MY195977A - Heterocyclic Compounds and uses Thereof - Google Patents

Heterocyclic Compounds and uses Thereof

Info

Publication number
MY195977A
MY195977A MYPI2018701064A MYPI2018701064A MY195977A MY 195977 A MY195977 A MY 195977A MY PI2018701064 A MYPI2018701064 A MY PI2018701064A MY PI2018701064 A MYPI2018701064 A MY PI2018701064A MY 195977 A MY195977 A MY 195977A
Authority
MY
Malaysia
Prior art keywords
heterocyclic compounds
compound
pharmaceutical compositions
compositions containing
therapeutic uses
Prior art date
Application number
MYPI2018701064A
Inventor
Prabha N Ibrahim
Wayne Spevak
Jiazhong Zhang
Songyuan Shi
Ben Powell
Yan Ma
Original Assignee
Plexxikon Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=57113709&utm_source=***_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=MY195977(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Plexxikon Inc filed Critical Plexxikon Inc
Publication of MY195977A publication Critical patent/MY195977A/en

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/444—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring heteroatom, e.g. amrinone
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
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    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
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    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
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Abstract

Provided herein are heterocyclic compounds of Formula (I), pharmaceutical compositions containing such a compound and their therapeutic uses, methods for their preparation, intermediate compounds, pharmaceutical compositions containing such a compound, and their therapeutic uses.
MYPI2018701064A 2015-09-21 2016-09-19 Heterocyclic Compounds and uses Thereof MY195977A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201562221508P 2015-09-21 2015-09-21
PCT/US2016/052538 WO2017053243A1 (en) 2015-09-21 2016-09-19 Heterocyclic compounds and uses thereof

Publications (1)

Publication Number Publication Date
MY195977A true MY195977A (en) 2023-02-27

Family

ID=57113709

Family Applications (1)

Application Number Title Priority Date Filing Date
MYPI2018701064A MY195977A (en) 2015-09-21 2016-09-19 Heterocyclic Compounds and uses Thereof

Country Status (22)

Country Link
US (6) US9771363B2 (en)
EP (2) EP4071149A3 (en)
JP (2) JP6863970B2 (en)
KR (1) KR20180052757A (en)
CN (2) CN113754656A (en)
AU (1) AU2016328619B2 (en)
BR (1) BR112018005497A2 (en)
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Families Citing this family (49)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2009012283A1 (en) 2007-07-17 2009-01-22 Plexxikon Inc. Compounds and methods for kinase modulation, and indications therefor
AU2012214762B2 (en) 2011-02-07 2015-08-13 Plexxikon Inc. Compounds and methods for kinase modulation, and indications therefor
US9358235B2 (en) 2012-03-19 2016-06-07 Plexxikon Inc. Kinase modulation, and indications therefor
US10227357B2 (en) 2012-09-06 2019-03-12 Plexxikon Inc. Compounds and methods for kinase modulation, and indications therefor
SG11201504754QA (en) 2012-12-21 2015-07-30 Plexxikon Inc Compounds and methods for kinase modulation, and indications therefor
US20140303121A1 (en) 2013-03-15 2014-10-09 Plexxikon Inc. Heterocyclic compounds and uses thereof
PE20151997A1 (en) * 2013-03-15 2016-01-13 Plexxikon Inc HETEROCYCLIC COMPOUNDS AND USES OF THEM
BR112015028845A2 (en) 2013-05-30 2017-07-25 Plexxikon Inc compounds for kinase modulation and indications thereof
SI3292123T1 (en) 2015-05-06 2020-10-30 Plexxikon Inc. Solid forms of a compound modulating kinases
CN112574196A (en) 2015-05-06 2021-03-30 普莱希科公司 Synthesis of kinase modulating 1H-pyrrolo [2,3-b ] pyridine derivatives
CN107771178B (en) 2015-05-22 2021-04-06 普莱希科公司 Synthesis of heterocyclic compounds
BR112017025045A2 (en) 2015-05-22 2018-08-07 Plexxikon Inc plx-8394 or plx-7904 for use in treating braf-v600 related diseases
US10829484B2 (en) 2015-07-28 2020-11-10 Plexxikon Inc. Compounds and methods for kinase modulation, and indications therefor
MY195977A (en) 2015-09-21 2023-02-27 Plexxikon Inc Heterocyclic Compounds and uses Thereof
KR20180086247A (en) 2015-12-07 2018-07-30 플렉시콘 인코퍼레이티드 Compounds and methods for kinase modulation and indications for them
AU2017232610B2 (en) 2016-03-16 2021-07-22 Plexxikon Inc. Compounds and methods for kinase modulation and indications therefore
TWI794171B (en) 2016-05-11 2023-03-01 美商滬亞生物國際有限公司 Combination therapies of hdac inhibitors and pd-l1 inhibitors
TWI808055B (en) 2016-05-11 2023-07-11 美商滬亞生物國際有限公司 Combination therapies of hdac inhibitors and pd-1 inhibitors
TW201815766A (en) 2016-09-22 2018-05-01 美商普雷辛肯公司 Compounds and methods for IDO and TDO modulation, and indications therefor
AU2017395023B2 (en) 2016-12-23 2022-04-07 Plexxikon Inc. Compounds and methods for CDK8 modulation and indications therefor
CN110291089B (en) 2017-01-17 2022-05-27 海帕瑞吉尼克斯股份有限公司 Protein kinase inhibitors for promoting liver regeneration or reducing or preventing liver cell death
JP2020511467A (en) * 2017-03-20 2020-04-16 プレキシコン インコーポレーテッドＰｌｅｘｘｉｋｏｎ Ｉｎｃ． 4- (1- (1,1-di (pyridin-2-yl) ethyl) -6- (3,5-dimethylisoxazol-4-yl) -1H-pyrrolo [3,2- that inhibits the bromodomain b] Pyridin-3-yl) benzoic acid crystalline form
US10617680B2 (en) 2017-04-18 2020-04-14 Celgene Quanticel Research, Inc. Therapeutic compounds
US10428067B2 (en) 2017-06-07 2019-10-01 Plexxikon Inc. Compounds and methods for kinase modulation
US11028058B2 (en) 2017-07-18 2021-06-08 Nuvation Bio Inc. Heterocyclic compounds as adenosine antagonists
JP2020527593A (en) 2017-07-18 2020-09-10 ニューベイション・バイオ・インコーポレイテッドＮｕｖａｔｉｏｎ Ｂｉｏ Ｉｎｃ． 1,8-naphthylidinone compounds and their use
TWI805599B (en) 2017-07-25 2023-06-21 美商第一三共公司 Formulations of a compound modulating kinases
CN111491655A (en) 2017-08-07 2020-08-04 加利福尼亚大学董事会 Platform for generating safe cell therapeutics
CA3079029A1 (en) 2017-10-13 2019-04-18 Plexxikon Inc. Solid forms of a compound for modulating kinases
BR112020007972A2 (en) 2017-10-27 2020-10-20 Plexxikon, Inc. compound formulations that modulate kinases
CN112119072A (en) 2018-03-20 2020-12-22 普莱希科公司 Compounds and methods for IDO and TDO modulation, and indications thereof
CN112770738A (en) * 2018-08-10 2021-05-07 范德堡大学 Anacardic acid for nerve repair
TWI731420B (en) * 2018-09-27 2021-06-21 大陸商深圳微芯生物科技股份有限公司 Quinoline derivative with indoleamine-2,3-dioxygenase inhibitory activity and preparation method, pharmaceutical composition, combined medicine and use thereof
EP3873474A4 (en) 2018-10-30 2022-07-13 Nuvation Bio Inc. Heterocyclic compounds as bet inhibitors
WO2020150674A1 (en) 2019-01-18 2020-07-23 Nuvation Bio Inc. Heterocyclic compounds as adenosine antagonists
JP2022523473A (en) 2019-01-18 2022-04-25 ニューベイション・バイオ・インコーポレイテッド 1,8-naphthylididinone compounds and their use
KR20220018475A (en) * 2019-04-09 2022-02-15 플렉시콘 인코퍼레이티드 Condensed azine for control and display of EP300 or CBP
CA3132855A1 (en) * 2019-04-12 2020-10-15 National Health Research Institutes Heterocyclic compounds as kinase inhibitors for therapeutic uses
CN114007671A (en) * 2019-04-26 2022-02-01 休斯敦大学体系 Methods and compositions for treating chronic inflammatory injury, metaplasia, dysplasia and cancer of epithelial tissue
CN111840289A (en) * 2019-04-28 2020-10-30 正大天晴药业集团股份有限公司 Quinoline compound or pharmaceutically acceptable salt thereof for treating giant cell tumor of bone
EP3997070A4 (en) 2019-07-02 2023-07-26 Nuvation Bio Inc. Heterocyclic compounds as bet inhibitors
CN110314162A (en) * 2019-08-20 2019-10-11 武汉威立得生物医药有限公司 Application of the Dasatinib in the drug of preparation treatment influenza infection
JP2023522949A (en) 2020-04-23 2023-06-01 オプナ バイオ ソシエテ アノニム Compounds and methods for modulating CD73 and indications thereof
EP4178982A1 (en) 2020-07-13 2023-05-17 Precirix N.V. Antibody fragment against folr1
EP4199926A1 (en) * 2020-08-21 2023-06-28 Plexxikon Inc. Combinational drug anticancer therapies
IT202100015467A1 (en) * 2021-06-14 2022-12-14 Univ Degli Studi Roma Tre BET protein inhibitors for use in the treatment of Niemann–Pick disease.
WO2023086547A1 (en) * 2021-11-12 2023-05-19 Albert Einstein College Of Medicine Cell impermeable kinase inhibitors to treat sars-cov-2 and/or hsv viral infections
WO2023203135A1 (en) 2022-04-22 2023-10-26 Precirix N.V. Improved radiolabelled antibody
WO2023213801A1 (en) 2022-05-02 2023-11-09 Precirix N.V. Pre-targeting

Family Cites Families (84)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20040171062A1 (en) 2002-02-28 2004-09-02 Plexxikon, Inc. Methods for the design of molecular scaffolds and ligands
EP1534340B1 (en) 2002-09-06 2011-11-16 Cerulean Pharma Inc. Cyclodextrin-based polymers for delivering the therapeutic agents covalently bound thereto
EP1558751A4 (en) 2002-09-16 2007-08-22 Plexxikon Inc Crystal structure of pim-1 kinase
US20050048573A1 (en) 2003-02-03 2005-03-03 Plexxikon, Inc. PDE5A crystal structure and uses
EP1627045A2 (en) 2003-02-28 2006-02-22 Plexxikon, Inc. Pyk2 crystal structure and uses
US20050079548A1 (en) 2003-07-07 2005-04-14 Plexxikon, Inc. Ligand development using PDE4B crystal structures
US7348338B2 (en) 2003-07-17 2008-03-25 Plexxikon, Inc. PPAR active compounds
JP4845730B2 (en) 2003-07-17 2011-12-28 プレキシコン，インコーポレーテッド PPAR active compounds
WO2005028624A2 (en) 2003-09-15 2005-03-31 Plexxikon, Inc. Molecular scaffolds for kinase ligand development
US7517970B2 (en) 2003-12-19 2009-04-14 Plexxikon, Inc. Nucleic acids encoding kinase and phosphatase enzymes, expression vectors and cells containing same
DK1696920T3 (en) 2003-12-19 2015-01-19 Plexxikon Inc RELATIONS AND PROCEDURES FOR THE DEVELOPMENT OF LAW MODULATORS
US20070066641A1 (en) 2003-12-19 2007-03-22 Prabha Ibrahim Compounds and methods for development of RET modulators
JP2008503446A (en) 2004-05-06 2008-02-07 プレキシコン，インコーポレーテッド PDE4B inhibitor and use thereof
US7498342B2 (en) 2004-06-17 2009-03-03 Plexxikon, Inc. Compounds modulating c-kit activity
JP2008503473A (en) 2004-06-17 2008-02-07 プレキシコン，インコーポレーテッド Compounds that modulate C-KIT activity
JP4989478B2 (en) * 2004-09-03 2012-08-01 ユーハン・コーポレイション Pyrrolo [3,2-b] pyridine derivative and process for producing the same
JP2008512380A (en) 2004-09-03 2008-04-24 プレキシコン，インコーポレーテッド PDE4B inhibitor
AU2005311826A1 (en) 2004-11-30 2006-06-08 Plexxikon, Inc. Indole derivatives for use as PPAR active compounds
US7531568B2 (en) 2004-11-30 2009-05-12 Plexxikon, Inc. PPAR active compounds
US20060160135A1 (en) 2004-12-08 2006-07-20 Weiru Wang SF-1 and LRH-1 modulator development
WO2007013896A2 (en) * 2005-05-17 2007-02-01 Plexxikon, Inc. Pyrrol (2,3-b) pyridine derivatives protein kinase inhibitors
DK1893612T3 (en) 2005-06-22 2011-11-21 Plexxikon Inc Pyrrole [2,3-B] pyridine derivatives as protein kinase inhibitors
US20080234349A1 (en) 2005-09-07 2008-09-25 Jack Lin PPAR active compounds
US20070072904A1 (en) 2005-09-07 2007-03-29 Jack Lin PPAR active compounds
TW200800872A (en) 2005-09-07 2008-01-01 Plexxikon Inc PPAR active compounds
WO2008063888A2 (en) 2006-11-22 2008-05-29 Plexxikon, Inc. Compounds modulating c-fms and/or c-kit activity and uses therefor
AU2007336811A1 (en) 2006-12-21 2008-07-03 Plexxikon, Inc. Compounds and methods for kinase modulation, and indications therefor
WO2008079909A1 (en) 2006-12-21 2008-07-03 Plexxikon, Inc. Pyrrolo [2,3-b] pyridines as kinase modulators
PE20121126A1 (en) 2006-12-21 2012-08-24 Plexxikon Inc PIRROLO [2,3-B] PYRIDINES COMPOUNDS AS KINASE MODULATORS
EP2121591A2 (en) 2007-03-08 2009-11-25 Plexxikon, Inc. Ppar active compounds
PE20090159A1 (en) 2007-03-08 2009-02-21 Plexxikon Inc INDOL-PROPIONIC ACID DERIVED COMPOUNDS AS PPARs MODULATORS
WO2009012283A1 (en) 2007-07-17 2009-01-22 Plexxikon Inc. Compounds and methods for kinase modulation, and indications therefor
PE20091846A1 (en) 2008-05-19 2009-12-16 Plexxikon Inc PIRROLO [2,3-d] -PYRIMIDINE DERIVATIVES AS KINE MODULATORS
US8158636B2 (en) 2008-05-19 2012-04-17 Plexxikon Inc. Compounds and methods for kinase modulation, and indications therefor
JP5767965B2 (en) 2008-06-10 2015-08-26 プレキシコン インコーポレーテッドＰｌｅｘｘｉｋｏｎ Ｉｎｃ． 5H-pyrrolo [2,3-B] pyrazine derivatives that regulate kinases and indications thereof
WO2009152087A1 (en) 2008-06-10 2009-12-17 Plexxikon, Inc. Bicyclic heteroaryl compounds and methods for kinase modulation, and indications therefor
KR20110130463A (en) 2009-03-11 2011-12-05 플렉시콘, 인코퍼레이티드 Pyrrolo[2,3-b]pyridine derivatives for the inhibition of raf kinases
WO2010104945A1 (en) 2009-03-11 2010-09-16 Plexxikon, Inc. Pyrrolo [2, 3-b] pyridine derivatives for the inhibition of raf kinases
WO2010111527A1 (en) 2009-03-26 2010-09-30 Plexxikon, Inc. Pyrazolo [ 3, 4 -b] pyridines as kinase inhibitors and their medical use
ES2552386T3 (en) 2009-04-03 2015-11-27 F. Hoffmann-La Roche Ag Propane-1-sulfonic acid {3- [5- (4-chloro-phenyl) -1H-pyrrole [2,3-b] pyridin-3-carbonyl] -2,4-difluoro-phenyl} -amide compositions and uses thereof
SG175877A1 (en) 2009-05-04 2011-12-29 Plexxikon Inc Compounds and methods for inhibition of renin, and indications therefor
TW201041888A (en) 2009-05-06 2010-12-01 Plexxikon Inc Compounds and methods for kinase modulation, and indications therefor
JP2013510166A (en) 2009-11-06 2013-03-21 プレキシコン インコーポレーテッド Compounds, methods and applications for kinase regulation
JP2013511541A (en) 2009-11-18 2013-04-04 プレキシコン インコーポレーテッド Compounds and methods for kinase regulation and indications thereof
CA2784393A1 (en) 2009-12-23 2011-06-30 Plexxikon, Inc. Compounds and methods for kinase modulation, and indications therefor
TWI619713B (en) 2010-04-21 2018-04-01 普雷辛肯公司 Compounds and methods for kinase modulation, and indications therefor
US8642606B2 (en) 2010-09-29 2014-02-04 Plexxikon Inc. ZAP-70 active compounds
AU2012214762B2 (en) 2011-02-07 2015-08-13 Plexxikon Inc. Compounds and methods for kinase modulation, and indications therefor
EP2487159A1 (en) * 2011-02-11 2012-08-15 MSD Oss B.V. RorgammaT inhibitors
TWI558702B (en) 2011-02-21 2016-11-21 普雷辛肯公司 Solid forms of a pharmaceutically active substance
AU2012255275B2 (en) 2011-05-17 2016-01-28 Plexxikon Inc. Kinase modulation and indications therefor
EP2721031B1 (en) 2011-06-17 2016-01-20 Constellation Pharmaceuticals, Inc. Bromodomain inhibitors and uses thereof
US9358235B2 (en) 2012-03-19 2016-06-07 Plexxikon Inc. Kinase modulation, and indications therefor
US9150570B2 (en) 2012-05-31 2015-10-06 Plexxikon Inc. Synthesis of heterocyclic compounds
WO2014026329A1 (en) * 2012-08-15 2014-02-20 Merck Sharp & Dohme Corp. N-alkylated indole and indazole compounds as rorgammat inhibitors and uses thereof
WO2014026327A1 (en) * 2012-08-15 2014-02-20 Merck Sharp & Dohme Corp. 4-heteroaryl substituted benzoic acid compounds as rorgammat inhibitors and uses thereof
US10227357B2 (en) 2012-09-06 2019-03-12 Plexxikon Inc. Compounds and methods for kinase modulation, and indications therefor
SG11201504754QA (en) 2012-12-21 2015-07-30 Plexxikon Inc Compounds and methods for kinase modulation, and indications therefor
US9050346B2 (en) * 2013-03-11 2015-06-09 Abbvie Inc. Bromodomain inhibitors
CN105164113B (en) 2013-03-12 2018-03-02 艾伯维公司 Pyrrole amides inhibitor
US20140303121A1 (en) * 2013-03-15 2014-10-09 Plexxikon Inc. Heterocyclic compounds and uses thereof
PE20151997A1 (en) * 2013-03-15 2016-01-13 Plexxikon Inc HETEROCYCLIC COMPOUNDS AND USES OF THEM
TWI527811B (en) * 2013-05-09 2016-04-01 吉李德科學股份有限公司 Benzimidazole derivatives as bromodomain inhibitors
BR112015028845A2 (en) 2013-05-30 2017-07-25 Plexxikon Inc compounds for kinase modulation and indications thereof
WO2015134536A1 (en) 2014-03-04 2015-09-11 Plexxikon Inc. Compounds and methods for kinase modulation, and indications therefor
AU2015318233B2 (en) 2014-09-15 2020-03-12 Plexxikon Inc. Heterocyclic compounds and uses thereof
CN104610255B (en) * 2015-01-28 2017-01-18 常州工程职业技术学院 Method for synthesizing [1,2-a] imidazopyridine derivative containing isoxazole skeleton
US10160755B2 (en) 2015-04-08 2018-12-25 Plexxikon Inc. Compounds and methods for kinase modulation, and indications therefor
CN112574196A (en) 2015-05-06 2021-03-30 普莱希科公司 Synthesis of kinase modulating 1H-pyrrolo [2,3-b ] pyridine derivatives
SI3292123T1 (en) 2015-05-06 2020-10-30 Plexxikon Inc. Solid forms of a compound modulating kinases
CN107771178B (en) 2015-05-22 2021-04-06 普莱希科公司 Synthesis of heterocyclic compounds
BR112017025045A2 (en) 2015-05-22 2018-08-07 Plexxikon Inc plx-8394 or plx-7904 for use in treating braf-v600 related diseases
US10829484B2 (en) 2015-07-28 2020-11-10 Plexxikon Inc. Compounds and methods for kinase modulation, and indications therefor
MY195977A (en) 2015-09-21 2023-02-27 Plexxikon Inc Heterocyclic Compounds and uses Thereof
KR20180086247A (en) 2015-12-07 2018-07-30 플렉시콘 인코퍼레이티드 Compounds and methods for kinase modulation and indications for them
AU2017232610B2 (en) 2016-03-16 2021-07-22 Plexxikon Inc. Compounds and methods for kinase modulation and indications therefore
TW201815766A (en) 2016-09-22 2018-05-01 美商普雷辛肯公司 Compounds and methods for IDO and TDO modulation, and indications therefor
AU2017395023B2 (en) 2016-12-23 2022-04-07 Plexxikon Inc. Compounds and methods for CDK8 modulation and indications therefor
JP2020511467A (en) 2017-03-20 2020-04-16 プレキシコン インコーポレーテッドＰｌｅｘｘｉｋｏｎ Ｉｎｃ． 4- (1- (1,1-di (pyridin-2-yl) ethyl) -6- (3,5-dimethylisoxazol-4-yl) -1H-pyrrolo [3,2- that inhibits the bromodomain b] Pyridin-3-yl) benzoic acid crystalline form
US10428067B2 (en) 2017-06-07 2019-10-01 Plexxikon Inc. Compounds and methods for kinase modulation
TWI805599B (en) 2017-07-25 2023-06-21 美商第一三共公司 Formulations of a compound modulating kinases
CA3079029A1 (en) 2017-10-13 2019-04-18 Plexxikon Inc. Solid forms of a compound for modulating kinases
BR112020007972A2 (en) 2017-10-27 2020-10-20 Plexxikon, Inc. compound formulations that modulate kinases
CN112119072A (en) 2018-03-20 2020-12-22 普莱希科公司 Compounds and methods for IDO and TDO modulation, and indications thereof

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