MX2013012385A - Combinacion de un inhibidor de cinasa de fosfatidil-inositol-3 (pi3k) y un inhibidor de mtor. - Google Patents

Combinacion de un inhibidor de cinasa de fosfatidil-inositol-3 (pi3k) y un inhibidor de mtor.

Info

Publication number
MX2013012385A
MX2013012385A MX2013012385A MX2013012385A MX2013012385A MX 2013012385 A MX2013012385 A MX 2013012385A MX 2013012385 A MX2013012385 A MX 2013012385A MX 2013012385 A MX2013012385 A MX 2013012385A MX 2013012385 A MX2013012385 A MX 2013012385A
Authority
MX
Mexico
Prior art keywords
inhibitor
combination
kinase
pi3k
phosphatidylinositol
Prior art date
Application number
MX2013012385A
Other languages
English (en)
Inventor
Christine Fritsch
Carlos Garcia-Echeverria
Xizhong Huang
Sauveur-Michel Maira
Original Assignee
Novartis Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
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First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=46018130&utm_source=***_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=MX2013012385(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Novartis Ag filed Critical Novartis Ag
Publication of MX2013012385A publication Critical patent/MX2013012385A/es

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    • A—HUMAN NECESSITIES
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
    • A—HUMAN NECESSITIES
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425—Thiazoles
    • A61K31/427—Thiazoles not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61K31/33—Heterocyclic compounds
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    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/436—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a six-membered ring having oxygen as a ring hetero atom, e.g. rapamycin
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/439—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom the ring forming part of a bridged ring system, e.g. quinuclidine
    • A—HUMAN NECESSITIES
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    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
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Abstract

La presente invención se refiere a una combinación farmacéutica que comprende un compuesto inhibidor de cinasa de fosfatidil-inositol-3 (PI3K), el cual es un derivado de 2-carboxamida-cicloamino-urea, o una sal farmacéuticamente aceptable del mismo, y cuando menos un inhibidor del objetivo de rapamicina de mamífero (mTOR), o una sal farmacéuticamente aceptable del mismo; a una composición farmacéutica, la cual comprende dicha combinación; y a los usos de esta combinación en el tratamiento de las enfermedades proliferativas, más específicamente de las enfermedades dependientes de la cinasa del objetivo de rapamicina de mamífero (mTOR).
MX2013012385A 2011-04-25 2012-04-23 Combinacion de un inhibidor de cinasa de fosfatidil-inositol-3 (pi3k) y un inhibidor de mtor. MX2013012385A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201161478572P 2011-04-25 2011-04-25
PCT/US2012/034647 WO2012148846A1 (en) 2011-04-25 2012-04-23 Combination of a phosphatidylinositol-3-kinase (pi3k) inhibitor and a mtor inhibitor

Publications (1)

Publication Number Publication Date
MX2013012385A true MX2013012385A (es) 2013-11-04

Family

ID=46018130

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2013012385A MX2013012385A (es) 2011-04-25 2012-04-23 Combinacion de un inhibidor de cinasa de fosfatidil-inositol-3 (pi3k) y un inhibidor de mtor.

Country Status (25)

Country Link
US (3) US20140066474A1 (es)
EP (1) EP2701703A1 (es)
JP (2) JP6086902B2 (es)
KR (1) KR101925656B1 (es)
CN (1) CN103491955B (es)
AR (1) AR086481A1 (es)
AU (2) AU2012250010A1 (es)
BR (1) BR112013027486A2 (es)
CA (1) CA2833962A1 (es)
CL (1) CL2013003078A1 (es)
CO (1) CO6801759A2 (es)
EA (1) EA025948B1 (es)
EC (1) ECSP13012994A (es)
GT (1) GT201300263A (es)
IL (1) IL229008A (es)
MA (1) MA35038B1 (es)
MX (1) MX2013012385A (es)
NZ (1) NZ615593A (es)
PE (1) PE20140601A1 (es)
SG (1) SG193919A1 (es)
TN (1) TN2013000392A1 (es)
TW (1) TWI602567B (es)
UA (1) UA110961C2 (es)
WO (1) WO2012148846A1 (es)
ZA (1) ZA201306973B (es)

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MX2016010482A (es) * 2014-02-11 2016-10-17 Novartis Ag Combinaciones farmaceuticas que comprenden un inhibidor de pi3k para el tratamiento de cancer.
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CN112957334B (zh) * 2014-10-03 2023-08-04 诺华股份有限公司 含alpelisib的药物组合物
US20160339030A1 (en) * 2015-05-19 2016-11-24 University Of Maryland, Baltimore Treatment agents for inhibiting hiv and cancer in hiv infected patients
GB202010627D0 (en) * 2020-07-10 2020-08-26 Qbd (Qs-Ip) Ltd Blocking method

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JP6086902B2 (ja) 2017-03-01
AR086481A1 (es) 2013-12-18
PE20140601A1 (es) 2014-05-24
CN103491955B (zh) 2015-12-23
TWI602567B (zh) 2017-10-21
JP2017061527A (ja) 2017-03-30
US20180085362A1 (en) 2018-03-29
UA110961C2 (uk) 2016-03-10
EA025948B1 (ru) 2017-02-28
AU2012250010A1 (en) 2013-10-10
AU2016202372B2 (en) 2017-07-20
BR112013027486A2 (pt) 2017-02-14
AU2016202372A1 (en) 2016-05-05
WO2012148846A1 (en) 2012-11-01
IL229008A0 (en) 2013-12-31
CA2833962A1 (en) 2012-11-01
ECSP13012994A (es) 2013-12-31
TN2013000392A1 (en) 2015-01-20
KR20140012147A (ko) 2014-01-29
JP2014513097A (ja) 2014-05-29
ZA201306973B (en) 2014-06-25
CO6801759A2 (es) 2013-11-29
US20170095463A1 (en) 2017-04-06
GT201300263A (es) 2015-11-24
IL229008A (en) 2017-11-30
TW201244716A (en) 2012-11-16
EA201391565A1 (ru) 2014-02-28
CN103491955A (zh) 2014-01-01
MA35038B1 (fr) 2014-04-03
SG193919A1 (en) 2013-11-29
CL2013003078A1 (es) 2014-05-30
NZ615593A (en) 2015-05-29
KR101925656B1 (ko) 2018-12-05
US20140066474A1 (en) 2014-03-06
EP2701703A1 (en) 2014-03-05

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