MX2018006856A - Compuestos y metodos para modulacion de la quinasa, e indicaciones de los mismos. - Google Patents

Compuestos y metodos para modulacion de la quinasa, e indicaciones de los mismos.

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Publication number
MX2018006856A
MX2018006856A MX2018006856A MX2018006856A MX2018006856A MX 2018006856 A MX2018006856 A MX 2018006856A MX 2018006856 A MX2018006856 A MX 2018006856A MX 2018006856 A MX2018006856 A MX 2018006856A MX 2018006856 A MX2018006856 A MX 2018006856A
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MX
Mexico
Prior art keywords
compounds
methods
kinase modulation
indications therefor
indications
Prior art date
Application number
MX2018006856A
Other languages
English (en)
Inventor
N Ibrahim Prabha
Zhang Ying
Spevak Wayne
Lin Jack
Ewing Todd
Wu Guoxian
Wu Jeffrey
Chan Katrina
dong Ken
Original Assignee
Plexxikon Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Plexxikon Inc filed Critical Plexxikon Inc
Publication of MX2018006856A publication Critical patent/MX2018006856A/es

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    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/444—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring heteroatom, e.g. amrinone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/4545—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring hetero atom, e.g. pipamperone, anabasine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
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    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/10—Antioedematous agents; Diuretics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/10—Spiro-condensed systems
    • C07D491/107—Spiro-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring

Abstract

Se divulgan compuestos de Fórmula I: (ver Fórmula) o una sal aceptable para uso farmacéutico, un solvato, un tautómero, un isómero o un análogo deuterado de los mismos, donde Z2, Z3, y Z5 son como se describen en la presente, composiciones de los mismos, y usos de los mismos.
MX2018006856A 2015-12-07 2016-12-06 Compuestos y metodos para modulacion de la quinasa, e indicaciones de los mismos. MX2018006856A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201562264180P 2015-12-07 2015-12-07
PCT/US2016/065179 WO2017100201A1 (en) 2015-12-07 2016-12-06 Compounds and methods for kinase modulation, and indications therefor

Publications (1)

Publication Number Publication Date
MX2018006856A true MX2018006856A (es) 2018-08-01

Family

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Family Applications (1)

Application Number Title Priority Date Filing Date
MX2018006856A MX2018006856A (es) 2015-12-07 2016-12-06 Compuestos y metodos para modulacion de la quinasa, e indicaciones de los mismos.

Country Status (16)

Country Link
US (1) US9938273B2 (es)
EP (1) EP3386980B1 (es)
JP (1) JP6862468B2 (es)
KR (1) KR20180086247A (es)
CN (1) CN108368110A (es)
AU (1) AU2016367147B2 (es)
BR (1) BR112018011475A2 (es)
CA (1) CA3007462C (es)
CO (1) CO2018007052A2 (es)
ES (1) ES2899581T3 (es)
IL (1) IL259803A (es)
MX (1) MX2018006856A (es)
PH (1) PH12018501179A1 (es)
RU (1) RU2018123825A (es)
SG (1) SG11201804711RA (es)
WO (1) WO2017100201A1 (es)

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