MX2015008578A - Diferenciacion de celulas madre embrionarias humanas en celulas endocrinas pancreaticas mediante el uso de relugadores de hb9. - Google Patents

Diferenciacion de celulas madre embrionarias humanas en celulas endocrinas pancreaticas mediante el uso de relugadores de hb9.

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Publication number
MX2015008578A
MX2015008578A MX2015008578A MX2015008578A MX2015008578A MX 2015008578 A MX2015008578 A MX 2015008578A MX 2015008578 A MX2015008578 A MX 2015008578A MX 2015008578 A MX2015008578 A MX 2015008578A MX 2015008578 A MX2015008578 A MX 2015008578A
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MX
Mexico
Prior art keywords
cells
differentiation
regulators
embryonic stem
human embryonic
Prior art date
Application number
MX2015008578A
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English (en)
Inventor
Alireza Rezania
Original Assignee
Janssen Biotech Inc
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Publication date
Application filed by Janssen Biotech Inc filed Critical Janssen Biotech Inc
Publication of MX2015008578A publication Critical patent/MX2015008578A/es

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    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0676—Pancreatic cells
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    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
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    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0603—Embryonic cells ; Embryoid bodies
    • C12N5/0606—Pluripotent embryonic cells, e.g. embryonic stem cells [ES]
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    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/30—Hormones
    • C12N2501/38—Hormones with nuclear receptors
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    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/999—Small molecules not provided for elsewhere
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    • C12N2506/00—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells
    • C12N2506/02—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells from embryonic cells
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    • C12N2533/00—Supports or coatings for cell culture, characterised by material
    • C12N2533/90—Substrates of biological origin, e.g. extracellular matrix, decellularised tissue

Abstract

La presente invención proporciona métodos para promover la diferenciación de células madre pluripotentes a células del endodermo pancreático que expresan PDX1, NKX6.1, y HB9; particularmente, los métodos abarcan cultivar células de la Etapa 4 a Etapa 6 con una hormona tiroidea (por ejemplo, T3), un inhibidor de ALK5, o ambos.
MX2015008578A 2012-12-31 2013-12-18 Diferenciacion de celulas madre embrionarias humanas en celulas endocrinas pancreaticas mediante el uso de relugadores de hb9. MX2015008578A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201261747672P 2012-12-31 2012-12-31
PCT/US2013/075959 WO2014105546A1 (en) 2012-12-31 2013-12-18 Differentiation of human embryonic stem cells into pancreatic endocrine cells using hb9 regulators

Publications (1)

Publication Number Publication Date
MX2015008578A true MX2015008578A (es) 2015-09-07

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US (3) US10138465B2 (es)
EP (2) EP4219683A1 (es)
JP (4) JP6557147B2 (es)
KR (2) KR101942769B1 (es)
CN (2) CN105073979B (es)
AR (1) AR094348A1 (es)
AU (4) AU2013368224B2 (es)
BR (1) BR112015015701A2 (es)
CA (1) CA2896658C (es)
DK (1) DK2938723T3 (es)
ES (1) ES2942484T3 (es)
HK (1) HK1217109A1 (es)
MX (1) MX2015008578A (es)
PH (1) PH12015501450A1 (es)
RU (1) RU2684215C2 (es)
SG (2) SG11201505112SA (es)
WO (1) WO2014105546A1 (es)

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