MX2021001453A - Uso de derivados de triptofano y l-metionina para una formulacion de proteinas. - Google Patents

Uso de derivados de triptofano y l-metionina para una formulacion de proteinas.

Info

Publication number
MX2021001453A
MX2021001453A MX2021001453A MX2021001453A MX2021001453A MX 2021001453 A MX2021001453 A MX 2021001453A MX 2021001453 A MX2021001453 A MX 2021001453A MX 2021001453 A MX2021001453 A MX 2021001453A MX 2021001453 A MX2021001453 A MX 2021001453A
Authority
MX
Mexico
Prior art keywords
methionine
protein formulation
tryptophan derivatives
tryptophan
polypeptide
Prior art date
Application number
MX2021001453A
Other languages
English (en)
Inventor
Vikas Sharma
Cleo Salisbury
Sreedhara Alavattam
Original Assignee
Genentech Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Genentech Inc filed Critical Genentech Inc
Publication of MX2021001453A publication Critical patent/MX2021001453A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/42—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against immunoglobulins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39591—Stabilisation, fragmentation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/20—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing sulfur, e.g. dimethyl sulfoxide [DMSO], docusate, sodium lauryl sulfate or aminosulfonic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/22—Heterocyclic compounds, e.g. ascorbic acid, tocopherol or pyrrolidones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/08—Solutions
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/31—Immunoglobulins specific features characterized by aspects of specificity or valency multispecific
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/52—Constant or Fc region; Isotype
    • C07K2317/524—CH2 domain
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/52—Constant or Fc region; Isotype
    • C07K2317/526—CH3 domain
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]

Abstract

La presente descripción proporciona métodos y formulaciones que comprenden un polipéptido que comprende residuos de aminoácidos accesibles al solvente susceptibles a la oxidación en donde el N-acetil-DL-triptófano (NAT) y/o la L-metionina se usa para evitar la oxidación del polipéptido.
MX2021001453A 2018-08-08 2019-08-07 Uso de derivados de triptofano y l-metionina para una formulacion de proteinas. MX2021001453A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201862716239P 2018-08-08 2018-08-08
PCT/US2019/045420 WO2020033485A1 (en) 2018-08-08 2019-08-07 Use of tryptophan derivatives and l-methionine for protein formulation

Publications (1)

Publication Number Publication Date
MX2021001453A true MX2021001453A (es) 2021-04-12

Family

ID=67777405

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2021001453A MX2021001453A (es) 2018-08-08 2019-08-07 Uso de derivados de triptofano y l-metionina para una formulacion de proteinas.

Country Status (14)

Country Link
US (1) US20210155715A1 (es)
EP (1) EP3833389A1 (es)
JP (1) JP2021533149A (es)
KR (1) KR20210042936A (es)
CN (1) CN112770775A (es)
AR (1) AR115925A1 (es)
AU (1) AU2019319822A1 (es)
BR (1) BR112021002130A2 (es)
CA (1) CA3106537A1 (es)
IL (1) IL280525A (es)
MX (1) MX2021001453A (es)
SG (1) SG11202100601TA (es)
TW (1) TW202019478A (es)
WO (1) WO2020033485A1 (es)

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Also Published As

Publication number Publication date
SG11202100601TA (en) 2021-02-25
CN112770775A (zh) 2021-05-07
TW202019478A (zh) 2020-06-01
IL280525A (en) 2021-03-01
WO2020033485A1 (en) 2020-02-13
CA3106537A1 (en) 2020-02-13
AU2019319822A1 (en) 2021-03-18
BR112021002130A2 (pt) 2021-05-04
JP2021533149A (ja) 2021-12-02
AR115925A1 (es) 2021-03-10
KR20210042936A (ko) 2021-04-20
US20210155715A1 (en) 2021-05-27
EP3833389A1 (en) 2021-06-16

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