MX2023008306A - Preparacion estable de una vacuna con particulas similares al virus de papilomavirus humano. - Google Patents

Preparacion estable de una vacuna con particulas similares al virus de papilomavirus humano.

Info

Publication number
MX2023008306A
MX2023008306A MX2023008306A MX2023008306A MX2023008306A MX 2023008306 A MX2023008306 A MX 2023008306A MX 2023008306 A MX2023008306 A MX 2023008306A MX 2023008306 A MX2023008306 A MX 2023008306A MX 2023008306 A MX2023008306 A MX 2023008306A
Authority
MX
Mexico
Prior art keywords
vaccine
human papillomavirus
virus
preparation
stable preparation
Prior art date
Application number
MX2023008306A
Other languages
English (en)
Inventor
Ping Hu
Yan Liu
Xinrong Chang
Original Assignee
Sinocelltech Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sinocelltech Ltd filed Critical Sinocelltech Ltd
Publication of MX2023008306A publication Critical patent/MX2023008306A/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/12—Viral antigens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/22—Heterocyclic compounds, e.g. ascorbic acid, tocopherol or pyrrolidones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/20—Antivirals for DNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • A61K2039/525—Virus
    • A61K2039/5258—Virus-like particles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55505—Inorganic adjuvants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/70—Multivalent vaccine
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
    • C12N2710/00011—Details
    • C12N2710/20011—Papillomaviridae
    • C12N2710/20034—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • Virology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Molecular Biology (AREA)
  • Immunology (AREA)
  • Oncology (AREA)
  • Mycology (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Communicable Diseases (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Biochemistry (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicinal Preparation (AREA)

Abstract

Se proporciona una formulación estable de una vacuna con partículas similares al virus de Papilomavirus Humano. La formulación estable se compone de una partícula similar al virus de Papilomavirus Humano, una solución de amortiguación, un regulador de la presión osmótica, un tensioactivo y un adyuvante de aluminio, en donde los componentes de las vacuna con partículas similares al virus de VPH ensambladas por las proteínas L1 de los tipos 6, 11, 16, 18, 31, 33, 45, 52 y 58 de VPH y una o más partículas similares al virus de VPH ensambladas por las proteínas L1 de otros tipos patogénicos de VPH. la formulación puede intensificar la estabilidad de la vacuna y prolongar el período de validez de la vacuna en una formulación acuosa.
MX2023008306A 2021-01-14 2022-01-13 Preparacion estable de una vacuna con particulas similares al virus de papilomavirus humano. MX2023008306A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CN202110049777 2021-01-14
PCT/CN2022/071782 WO2022152204A1 (zh) 2021-01-14 2022-01-13 一种人***瘤病毒病毒样颗粒疫苗的稳定制剂

Publications (1)

Publication Number Publication Date
MX2023008306A true MX2023008306A (es) 2023-07-19

Family

ID=82446926

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2023008306A MX2023008306A (es) 2021-01-14 2022-01-13 Preparacion estable de una vacuna con particulas similares al virus de papilomavirus humano.

Country Status (9)

Country Link
US (1) US20240075124A1 (es)
EP (1) EP4292607A1 (es)
JP (1) JP2024503452A (es)
KR (1) KR20230129506A (es)
CN (1) CN117083078A (es)
AU (1) AU2022207569A1 (es)
CA (1) CA3204802A1 (es)
MX (1) MX2023008306A (es)
WO (1) WO2022152204A1 (es)

Family Cites Families (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6908613B2 (en) * 2000-06-21 2005-06-21 Medimmune, Inc. Chimeric human papillomavirus (HPV) L1 molecules and uses therefor
CN101245099A (zh) * 2007-02-14 2008-08-20 马润林 重组人***瘤病毒l1衣壳蛋白的氨基酸序列及其应用
CN102349996B (zh) * 2011-10-17 2014-06-25 沈阳三生制药有限责任公司 人***瘤病毒药物组合物及其应用
WO2021013076A1 (zh) * 2019-07-19 2021-01-28 神州细胞工程有限公司 嵌合的人***瘤病毒45型l1蛋白
CN114127095B (zh) * 2019-07-19 2024-04-09 神州细胞工程有限公司 嵌合的人***瘤病毒11型l1蛋白
CN114174319B (zh) * 2019-07-19 2024-05-14 神州细胞工程有限公司 嵌合的人***瘤病毒52型l1蛋白
WO2021013063A1 (zh) * 2019-07-19 2021-01-28 神州细胞工程有限公司 嵌合的人***瘤病毒16型l1蛋白
CA3147850A1 (en) * 2019-07-19 2021-01-28 Sinocelltech Ltd. Chimeric papillomavirus l1 protein
WO2021013077A1 (zh) * 2019-07-19 2021-01-28 神州细胞工程有限公司 嵌合的人***瘤病毒58型l1蛋白
CN114127097A (zh) * 2019-07-19 2022-03-01 神州细胞工程有限公司 嵌合的人***瘤病毒56型l1蛋白
CN114127099B (zh) * 2019-07-19 2024-04-19 神州细胞工程有限公司 嵌合的人***瘤病毒6型l1蛋白
WO2021013072A1 (zh) * 2019-07-19 2021-01-28 神州细胞工程有限公司 嵌合的人***瘤病毒39型l1蛋白
BR112022001070A2 (pt) * 2019-07-19 2022-04-19 Sinocelltech Ltd Composição de imunogenicidade polivalente para papilomavírus humano
WO2021013060A1 (zh) * 2019-07-19 2021-01-28 神州细胞工程有限公司 嵌合的人***瘤病毒51型l1蛋白
WO2021013070A1 (zh) * 2019-07-19 2021-01-28 神州细胞工程有限公司 嵌合的人***瘤病毒35型l1蛋白
WO2021013075A1 (zh) * 2019-07-19 2021-01-28 神州细胞工程有限公司 嵌合的人***瘤病毒18型l1蛋白
CN114127096B (zh) * 2019-07-19 2024-04-05 神州细胞工程有限公司 嵌合的人***瘤病毒31型l1蛋白

Also Published As

Publication number Publication date
CA3204802A1 (en) 2022-07-21
WO2022152204A1 (zh) 2022-07-21
EP4292607A1 (en) 2023-12-20
CN117083078A (zh) 2023-11-17
US20240075124A1 (en) 2024-03-07
AU2022207569A1 (en) 2023-08-10
KR20230129506A (ko) 2023-09-08
JP2024503452A (ja) 2024-01-25

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