MX2021014919A - Induccion de celulas pluripotentes. - Google Patents

Induccion de celulas pluripotentes.

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Publication number
MX2021014919A
MX2021014919A MX2021014919A MX2021014919A MX2021014919A MX 2021014919 A MX2021014919 A MX 2021014919A MX 2021014919 A MX2021014919 A MX 2021014919A MX 2021014919 A MX2021014919 A MX 2021014919A MX 2021014919 A MX2021014919 A MX 2021014919A
Authority
MX
Mexico
Prior art keywords
reprogramming
induction
human
pluripotent cells
methods
Prior art date
Application number
MX2021014919A
Other languages
English (en)
Inventor
Sheng Ding
Tongxiang Lin
Original Assignee
Scripps Research Inst
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Scripps Research Inst filed Critical Scripps Research Inst
Publication of MX2021014919A publication Critical patent/MX2021014919A/es

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    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0696—Artificially induced pluripotent stem cells, e.g. iPS
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/065—Modulators of histone acetylation
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/60—Transcription factors
    • C12N2501/602—Sox-2
    • C—CHEMISTRY; METALLURGY
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    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/60—Transcription factors
    • C12N2501/603—Oct-3/4
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    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/60—Transcription factors
    • C12N2501/604—Klf-4
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/60—Transcription factors
    • C12N2501/606—Transcription factors c-Myc
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/70—Enzymes
    • C12N2501/72—Transferases (EC 2.)
    • C12N2501/727—Kinases (EC 2.7.)
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    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/999—Small molecules not provided for elsewhere
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    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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    • C12N2506/00—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells
    • C12N2506/09—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells from epidermal cells, from skin cells, from oral mucosa cells
    • C12N2506/094—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells from epidermal cells, from skin cells, from oral mucosa cells from keratinocytes
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    • C12N2506/00—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells
    • C12N2506/13—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells from connective tissue cells, from mesenchymal cells
    • C12N2506/1307—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells from connective tissue cells, from mesenchymal cells from adult fibroblasts
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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    • C12N2506/00—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells
    • C12N2506/28—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells from vascular endothelial cells
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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    • C12N2510/00—Genetically modified cells

Abstract

La lenta cinética y baja eficiencia de métodos de reprogramación para generar células madre pluripotentes inducidas (iPSCs) humanas imponen mayores limitaciones en su utilidad en las aplicaciones biomédicas. En la presente describimos una aproximación química que mejora dramáticamente (>200 pliegues) la eficiencia de generación de iPSC a partir de fibroblastos humanos, dentro de siete días de tratamiento. Esto mejorará una base para el desarrollo de métodos no virales más eficientes y más seguros para reprogramar las células somáticas humanas.
MX2021014919A 2009-10-16 2012-04-12 Induccion de celulas pluripotentes. MX2021014919A (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US25254809P 2009-10-16 2009-10-16

Publications (1)

Publication Number Publication Date
MX2021014919A true MX2021014919A (es) 2022-07-21

Family

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Family Applications (2)

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MX2012004283A MX337982B (es) 2009-10-16 2010-10-15 Induccion de celulas pluripotentes.
MX2021014919A MX2021014919A (es) 2009-10-16 2012-04-12 Induccion de celulas pluripotentes.

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MX2012004283A MX337982B (es) 2009-10-16 2010-10-15 Induccion de celulas pluripotentes.

Country Status (12)

Country Link
US (4) US9005968B2 (es)
EP (3) EP4206319A1 (es)
JP (6) JP5808331B2 (es)
CN (3) CN105861446B (es)
AU (1) AU2010306627B2 (es)
BR (1) BR112012008848A2 (es)
CA (3) CA3194845A1 (es)
ES (2) ES2938049T3 (es)
HK (1) HK1175811A1 (es)
MX (2) MX337982B (es)
RU (1) RU2012117719A (es)
WO (1) WO2011047300A1 (es)

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