MX2018006781A - Inhibidores de mat2a para el tratamiento del cancer que no expresen mtap. - Google Patents
Inhibidores de mat2a para el tratamiento del cancer que no expresen mtap.Info
- Publication number
- MX2018006781A MX2018006781A MX2018006781A MX2018006781A MX2018006781A MX 2018006781 A MX2018006781 A MX 2018006781A MX 2018006781 A MX2018006781 A MX 2018006781A MX 2018006781 A MX2018006781 A MX 2018006781A MX 2018006781 A MX2018006781 A MX 2018006781A
- Authority
- MX
- Mexico
- Prior art keywords
- mat2a
- mtap null
- inhibitors
- null cancer
- mat2a inhibitors
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/01—Hydrocarbons
- A61K31/015—Hydrocarbons carbocyclic
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
- C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
- C12Q1/6886—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/02—Halogenated hydrocarbons
- A61K31/025—Halogenated hydrocarbons carbocyclic
- A61K31/03—Halogenated hydrocarbons carbocyclic aromatic
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
- A61K31/136—Amines having aromatic rings, e.g. ketamine, nortriptyline having the amino group directly attached to the aromatic ring, e.g. benzeneamine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/156—Polymorphic or mutational markers
Abstract
La presente invención proporciona métodos diagnósticos y pronósticos para predecir la efectividad de tratamiento de un paciente con cáncer con un inhibidor de MAT2A. Se proporcionan métodos para predecir la sensibilidad de crecimiento de células de tumor a inhibición por un inhibidor de MA2A, que comprende valorar si la célula de tumor está ausente de un gen de MTAP, por lo cual las células son MTAP nulas son sensibles a inhibición por inhibidores de MAT2A.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201562262750P | 2015-12-03 | 2015-12-03 | |
US201662297572P | 2016-02-19 | 2016-02-19 | |
PCT/US2016/064619 WO2017096165A1 (en) | 2015-12-03 | 2016-12-02 | Mat2a inhibitors for treating mtap null cancer |
Publications (1)
Publication Number | Publication Date |
---|---|
MX2018006781A true MX2018006781A (es) | 2018-11-09 |
Family
ID=57614465
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX2018006781A MX2018006781A (es) | 2015-12-03 | 2016-12-02 | Inhibidores de mat2a para el tratamiento del cancer que no expresen mtap. |
Country Status (12)
Country | Link |
---|---|
US (1) | US20180371551A1 (es) |
EP (1) | EP3383375A1 (es) |
JP (2) | JP6877429B2 (es) |
KR (1) | KR20180100125A (es) |
CN (1) | CN108601752A (es) |
AU (1) | AU2016364855B2 (es) |
CA (1) | CA3006743A1 (es) |
EA (1) | EA201891304A1 (es) |
IL (1) | IL259773A (es) |
MX (1) | MX2018006781A (es) |
SG (1) | SG11201804360XA (es) |
WO (1) | WO2017096165A1 (es) |
Families Citing this family (11)
Publication number | Priority date | Publication date | Assignee | Title |
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EP3795215A1 (en) | 2012-05-30 | 2021-03-24 | Chugai Seiyaku Kabushiki Kaisha | Target tissue-specific antigen-binding molecule |
TWI664331B (zh) | 2013-12-04 | 2019-07-01 | 日商中外製藥股份有限公司 | 因應化合物濃度使抗原結合能力變化的抗原結合分子及其資料庫 |
US11376256B2 (en) | 2018-07-19 | 2022-07-05 | Agency For Science, Technology And Research | Method of treating a methionine-dependent cancer |
MA54452A (fr) | 2018-12-10 | 2022-03-16 | Ideaya Biosciences Inc | Dérivés de 2-oxoquinazoline utilisés en tant qu'inhibiteurs de la méthionine adénosyltransférase 2a |
US20220153875A1 (en) * | 2019-03-19 | 2022-05-19 | Chugai Seiyaku Kabushiki Kaisha | Antigen-binding molecule containing antigen-binding domain of which binding activity to antigen is changed depending on mta, and library for obtaining said antigen-binding domain |
WO2021023609A1 (en) * | 2019-08-02 | 2021-02-11 | Glaxosmithkline Intellectual Property Development Limited | Combination of a type i protein arginine methyltransferase (type i prmt) inhibitor and a methionine adenosyltransferase ii alpha (mat2a) inhibitor |
WO2021158792A1 (en) * | 2020-02-04 | 2021-08-12 | Agios Pharmaceuticals, Inc. | Methods of treating autoimmune or inflammatory diseases or disorders |
AR123227A1 (es) * | 2020-08-12 | 2022-11-09 | Servier Pharmaceuticals Llc | Terapias combinadas para su uso en el tratamiento del cáncer |
WO2022256806A1 (en) * | 2021-06-02 | 2022-12-08 | Ideaya Biosciences, Inc. | Combination therapy comprising a mat2a inhibitor and a type ii prmt inhibitor |
CN113476450B (zh) * | 2021-08-10 | 2023-04-28 | 江南大学 | Epz015666在制备用于防治血管内膜增生类疾病的药物中的应用 |
CN114028572B (zh) * | 2021-11-30 | 2022-11-25 | 清华大学 | Mat2a抑制剂用于治疗哮喘的新应用 |
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-
2016
- 2016-12-02 CA CA3006743A patent/CA3006743A1/en not_active Abandoned
- 2016-12-02 AU AU2016364855A patent/AU2016364855B2/en active Active
- 2016-12-02 KR KR1020187018814A patent/KR20180100125A/ko not_active Application Discontinuation
- 2016-12-02 EA EA201891304A patent/EA201891304A1/ru unknown
- 2016-12-02 MX MX2018006781A patent/MX2018006781A/es unknown
- 2016-12-02 CN CN201680080863.1A patent/CN108601752A/zh active Pending
- 2016-12-02 EP EP16819232.6A patent/EP3383375A1/en not_active Withdrawn
- 2016-12-02 JP JP2018528729A patent/JP6877429B2/ja active Active
- 2016-12-02 SG SG11201804360XA patent/SG11201804360XA/en unknown
- 2016-12-02 US US15/780,494 patent/US20180371551A1/en not_active Abandoned
- 2016-12-02 WO PCT/US2016/064619 patent/WO2017096165A1/en active Application Filing
-
2018
- 2018-06-03 IL IL259773A patent/IL259773A/en unknown
-
2021
- 2021-03-10 JP JP2021037941A patent/JP2021098736A/ja active Pending
Also Published As
Publication number | Publication date |
---|---|
JP2021098736A (ja) | 2021-07-01 |
WO2017096165A1 (en) | 2017-06-08 |
AU2016364855A1 (en) | 2018-07-05 |
EP3383375A1 (en) | 2018-10-10 |
CN108601752A (zh) | 2018-09-28 |
JP2018537473A (ja) | 2018-12-20 |
US20180371551A1 (en) | 2018-12-27 |
EA201891304A1 (ru) | 2019-01-31 |
CA3006743A1 (en) | 2017-06-08 |
SG11201804360XA (en) | 2018-06-28 |
IL259773A (en) | 2018-07-31 |
AU2016364855B2 (en) | 2019-08-29 |
KR20180100125A (ko) | 2018-09-07 |
JP6877429B2 (ja) | 2021-05-26 |
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