KR980002066A - 변이형 인간 성장호르몬 및 그의 용도 - Google Patents

변이형 인간 성장호르몬 및 그의 용도 Download PDF

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Publication number
KR980002066A
KR980002066A KR1019970004208A KR19970004208A KR980002066A KR 980002066 A KR980002066 A KR 980002066A KR 1019970004208 A KR1019970004208 A KR 1019970004208A KR 19970004208 A KR19970004208 A KR 19970004208A KR 980002066 A KR980002066 A KR 980002066A
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growth hormone
protein
amino acid
acid sequence
human growth
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KR1019970004208A
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English (en)
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가즈오 지하라
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아시다 신
닛뽕 케미카루 리사치 가부시끼가이샤
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Application filed by 아시다 신, 닛뽕 케미카루 리사치 가부시끼가이샤 filed Critical 아시다 신
Publication of KR980002066A publication Critical patent/KR980002066A/ko

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/26—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against hormones ; against hormone releasing or inhibiting factors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22—Hormones
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/61—Growth hormone [GH], i.e. somatotropin
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/22—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against growth factors ; against growth regulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S930/00—Peptide or protein sequence
    • Y10S930/01—Peptide or protein sequence
    • Y10S930/12—Growth hormone, growth factor other than t-cell or b-cell growth factor, and growth hormone releasing factor; related peptides

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Endocrinology (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Zoology (AREA)
  • Immunology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Toxicology (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biotechnology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Farming Of Fish And Shellfish (AREA)
  • Physical Deposition Of Substances That Are Components Of Semiconductor Devices (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)

Abstract

본 발명은 성장호르몬에 대해 증진된 친화성 및 저하된 호르몬 활성을 나타내는 변이형 인간 성장호르몬, 그를 코드하는 염기배열, 그의 제조 방법 및 그의 용도를 제공한다. 성장호르몬 수용체에 대한 증진된 친화성을 갖는 본 발명의 단백질은, 저화된 성장호르몬 활성을 유지하면서, 수용체에 대한 성장호르몬의 결합을 저해하며, 따라서 거인증 및 말단비대증 치료제로서 적용할 수 있다.

Description

변이형 인간 성장호르몬 및 그의 용도
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음
제1도는 실시예 1에서 수득된, 변이형 성장호르몬 (77번째 위치, R→C)아미노산 배열 및 상기 단백질을 코드하는 염기배열이다.

Claims (14)

  1. 제1도에 주어진 아미노산 배열을 나타내는 변이형 인간 성장호르몬 단백질.
  2. 청구항 1에서 청구된 아미노산 배열을 코드하는, 제1도에서 주어진 염기서열을 나타내는 데옥시리보뉴클레오티드.
  3. 제1항에 있어서, 상기 변이형 인간 성장호르몬이 성장호르몬 수용체 단백질에 대해 증진된 친화성을 나타내고 또한 감소된 성장호르몬 활성을 유지하는 것을 특징으로 하는 변이형 인간 성장호르몬 단백질.
  4. 성장호르몬 수용체에 대해 증진된 친화력을 나타내고 감소된 성장호르몬 활성이 유지되는 그들의 특징적인 성질을 잃지 않을 정도로 그의 아미노산 잔기 부위에 부분적인 치환, 삽입 또는 소실을 실시한, 청구항 1에서 청구한 아미노산 배열을 나타내는 변이형 인간 성장호르몬 단백질.
  5. 제2도에서 주어진 아미노산 배열, 및 그를 코드하는 데옥시리보뉴클레오티드를 나타내는 단백질.
  6. 제3도에 주어진 염기서열의 데옥시리보뉴클레오티드가 코드하는 아미노산 배열을 나타내는 단백질.
  7. 청구항 1에서 청구된 단백질의 수용체 단백질 결합 부위를 구성하는 펩티드 및 상기 펩티드의 아미노산 배열을 코드하는 데옥시뉴클레오티드.
  8. 청구항 4에서 청구된 단백질의 아미노산 배열을 코드하는 염기서열을 나타내는 데옥시리보뉴클레오티드.
  9. 청구항 2, 5, 6, 7 또는 8에서 청구된 데옥시리보뉴클레오티드를 프로모터의 하류에 각각 배열시킨 발현 플라스미드.
  10. 청구항 9에서 청구된 플라스미드로 형질전환된 생물체 세포에 의한 발현을 통해 산출된 생성물.
  11. 청구항 1, 4, 5 또는 6에서 청구된 변이형 인간 성장호르몬 단백질과 상호반응을 나타내는 항체.
  12. 제11항에 있어서, 단성항체인 것을 특징으로 하는 항체.
  13. 청구항 1, 4, 5, 6 또는 7에서 청구된 단백질 또는 펩티드를 활성성분으로 함유하는 거인증 및 말단비대증 치료제.
  14. 청구항 2, 5, 6, 7 또는 8에서 청구된 데옥시리보뉴클레오티드를 이용하는 유전자요법용 약제.
    ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
KR1019970004208A 1996-02-13 1997-02-13 변이형 인간 성장호르몬 및 그의 용도 KR980002066A (ko)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
JP96-50940 1996-02-13
JP5094096 1996-02-13
JP17864396 1996-06-18
JP96-178643 1996-06-18

Publications (1)

Publication Number Publication Date
KR980002066A true KR980002066A (ko) 1998-03-30

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Country Link
US (1) US6238915B1 (ko)
EP (1) EP0790305B1 (ko)
KR (1) KR980002066A (ko)
AT (1) ATE216723T1 (ko)
AU (1) AU723494B2 (ko)
BR (1) BR9700957A (ko)
CA (1) CA2197408A1 (ko)
DE (1) DE69712124T2 (ko)

Families Citing this family (17)

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Publication number Priority date Publication date Assignee Title
US6780613B1 (en) 1988-10-28 2004-08-24 Genentech, Inc. Growth hormone variants
CA2345497A1 (en) 1988-10-28 1990-04-28 Genentech, Inc. Growth hormone variants and method for forming growth hormone variants
WO1992021029A1 (en) 1991-05-10 1992-11-26 Genentech, Inc. Selecting ligand agonists and antagonists
US6506595B2 (en) * 1998-03-31 2003-01-14 Itoham Foods Inc. DNAs encoding new fusion proteins and processes for preparing useful polypeptides through expression of the DNAs
GB0011459D0 (en) * 2000-05-12 2000-06-28 Univ Wales Medicine Sequences
BR0110756A (pt) * 2000-05-12 2003-07-08 Univ Wales Medicine Método de detecção para detectar uma variação em gh1 efetiva para atuar como um indicador de disfunção de gh em um indivìduo, variante de gh1, proteìna ou sequência de aminoácidos, variante de gh humano, método de triagem para triar um indivìduo suspeito de ter disfunção de gh, kit, sequência de ácido nucleico isolada, purificada ou recombinante, vetor, célula hospedeira, processo para preparar uma variante de gh, sequência de aminoácidos, composição, e, uso de variante de gh1 ou uma variante de gh
BR0214017A (pt) * 2001-11-09 2005-01-04 Upjohn Co Polimorfismos de um único nucleotìdeo em gh-1
GB0127213D0 (en) * 2001-11-12 2002-01-02 Univ Wales Medicine Method of detecting growth hormone variations in humans the variations and their uses
GB2384001B (en) * 2001-12-14 2004-02-04 Asterion Ltd Chimeric growth hormone-growth hormone receptor proteins
US7611700B2 (en) * 2002-09-09 2009-11-03 Hanall Pharmaceuticals, Co., Ltd. Protease resistant modified interferon alpha polypeptides
GB0229725D0 (en) * 2002-12-19 2003-01-29 Univ Wales Medicine Haplotype partitioning and growth hormone SNPs
SE0300959D0 (sv) * 2002-12-19 2003-04-02 Pharmacia Ab Methods for predicting therapeutic response to agents acting on the growth hormone receptor
CA2423904A1 (en) * 2002-12-19 2004-06-19 University Of Wales College Of Medicine Haplotype partitioning in the proximal promoter of the human growth hormone (gh1) gene
US7998930B2 (en) 2004-11-04 2011-08-16 Hanall Biopharma Co., Ltd. Modified growth hormones
EP2386571B1 (en) 2005-04-08 2016-06-01 ratiopharm GmbH Compositions and methods for the preparation of protease resistant human growth hormone glycosylation mutants
EP2446898A1 (en) 2010-09-30 2012-05-02 Laboratorios Del. Dr. Esteve, S.A. Use of growth hormone to enhance the immune response in immunosuppressed patients
WO2020014307A1 (en) * 2018-07-11 2020-01-16 Ohio University Peptide-based inhibitors of growth hormone action and methods of the thereof

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BG49718A3 (en) * 1983-07-15 1992-01-15 Bio Technology General Corp Method for preparing of polypeptid with superoxiddismutasne activitty
CA2345497A1 (en) * 1988-10-28 1990-04-28 Genentech, Inc. Growth hormone variants and method for forming growth hormone variants
US5534617A (en) * 1988-10-28 1996-07-09 Genentech, Inc. Human growth hormone variants having greater affinity for human growth hormone receptor at site 1
US5350836A (en) * 1989-10-12 1994-09-27 Ohio University Growth hormone antagonists
CA2102129C (en) 1991-05-01 2003-04-01 John J. Kopchick Growth hormone antagonists

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BR9700957A (pt) 1998-12-08
AU723494B2 (en) 2000-08-31
DE69712124D1 (de) 2002-05-29
DE69712124T2 (de) 2002-12-12
EP0790305B1 (en) 2002-04-24
CA2197408A1 (en) 1997-08-14
ATE216723T1 (de) 2002-05-15
AU1266497A (en) 1997-08-21
US6238915B1 (en) 2001-05-29
EP0790305A1 (en) 1997-08-20

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