MX2014003080A - Inhibidores sustituidos de n-[1-ciano-2- (fenil) etil]-2-azabiciclo[2.2.1] heptan-3-carboxamida de catepsina c. - Google Patents

Inhibidores sustituidos de n-[1-ciano-2- (fenil) etil]-2-azabiciclo[2.2.1] heptan-3-carboxamida de catepsina c.

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Publication number
MX2014003080A
MX2014003080A MX2014003080A MX2014003080A MX2014003080A MX 2014003080 A MX2014003080 A MX 2014003080A MX 2014003080 A MX2014003080 A MX 2014003080A MX 2014003080 A MX2014003080 A MX 2014003080A MX 2014003080 A MX2014003080 A MX 2014003080A
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MX
Mexico
Prior art keywords
cathepsin
azabicyclo
heptane
cyano
phenyl
Prior art date
Application number
MX2014003080A
Other languages
English (en)
Other versions
MX335941B (es
Inventor
Doris Riether
Alexander Pautsch
Stefan Peters
Wolfgang Wienen
Marc Grundl
Thorsten Oost
Original Assignee
Boehringer Ingelheim Int
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Filing date
Publication date
Application filed by Boehringer Ingelheim Int filed Critical Boehringer Ingelheim Int
Publication of MX2014003080A publication Critical patent/MX2014003080A/es
Publication of MX335941B publication Critical patent/MX335941B/es

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/08—Bridged systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/52—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring condensed with a ring other than six-membered
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    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
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    • A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
    • A61K31/4035—Isoindoles, e.g. phthalimide
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    • A61K31/4365—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system having sulfur as a ring hetero atom, e.g. ticlopidine
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Abstract

Esta invención se refiere a N-1-ciano-2-(fenil)etil)-2-azabiciclo[ 2.2.1]heptan-3-carboxamidas de la fórmula I (ver Fórmula) y a su uso como inhibidores de catepsina C, composiciones farmacéuticas que las contienen y métodos de uso de ellas como agentes para el tratamiento y/o la prevención de enfermedades respiratorias.
MX2014003080A 2011-09-19 2012-09-18 Inhibidores sustituidos de n-[1-ciano-2- (fenil) etil]-2-azabiciclo[2.2.1] heptan-3-carboxamida de catepsina c. MX335941B (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP11181805 2011-09-19
PCT/EP2012/068284 WO2013041497A1 (en) 2011-09-19 2012-09-18 Substituted n- [1-cyano-2- (phenyl) ethyl] -2-azabicyclo [2.2.1] heptane-3-carboxamide inhibitors of cathepsin c

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MX2014003080A true MX2014003080A (es) 2014-04-25
MX335941B MX335941B (es) 2016-01-04

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EP2925732A1 (en) 2012-11-27 2015-10-07 Basf Se Substituted [1,2,4]triazole compounds
US20160029630A1 (en) 2012-11-27 2016-02-04 Basf Se Substituted 2-[phenoxy-phenyl]-1-[1,2,4]triazol-1-yl-ethanol compounds and their use as fungicides
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JP6437929B2 (ja) 2013-03-14 2018-12-12 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング カテプシンｃの置換二環式１−カルボン酸（ベンジル−シアノ−メチル）−アミド阻害剤
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JP2017526716A (ja) * 2014-09-12 2017-09-14 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング カテプシンｃのスピロ環状阻害剤
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CA3181285A1 (en) * 2020-07-20 2022-01-27 Jessica BASSO Methods for extracting neutrophil serine proteases and treating dipeptidyl peptidase 1-mediated conditions
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CN103814028B (zh) 2016-02-17
KR20140078626A (ko) 2014-06-25
BR112014006297A2 (pt) 2017-04-11
EA024817B1 (ru) 2016-10-31
JP6012736B2 (ja) 2016-10-25
MX335941B (es) 2016-01-04
US20130172327A1 (en) 2013-07-04
CL2014000299A1 (es) 2014-09-26
WO2013041497A1 (en) 2013-03-28
EP2758398B1 (en) 2017-08-02
EA201400358A1 (ru) 2014-09-30
AU2012311656B2 (en) 2016-10-06
CN103814028A (zh) 2014-05-21
CA2848929A1 (en) 2013-03-28
IL230820A0 (en) 2014-03-31
AU2012311656A1 (en) 2014-02-13
EP2758398A1 (en) 2014-07-30
US8999975B2 (en) 2015-04-07
IL230820A (en) 2017-03-30
NZ620208A (en) 2015-10-30
JP2014526492A (ja) 2014-10-06

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