MX2021003213A - Metodos de diagnostico para cancer de mama triple negativo. - Google Patents

Metodos de diagnostico para cancer de mama triple negativo.

Info

Publication number
MX2021003213A
MX2021003213A MX2021003213A MX2021003213A MX2021003213A MX 2021003213 A MX2021003213 A MX 2021003213A MX 2021003213 A MX2021003213 A MX 2021003213A MX 2021003213 A MX2021003213 A MX 2021003213A MX 2021003213 A MX2021003213 A MX 2021003213A
Authority
MX
Mexico
Prior art keywords
methods
locally advanced
paclitaxel
patient suffering
tnbc
Prior art date
Application number
MX2021003213A
Other languages
English (en)
Inventor
Luciana Lorena Molinero
Stephen Chui
Roel Funke
Original Assignee
Genentech Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Genentech Inc filed Critical Genentech Inc
Publication of MX2021003213A publication Critical patent/MX2021003213A/es

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/574—Immunoassay; Biospecific binding assay; Materials therefor for cancer
    • G01N33/57407—Specifically defined cancers
    • G01N33/57415—Specifically defined cancers of breast
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/337—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having four-membered rings, e.g. taxol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/39558—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against tumor tissues, cells, antigens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/574—Immunoassay; Biospecific binding assay; Materials therefor for cancer
    • G01N33/57484—Immunoassay; Biospecific binding assay; Materials therefor for cancer involving compounds serving as markers for tumor, cancer, neoplasia, e.g. cellular determinants, receptors, heat shock/stress proteins, A-protein, oligosaccharides, metabolites
    • G01N33/57492—Immunoassay; Biospecific binding assay; Materials therefor for cancer involving compounds serving as markers for tumor, cancer, neoplasia, e.g. cellular determinants, receptors, heat shock/stress proteins, A-protein, oligosaccharides, metabolites involving compounds localized on the membrane of tumor or cancer cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/52—Predicting or monitoring the response to treatment, e.g. for selection of therapy based on assay results in personalised medicine; Prognosis

Abstract

La invención proporciona métodos y composiciones para diagnosticar y tratar cáncer de mama metastásico o localmente avanzado (por ejemplo, TNBC). Los métodos pueden incluir determinar la presencia y/o el nivel de expresión de uno o más de PD-L1, CD8 y/o linfocitos infiltrantes de tumores estromales (sTIL). En la presente se proporcionan métodos para identificar a un paciente que padece TNBC localmente avanzado o metastásico que es probable que responda al tratamiento con una terapia contra el cáncer que incluye un antagonista de unión al eje de PD-1 (por ejemplo, un anticuerpo anti-PD-L1 (por ejemplo, atezolizumab) o un anticuerpo anti-PD-1) y un taxano (por ejemplo, nab-paclitaxel o paclitaxel). También se proporcionan métodos para seleccionar una terapia para un paciente que padece TNBC localmente avanzado o metastásico. Se proporcionan además métodos para tratar a un paciente que padece TNBC localmente avanzado o metastásico. Los métodos pueden incluir la administración de un antagonista de unión al eje de PD-1 (por ejemplo, atezolizumab) y un taxano (por ejemplo, nab-paclitaxel o paclitaxel) al paciente, por ejemplo, un paciente identificado como uno que es probable que responda al tratamiento. También se proporcionan composiciones farmacéuticas para su uso en el tratamiento de un paciente que padece TNBC localmente avanzado o metastásico.
MX2021003213A 2018-09-21 2019-09-19 Metodos de diagnostico para cancer de mama triple negativo. MX2021003213A (es)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US201862734677P 2018-09-21 2018-09-21
US201962837507P 2019-04-23 2019-04-23
US201962848163P 2019-05-15 2019-05-15
PCT/US2019/051984 WO2020061349A1 (en) 2018-09-21 2019-09-19 Diagnostic methods for triple-negative breast cancer

Publications (1)

Publication Number Publication Date
MX2021003213A true MX2021003213A (es) 2021-05-12

Family

ID=68109481

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2021003213A MX2021003213A (es) 2018-09-21 2019-09-19 Metodos de diagnostico para cancer de mama triple negativo.

Country Status (12)

Country Link
US (1) US20210208145A1 (es)
EP (2) EP3857230B1 (es)
JP (1) JP2022500638A (es)
KR (1) KR20210062634A (es)
AU (1) AU2019342133A1 (es)
CA (1) CA3111809A1 (es)
ES (1) ES2955032T3 (es)
IL (1) IL281556A (es)
MX (1) MX2021003213A (es)
PL (1) PL3857230T3 (es)
TW (1) TW202104899A (es)
WO (1) WO2020061349A1 (es)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP4314833A1 (en) * 2021-04-01 2024-02-07 Prelude Corporation Pd-l1 as a predictive marker for therapy in cancer

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