UA111725C2 - Кристалічний (r)-(e)-2-(4-(2-(5-(1-(3,5-дихлорпіридин-4-іл)етоксі)-1h-індазол-3-іл)вініл)-1h-піразол-1-іл)етанол - Google Patents

Кристалічний (r)-(e)-2-(4-(2-(5-(1-(3,5-дихлорпіридин-4-іл)етоксі)-1h-індазол-3-іл)вініл)-1h-піразол-1-іл)етанол

Info

Publication number
UA111725C2
UA111725C2 UAA201303378A UAA201303378A UA111725C2 UA 111725 C2 UA111725 C2 UA 111725C2 UA A201303378 A UAA201303378 A UA A201303378A UA A201303378 A UAA201303378 A UA A201303378A UA 111725 C2 UA111725 C2 UA 111725C2
Authority
UA
Ukraine
Prior art keywords
dichloropyridin
indazol
pyrazol
ethoxy
vinyl
Prior art date
Application number
UAA201303378A
Other languages
English (en)
Inventor
Бенджамін Алан Дісероуд
Original Assignee
Елі Ліллі Енд Компані
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
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First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=44999860&utm_source=***_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=UA111725(C2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Елі Ліллі Енд Компані filed Critical Елі Ліллі Енд Компані
Publication of UA111725C2 publication Critical patent/UA111725C2/uk

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

Даний винахід стосується кристалічного (R)-(E)-2-(4-(2-(5-(1-(3,5-дихлорпіридин-4-іл)етокси)-1Н-індазол-3-іл)вініл)-1Н-піразол-1-іл)етанолу, придатного для лікування раку.
UAA201303378A 2010-10-05 2011-09-29 Кристалічний (r)-(e)-2-(4-(2-(5-(1-(3,5-дихлорпіридин-4-іл)етоксі)-1h-індазол-3-іл)вініл)-1h-піразол-1-іл)етанол UA111725C2 (uk)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US38991110P 2010-10-05 2010-10-05
PCT/US2011/053798 WO2012047699A1 (en) 2010-10-05 2011-09-29 Crystalline (r) - (e) -2- (4- (2- (5- (1- (3, 5 -dichloropyridin-4 -yl) ethoxy) - 1h - indazol - 3 - yl) vinyl) -1 h- pyrazol- 1 -yl) ethanol and its use as fgfr inhibitor

Publications (1)

Publication Number Publication Date
UA111725C2 true UA111725C2 (uk) 2016-06-10

Family

ID=44999860

Family Applications (1)

Application Number Title Priority Date Filing Date
UAA201303378A UA111725C2 (uk) 2010-10-05 2011-09-29 Кристалічний (r)-(e)-2-(4-(2-(5-(1-(3,5-дихлорпіридин-4-іл)етоксі)-1h-індазол-3-іл)вініл)-1h-піразол-1-іл)етанол

Country Status (35)

Country Link
US (1) US8530665B2 (uk)
EP (1) EP2625175B1 (uk)
JP (1) JP5940547B2 (uk)
KR (1) KR101527661B1 (uk)
CN (1) CN103153983B (uk)
AR (1) AR083091A1 (uk)
AU (1) AU2011312485B2 (uk)
BR (1) BR112013006336A2 (uk)
CA (1) CA2813329C (uk)
CL (1) CL2013000884A1 (uk)
CO (1) CO6710911A2 (uk)
DK (1) DK2625175T3 (uk)
DO (1) DOP2013000072A (uk)
EA (1) EA021817B1 (uk)
EC (1) ECSP13012539A (uk)
ES (1) ES2558777T3 (uk)
HK (1) HK1184147A1 (uk)
HR (1) HRP20151299T1 (uk)
HU (1) HUE026379T2 (uk)
IL (1) IL224850A (uk)
JO (1) JO3062B1 (uk)
MA (1) MA34552B1 (uk)
ME (1) ME02307B (uk)
MX (1) MX2013003907A (uk)
NZ (1) NZ608482A (uk)
PE (1) PE20140252A1 (uk)
PL (1) PL2625175T3 (uk)
PT (1) PT2625175E (uk)
RS (1) RS54457B1 (uk)
SG (1) SG188286A1 (uk)
SI (1) SI2625175T1 (uk)
TW (1) TWI418554B (uk)
UA (1) UA111725C2 (uk)
WO (1) WO2012047699A1 (uk)
ZA (1) ZA201301560B (uk)

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DE19945982A1 (de) * 1999-09-24 2001-03-29 Knoll Ag Geschwindigkeitsbestimmte Partikel
WO2012088266A2 (en) 2010-12-22 2012-06-28 Incyte Corporation Substituted imidazopyridazines and benzimidazoles as inhibitors of fgfr3
ME02651B (me) 2012-06-13 2017-06-20 Incyte Holdings Corp Substituisana triciklična jedinjenja kao inhibitori fgfr
US9388185B2 (en) 2012-08-10 2016-07-12 Incyte Holdings Corporation Substituted pyrrolo[2,3-b]pyrazines as FGFR inhibitors
US9266892B2 (en) 2012-12-19 2016-02-23 Incyte Holdings Corporation Fused pyrazoles as FGFR inhibitors
CA2909207C (en) 2013-04-19 2021-11-02 Incyte Corporation Bicyclic heterocycles as fgfr inhibitors
CN103819396B (zh) * 2014-02-26 2016-06-15 四川大学 一种手性的1-（3,5-二氯吡啶-4-基）-乙醇的合成方法
US10851105B2 (en) 2014-10-22 2020-12-01 Incyte Corporation Bicyclic heterocycles as FGFR4 inhibitors
WO2016134294A1 (en) 2015-02-20 2016-08-25 Incyte Corporation Bicyclic heterocycles as fgfr4 inhibitors
MA41551A (fr) 2015-02-20 2017-12-26 Incyte Corp Hétérocycles bicycliques utilisés en tant qu'inhibiteurs de fgfr4
CR20170390A (es) 2015-02-20 2017-10-23 Incyte Holdings Corp Heterociclos biciclicos como inhibidores de fgfr
AR111960A1 (es) 2017-05-26 2019-09-04 Incyte Corp Formas cristalinas de un inhibidor de fgfr y procesos para su preparación
BR112020022373A2 (pt) 2018-05-04 2021-02-02 Incyte Corporation sais de um inibidor de fgfr
WO2019213544A2 (en) 2018-05-04 2019-11-07 Incyte Corporation Solid forms of an fgfr inhibitor and processes for preparing the same
WO2020185532A1 (en) 2019-03-08 2020-09-17 Incyte Corporation Methods of treating cancer with an fgfr inhibitor
MX2021009863A (es) 2019-03-21 2021-11-12 Onxeo Una molecula dbait en combinacion con inhibidor de quinasa para el tratamiento del cancer.
US11591329B2 (en) 2019-07-09 2023-02-28 Incyte Corporation Bicyclic heterocycles as FGFR inhibitors
JOP20220083A1 (ar) 2019-10-14 2023-01-30 Incyte Corp حلقات غير متجانسة ثنائية الحلقة كمثبطات لـ fgfr
US11566028B2 (en) 2019-10-16 2023-01-31 Incyte Corporation Bicyclic heterocycles as FGFR inhibitors
KR20220098759A (ko) 2019-11-08 2022-07-12 인쎄름 (엥스띠뛰 나씨오날 드 라 쌍떼 에 드 라 흐쉐르슈 메디깔) 키나제 억제제에 대해 내성을 획득한 암의 치료 방법
BR112022010664A2 (pt) 2019-12-04 2022-08-16 Incyte Corp Derivados de um inibidor de fgfr
JP2023505258A (ja) 2019-12-04 2023-02-08 インサイト・コーポレイション Ｆｇｆｒ阻害剤としての三環式複素環
WO2021146424A1 (en) 2020-01-15 2021-07-22 Incyte Corporation Bicyclic heterocycles as fgfr inhibitors
WO2021148581A1 (en) 2020-01-22 2021-07-29 Onxeo Novel dbait molecule and its use
CN111705099B (zh) * 2020-07-01 2022-03-08 天津药明康德新药开发有限公司 一种(s)-1-(3,5-二氯吡啶-4-取代)乙醇的制备方法
IL303419A (en) * 2020-12-17 2023-08-01 Blossomhill Therapeutics Inc Macrocyclic compounds and their use
TW202313611A (zh) 2021-06-09 2023-04-01 美商英塞特公司 作為ｆｇｆｒ抑制劑之三環雜環

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US6897231B2 (en) * 2000-07-31 2005-05-24 Signal Pharmaceuticals, Inc. Indazole derivatives as JNK inhibitors and compositions and methods related thereto
ES2302106T3 (es) * 2000-09-11 2008-07-01 Novartis Vaccines And Diagnostics, Inc. Procedimiento de preparacion de derivados de bencimidazol-2-il quinolina.
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AR078411A1 (es) * 2009-05-07 2011-11-09 Lilly Co Eli Compuesto de vinil imidazolilo y composicion farmaceutica que lo comprende

Also Published As

Publication number Publication date
RS54457B1 (en) 2016-06-30
PT2625175E (pt) 2016-01-22
PE20140252A1 (es) 2014-03-12
KR20130052680A (ko) 2013-05-22
ME02307B (me) 2016-06-20
JP2013538875A (ja) 2013-10-17
CL2013000884A1 (es) 2013-10-18
US8530665B2 (en) 2013-09-10
HRP20151299T1 (hr) 2016-01-01
KR101527661B1 (ko) 2015-06-09
IL224850A (en) 2016-09-29
DOP2013000072A (es) 2013-08-15
US20120083511A1 (en) 2012-04-05
TW201249826A (en) 2012-12-16
JP5940547B2 (ja) 2016-06-29
MA34552B1 (fr) 2013-09-02
SG188286A1 (en) 2013-04-30
CA2813329A1 (en) 2012-04-12
CN103153983A (zh) 2013-06-12
WO2012047699A1 (en) 2012-04-12
EA201390275A1 (ru) 2013-07-30
CN103153983B (zh) 2014-11-05
CO6710911A2 (es) 2013-07-15
ZA201301560B (en) 2014-08-27
ECSP13012539A (es) 2013-06-28
TWI418554B (zh) 2013-12-11
EP2625175A1 (en) 2013-08-14
EA021817B1 (ru) 2015-09-30
ES2558777T3 (es) 2016-02-08
NZ608482A (en) 2014-03-28
SI2625175T1 (sl) 2016-01-29
PL2625175T3 (pl) 2016-04-29
HK1184147A1 (en) 2014-01-17
AU2011312485A1 (en) 2013-03-07
HUE026379T2 (en) 2016-06-28
AU2011312485B2 (en) 2014-09-04
BR112013006336A2 (pt) 2019-09-24
JO3062B1 (ar) 2017-03-15
DK2625175T3 (en) 2016-02-01
EP2625175B1 (en) 2015-11-18
MX2013003907A (es) 2013-06-03
CA2813329C (en) 2015-05-26
AR083091A1 (es) 2013-01-30

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