MX2020001598A - Inhibidores selectivos de proteína arginina metiltransferasa 5 (prmt5). - Google Patents
Inhibidores selectivos de proteína arginina metiltransferasa 5 (prmt5).Info
- Publication number
- MX2020001598A MX2020001598A MX2020001598A MX2020001598A MX2020001598A MX 2020001598 A MX2020001598 A MX 2020001598A MX 2020001598 A MX2020001598 A MX 2020001598A MX 2020001598 A MX2020001598 A MX 2020001598A MX 2020001598 A MX2020001598 A MX 2020001598A
- Authority
- MX
- Mexico
- Prior art keywords
- prmt5
- selective inhibitors
- protein arginine
- arginine methyltransferase
- methyltransferase
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/14—Pyrrolo-pyrimidine radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
- A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
- A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
- A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
Abstract
La divulgación se refiere a compuestos de fórmula I (ver fórmula) También se describen composiciones farmacéuticas que comprenden los compuestos de fórmula I, así como métodos para su uso y preparación.
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201762543141P | 2017-08-09 | 2017-08-09 | |
US201862630581P | 2018-02-14 | 2018-02-14 | |
US201862664442P | 2018-04-30 | 2018-04-30 | |
PCT/US2018/046057 WO2019032859A1 (en) | 2017-08-09 | 2018-08-09 | SELECTIVE INHIBITORS OF THE PROTEIN ARGININE METHYLTRANSFERASE 5 (PRMT5) |
Publications (1)
Publication Number | Publication Date |
---|---|
MX2020001598A true MX2020001598A (es) | 2020-10-28 |
Family
ID=63405398
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX2020001598A MX2020001598A (es) | 2017-08-09 | 2018-08-09 | Inhibidores selectivos de proteína arginina metiltransferasa 5 (prmt5). |
Country Status (18)
Country | Link |
---|---|
US (4) | US10570140B2 (es) |
EP (2) | EP3665179B1 (es) |
JP (1) | JP2020530496A (es) |
KR (1) | KR20200036922A (es) |
CN (1) | CN111527099B (es) |
AU (1) | AU2018313910B2 (es) |
BR (1) | BR112020002736A2 (es) |
CA (1) | CA3072439A1 (es) |
DK (1) | DK3665179T3 (es) |
ES (1) | ES2885180T3 (es) |
IL (1) | IL272519B (es) |
MA (1) | MA49840A (es) |
MX (1) | MX2020001598A (es) |
PL (1) | PL3665179T3 (es) |
PT (1) | PT3665179T (es) |
UA (1) | UA126481C2 (es) |
WO (1) | WO2019032859A1 (es) |
ZA (1) | ZA202000773B (es) |
Families Citing this family (27)
Publication number | Priority date | Publication date | Assignee | Title |
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US10570140B2 (en) | 2017-08-09 | 2020-02-25 | Prelude Therapeutics Incorporated | Selective inhibitors of protein arginine methyltransferase 5 (PRMT5) |
CA3092357A1 (en) | 2018-03-14 | 2019-09-19 | Prelude Therapeutics, Incorporated | Selective inhibitors of protein arginine methyltransferase 5 (prmt5) |
US10711007B2 (en) | 2018-03-14 | 2020-07-14 | Prelude Therapeutics Incorporated | Selective inhibitors of protein arginine methyltransferase 5 (PRMT5) |
US11077101B1 (en) | 2018-07-18 | 2021-08-03 | Tango Therapeutics, Inc. | Compounds and methods of use |
MA53287A (fr) * | 2018-08-07 | 2022-05-11 | Merck Sharp & Dohme | Inhibiteurs de prmt5 |
US20210309687A1 (en) * | 2018-08-07 | 2021-10-07 | Merck Sharp & Dohme Corp. | Prmt5 inhibitors |
BR112021015796A2 (pt) * | 2019-02-13 | 2021-10-13 | Prelude Therapeutics, Incorporated | Inibidor seletivo de proteína arginina metiltransferase 5 (prmt5) |
MX2021011524A (es) * | 2019-03-25 | 2021-12-15 | California Inst Of Techn | Inhibidores de proteina arginina n-metiltransferasa 5 (prmt5) y usos de los mismos. |
EP3952874A4 (en) * | 2019-04-05 | 2022-12-28 | Prelude Therapeutics, Incorporated | SELECTIVE ARGININE METHYLTRANSFERASE 5 PROTEIN INHIBITORS |
WO2020206299A1 (en) * | 2019-04-05 | 2020-10-08 | Prelude Therapeutics, Incorporated | Selective inhibitors of protein arginine methyltransferase 5 |
JP2022534998A (ja) * | 2019-05-30 | 2022-08-04 | エンジェクス ファーマシューティカル インコーポレイテッド | Prmt5阻害剤としての複素環式化合物 |
MX2022003340A (es) * | 2019-09-18 | 2022-06-14 | Prelude Therapeutics Inc | Inhibidores selectivos de la proteina arginina metiltransferasa 5 (prmt5). |
US20230027361A1 (en) * | 2019-10-21 | 2023-01-26 | Accent Therapeutics, Inc. | Mettl3 modulators |
CR20220175A (es) * | 2019-10-22 | 2022-06-21 | Lupin Ltd | Combinación farmacéutica de inhibidores de PRMT5 |
KR20230094196A (ko) | 2020-07-31 | 2023-06-27 | 탱고 테라퓨틱스, 인크. | Mtap-결핍 및/또는 mta 축적 암의 치료에 유용한 피페리딘-1-일-n-피리딘-3-일-2-옥소아세트아마이드 유도체 |
MX2023003264A (es) | 2020-09-21 | 2023-06-06 | Prelude Therapeutics Inc | Inhibidores de cdk y su uso como productos fármaceuticos. |
WO2022125735A1 (en) | 2020-12-10 | 2022-06-16 | Prelude Therapeutics Incorporated | Processes for making prmt5 inhibitors |
AR124369A1 (es) * | 2020-12-16 | 2023-03-22 | Amgen Inc | Inhibidores de prmt5 novedosos |
IL303779A (en) | 2020-12-18 | 2023-08-01 | Prelude Therapeutics Inc | CDK inhibitors and their use as drugs |
CN117157297A (zh) * | 2021-07-20 | 2023-12-01 | 上海齐鲁制药研究中心有限公司 | Prmt5抑制剂 |
US20230181589A1 (en) * | 2021-12-03 | 2023-06-15 | The Trustees Of Indiana University | Prmt5 inhibitors for ocular therapy |
US11939340B2 (en) | 2022-01-21 | 2024-03-26 | Prelude Therapeutics Incorporated | CDK inhibitors and their use as pharmaceuticals |
US20230257394A1 (en) | 2022-02-03 | 2023-08-17 | Prelude Therapeutics, Incorporated | CDK Inhibitors And Their Use As Pharmaceuticals |
WO2023172957A1 (en) | 2022-03-09 | 2023-09-14 | Prelude Therapeutics, Incorporated | Thaizole-pyrimdiine cdk inhibitors and their use as pharmaceuticals |
WO2023178547A1 (en) | 2022-03-23 | 2023-09-28 | Prelude Therapeutics, Incorporated | Polymorphic compounds and uses thereof |
CN116655638B (zh) * | 2022-05-12 | 2024-01-26 | 上海齐鲁制药研究中心有限公司 | 氘代prmt5抑制剂 |
WO2024077216A1 (en) | 2022-10-06 | 2024-04-11 | Prelude Therapeutics Incorporated | Cdk inhibitors and their use as pharmaceuticals |
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US3657744A (en) | 1970-05-08 | 1972-04-25 | Univ Minnesota | Method for fixing prosthetic implants in a living body |
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US5023252A (en) | 1985-12-04 | 1991-06-11 | Conrex Pharmaceutical Corporation | Transdermal and trans-membrane delivery of drugs |
US5040548A (en) | 1989-06-01 | 1991-08-20 | Yock Paul G | Angioplasty mehtod |
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DE102010060118A1 (de) * | 2010-10-22 | 2012-04-26 | Röhm Gmbh | Stirnseitenmitnehmer |
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WO2012129562A2 (en) | 2011-03-24 | 2012-09-27 | The Scripps Research Institute | Compounds and methods for inducing chondrogenesis |
UA118548C2 (uk) * | 2012-12-21 | 2019-02-11 | Епізайм, Інк. | Тетрагідро- та дигідроізохіноліни як інгібітори prmt5 та їх застосування |
EP2970136A1 (en) * | 2013-03-14 | 2016-01-20 | Epizyme, Inc. | Arginine methyl transferase inhibtors and uses thereof |
EP2975938A4 (en) * | 2013-03-15 | 2017-02-15 | Ohio State Innovation Foundation | Inhibitors of prmt5 and methods of their use |
WO2015200677A2 (en) * | 2014-06-25 | 2015-12-30 | Epizyme, Inc. | Prmt5 inhibitors and uses thereof |
EP3160477A4 (en) * | 2014-06-25 | 2018-07-04 | Epizyme, Inc. | Prmt5 inhibitors and uses thereof |
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KR101719881B1 (ko) * | 2014-12-22 | 2017-03-24 | 삼성전기주식회사 | 렌즈 모듈 |
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AR104326A1 (es) * | 2015-05-04 | 2017-07-12 | Lilly Co Eli | Compuestos nucleósidos 5-sustituidos |
TW202321249A (zh) | 2015-08-26 | 2023-06-01 | 比利時商健生藥品公司 | 使用作為prmt5抑制劑之新穎經6-6雙環芳香環取代之核苷類似物 |
CN108884108B (zh) | 2016-03-10 | 2021-08-31 | 詹森药业有限公司 | 用于用作prmt5抑制剂的取代核苷类似物 |
WO2017218802A1 (en) | 2016-06-15 | 2017-12-21 | Prelude Therapeutics, Incorporated | Selective inhibitors of protein arginine methyltransferase 5 (prmt5) |
WO2018075601A1 (en) | 2016-10-18 | 2018-04-26 | Prelude Therapeutics, Incorporated | Selective inhibitors of protein arginine methyltransferase 5 (prmt5) |
WO2018085833A2 (en) | 2016-11-07 | 2018-05-11 | Prelude Therapeutics, Incorporated | Selective inhibitors of protein arginine methyl transferase 5 (prmt5) |
WO2018085818A1 (en) | 2016-11-07 | 2018-05-11 | Prelude Therapeutics, Incorporated | Selective inhibitors of protein arginine methyltransferase 5 (prmt5) |
WO2018152501A1 (en) | 2017-02-20 | 2018-08-23 | Prelude Therapeutics, Incorporated | Selective inhibitors of protein arginine methyltransferase 5 (prmt5) |
US11220524B2 (en) | 2017-02-20 | 2022-01-11 | Prelude Therapeutics Incorporated | Selective inhibitors of protein arginine methyltransferase 5 (PRMT5) |
EA201990851A1 (ru) | 2017-02-24 | 2019-09-30 | Янссен Фармацевтика Нв | Новые аналоги карбануклеозида, замещенные моноциклической и бициклической кольцевой системой, для применения в качестве ингибиторов prmt5 |
WO2018160855A1 (en) | 2017-03-01 | 2018-09-07 | Prelude Therapeutics, Incorporated | Selective inhibitors of protein arginine methyltransferase 5 (prmt5) |
WO2018160824A1 (en) | 2017-03-01 | 2018-09-07 | Prelude Therapeutics, Incorporated | Selective inhibitors of protein arginine methyltransferase 5 (prmt5) |
US10570140B2 (en) | 2017-08-09 | 2020-02-25 | Prelude Therapeutics Incorporated | Selective inhibitors of protein arginine methyltransferase 5 (PRMT5) |
CN111542525B (zh) | 2017-10-26 | 2023-06-27 | 普莱鲁德疗法有限公司 | 蛋白质精氨酸甲基转移酶5(prmt5)的选择性抑制剂 |
US20210309687A1 (en) | 2018-08-07 | 2021-10-07 | Merck Sharp & Dohme Corp. | Prmt5 inhibitors |
-
2018
- 2018-08-09 US US16/059,909 patent/US10570140B2/en active Active
- 2018-08-09 WO PCT/US2018/046057 patent/WO2019032859A1/en unknown
- 2018-08-09 CA CA3072439A patent/CA3072439A1/en active Pending
- 2018-08-09 KR KR1020207006384A patent/KR20200036922A/ko not_active Application Discontinuation
- 2018-08-09 CN CN201880065979.7A patent/CN111527099B/zh active Active
- 2018-08-09 MX MX2020001598A patent/MX2020001598A/es unknown
- 2018-08-09 EP EP18760136.4A patent/EP3665179B1/en active Active
- 2018-08-09 EP EP21178139.8A patent/EP3939986A1/en active Pending
- 2018-08-09 UA UAA202000927A patent/UA126481C2/uk unknown
- 2018-08-09 DK DK18760136.4T patent/DK3665179T3/da active
- 2018-08-09 ES ES18760136T patent/ES2885180T3/es active Active
- 2018-08-09 PT PT187601364T patent/PT3665179T/pt unknown
- 2018-08-09 PL PL18760136T patent/PL3665179T3/pl unknown
- 2018-08-09 MA MA049840A patent/MA49840A/fr unknown
- 2018-08-09 AU AU2018313910A patent/AU2018313910B2/en active Active
- 2018-08-09 JP JP2020530436A patent/JP2020530496A/ja active Pending
- 2018-08-09 BR BR112020002736-7A patent/BR112020002736A2/pt unknown
-
2020
- 2020-01-16 US US16/744,771 patent/US11078205B2/en active Active
- 2020-02-05 ZA ZA2020/00773A patent/ZA202000773B/en unknown
- 2020-02-06 IL IL272519A patent/IL272519B/en unknown
- 2020-08-05 US US16/985,643 patent/US11208416B2/en active Active
-
2021
- 2021-11-18 US US17/529,781 patent/US20220153747A1/en active Pending
Also Published As
Publication number | Publication date |
---|---|
US20190048014A1 (en) | 2019-02-14 |
JP2020530496A (ja) | 2020-10-22 |
IL272519B (en) | 2022-05-01 |
UA126481C2 (uk) | 2022-10-12 |
ES2885180T3 (es) | 2021-12-13 |
MA49840A (fr) | 2020-06-17 |
DK3665179T3 (da) | 2021-08-16 |
US10570140B2 (en) | 2020-02-25 |
KR20200036922A (ko) | 2020-04-07 |
US20220153747A1 (en) | 2022-05-19 |
EP3665179A1 (en) | 2020-06-17 |
EP3665179B1 (en) | 2021-06-09 |
US20200361946A1 (en) | 2020-11-19 |
BR112020002736A2 (pt) | 2020-07-28 |
EP3939986A1 (en) | 2022-01-19 |
CA3072439A1 (en) | 2019-02-14 |
US11078205B2 (en) | 2021-08-03 |
US11208416B2 (en) | 2021-12-28 |
AU2018313910A1 (en) | 2020-03-05 |
ZA202000773B (en) | 2022-07-27 |
CN111527099A (zh) | 2020-08-11 |
IL272519A (en) | 2020-03-31 |
CN111527099B (zh) | 2024-03-22 |
PL3665179T3 (pl) | 2021-11-29 |
PT3665179T (pt) | 2021-09-10 |
AU2018313910B2 (en) | 2022-12-08 |
US20200148692A1 (en) | 2020-05-14 |
WO2019032859A1 (en) | 2019-02-14 |
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