MX2016003522A - Derivados de quinazolinas y su uso como inhibidores de la adn metiltransferasa. - Google Patents

Derivados de quinazolinas y su uso como inhibidores de la adn metiltransferasa.

Info

Publication number
MX2016003522A
MX2016003522A MX2016003522A MX2016003522A MX2016003522A MX 2016003522 A MX2016003522 A MX 2016003522A MX 2016003522 A MX2016003522 A MX 2016003522A MX 2016003522 A MX2016003522 A MX 2016003522A MX 2016003522 A MX2016003522 A MX 2016003522A
Authority
MX
Mexico
Prior art keywords
dna methyltransferase
quinazoline derivatives
methyltransferase inhibitors
compounds
inhibitors
Prior art date
Application number
MX2016003522A
Other languages
English (en)
Inventor
Barbara Arimondo Paola
Halby Ludovic
Original Assignee
Pf Medicament
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pf Medicament filed Critical Pf Medicament
Publication of MX2016003522A publication Critical patent/MX2016003522A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/517—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with carbocyclic ring systems, e.g. quinazoline, perimidine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings

Abstract

La presente invención se refiere a compuestos con la siguiente fórmula (I) (ver Fórmula) y sales farmacéuticamente aceptables y solvatos de la misma, sus métodos de preparación, su uso como un fármaco, en particular para el tratamiento del cáncer y composiciones farmacéuticas que contienen tales compuestos.
MX2016003522A 2013-09-19 2014-09-19 Derivados de quinazolinas y su uso como inhibidores de la adn metiltransferasa. MX2016003522A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP13306281 2013-09-19
PCT/EP2014/070011 WO2015040169A1 (en) 2013-09-19 2014-09-19 Quinazoline derivatives and their use as dna methyltransferase inhibitors

Publications (1)

Publication Number Publication Date
MX2016003522A true MX2016003522A (es) 2016-12-15

Family

ID=49261480

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2016003522A MX2016003522A (es) 2013-09-19 2014-09-19 Derivados de quinazolinas y su uso como inhibidores de la adn metiltransferasa.

Country Status (10)

Country Link
US (1) US9951044B2 (es)
EP (1) EP3046917B1 (es)
JP (1) JP6567505B2 (es)
KR (1) KR20160060071A (es)
CN (1) CN105555781A (es)
BR (1) BR112016005317A2 (es)
ES (1) ES2659337T3 (es)
MX (1) MX2016003522A (es)
RU (1) RU2016112013A (es)
WO (1) WO2015040169A1 (es)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2016151144A1 (en) * 2015-03-25 2016-09-29 Pierre Fabre Medicament Substituted quinazoline derivatives as dna methyltransferase inhibitors
CA3073952A1 (en) 2017-08-31 2019-03-07 University Of Louisville Research Foundation, Inc. Quinoline derivative, compositions comprising this compound and uses thereof in the treatment of cancer
US10774046B2 (en) 2017-10-26 2020-09-15 University Of Louisville Research Foundation, Inc. Inhibitors for the treatment of cancer and related methods
KR102392896B1 (ko) * 2020-04-07 2022-05-03 충북대학교 산학협력단 신규한 3-((1-벤질-1h-1,2,3-트리아졸-4-일)메틸)퀴나졸린-4(3h)-원 및 n-(1-벤질피페리딘-4-일)퀴나졸린-4-아민 및 이의 용도
WO2022015974A2 (en) * 2020-07-15 2022-01-20 St. Jude Children's Research Hospital, Inc. Substituted 4-(3-aminoprop-1-yl)aminoquinoline analogs as modulators of melanoma-associated antigen 11 ubiquitin ligase
WO2023107687A1 (en) * 2021-12-09 2023-06-15 Bala Therapeutics, Inc. Inhibitors of menin-mll interaction
US11957759B1 (en) 2022-09-07 2024-04-16 Arvinas Operations, Inc. Rapidly accelerated fibrosarcoma (RAF) degrading compounds and associated methods of use

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN86100512A (zh) * 1986-02-21 1987-09-02 国家医药管理局上海医药工业研究院 有抗肿瘤作用的2，4-二氨基-6-(n-甲基或甲酰基-取代苄氨基)喹啉类衍生物合成
CA2373279A1 (en) * 1999-05-25 2000-12-14 The Penn State Research Foundation Dna methyltransferase inhibitors
DE10042059A1 (de) * 2000-08-26 2002-03-07 Boehringer Ingelheim Pharma Bicyclische Heterocyclen, diese Verbindungen enthaltende Arzneimittel, deren Verwendung und Verfahren zu ihrer Herstellung
ES2301981T3 (es) 2003-04-16 2008-07-01 Astrazeneca Ab Derivados de quinazolina para el tratamiento del cancer.
GB0326459D0 (en) * 2003-11-13 2003-12-17 Astrazeneca Ab Quinazoline derivatives
AU2005214373B2 (en) * 2004-02-19 2011-07-28 Rexahn Corporation Quinazoline derivatives and therapeutic use thereof
CA2471177A1 (en) * 2004-06-14 2005-12-14 Fouad Brahimi Novel combi-molecules having egfr and dna targeting properties
EP1844062A2 (en) * 2005-01-21 2007-10-17 Methylgene, Inc. Inhibitors of dna methyltransferase
US7790746B2 (en) * 2007-10-12 2010-09-07 Supergen, Inc. Quinoline derivatives for modulating DNA methylation
CN101857617A (zh) * 2010-04-28 2010-10-13 中国海洋大学 喹唑啉类糖衍生物及其制备方法和应用
CN101857618B (zh) * 2010-06-13 2015-11-25 中国海洋大学 作为蛋白酪氨酸激酶抑制剂的一系列喹唑啉糖衍生物，其制备方法和应用

Also Published As

Publication number Publication date
RU2016112013A (ru) 2017-10-24
CN105555781A (zh) 2016-05-04
JP6567505B2 (ja) 2019-08-28
US9951044B2 (en) 2018-04-24
ES2659337T3 (es) 2018-03-14
JP2016531848A (ja) 2016-10-13
EP3046917A1 (en) 2016-07-27
EP3046917B1 (en) 2017-11-08
BR112016005317A2 (pt) 2017-09-12
WO2015040169A1 (en) 2015-03-26
US20160229834A1 (en) 2016-08-11
KR20160060071A (ko) 2016-05-27

Similar Documents

Publication Publication Date Title
PH12017500281A1 (en) Pyrrolopyrimidine compounds used as tlr7 agonist
PH12017502141A1 (en) Compounds and their methods of use
UA114906C2 (uk) Гетероциклільні сполуки як інгібітори мек
MD4684B1 (ro) Formulări pe bază de imidazopirazine în calitate de inhibitori SYK
MD20170016A2 (ro) Compuşi aminopirimidinici ca inhibitori JAK
MX2015012432A (es) Inhibidores piridinicos de la cinasa cdk9.
UA109010C2 (en) MORPHOLINOPYRIMIDINES AND THEIR APPLICATIONS IN THERAPY
IN2014MN02598A (es)
MX2015012850A (es) Inhibidores de la arginina metiltransferasa y usos de los mismos.
EA201490891A1 (ru) Пиридопиразины, обладающие противораковой активностью через ингибирование fgfr киназ
UA117122C2 (uk) Хінолонові похідні
EA201891063A1 (ru) Производные дигидроимидазопиразинона, применимые в лечении рака
MX338515B (es) Derivados de tetrahidroquinolina utiles como inhibidores de bromodominio.
PH12015502159A1 (en) Chemical entities
MX2016003522A (es) Derivados de quinazolinas y su uso como inhibidores de la adn metiltransferasa.
JO3115B1 (ar) مركبات بيريدازينون واستخدامها كمثبطات daao
PH12016502353A1 (en) Pharmaceutical composition
TW201613577A (en) Pharmaceutical combinations
MX2015012153A (es) Inhibidores de la quinasa pirrolopirimidina cdk9.
MX2017002544A (es) Derivados de isoquinolinona utiles en el tratamiento contra el cancer.
MX2017002627A (es) Derivados de polieteres macrociclicos de n-aril-2-amino-4-aril-pir imidina como inhibidores de ftl3 y jak.
MX2017002747A (es) Derivados de polieteres macrociclicos de n-aril-triciclopirimidin- 2-amino como inhibidores de ftl3 y jak.
TN2014000077A1 (en) Pyridazinone compounds and their use as daao inhibitors
UA111851C2 (uk) Сполуки піридазинону та їх використання як інгібіторів daao