MX9704738A - Analogos de peptido p277 y composiciones farmaceuticas que los contienen, metodo de diagnostico de diabetes mellitus dependiente de la insulina y uso de los mismos. - Google Patents

Analogos de peptido p277 y composiciones farmaceuticas que los contienen, metodo de diagnostico de diabetes mellitus dependiente de la insulina y uso de los mismos.

Info

Publication number
MX9704738A
MX9704738A MX9704738A MX9704738A MX9704738A MX 9704738 A MX9704738 A MX 9704738A MX 9704738 A MX9704738 A MX 9704738A MX 9704738 A MX9704738 A MX 9704738A MX 9704738 A MX9704738 A MX 9704738A
Authority
MX
Mexico
Prior art keywords
peptide
analogs
diabetes
diagnosis
treatment
Prior art date
Application number
MX9704738A
Other languages
English (en)
Inventor
Irun R Cohen
Dana Elias
Matityahu Fridkin
Original Assignee
Yenda Res And Dev Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=26322965&utm_source=***_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=MX9704738(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Priority claimed from IL11209494A external-priority patent/IL112094A0/xx
Priority claimed from IL11446095A external-priority patent/IL114460A0/xx
Application filed by Yenda Res And Dev Co Ltd filed Critical Yenda Res And Dev Co Ltd
Publication of MX9704738A publication Critical patent/MX9704738A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4713—Autoimmune diseases, e.g. Insulin-dependent diabetes mellitus, multiple sclerosis, rheumathoid arthritis, systemic lupus erythematosus; Autoantigens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Diabetes (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Hematology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Obesity (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Endocrinology (AREA)
  • Emergency Medicine (AREA)
  • Veterinary Medicine (AREA)
  • Rehabilitation Therapy (AREA)
  • Biophysics (AREA)
  • Rheumatology (AREA)
  • Toxicology (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biochemistry (AREA)
  • Immunology (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)

Abstract

Un péptido que tiene la estructura de la secuencia p277 de hsp60, en donde uno o ambos residuos de cisteina están reemplazados por residuos de valina y/o en donde el residuo Thr19 está reemplazado por Lys, tiene sustancialmente la misma actividad biologica que p277, peor con estabilidad sustancialmente mejorada. Los análogos de p277 novedosos pueden ser usados para todos los propositos para los que puede usarse p277.
MX9704738A 1994-12-21 1995-12-20 Analogos de peptido p277 y composiciones farmaceuticas que los contienen, metodo de diagnostico de diabetes mellitus dependiente de la insulina y uso de los mismos. MX9704738A (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
IL11209494A IL112094A0 (en) 1994-12-21 1994-12-21 Novel peptides and pharmaceutical compositions comprising them
IL11446095A IL114460A0 (en) 1995-07-05 1995-07-05 Peptide p277 analogs and pharmaceutical compositions comprising them for treatment or diagnosis of diabetes
PCT/US1995/016596 WO1996019236A1 (en) 1994-12-21 1995-12-20 PEPTIDE p277 ANALOGS, AND PHARMACEUTICAL COMPOSITIONS COMPRISING THEM FOR TREATMENT OR DIAGNOSIS OF DIABETES

Publications (1)

Publication Number Publication Date
MX9704738A true MX9704738A (es) 1997-10-31

Family

ID=26322965

Family Applications (1)

Application Number Title Priority Date Filing Date
MX9704738A MX9704738A (es) 1994-12-21 1995-12-20 Analogos de peptido p277 y composiciones farmaceuticas que los contienen, metodo de diagnostico de diabetes mellitus dependiente de la insulina y uso de los mismos.

Country Status (31)

Country Link
EP (1) EP0820303B1 (es)
JP (2) JP3420245B2 (es)
KR (1) KR100400480B1 (es)
CN (1) CN1233417C (es)
AR (1) AR002949A1 (es)
AT (1) ATE242005T1 (es)
AU (1) AU707835B2 (es)
BR (1) BR9510102A (es)
CA (1) CA2208274C (es)
CZ (1) CZ293784B6 (es)
DE (2) DE820303T1 (es)
DK (1) DK0820303T3 (es)
ES (1) ES2201137T3 (es)
FI (1) FI118373B (es)
HR (1) HRP950612B1 (es)
HU (1) HU224160B1 (es)
IL (1) IL116499A0 (es)
IS (1) IS1966B (es)
MX (1) MX9704738A (es)
NO (1) NO317350B1 (es)
NZ (1) NZ301440A (es)
PL (1) PL184145B1 (es)
PT (1) PT820303E (es)
RO (1) RO116777B1 (es)
RS (1) RS49517B (es)
SI (1) SI0820303T1 (es)
TR (1) TR199501630A2 (es)
TW (1) TW496872B (es)
UA (1) UA42040C2 (es)
UY (1) UY24130A1 (es)
WO (1) WO1996019236A1 (es)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6488933B2 (en) 1995-07-05 2002-12-03 Yeda Research And Development Co. Ltd. Preparations for the treatment of T cell mediated diseases
DE69724619T2 (de) * 1996-05-14 2004-07-01 Winnacker, Ernst-Ludwig, Prof. Chaperone, die prionproteine binden und zwischen den isoformen prpc und prpsc unterscheiden können
EP1335741A4 (en) * 2000-08-25 2005-10-26 Yeda Res & Dev METHOD FOR THE PREVENTION OF AUTOIMMUNE DISEASES WITH CpG-CONTAINING POLYNUCLEOTIDES (04.03.02)
IL140233A0 (en) * 2000-12-11 2002-02-10 Peptor Ltd Backbone cyclized analogs of heat shock proteins
WO2003063759A2 (en) 2002-01-31 2003-08-07 Peptor Ltd. Hsp peptides and analogs for modulation of immune responses via antigen presenting cells
CA2595520A1 (en) 2004-01-28 2005-08-11 Develogen Israel Ltd. Hsp therapy in conjunction with a low antigenicity diet
DE102004043750A1 (de) * 2004-09-10 2006-03-30 Sanofi-Aventis Deutschland Gmbh Formulierungen des Peptids p277 oder dessen Varianten mit optimierter Stabilität
CN100352502C (zh) * 2004-12-29 2007-12-05 中国药科大学 能通过免疫防治ⅰ型糖尿病的重组蛋白和重组基因
US8691772B2 (en) 2005-01-04 2014-04-08 Yeda Research And Development Co. Ltd. HSP60, HSP60 peptides and T cell vaccines for immunomodulation
EP1858545A2 (en) * 2005-03-04 2007-11-28 Curedm Inc. Methods and pharmaceutical compositions for treating type 1 diabetes mellitus and other conditions
EP2295066B1 (en) 2005-05-25 2016-04-27 CureDM Group Holdings, LLC Peptides, derivatives and analogs thereof, and methods of using same
JP4283812B2 (ja) * 2006-01-06 2009-06-24 財団法人工業技術研究院 重症筋無力症の診断方法およびそのキット
WO2008064306A2 (en) 2006-11-22 2008-05-29 Curedm, Inc. Methods and compositions relating to islet cell neogenesis
MX337147B (es) 2007-08-30 2016-02-15 Curedm Group Holdings Llc Composiciones y metodos para utilizar peptidos proislet y sus analogos.
CU23701A1 (es) * 2008-12-29 2011-09-21 Ct Ingenieria Genetica Biotech Método de tratamiento de enfermedades inflamatorias intestinales y diabetes tipo i
CN104203263A (zh) 2012-03-01 2014-12-10 耶达研究与发展有限公司 利用HSP60衍生肽再生胰岛β细胞
WO2013128450A1 (en) 2012-03-01 2013-09-06 Yeda Research And Development Co. Ltd. Hsp60 derived peptides and peptide analogs for suppression and treatment of non-autoimmune diabetes
CN104418948B (zh) * 2013-09-10 2019-08-16 深圳翰宇药业股份有限公司 一种制备多肽药物的方法
CN104650209B (zh) * 2013-11-19 2018-04-06 深圳翰宇药业股份有限公司 多肽药物DiaPep277 的合成方法
CN104650244B (zh) * 2015-01-21 2017-12-08 中国药科大学 一种具有降血糖兼调脂作用的表位组合肽及其用途

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5114844A (en) * 1989-03-14 1992-05-19 Yeda Research And Development Co., Ltd. Diagnosis and treatment of insulin dependent diabetes mellitus

Also Published As

Publication number Publication date
KR100400480B1 (ko) 2003-12-31
RS49517B (sr) 2006-10-27
UY24130A1 (es) 1996-06-11
NO972849D0 (no) 1997-06-19
WO1996019236A1 (en) 1996-06-27
JPH10511649A (ja) 1998-11-10
FI972669A (fi) 1997-08-15
CA2208274C (en) 2005-12-06
HU224160B1 (hu) 2005-06-28
ES2201137T3 (es) 2004-03-16
TW496872B (en) 2002-08-01
FI972669A0 (fi) 1997-06-19
AR002949A1 (es) 1998-05-27
NO317350B1 (no) 2004-10-18
IS1966B (is) 2004-12-15
PL321091A1 (en) 1997-11-24
EP0820303A1 (en) 1998-01-28
PL184145B1 (pl) 2002-09-30
IS4510A (is) 1997-06-19
JP3420245B2 (ja) 2003-06-23
HRP950612B1 (en) 2003-12-31
SI0820303T1 (en) 2003-10-31
DE69531004D1 (de) 2003-07-10
JP3554319B2 (ja) 2004-08-18
AU707835B2 (en) 1999-07-22
CA2208274A1 (en) 1996-06-27
AU4686696A (en) 1996-07-10
NZ301440A (en) 2000-01-28
EP0820303B1 (en) 2003-06-04
HUT78092A (hu) 1999-09-28
HRP950612A2 (en) 1997-10-31
RO116777B1 (ro) 2001-06-29
PT820303E (pt) 2003-10-31
IL116499A0 (en) 1996-03-31
TR199501630A2 (tr) 1996-07-21
ATE242005T1 (de) 2003-06-15
DK0820303T3 (da) 2003-10-06
DE69531004T2 (de) 2004-02-05
JP2004026797A (ja) 2004-01-29
DE820303T1 (de) 1999-05-20
UA42040C2 (uk) 2001-10-15
CZ190897A3 (en) 1997-11-12
YU78795A (sh) 1998-05-15
BR9510102A (pt) 1997-11-25
NO972849L (no) 1997-08-13
FI118373B (fi) 2007-10-31
CN1175214A (zh) 1998-03-04
CN1233417C (zh) 2005-12-28
EP0820303A4 (es) 1998-03-11
CZ293784B6 (cs) 2004-07-14

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