EA201500910A1 - Вакцины против гриппа со сниженным количеством сквалена - Google Patents

Вакцины против гриппа со сниженным количеством сквалена

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Publication number
EA201500910A1
EA201500910A1 EA201500910A EA201500910A EA201500910A1 EA 201500910 A1 EA201500910 A1 EA 201500910A1 EA 201500910 A EA201500910 A EA 201500910A EA 201500910 A EA201500910 A EA 201500910A EA 201500910 A1 EA201500910 A1 EA 201500910A1
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EA
Eurasian Patent Office
Prior art keywords
influenza
virus
squales
vaccine
strain
Prior art date
Application number
EA201500910A
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English (en)
Inventor
Марио КОНТОРНИ
Дерек О'Хейган
Никола Грот
Original Assignee
Новартис Аг
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Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=42307898&utm_source=***_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=EA201500910(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Новартис Аг filed Critical Новартис Аг
Publication of EA201500910A1 publication Critical patent/EA201500910A1/ru

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/12—Viral antigens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/12—Viral antigens
    • A61K39/145—Orthomyxoviridae, e.g. influenza virus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/12—Viral antigens
    • A61K39/295—Polyvalent viral antigens; Mixtures of viral and bacterial antigens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/16—Antivirals for RNA viruses for influenza or rhinoviruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N7/00—Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/545—Medicinal preparations containing antigens or antibodies characterised by the dose, timing or administration schedule
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55511—Organic adjuvants
    • A61K2039/55566—Emulsions, e.g. Freund's adjuvant, MF59
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/70—Multivalent vaccine
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
    • C12N2760/00011—Details
    • C12N2760/16011—Orthomyxoviridae
    • C12N2760/16111—Influenzavirus A, i.e. influenza A virus
    • C12N2760/16134—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
    • C12N2760/00011—Details
    • C12N2760/16011—Orthomyxoviridae
    • C12N2760/16211—Influenzavirus B, i.e. influenza B virus
    • C12N2760/16234—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Virology (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Epidemiology (AREA)
  • Organic Chemistry (AREA)
  • Pulmonology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biomedical Technology (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicinal Preparation (AREA)

Abstract

Вакцины против вируса гриппа включают гемагглютинин по меньшей мере из одного штамма вируса гриппа А и по меньшей мере из одного штамма вируса гриппа В. Они также включают адъювант в виде эмульсии "масло-в-воде" с субмикронными масляными каплями, содержащий сквален. В некоторых вариантах осуществления концентрация гемагглютинина составляет >12 мкг/мл на штамм. В некоторых вариантах осуществления концентрация сквалена составляет <19 мг/мл. В некоторых вариантах осуществления вакцина не содержит ртути. В некоторых вариантах осуществления объем единичной дозы вакцины находится в диапазоне от 0,2 до 0,3 мл. В некоторых вариантах осуществления концентрация сквалена составляет 9,75 мг/мл или 4,88 мг/мл. В некоторых вариантах осуществления вакцина содержит антигены из двух штаммов вируса гриппа А и двух штаммов вируса гриппа В.
EA201500910A 2009-02-10 2010-02-10 Вакцины против гриппа со сниженным количеством сквалена EA201500910A1 (ru)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US20738509P 2009-02-10 2009-02-10

Publications (1)

Publication Number Publication Date
EA201500910A1 true EA201500910A1 (ru) 2016-04-29

Family

ID=42307898

Family Applications (2)

Application Number Title Priority Date Filing Date
EA201500910A EA201500910A1 (ru) 2009-02-10 2010-02-10 Вакцины против гриппа со сниженным количеством сквалена
EA201171033A EA023662B1 (ru) 2009-02-10 2010-02-10 Вакцины против гриппа со сниженным количеством сквалена

Family Applications After (1)

Application Number Title Priority Date Filing Date
EA201171033A EA023662B1 (ru) 2009-02-10 2010-02-10 Вакцины против гриппа со сниженным количеством сквалена

Country Status (12)

Country Link
US (3) US9278126B2 (ru)
EP (2) EP2396032B1 (ru)
JP (3) JP5642712B2 (ru)
KR (1) KR101825697B1 (ru)
CN (2) CN105727281A (ru)
AU (3) AU2010212550B2 (ru)
CA (1) CA2751379C (ru)
DK (1) DK2396032T3 (ru)
EA (2) EA201500910A1 (ru)
ES (1) ES2608841T3 (ru)
PL (1) PL2396032T3 (ru)
WO (1) WO2010092479A2 (ru)

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US20100221284A1 (en) * 2001-05-30 2010-09-02 Saech-Sisches Serumwerk Dresden Novel vaccine composition
JP2007512846A (ja) 2003-12-04 2007-05-24 ゼンコー・インコーポレイテッド 増加した宿主ストリング含有量を有する変異体タンパク質の生成方法およびその組成物
US11707520B2 (en) * 2005-11-03 2023-07-25 Seqirus UK Limited Adjuvanted vaccines with non-virion antigens prepared from influenza viruses grown in cell culture
PL2396032T3 (pl) * 2009-02-10 2017-05-31 Seqirus UK Limited Szczepionki przeciw grypie o obniżonych zawartościach skwalenu
WO2011141819A1 (en) † 2010-05-12 2011-11-17 Novartis Ag Improved methods for preparing squalene
CN104043119B (zh) * 2013-03-13 2016-05-25 上海医药工业研究院 一种新型疫苗佐剂及其制备方法
US10872313B2 (en) 2015-06-02 2020-12-22 ROCA Medical Ltd. Method for repurposing NDC codes in a pharmaceutical database for venom derived allergens involved in venom immunotherapy
US20170304429A1 (en) * 2014-09-26 2017-10-26 Seqirus UK Limited Vaccination of immunocompromised subjects
US10548974B2 (en) * 2015-06-02 2020-02-04 ROCA Medical Ltd. Therapeutic treatment kit for allergies based on DNA profiles
RU2740751C1 (ru) * 2019-08-28 2021-01-20 Общество с ограниченной ответственностью "Развитие БиоТехнологий" Способ получения тетравалентной субъединичной противогриппозной вакцины
CN117582491A (zh) * 2024-01-18 2024-02-23 江苏瑞科生物技术股份有限公司 流感疫苗组合物及其制备方法和应用

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AU2010212550A1 (en) 2011-08-18
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