modular la actividad de la quinasa de proteina y para utilizarse en la quimioterapia de cancer.

Info

Publication number
MXPA01006742A
MXPA01006742A MXPA01006742A MXPA01006742A MXPA01006742A MX PA01006742 A MXPA01006742 A MX PA01006742A MX PA01006742 A MXPA01006742 A MX PA01006742A MX PA01006742 A MXPA01006742 A MX PA01006742A MX PA01006742 A MXPA01006742 A MX PA01006742A
Authority
MX
Mexico
Prior art keywords
heteroarylidenyl
protein kinase
kinase activity
cancer chemotherapy
indolinone compounds
Prior art date
Application number
MXPA01006742A
Other languages
English (en)
Inventor
Peng Cho Tang
Original Assignee
Sugen Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sugen Inc filed Critical Sugen Inc
Publication of MXPA01006742A publication Critical patent/MXPA01006742A/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
    • A61K31/404—Indoles, e.g. pindolol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Abstract

La presente invencion se refiere a los compuestos 3-heteroarilidenil-2-indolinona que modulan la actividad enzimatica de las quinasas de proteina y por lo tanto se espera que sean utiles en la prevencion y tratamiento de la quinasa de proteina relacionada a los desordenes celulares tal como el cancer. Ademas, se espera que estos compuestos mejoren la eficacia de otros agentes quimioterapeuticos, en particular, pirimidinas fluoradas, en el tratamiento del cancer.
MXPA01006742A 1998-12-31 1999-12-30 Compuestos 3-heteroarilidenil-2-indolinona para modular la actividad de la quinasa de proteina y para utilizarse en la quimioterapia de cancer. MXPA01006742A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US11431398P 1998-12-31 1998-12-31
PCT/US1999/031232 WO2000038519A1 (en) 1998-12-31 1999-12-30 3-heteroarylidenyl-2-indolinone compounds for modulating protein kinase activity and for use in cancer chemotherapy

Publications (1)

Publication Number Publication Date
MXPA01006742A true MXPA01006742A (es) 2004-04-21

Family

ID=22354480

Family Applications (1)

Application Number Title Priority Date Filing Date
MXPA01006742A MXPA01006742A (es) 1998-12-31 1999-12-30 Compuestos 3-heteroarilidenil-2-indolinona para modular la actividad de la quinasa de proteina y para utilizarse en la quimioterapia de cancer.

Country Status (10)

Country Link
EP (1) EP1139754A4 (es)
JP (1) JP2002533360A (es)
KR (1) KR20010108063A (es)
CN (1) CN1356872A (es)
AU (1) AU760964B2 (es)
BR (1) BR9916735A (es)
CA (1) CA2357042A1 (es)
IL (1) IL143920A0 (es)
MX (1) MXPA01006742A (es)
WO (1) WO2000038519A1 (es)

Families Citing this family (31)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6569868B2 (en) 1998-04-16 2003-05-27 Sugen, Inc. 2-indolinone derivatives as modulators of protein kinase activity
JP5336686B2 (ja) * 1999-11-24 2013-11-06 スージェン， インク． 遊離酸または遊離塩基としてイオン化可能な医薬品のための処方
US6878733B1 (en) 1999-11-24 2005-04-12 Sugen, Inc. Formulations for pharmaceutical agents ionizable as free acids or free bases
AR034118A1 (es) * 2000-02-15 2004-02-04 Sugen Inc Compuestos de 2-indolinonas sustituidas con pirroles inhibidoras de proteinquinasas; sus composiciones farmaceuticas e intermediarios de sintesis
PL363110A1 (en) * 2000-02-28 2004-11-15 Aventis Pharma S.A. A composition comprising camptothecin and a pyrimidine derivative for the treatment of cancer
TWI270545B (en) 2000-05-24 2007-01-11 Sugen Inc Mannich base prodrugs of 3-(pyrrol-2-ylmethylidene)-2-indolinone derivatives
WO2001094312A2 (en) 2000-06-02 2001-12-13 Sugen, Inc. Indolinone derivatives as protein kinase/phosphatase inhibitors
SK11082003A3 (sk) 2001-03-14 2004-08-03 Bristol-Myers Squibb Company Kombinácia analógov epotilónu a chemoterapeutických činidiel na liečenie proliferatívnych ochorení
US6599902B2 (en) 2001-05-30 2003-07-29 Sugen, Inc. 5-aralkysufonyl-3-(pyrrol-2-ylmethylidene)-2-indolinone derivatives as kinase inhibitors
AR038957A1 (es) * 2001-08-15 2005-02-02 Pharmacia Corp Terapia de combinacion para el tratamiento del cancer
AU2002348393A1 (en) * 2001-10-25 2003-05-06 Merck And Co., Inc. Tyrosine kinase inhibitors
WO2003035616A2 (en) * 2001-10-25 2003-05-01 Merck & Co., Inc. Tyrosine kinase inhibitors
WO2003035619A1 (en) * 2001-10-25 2003-05-01 Merck & Co., Inc. Tyrosine kinase inhibitors
MXPA04004804A (es) * 2001-11-21 2005-02-17 Sugen Inc Formulaciones farmaceuticas que comprenden derivados de indolinona.
US20030187026A1 (en) 2001-12-13 2003-10-02 Qun Li Kinase inhibitors
US6797825B2 (en) 2001-12-13 2004-09-28 Abbott Laboratories Protein kinase inhibitors
CA2470480C (en) 2001-12-27 2010-12-14 Theravance, Inc. Indolinone derivatives useful as protein kinase inhibitors
KR20050012831A (ko) 2002-06-25 2005-02-02 와이어쓰 피부 질환을 치료하는 데 있어서의 티오-옥스인돌유도체의 용도
US7488734B2 (en) 2002-06-25 2009-02-10 Wyeth Methods of treating hormone-related conditions using thio-oxindole derivatives
EP1525200B1 (en) 2002-08-02 2007-10-10 AB Science 2-(3-aminoaryl)amino-4-aryl-thiazoles and their use as c-kit inhibitors
US8450302B2 (en) 2002-08-02 2013-05-28 Ab Science 2-(3-aminoaryl) amino-4-aryl-thiazoles and their use as c-kit inhibitors
MXPA05003431A (es) * 2002-11-15 2005-07-05 Warner Lambert Co Quimioterapia de combinacion.
ATE465731T1 (de) 2003-10-23 2010-05-15 Ab Science 2-aminoaryloxazol-verbindungen als tyrosinkinase- hemmer
CN100432071C (zh) * 2004-11-05 2008-11-12 中国科学院上海药物研究所 取代1h－吲哚－2－酮类化合物及其制备方法和用途
RU2445308C2 (ru) 2005-04-04 2012-03-20 Аб Сьянс Замещенные производные оксазола и их применение в качестве ингибиторов тирозинкиназы
US8246966B2 (en) 2006-08-07 2012-08-21 University Of Georgia Research Foundation, Inc. Trypanosome microsome system and uses thereof
EP2088863A2 (en) 2006-11-22 2009-08-19 University Of Georgia Research Foundation, Inc. Tyrosine kinase inhibitors as anti-kinetolastid and anti-apicomplexan agents
ES2671730T3 (es) 2011-11-11 2018-06-08 Eli Lilly And Company Terapia de combinación para el cáncer de ovario
WO2016112111A1 (en) 2015-01-08 2016-07-14 The Board Of Trustees Of The Leland Stanford Junior University Factors and cells that provide for induction of bone, bone marrow, and cartilage
UY36654A (es) 2015-04-29 2016-10-31 Janssen Pharmaceutica Nv Azabenzimidazoles con propiedades moduladoras del receptor ampa y composiciones farmacéuticas que los contienen
CN105585558A (zh) * 2015-12-15 2016-05-18 贵州大学 双烷氧基嘧啶拼接3-烯键氧化吲哚衍生物及其制备方法及应用

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5880141A (en) * 1995-06-07 1999-03-09 Sugen, Inc. Benzylidene-Z-indoline compounds for the treatment of disease
WO1998007695A1 (en) * 1996-08-23 1998-02-26 Sugen, Inc. Indolinone combinatorial libraries and related products and methods for the treatment of disease

Also Published As

Publication number Publication date
AU760964B2 (en) 2003-05-22
EP1139754A1 (en) 2001-10-10
KR20010108063A (ko) 2001-12-07
BR9916735A (pt) 2001-09-25
EP1139754A4 (en) 2002-12-18
CA2357042A1 (en) 2000-07-06
WO2000038519A1 (en) 2000-07-06
IL143920A0 (en) 2002-04-21
AU2221500A (en) 2000-07-31
CN1356872A (zh) 2002-07-03
JP2002533360A (ja) 2002-10-08

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