MX363848B - Nuevas formas polimorficas de sal de clorhidrato de 3-(1-{3-[5-(1-metil-piperidin-4-ilmetoxi)-pirimidin-2-il]-bencil} -6-oxo-1,6-dihidro-piridazin-3-il)-benzonitrilo y sus procesos de preparacion. - Google Patents

Nuevas formas polimorficas de sal de clorhidrato de 3-(1-{3-[5-(1-metil-piperidin-4-ilmetoxi)-pirimidin-2-il]-bencil} -6-oxo-1,6-dihidro-piridazin-3-il)-benzonitrilo y sus procesos de preparacion.

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Publication number
MX363848B
MX363848B MX2017012152A MX2017012152A MX363848B MX 363848 B MX363848 B MX 363848B MX 2017012152 A MX2017012152 A MX 2017012152A MX 2017012152 A MX2017012152 A MX 2017012152A MX 363848 B MX363848 B MX 363848B
Authority
MX
Mexico
Prior art keywords
pyridazin
pyrimidin
piperidin
dihydro
oxo
Prior art date
Application number
MX2017012152A
Other languages
English (en)
Inventor
Dorsch Dieter
Saal Christoph
Stieber Frank
Becker Axel
Kuehn Clemens
Schadt Oliver
Hermann Bokel Heinz-
Donini Cristina
Original Assignee
Merck Patent Gmbh
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Publication date
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First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=41572530&utm_source=***_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=MX363848(B) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Merck Patent Gmbh filed Critical Merck Patent Gmbh
Publication of MX363848B publication Critical patent/MX363848B/es

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/517—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with carbocyclic ring systems, e.g. quinazoline, perimidine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/18—Drugs for disorders of the alimentary tract or the digestive system for pancreatic disorders, e.g. pancreatic enzymes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/08—Drugs for disorders of the urinary system of the prostate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/10—Drugs for disorders of the urinary system of the bladder
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Urology & Nephrology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Neurology (AREA)
  • Endocrinology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Dermatology (AREA)
  • Diabetes (AREA)
  • Ophthalmology & Optometry (AREA)
  • Reproductive Health (AREA)
  • Pulmonology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Oncology (AREA)
  • Hematology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

La presente invención se refiere a solvatos de clorhidrato de 3-(1-{3-[5-(1-metil-piperidin-4-ilmetoxi) -pirimidin-2-il)-bencil} -6-oxo-1,6-dihidro-piridazin-3-il) -benzonitrilo y sus modificaciones cristalinas. La presente invención también se refiere a procesos de preparación de estas modificaciones cristalinas así como a su uso en el tratamiento y/o la profilaxis de condiciones fisiológicas y/o patofisiológicas, las cuales son causadas, mediadas y/o propagadas por la inhibición, regulación y/o modulación de señales de transducción de cinasas, en particular por la inhibición de tirosina cinasas, por ejemplo condiciones patofisiológicas tales como cáncer.
MX2017012152A 2009-01-08 2009-12-04 Nuevas formas polimorficas de sal de clorhidrato de 3-(1-{3-[5-(1-metil-piperidin-4-ilmetoxi)-pirimidin-2-il]-bencil} -6-oxo-1,6-dihidro-piridazin-3-il)-benzonitrilo y sus procesos de preparacion. MX363848B (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP09000140 2009-01-08
PCT/EP2009/008684 WO2010078897A1 (en) 2009-01-08 2009-12-04 Novel polymorphic forms of 3-(1-{3-[5-(1-methyl-piperidin-4ylmethoxy)-pyrimidin-2-yl]-benzyl}-6-oxo-1,6-dihydro-pyridazin-3-yl)-benzonitrile hydrochloride salt and processes of manufacturing thereof

Publications (1)

Publication Number Publication Date
MX363848B true MX363848B (es) 2019-04-05

Family

ID=41572530

Family Applications (3)

Application Number Title Priority Date Filing Date
MX2011007322A MX350894B (es) 2009-01-08 2009-12-04 Nuevas formas polimorficas de sal de clorhidrato de 3-(1-{3-[5-(1-metil-piperidin-4-ilmetoxi)-pirimidin-2-il]-bencil} -6-oxo-1,6-dihidro-piridazin-3-il)-benzonitrilo y sus procesos de preparacion.
MX2017012151A MX363852B (es) 2009-01-08 2009-12-04 Nuevas formas polimorficas de sal de clorhidrato de 3-(1-{3-[5-(1-metil-piperidin-4-ilmetoxi)-pirimidin-2-il]-bencil} -6-oxo-1,6-dihidro-piridazin-3-il)-benzonitrilo y sus procesos de preparacion.
MX2017012152A MX363848B (es) 2009-01-08 2009-12-04 Nuevas formas polimorficas de sal de clorhidrato de 3-(1-{3-[5-(1-metil-piperidin-4-ilmetoxi)-pirimidin-2-il]-bencil} -6-oxo-1,6-dihidro-piridazin-3-il)-benzonitrilo y sus procesos de preparacion.

Family Applications Before (2)

Application Number Title Priority Date Filing Date
MX2011007322A MX350894B (es) 2009-01-08 2009-12-04 Nuevas formas polimorficas de sal de clorhidrato de 3-(1-{3-[5-(1-metil-piperidin-4-ilmetoxi)-pirimidin-2-il]-bencil} -6-oxo-1,6-dihidro-piridazin-3-il)-benzonitrilo y sus procesos de preparacion.
MX2017012151A MX363852B (es) 2009-01-08 2009-12-04 Nuevas formas polimorficas de sal de clorhidrato de 3-(1-{3-[5-(1-metil-piperidin-4-ilmetoxi)-pirimidin-2-il]-bencil} -6-oxo-1,6-dihidro-piridazin-3-il)-benzonitrilo y sus procesos de preparacion.

Country Status (32)

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US (3) US8710058B2 (es)
EP (1) EP2373640B1 (es)
JP (2) JP5719781B2 (es)
KR (2) KR101730791B1 (es)
CN (1) CN102272121B (es)
AR (1) AR074996A1 (es)
AU (1) AU2009336839B2 (es)
BR (1) BRPI0922642B8 (es)
CA (4) CA2749012C (es)
CL (1) CL2011001356A1 (es)
CO (1) CO6400191A2 (es)
CY (1) CY1115631T1 (es)
DK (1) DK2373640T3 (es)
EA (1) EA019342B1 (es)
EC (1) ECSP11011248A (es)
ES (1) ES2522629T3 (es)
HK (1) HK1164856A1 (es)
HR (1) HRP20140908T1 (es)
IL (1) IL213829A0 (es)
MX (3) MX350894B (es)
MY (1) MY160017A (es)
NZ (1) NZ594404A (es)
PE (2) PE20141317A1 (es)
PL (1) PL2373640T3 (es)
PT (1) PT2373640E (es)
SG (2) SG10201504735QA (es)
SI (1) SI2373640T1 (es)
SM (1) SMT201400161B (es)
TW (1) TWI475997B (es)
UA (1) UA106220C2 (es)
WO (1) WO2010078897A1 (es)
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TWI475997B (zh) 2015-03-11
DK2373640T3 (da) 2014-10-06
CA2949515A1 (en) 2010-07-15
PL2373640T3 (pl) 2014-12-31
EA019342B1 (ru) 2014-02-28
IL213829A0 (en) 2011-07-31
PE20141317A1 (es) 2014-09-26
CN102272121A (zh) 2011-12-07
JP2012514609A (ja) 2012-06-28
KR20110111472A (ko) 2011-10-11
JP5860126B2 (ja) 2016-02-16
US9289427B2 (en) 2016-03-22
BRPI0922642B8 (pt) 2021-05-25
MX363852B (es) 2019-04-05
US20140200221A1 (en) 2014-07-17
EP2373640A1 (en) 2011-10-12
CA2749012A1 (en) 2010-07-15
AR074996A1 (es) 2011-03-02
MY160017A (en) 2017-02-15
SG10201504735QA (en) 2015-07-30
CL2011001356A1 (es) 2011-09-30
CA2949515C (en) 2018-10-23
AU2009336839A8 (en) 2011-09-08
KR101829595B1 (ko) 2018-02-14
AU2009336839B2 (en) 2015-12-24
KR20170047408A (ko) 2017-05-04
KR101730791B1 (ko) 2017-04-27
CA3097370A1 (en) 2010-07-15
AU2009336839A1 (en) 2011-08-25
JP5719781B2 (ja) 2015-05-20
MX2011007322A (es) 2011-07-29
PT2373640E (pt) 2014-09-30
CA3014648C (en) 2021-06-01
NZ594404A (en) 2013-04-26
SG172831A1 (en) 2011-08-29
US9308205B2 (en) 2016-04-12
HRP20140908T1 (hr) 2014-11-07
CA3014648A1 (en) 2010-07-15
CN102272121B (zh) 2014-12-10
US20150148351A1 (en) 2015-05-28
ZA201105782B (en) 2012-04-25
US20110269767A1 (en) 2011-11-03
ECSP11011248A (es) 2011-10-31
EP2373640B1 (en) 2014-07-30
ES2522629T3 (es) 2014-11-17
BRPI0922642A2 (pt) 2016-01-05
EA201101039A1 (ru) 2012-02-28
SI2373640T1 (sl) 2014-11-28
JP2015038148A (ja) 2015-02-26
WO2010078897A1 (en) 2010-07-15
CA2749012C (en) 2017-01-31
CO6400191A2 (es) 2012-03-15
TW201029655A (en) 2010-08-16
PE20120474A1 (es) 2012-05-04
UA106220C2 (ru) 2014-08-11
MX350894B (es) 2017-09-22
BRPI0922642B1 (pt) 2020-09-29
CY1115631T1 (el) 2017-01-04
US8710058B2 (en) 2014-04-29
HK1164856A1 (en) 2012-09-28
SMT201400161B (it) 2015-01-15

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