BR9607543A - Inibidores de protease retroviral sulfonamida hidroxietilamino de bis-amino ácido - Google Patents

Inibidores de protease retroviral sulfonamida hidroxietilamino de bis-amino ácido

Info

Publication number: BR9607543A
Authority: BR; Brazil
Prior art keywords: hydroxyethylamino; retroviral; amino acid; protease inhibitors; bis
Prior art date: 1995-03-10

Application number

BR9607543A

Other languages

English (en)

Inventor

Daniel P Getman

Gary A Decrescenzo

John N Freskos

Michael L Vasquez

James A Sikorski

Balekudru Devadas

Srinivasan Nagarajan

David L Brown

Joseph J Mcdonald

Original Assignee

Searle & Co

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1995-03-10

Filing date

1996-03-07

Publication date

1997-12-23

1996-03-07 Application filed by Searle & Co filed Critical Searle & Co

1997-12-23 Publication of BR9607543A publication Critical patent/BR9607543A/pt

Links

230000001177 retroviral effect Effects 0.000 title abstract 4
229940042399 direct acting antivirals protease inhibitors Drugs 0.000 title abstract 3
239000000137 peptide hydrolase inhibitor Substances 0.000 title abstract 3
241000725303 Human immunodeficiency virus Species 0.000 abstract 2
108091005804 Peptidases Proteins 0.000 abstract 2
239000004365 Protease Substances 0.000 abstract 2
206010038997 Retroviral infections Diseases 0.000 abstract 2
108010010369 HIV Protease Proteins 0.000 abstract 1
102000035195 Peptidases Human genes 0.000 abstract 1
102100037486 Reverse transcriptase/ribonuclease H Human genes 0.000 abstract 1
150000001875 compounds Chemical class 0.000 abstract 1
239000003112 inhibitor Substances 0.000 abstract 1
230000002401 inhibitory effect Effects 0.000 abstract 1
241001430294 unidentified retrovirus Species 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06008—Dipeptides with the first amino acid being neutral
- C07K5/06017—Dipeptides with the first amino acid being neutral and aliphatic
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06008—Dipeptides with the first amino acid being neutral
- C07K5/06017—Dipeptides with the first amino acid being neutral and aliphatic
- C07K5/06026—Dipeptides with the first amino acid being neutral and aliphatic the side chain containing 0 or 1 carbon atom, i.e. Gly or Ala
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/55—Protease inhibitors
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Organic Chemistry (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
Animal Behavior & Ethology (AREA)
Pharmacology & Pharmacy (AREA)
Molecular Biology (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Oncology (AREA)
Communicable Diseases (AREA)
Genetics & Genomics (AREA)
Virology (AREA)
Biophysics (AREA)
Biochemistry (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Obesity (AREA)
Hematology (AREA)
Diabetes (AREA)
Tropical Medicine & Parasitology (AREA)
AIDS & HIV (AREA)
Gastroenterology & Hepatology (AREA)
Immunology (AREA)
Epidemiology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Medicinal Preparation (AREA)

BR9607543A 1995-03-10 1996-03-07 Inibidores de protease retroviral sulfonamida hidroxietilamino de bis-amino ácido BR9607543A (pt)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
US40245095A	1995-03-10	1995-03-10
US08/479,071 US6150556A (en)	1995-03-10	1995-06-07	Bis-amino acid hydroxyethylamino sulfonamide retroviral protease inhibitors
PCT/US1996/002685 WO1996028464A1 (en)	1995-03-10	1996-03-07	Bis-amino acid hydroxyethylamino sulfonamide retroviral protease inhibitors

Publications (1)

Publication Number	Publication Date
BR9607543A true BR9607543A (pt)	1997-12-23

Family

ID=27017890

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
BR9607543A BR9607543A (pt)	1995-03-10	1996-03-07	Inibidores de protease retroviral sulfonamida hidroxietilamino de bis-amino ácido

Country Status (23)

Country	Link
US (2)	US6150556A (pt)
EP (2)	EP1076062A1 (pt)
JP (1)	JPH11501921A (pt)
KR (1)	KR100428499B1 (pt)
CN (1)	CN1178954C (pt)
AT (1)	ATE304550T1 (pt)
AU (1)	AU704360B2 (pt)
BR (1)	BR9607543A (pt)
CA (1)	CA2215025A1 (pt)
CZ (1)	CZ294966B6 (pt)
DE (1)	DE69635183T2 (pt)
DK (1)	DK0813543T3 (pt)
EA (1)	EA000578B1 (pt)
EE (1)	EE04376B1 (pt)
ES (1)	ES2249779T3 (pt)
HU (1)	HUP9802647A3 (pt)
MX (1)	MX9706913A (pt)
NO (3)	NO325230B1 (pt)
NZ (1)	NZ305544A (pt)
PL (2)	PL185543B1 (pt)
SK (2)	SK285930B6 (pt)
UA (1)	UA55384C2 (pt)
WO (1)	WO1996028464A1 (pt)

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US20040122000A1 (en)	1981-01-07	2004-06-24	Vertex Pharmaceuticals Incorporated.	Inhibitors of aspartyl protease
EP1188766A1 (en) *	1995-03-10	2002-03-20	G.D. Searle & Co.	Bis-amino acid hydroxyethylamino sulfonamide retroviral protease inhibitors
US6861539B1 (en) *	1995-03-10	2005-03-01	G. D. Searle & Co.	Bis-amino acid hydroxyethylamino sulfonamide retroviral protease inhibitors
US7339078B2 (en) *	1995-03-10	2008-03-04	G.D. Searle Llc	Bis-amino acid hydroxyethylamino sulfonamide retroviral protease inhibitors
EP1095022A1 (en)	1998-07-08	2001-05-02	G.D. Searle & Co.	Retroviral protease inhibitors
HUP0105235A3 (en) *	1999-01-13	2002-08-28	Pont Pharmaceuticals Company W	Bis-amino acid sulfonamides containing n-terminally a substituted benzyl group as hiv protease inhibitors, pharmaceutical compositions comprising thereof and their use
AR031520A1 (es) *	1999-06-11	2003-09-24	Vertex Pharma	Un compuesto inhibidor de aspartilo proteasa, una composicion que lo comprende y un metodo para tratar un paciente con dicha composicion
US6391919B1 (en)	2000-01-12	2002-05-21	Bristol-Myers Squibb Pharma Company	Bis-amino acid sulfonamides containing substituted benzyl amines HIV protease inhibitors
US20020022659A1 (en) *	2000-07-19	2002-02-21	Harris Gregory D.	Crystalline and salt forms of an HIV protease inhibitor
US20020022742A1 (en) *	2000-07-19	2002-02-21	Harris Gregory D.	Salt forms of an HIV protease inhibitor
US6617310B2 (en)	2000-07-19	2003-09-09	Bristol-Myers Squibb Pharma Company	Phosphate esters of bis-amino acid sulfonamides containing substituted benzyl amines
CN101230067B (zh) *	2001-02-14	2011-06-15	泰博特克药品有限公司	广谱的2-(取代-氨基)-苯并噻唑磺酰胺hiv蛋白酶抑制剂
AU2002257774B2 (en) *	2001-04-09	2007-08-30	Tibotec Pharmaceuticals Ltd.	Broadspectrum 2-(substituted-amino)-benzoxazole sulfonamide HIV protease inhibitors
EP1387842B1 (en)	2001-05-11	2009-04-22	Tibotec Pharmaceuticals Ltd.	Broadspectrum 2-amino-benzoxazole sulfonamide hiv protease inhibitors
US6562848B1 (en)	2001-09-18	2003-05-13	Bristol-Myers Squibb Company	Bis-amino acid sulfonamides as HIV protease inhibitors
EP1463502B1 (en)	2001-12-21	2011-07-13	Tibotec Pharmaceuticals	Broadspectrum heterocyclic substituted phenyl containing sulfonamide hiv protease inhibitors
MY142238A (en) *	2002-03-12	2010-11-15	Tibotec Pharm Ltd	Broadspectrum substituted benzimidazole sulfonamide hiv protease inhibitors
KR20100130234A (ko) *	2002-05-17	2010-12-10	티보텍 파마슈티컬즈	광범위 스펙트럼의 치환된 벤즈이속사졸 설폰아미드 ｈｉｖ 프로테아제 저해제
JP4681296B2 (ja)	2002-08-14	2011-05-11	テイボテク・フアーマシユーチカルズ・リミテツド	スペクトルの広い置換オキシインドールスルホンアミドｈｉｖプロテアーゼ阻害剤
US20060128634A1 (en) *	2002-11-14	2006-06-15	Carini David J	Alpha, alpha-disubstituted benzylglycine derivatives as HIV protease inhibitors
US6943170B2 (en) *	2002-11-14	2005-09-13	Bristol-Myers Squibb Company	N-cycloalkylglycines as HIV protease inhibitors
CN1845725A (zh) *	2003-08-06	2006-10-11	尼马尔·穆利耶	包含水溶性药物的药物组合物
US20050131042A1 (en) *	2003-12-11	2005-06-16	Flentge Charles A.	HIV protease inhibiting compounds
US8193227B2 (en)	2003-12-11	2012-06-05	Abbott Laboratories	HIV protease inhibiting compounds
JP4818124B2 (ja)	2003-12-23	2011-11-16	テイボテク・フアーマシユーチカルズ・リミテツド	（３Ｒ，３ａＳ，６ａＲ）−ヘキサヒドロフロ〔２，３−ｂ〕フラン−３−イル（１Ｓ，１Ｒ）−３−〔〔（４−アミノフェニル）スルホニル〕（イソブチル）アミノ〕−１−ベンジル−２−ヒドロキシプロピルカルバマートの製造方法
ES2328701T3 (es)	2003-12-23	2009-11-17	Tibotec Pharmaceuticals Ltd.	Proceso para la preparacion de (3r,3as,6ar)-hexahydrofuro (2,3-b) furan-3-il(1s,2r)-3-(((4-aminofenil)sulfonil)(isobutil)amino)-1-benzil-2-hidroxipropilcarbamato.
RU2460538C2 (ru) *	2006-11-03	2012-09-10	Шеринг-Плоу Лтд.	Вакцина против лаймской болезни собак
JP5745855B2 (ja) *	2007-11-28	2015-07-08	セコイア、ファーマシューティカルズ、インコーポレイテッドＳｅｑｕｏｉａＰｈａｒｍａｃｅｕｔｉｃａｌｓ，Ｉｎｃ．	シトクロムｐ４５０２ｄ６を阻害するための組成物および方法
WO2013009923A1 (en)	2011-07-13	2013-01-17	Creighton University	Methods of promoting neuron growth
US20150113867A1 (en)	2013-10-24	2015-04-30	Basf Se	Use of an alkoxylated polytetrahydrofuran to reduce fuel consumption
CN104478830B (zh) *	2014-12-31	2016-06-22	中国医学科学院医药生物技术研究所	一组叔胺类拟肽衍生物及其在抑制hiv-1蛋白酶中的应用

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TW225540B (pt) *	1990-06-28	1994-06-21	Shionogi & Co
EP0558673B1 (en) *	1990-11-19	1996-04-17	Monsanto Company	Retroviral protease inhibitors
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EP0656888B1 (en) *	1992-08-25	1998-01-07	G.D. Searle & Co.	Sulfonylalkanoylamino hydroxyethylamino sulfonamides useful as retroviral protease inhibitors
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IS2334B (is) *	1992-09-08	2008-02-15	Vertex Pharmaceuticals Inc., (A Massachusetts Corporation)	Aspartyl próteasi hemjari af nýjum flokki súlfonamíða
DK0810208T3 (da) *	1992-10-30	2002-03-18	Monsanto Co	N-substituerede hydroxyethylamino sulfaminsyrederivater til anvendelse som inhibitorer af retrovirale proteaser
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UA49803C2 (uk) *	1994-06-03	2002-10-15	Дж.Д. Сьорль Енд Ко	Спосіб лікування ретровірусних інфекцій

1995
- 1995-06-07 US US08/479,071 patent/US6150556A/en not_active Expired - Fee Related
1996
- 1996-03-07 AT AT96910337T patent/ATE304550T1/de not_active IP Right Cessation
- 1996-03-07 EA EA199700220A patent/EA000578B1/ru not_active IP Right Cessation
- 1996-03-07 DK DK96910337T patent/DK0813543T3/da active
- 1996-03-07 MX MX9706913A patent/MX9706913A/es not_active IP Right Cessation
- 1996-03-07 CN CNB961936185A patent/CN1178954C/zh not_active Expired - Fee Related
- 1996-03-07 KR KR1019970706316A patent/KR100428499B1/ko not_active IP Right Cessation
- 1996-03-07 SK SK1222-97A patent/SK285930B6/sk unknown
- 1996-03-07 EP EP00114911A patent/EP1076062A1/en not_active Withdrawn
- 1996-03-07 WO PCT/US1996/002685 patent/WO1996028464A1/en active Application Filing
- 1996-03-07 CA CA002215025A patent/CA2215025A1/en not_active Abandoned
- 1996-03-07 DE DE69635183T patent/DE69635183T2/de not_active Expired - Fee Related
- 1996-03-07 BR BR9607543A patent/BR9607543A/pt not_active Application Discontinuation
- 1996-03-07 NZ NZ305544A patent/NZ305544A/en unknown
- 1996-03-07 SK SK5091-2006A patent/SK285958B6/sk unknown
- 1996-03-07 AU AU53561/96A patent/AU704360B2/en not_active Ceased
- 1996-03-07 EE EE9700200A patent/EE04376B1/xx not_active IP Right Cessation
- 1996-03-07 EP EP96910337A patent/EP0813543B1/en not_active Expired - Lifetime
- 1996-03-07 CZ CZ19972825A patent/CZ294966B6/cs not_active IP Right Cessation
- 1996-03-07 JP JP8527649A patent/JPH11501921A/ja not_active Ceased
- 1996-03-07 PL PL96352508A patent/PL185543B1/pl not_active IP Right Cessation
- 1996-03-07 PL PL96322163A patent/PL185108B1/pl not_active IP Right Cessation
- 1996-03-07 HU HU9802647A patent/HUP9802647A3/hu unknown
- 1996-03-07 ES ES96910337T patent/ES2249779T3/es not_active Expired - Lifetime
- 1996-07-03 UA UA97104994A patent/UA55384C2/uk unknown
1997
- 1997-09-09 NO NO19974149A patent/NO325230B1/no unknown
2000
- 2000-02-01 US US09/495,334 patent/US6316496B1/en not_active Expired - Fee Related
2007
- 2007-11-12 NO NO20075810A patent/NO20075810L/no not_active Application Discontinuation
- 2007-11-12 NO NO20075806A patent/NO20075806L/no not_active Application Discontinuation

Also Published As

Publication number	Publication date
US6150556A (en)	2000-11-21
CZ294966B6 (cs)	2005-04-13
EP0813543A1 (en)	1997-12-29
SK122297A3 (en)	1998-02-04
ATE304550T1 (de)	2005-09-15
CN1178954C (zh)	2004-12-08
CA2215025A1 (en)	1996-09-19
HUP9802647A3 (en)	2000-10-30
JPH11501921A (ja)	1999-02-16
PL322163A1 (en)	1998-01-19
US6316496B1 (en)	2001-11-13
EP1076062A1 (en)	2001-02-14
NO974149D0 (no)	1997-09-09
DE69635183D1 (de)	2005-10-20
ES2249779T3 (es)	2006-04-01
CN1196732A (zh)	1998-10-21
WO1996028464A1 (en)	1996-09-19
AU5356196A (en)	1996-10-02
EP0813543B1 (en)	2005-09-14
HUP9802647A2 (hu)	1999-02-01
EA199700220A1 (ru)	1998-02-26
UA55384C2 (uk)	2003-04-15
NO20075806L (no)	1997-11-05
NO20075810L (no)	1997-11-05
EE9700200A (et)	1998-02-16
KR100428499B1 (ko)	2004-11-16
PL185543B1 (pl)	2003-05-30
PL185108B1 (pl)	2003-02-28
EE04376B1 (et)	2004-10-15
CZ282597A3 (cs)	1998-02-18
EA000578B1 (ru)	1999-12-29
KR19980702908A (ko)	1998-09-05
SK285930B6 (sk)	2007-11-02
NO974149L (no)	1997-11-05
MX9706913A (es)	1997-11-29
NO325230B1 (no)	2008-03-03
DK0813543T3 (da)	2006-01-16
NZ305544A (en)	1999-04-29
AU704360B2 (en)	1999-04-22
SK285958B6 (sk)	2007-12-06
DE69635183T2 (de)	2006-06-29

Legal Events

Date	Code	Title	Description
2007-09-18	B07A	Application suspended after technical examination (opinion) [chapter 7.1 patent gazette]
2008-03-11	B07A	Application suspended after technical examination (opinion) [chapter 7.1 patent gazette]
2008-08-26	B09B	Patent application refused [chapter 9.2 patent gazette]	Free format text: DE ACORDO COM O ART. 36 DA LPI (LEI 9279/96) 2O, O PEDIDO VOLTA A EXAME SENDO CONSIDERADO NAO PATENTEAVEL PELAS RAZOES EXPOSTAS NO PARECER TECNICO ANTERIOR.

Publication	Publication Date	Title
BR9607543A (pt)	1997-12-23	Inibidores de protease retroviral sulfonamida hidroxietilamino de bis-amino ácido
BR9607638A (pt)	1998-05-26	Inibidores de protease retrovirais de hidroxietilamino sulfonamida de aminoácido
BR9607450A (pt)	1998-06-30	Inibidores de protease retroviral sulfonilalcanoilamino hidroxietilamino sulfonamida
NO974147D0 (no)	1997-09-09	Heterocykelkarbonyl aminosyre hydroksyetylamino sulfonamid retroviral protease
MX9706912A (es)	1998-01-31	Inhibidores de protesa retroviral de sulfonamida de hidroxietilamino de amino acido y uso de los mismos.