MX2015008741A - Ftalazinonas e isoquinolinonas como inhibidores de cinasa rho. - Google Patents
Ftalazinonas e isoquinolinonas como inhibidores de cinasa rho.Info
- Publication number
- MX2015008741A MX2015008741A MX2015008741A MX2015008741A MX2015008741A MX 2015008741 A MX2015008741 A MX 2015008741A MX 2015008741 A MX2015008741 A MX 2015008741A MX 2015008741 A MX2015008741 A MX 2015008741A MX 2015008741 A MX2015008741 A MX 2015008741A
- Authority
- MX
- Mexico
- Prior art keywords
- rock inhibitors
- isoquinolinones
- phthalazinones
- compounds
- neuropathologic
- Prior art date
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Classifications
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- C07D237/26—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings condensed with carbocyclic rings or ring systems
- C07D237/30—Phthalazines
- C07D237/32—Phthalazines with oxygen atoms directly attached to carbon atoms of the nitrogen-containing ring
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- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
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- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
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- A61K31/422—Oxazoles not condensed and containing further heterocyclic rings
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- A61K31/445—Non condensed piperidines, e.g. piperocaine
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- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/04—Ortho-condensed systems
- C07D491/044—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring
- C07D491/048—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring the oxygen-containing ring being five-membered
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
- C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
- C07D513/04—Ortho-condensed systems
Abstract
La presente invención proporciona compuestos de la Fórmula (I) (ver Fórmula) o estereoisómeros, tautómeros o sales de aquellos aceptables desde el punto de vista farmacéutico, en donde todas las variables son como se definen en la presente. Estos compuestos son inhibidores de ROCK selectivos. La presente invención también se refiere a composiciones farmacéuticas que comprenden estos compuestos y a métodos para tratar trastornos cardiovasculares, trastornos relacionados con el músculo liso, trastornos oncológicos, trastornos neuropatológicos, trastornos autoinmunes, trastornos fibróticos y/o trastornos inflamatorios mediante su uso.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201361754007P | 2013-01-18 | 2013-01-18 | |
PCT/US2014/011957 WO2014113620A2 (en) | 2013-01-18 | 2014-01-17 | Phthalazinones and isoquinolinones as rock inhibitors |
Publications (1)
Publication Number | Publication Date |
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MX2015008741A true MX2015008741A (es) | 2015-11-06 |
Family
ID=50031626
Family Applications (1)
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MX2015008741A MX2015008741A (es) | 2013-01-18 | 2014-01-17 | Ftalazinonas e isoquinolinonas como inhibidores de cinasa rho. |
Country Status (12)
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US (3) | US9926282B2 (es) |
EP (3) | EP3252049A1 (es) |
JP (3) | JP6488239B2 (es) |
CN (1) | CN105073741B (es) |
BR (1) | BR112015017008A2 (es) |
CA (1) | CA2898440A1 (es) |
EA (3) | EA033220B1 (es) |
ES (2) | ES2785498T3 (es) |
HK (1) | HK1212979A1 (es) |
MX (1) | MX2015008741A (es) |
TW (1) | TW201443023A (es) |
WO (1) | WO2014113620A2 (es) |
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US10954217B2 (en) * | 2016-04-29 | 2021-03-23 | Board Of Regents, The University Of Texas System | Sigma receptor binders |
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ES2821877T3 (es) | 2016-07-07 | 2021-04-28 | Bristol Myers Squibb Co | Espirolactamas como inhibidores de ROCK |
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JP7313331B2 (ja) | 2017-07-12 | 2023-07-24 | ブリストル-マイヤーズ スクイブ カンパニー | Rock阻害剤としてのスピロヘプタニルヒダントイン |
JP7234201B2 (ja) | 2017-07-12 | 2023-03-07 | ブリストル-マイヤーズ スクイブ カンパニー | 心不全の治療のためのrockの5員アミノヘテロ環および5,6-または6,6員二環式アミノヘテロ環の阻害剤 |
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EA027138B1 (ru) | 2017-06-30 |
US20140206686A1 (en) | 2014-07-24 |
JP2019077689A (ja) | 2019-05-23 |
WO2014113620A3 (en) | 2014-10-09 |
JP6770053B2 (ja) | 2020-10-14 |
CN105073741B (zh) | 2017-08-08 |
JP6488239B2 (ja) | 2019-03-20 |
JP2016505042A (ja) | 2016-02-18 |
EA201591296A1 (ru) | 2015-11-30 |
US20180162823A1 (en) | 2018-06-14 |
US9221767B2 (en) | 2015-12-29 |
EP3252050B1 (en) | 2020-02-26 |
US20150353505A1 (en) | 2015-12-10 |
JP6622378B2 (ja) | 2019-12-18 |
ES2684776T3 (es) | 2018-10-04 |
WO2014113620A2 (en) | 2014-07-24 |
EP3252049A1 (en) | 2017-12-06 |
EA034395B1 (ru) | 2020-02-04 |
EA201891501A1 (ru) | 2019-04-30 |
CA2898440A1 (en) | 2014-07-24 |
JP2019073521A (ja) | 2019-05-16 |
TW201443023A (zh) | 2014-11-16 |
HK1212979A1 (zh) | 2016-06-24 |
ES2785498T3 (es) | 2020-10-07 |
EA033220B1 (ru) | 2019-09-30 |
BR112015017008A2 (pt) | 2017-07-11 |
EA201790202A1 (ru) | 2017-09-29 |
US10385026B2 (en) | 2019-08-20 |
CN105073741A (zh) | 2015-11-18 |
US9926282B2 (en) | 2018-03-27 |
EP2945943A2 (en) | 2015-11-25 |
EP2945943B1 (en) | 2018-05-30 |
EP3252050A1 (en) | 2017-12-06 |
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