MD4556C1 - Compuşi inhibitori ai activităţii catehol O-metiltransferazei - Google Patents

Compuşi inhibitori ai activităţii catehol O-metiltransferazei

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Publication number
MD4556C1
MD4556C1 MDA20140124A MD20140124A MD4556C1 MD 4556 C1 MD4556 C1 MD 4556C1 MD A20140124 A MDA20140124 A MD A20140124A MD 20140124 A MD20140124 A MD 20140124A MD 4556 C1 MD4556 C1 MD 4556C1
Authority
MD
Moldova
Prior art keywords
catechol
inhibiting compounds
methyltransferase activity
activity inhibiting
comt
Prior art date
Application number
MDA20140124A
Other languages
English (en)
Russian (ru)
Other versions
MD4556B1 (ro
MD20140124A2 (ro
Inventor
Марко АЛЬМАРК
БЕЛЛЕ Дэвид ДИН
Мика Кауппала
Анне Луйро
Тайна Паюнен
Ярмо Пюстюнен
Эйя ТАЙНЕН
Матти Вайсмаа
Йосеф МЕССИНЯР
Original Assignee
Orion Corporation
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Orion Corporation filed Critical Orion Corporation
Publication of MD20140124A2 publication Critical patent/MD20140124A2/ro
Publication of MD4556B1 publication Critical patent/MD4556B1/ro
Publication of MD4556C1 publication Critical patent/MD4556C1/ro

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    • A61K31/275Nitriles; Isonitriles
    • A61K31/277Nitriles; Isonitriles having a ring, e.g. verapamil
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/185Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19Carboxylic acids, e.g. valproic acid
    • A61K31/195Carboxylic acids, e.g. valproic acid having an amino group
    • A61K31/197Carboxylic acids, e.g. valproic acid having an amino group the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid, pantothenic acid
    • A61K31/198Alpha-aminoacids, e.g. alanine, edetic acids [EDTA]
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    • A61K31/335Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/34Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide
    • A61K31/341Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide not condensed with another ring, e.g. ranitidine, furosemide, bufetolol, muscarine
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    • A61K31/343Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide condensed with a carbocyclic ring, e.g. coumaran, bufuralol, befunolol, clobenfurol, amiodarone
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    • A61K31/40Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
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Abstract

Invenţia se referă la 4,5-dihidroxiizoftalonitrili 2-substituiţi cu activitate farmacologică sau la săruri şi esteri farmaceutic acceptabili ai acestora, precum şi la compoziţii farmaceutice care îi conţin şi la utilizarea lor ca inhibitori ai enzimei catehol O-metiltransferazei (COMT).Sunt descrişi compuşi cu formula I,în care R1 are semnificaţiile definite în revendicări, şi care exercită activitate de inhibare a enzimei COMT.Revendicări: 37
MDA20140124A 2012-05-24 2013-05-23 Compuşi inhibitori ai activităţii catehol O-metiltransferazei MD4556C1 (ro)

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