MX9703642A - Metodos para el tratamiento de esclerosis multiple utilizando analogos de peptido en la posicion 91 de la proteina basica de mielina humana. - Google Patents
Metodos para el tratamiento de esclerosis multiple utilizando analogos de peptido en la posicion 91 de la proteina basica de mielina humana.Info
- Publication number
- MX9703642A MX9703642A MX9703642A MX9703642A MX9703642A MX 9703642 A MX9703642 A MX 9703642A MX 9703642 A MX9703642 A MX 9703642A MX 9703642 A MX9703642 A MX 9703642A MX 9703642 A MX9703642 A MX 9703642A
- Authority
- MX
- Mexico
- Prior art keywords
- peptide analogues
- multiple sclerosis
- myelin basic
- basic protein
- treatment
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
- C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
- C07K14/4713—Autoimmune diseases, e.g. Insulin-dependent diabetes mellitus, multiple sclerosis, rheumathoid arthritis, systemic lupus erythematosus; Autoantigens
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Immunology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Diabetes (AREA)
- Zoology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Hematology (AREA)
- Rehabilitation Therapy (AREA)
- Rheumatology (AREA)
- Toxicology (AREA)
- Molecular Biology (AREA)
- Gastroenterology & Hepatology (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Psychiatry (AREA)
- Hospice & Palliative Care (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
Se proveen análogos de péptido de proteína básica de mielina humana que contienen los residuos 87-99. El residuo 91 de los análogos de péptido es alterado del residuo de L-lisina encontrado en la proteína nativa a cualquier otro aminoácido. Se proveen composiciones farmacéuticas de los análogos de péptido. Además, los análogos de péptido se administran a pacientes con esclerosis multiple.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US34207894A | 1994-11-18 | 1994-11-18 |
Publications (1)
Publication Number | Publication Date |
---|---|
MX9703642A true MX9703642A (es) | 1998-11-29 |
Family
ID=23340234
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX9703642A MX9703642A (es) | 1994-11-18 | 1997-05-16 | Metodos para el tratamiento de esclerosis multiple utilizando analogos de peptido en la posicion 91 de la proteina basica de mielina humana. |
Country Status (9)
Country | Link |
---|---|
US (4) | US6369033B1 (es) |
EP (2) | EP0792286B1 (es) |
JP (1) | JPH10509714A (es) |
AT (1) | ATE213499T1 (es) |
AU (1) | AU721898B2 (es) |
CA (1) | CA2205532A1 (es) |
DE (1) | DE69525544T2 (es) |
MX (1) | MX9703642A (es) |
WO (1) | WO1996016085A1 (es) |
Families Citing this family (21)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7090982B2 (en) | 1991-10-22 | 2006-08-15 | The Governors Of The University Of Alberta | Methods of predicting therapeutic efficacy of treatment of a multiple sclerosis patient |
US6252040B1 (en) | 1991-10-22 | 2001-06-26 | The Governors Of The University Of Alberta | Peptide specificity of anti-myelin basic protein and the administration of myelin basic protein peptides to multiple sclerosis patients |
EP0863155B1 (en) * | 1992-04-09 | 2002-01-23 | Autoimmune, Inc. | Suppression of T-cell proliferation using peptide fragments of myelin basic protein |
CZ122697A3 (en) * | 1994-10-25 | 1997-09-17 | Immulogic Pharma Corp | Preparations and methods of treating disseminated sclerosis |
EP0792286B1 (en) * | 1994-11-18 | 2002-02-20 | Neurocrine Biosciences, Inc. | Peptide analogues at position 91 of human myelin basis protein for treatment of multiple scerosis |
US6329499B1 (en) | 1994-11-18 | 2001-12-11 | Neurocrine Biosciences, Inc. | Methods for treatment of multiple sclerosis using peptide analogues of human myelin basic protein |
US6379670B1 (en) | 1994-11-18 | 2002-04-30 | Neurocrine Biosciences, Inc. | Methods for treatment of multiple sclerosis using peptide analogs of human myelin basic protein |
US6251396B1 (en) | 1994-11-18 | 2001-06-26 | Neurocrine Biosciences, Inc. | Methods for treatment of multiple sclerosis using peptide analogs of human myelin basic protein |
WO1996028470A2 (en) * | 1995-03-09 | 1996-09-19 | Neurocrine Biosciences, Inc. | Peptide analogues of human myelin basic protein useful in treating multiple sclerosis |
WO1997030150A2 (en) * | 1996-02-15 | 1997-08-21 | Pangenetics B.V. | Molecules for the induction of immunological tolerance |
US20020072493A1 (en) | 1998-05-19 | 2002-06-13 | Yeda Research And Development Co. Ltd. | Activated T cells, nervous system-specific antigens and their uses |
US6541608B1 (en) * | 1999-02-23 | 2003-04-01 | Baylor College Of Medicine | T cell receptor Vβ-Dβ-Jβ sequence and methods for its detection |
CA2445640A1 (en) * | 2001-03-23 | 2002-10-03 | John Matsoukas | Peptide analogues of myelin basic protein epitopes in the treatment of experimental autoimmune encephalomyelitis (eae) and multiple sclerosis (ms) |
US7658926B2 (en) * | 2001-09-14 | 2010-02-09 | Opexa Pharmaceuticals, Inc. | Autologous T-cell vaccines materials and methods |
CA2492848C (en) * | 2002-08-08 | 2012-01-24 | Baylor College Of Medicine | Isolation and identification of t cells |
EP1874343A4 (en) | 2005-04-19 | 2009-07-22 | Lilly Co Eli | MONOVALENT AND MULTIPURPOSE SYNTHETIC POLYSACCHARIDIC ANATIGENS FOR IMMUNOLOGICAL INTERVENTION IN PATHOLOGY |
EP2712623A1 (en) * | 2006-05-05 | 2014-04-02 | Opexa Therapeutics | T-cell vaccine |
AU2009328505B2 (en) | 2008-12-19 | 2014-11-27 | Panima Pharmaceuticals Ag | Human anti-alpha-synuclein autoantibodies |
US20140348861A1 (en) | 2011-05-05 | 2014-11-27 | National Institute Of Immunology | Synthetic peptides and random copolymers for the treatment of autoimmune disorders |
HUE041391T2 (hu) | 2011-06-23 | 2019-05-28 | Biogen Int Neuroscience Gmbh | Anti-alfa-szinukleinkötõ molekulák |
CN103102393B (zh) * | 2013-01-30 | 2015-01-07 | 北京大学 | 一种多肽及其在制备抑郁症治疗药物中的应用 |
Family Cites Families (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5468481A (en) * | 1988-06-23 | 1995-11-21 | Amergen, Inc. | MHC class II-peptide conjugates useful in ameliorating autoimmunity |
JPH05508621A (ja) * | 1990-03-02 | 1993-12-02 | オートイミューン インク | 自己抗原の経口投与による自己免疫疾患のダウンコントロール |
US5858980A (en) * | 1990-03-30 | 1999-01-12 | Autoimmune, Inc. | Peptide fragments of myelin basic protein |
EP0587735B1 (en) * | 1991-05-31 | 2000-01-26 | Connetics Corporation | T cell receptor peptides as therapeutics for immune-related disease |
CA2053799C (en) * | 1991-10-22 | 2002-03-12 | Kenneth G. Warren | Synthetic peptide specificity of anti-myelin basic protein from multiple sclerosis cerebrospinal fluid |
EP0863155B1 (en) * | 1992-04-09 | 2002-01-23 | Autoimmune, Inc. | Suppression of T-cell proliferation using peptide fragments of myelin basic protein |
CA2172512A1 (en) * | 1993-09-22 | 1995-03-30 | Lawrence Steinman | Interaction of t-cell receptors and antigen in autoimmune disease |
US6329499B1 (en) * | 1994-11-18 | 2001-12-11 | Neurocrine Biosciences, Inc. | Methods for treatment of multiple sclerosis using peptide analogues of human myelin basic protein |
EP0792286B1 (en) * | 1994-11-18 | 2002-02-20 | Neurocrine Biosciences, Inc. | Peptide analogues at position 91 of human myelin basis protein for treatment of multiple scerosis |
-
1995
- 1995-11-16 EP EP95942842A patent/EP0792286B1/en not_active Expired - Lifetime
- 1995-11-16 EP EP01115315A patent/EP1172376A1/en not_active Withdrawn
- 1995-11-16 AT AT95942842T patent/ATE213499T1/de not_active IP Right Cessation
- 1995-11-16 JP JP8516910A patent/JPH10509714A/ja not_active Ceased
- 1995-11-16 WO PCT/US1995/014402 patent/WO1996016085A1/en active IP Right Grant
- 1995-11-16 DE DE69525544T patent/DE69525544T2/de not_active Expired - Fee Related
- 1995-11-16 AU AU44057/96A patent/AU721898B2/en not_active Ceased
- 1995-11-16 CA CA002205532A patent/CA2205532A1/en not_active Abandoned
-
1997
- 1997-05-16 MX MX9703642A patent/MX9703642A/es not_active Application Discontinuation
- 1997-10-20 US US08/953,937 patent/US6369033B1/en not_active Expired - Fee Related
-
2001
- 2001-11-19 US US09/989,476 patent/US6489299B2/en not_active Expired - Fee Related
-
2002
- 2002-10-11 US US10/270,707 patent/US6740638B2/en not_active Expired - Fee Related
-
2004
- 2004-04-08 US US10/820,983 patent/US20040214775A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
EP0792286A1 (en) | 1997-09-03 |
US20030114380A1 (en) | 2003-06-19 |
AU4405796A (en) | 1996-06-17 |
US6369033B1 (en) | 2002-04-09 |
ATE213499T1 (de) | 2002-03-15 |
CA2205532A1 (en) | 1996-05-30 |
US20020058627A1 (en) | 2002-05-16 |
US20040214775A1 (en) | 2004-10-28 |
WO1996016085A1 (en) | 1996-05-30 |
US6489299B2 (en) | 2002-12-03 |
EP0792286B1 (en) | 2002-02-20 |
EP1172376A1 (en) | 2002-01-16 |
DE69525544T2 (de) | 2002-08-22 |
JPH10509714A (ja) | 1998-09-22 |
DE69525544D1 (de) | 2002-03-28 |
US6740638B2 (en) | 2004-05-25 |
AU721898B2 (en) | 2000-07-20 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FA | Abandonment or withdrawal |