MX2013000674A - Metodo para identificar a un paciente con incrementada probabilidad de responder a una terapia anticancer. - Google Patents
Metodo para identificar a un paciente con incrementada probabilidad de responder a una terapia anticancer.Info
- Publication number
- MX2013000674A MX2013000674A MX2013000674A MX2013000674A MX2013000674A MX 2013000674 A MX2013000674 A MX 2013000674A MX 2013000674 A MX2013000674 A MX 2013000674A MX 2013000674 A MX2013000674 A MX 2013000674A MX 2013000674 A MX2013000674 A MX 2013000674A
- Authority
- MX
- Mexico
- Prior art keywords
- cancer therapy
- patient
- responding
- identify
- increased likelihood
- Prior art date
Links
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/574—Immunoassay; Biospecific binding assay; Materials therefor for cancer
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/22—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against growth factors ; against growth regulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/337—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having four-membered rings, e.g. taxol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/513—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim having oxo groups directly attached to the heterocyclic ring, e.g. cytosine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/517—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with carbocyclic ring systems, e.g. quinazoline, perimidine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
- A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
- A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
- A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
- A61K31/7068—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines having oxo groups directly attached to the pyrimidine ring, e.g. cytidine, cytidylic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
- A61K33/24—Heavy metals; Compounds thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
- A61K33/24—Heavy metals; Compounds thereof
- A61K33/243—Platinum; Compounds thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/43—Enzymes; Proenzymes; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
- A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
- A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
- A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
- A61K39/39558—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against tumor tissues, cells, antigens
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/18—Drugs for disorders of the alimentary tract or the digestive system for pancreatic disorders, e.g. pancreatic enzymes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
- G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/574—Immunoassay; Biospecific binding assay; Materials therefor for cancer
- G01N33/57407—Specifically defined cancers
- G01N33/57434—Specifically defined cancers of prostate
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/574—Immunoassay; Biospecific binding assay; Materials therefor for cancer
- G01N33/57484—Immunoassay; Biospecific binding assay; Materials therefor for cancer involving compounds serving as markers for tumor, cancer, neoplasia, e.g. cellular determinants, receptors, heat shock/stress proteins, A-protein, oligosaccharides, metabolites
- G01N33/57492—Immunoassay; Biospecific binding assay; Materials therefor for cancer involving compounds serving as markers for tumor, cancer, neoplasia, e.g. cellular determinants, receptors, heat shock/stress proteins, A-protein, oligosaccharides, metabolites involving compounds localized on the membrane of tumor or cancer cells
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
- G01N33/6893—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids related to diseases not provided for elsewhere
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
- G01N2333/475—Assays involving growth factors
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2800/00—Detection or diagnosis of diseases
- G01N2800/52—Predicting or monitoring the response to treatment, e.g. for selection of therapy based on assay results in personalised medicine; Prognosis
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/74—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving hormones or other non-cytokine intercellular protein regulatory factors such as growth factors, including receptors to hormones and growth factors
Abstract
La invención proporciona métodos para identificar pacientes que pueden beneficiarse del tratamiento con una terapia anticáncer que comprenden un antagonista de VEGF. La invención también proporciona métodos para supervisar la respuesta de un paciente a la terapia anticáncer. La invención también proporciona equipos y artículos de fabricación para el uso en los métodos.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP10170004 | 2010-07-19 | ||
EP10170008 | 2010-07-19 | ||
PCT/EP2011/062228 WO2012010548A1 (en) | 2010-07-19 | 2011-07-18 | Method to identify a patient with an increased likelihood of responding to an anti-cancer therapy |
Publications (1)
Publication Number | Publication Date |
---|---|
MX2013000674A true MX2013000674A (es) | 2013-04-03 |
Family
ID=45496541
Family Applications (4)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX2013000674A MX2013000674A (es) | 2010-07-19 | 2011-07-18 | Metodo para identificar a un paciente con incrementada probabilidad de responder a una terapia anticancer. |
MX2013000672A MX2013000672A (es) | 2010-07-19 | 2011-07-18 | Metodo para identificar un paciente con probabilidad incrementada de responder a una terapia anti-cancer. |
MX2013000675A MX2013000675A (es) | 2010-07-19 | 2011-07-18 | Metodo para identificar a un paciente con incrementada probabilidad de responder a una terapia anticancer. |
MX2013000676A MX2013000676A (es) | 2010-07-19 | 2011-07-18 | Metodo para identificar pacientes con probabilidad incrementada de responder a una terapia anti-cancer. |
Family Applications After (3)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX2013000672A MX2013000672A (es) | 2010-07-19 | 2011-07-18 | Metodo para identificar un paciente con probabilidad incrementada de responder a una terapia anti-cancer. |
MX2013000675A MX2013000675A (es) | 2010-07-19 | 2011-07-18 | Metodo para identificar a un paciente con incrementada probabilidad de responder a una terapia anticancer. |
MX2013000676A MX2013000676A (es) | 2010-07-19 | 2011-07-18 | Metodo para identificar pacientes con probabilidad incrementada de responder a una terapia anti-cancer. |
Country Status (14)
Country | Link |
---|---|
US (12) | US20130171135A1 (es) |
EP (8) | EP2848939A1 (es) |
JP (8) | JP2013534305A (es) |
KR (5) | KR20130126588A (es) |
CN (8) | CN104634971A (es) |
AU (4) | AU2011281701A1 (es) |
BR (3) | BR112013001433A2 (es) |
CA (4) | CA2805708A1 (es) |
HK (1) | HK1216039A1 (es) |
MX (4) | MX2013000674A (es) |
RU (4) | RU2013104300A (es) |
SG (8) | SG187018A1 (es) |
WO (4) | WO2012010550A1 (es) |
ZA (3) | ZA201300305B (es) |
Families Citing this family (19)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
ES2705950T3 (es) | 2011-06-03 | 2019-03-27 | Eisai R&D Man Co Ltd | Biomarcadores para predecir y valorar la capacidad de respuesta de sujetos con cáncer de tiroides y de riñón a compuestos de lenvatinib |
JP2015502543A (ja) * | 2011-12-05 | 2015-01-22 | エフ・ホフマン−ラ・ロシュ・アクチェンゲゼルシャフト | 乳癌治療向けベバシズマブ併用療法用血漿バイオマーカー |
US9116159B2 (en) | 2012-05-22 | 2015-08-25 | Regeneron Pharmaceuticals, Inc. | VEGF-A121 assay |
BR112014032456A2 (pt) * | 2012-06-26 | 2017-06-27 | Hoffmann La Roche | métodos in vitro, composição farmacêutica, kit para realização do método e método para melhorar o efeito de tratamento |
US9953417B2 (en) * | 2013-10-04 | 2018-04-24 | The University Of Manchester | Biomarker method |
JO3783B1 (ar) | 2014-08-28 | 2021-01-31 | Eisai R&D Man Co Ltd | مشتق كوينولين عالي النقاء وطريقة لإنتاجه |
KR102471057B1 (ko) | 2014-09-16 | 2022-11-28 | 리제너론 파아마슈티컬스, 인크. | 전이성 결장직장암의 항-혈관신생 치료요법에 관한 예측 및 예후 바이오마커 |
WO2016065626A1 (zh) * | 2014-10-31 | 2016-05-06 | 深圳市大疆创新科技有限公司 | 一种气体泄漏的处理方法、装置及飞行器 |
JP2017535548A (ja) * | 2014-11-14 | 2017-11-30 | ジェネンテック, インコーポレイテッド | Vegfアンタゴニストの応答の予測 |
DK3263106T3 (da) | 2015-02-25 | 2024-01-08 | Eisai R&D Man Co Ltd | Fremgangsmåde til undertrykkelse af bitterhed af quinolinderivat |
CA2978226A1 (en) | 2015-03-04 | 2016-09-09 | Merck Sharpe & Dohme Corp. | Combination of a pd-1 antagonist and a vegfr/fgfr/ret tyrosine kinase inhibitor for treating cancer |
IL276944B (en) * | 2015-04-02 | 2022-07-01 | Molecular Partners Ag | Designed regions containing ankyrin repeats with specific binding to serum albumin |
CN107801379B (zh) | 2015-06-16 | 2021-05-25 | 卫材R&D管理有限公司 | 抗癌剂 |
JP6942135B2 (ja) * | 2016-01-25 | 2021-09-29 | サノフイSanofi | 血漿バイオマーカーのレベルを測定することによる、がんに罹患していることが疑われる患者のアフリベルセプトによる治療の転帰を予測するための方法 |
JP2019523404A (ja) * | 2016-07-15 | 2019-08-22 | エフ・ホフマン−ラ・ロシュ・アクチェンゲゼルシャフト | 全vegf−aのレベルを検出するための方法及び手段 |
RU2639253C1 (ru) * | 2016-12-30 | 2017-12-20 | Федеральное государственное бюджетное учреждение "Ростовский научно-исследовательский онкологический институт" Министерства здравоохранения Российской Федерации | Способ прогнозирования эффективности пролонгированной лучевой терапии при раке прямой кишки |
CN108753984B (zh) * | 2018-08-28 | 2021-07-13 | 北京市神经外科研究所 | 预测或诊断脑恶性胶质瘤术后复发的生物标志物组合及其应用和试剂盒 |
KR20200094110A (ko) * | 2019-01-29 | 2020-08-06 | (주)엠디바이오랩 | 스트렙토니그린 및 항암제를 포함하는 뇌종양 예방 또는 치료용 조성물 |
KR102261368B1 (ko) | 2020-09-16 | 2021-06-08 | 주식회사 라이브러리엔 | 자유로운 조합 구성이 가능한 조립식 소파 |
Family Cites Families (94)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3773919A (en) | 1969-10-23 | 1973-11-20 | Du Pont | Polylactide-drug mixtures |
US4018653A (en) | 1971-10-29 | 1977-04-19 | U.S. Packaging Corporation | Instrument for the detection of Neisseria gonorrhoeae without culture |
US4016043A (en) | 1975-09-04 | 1977-04-05 | Akzona Incorporated | Enzymatic immunological method for the determination of antigens and antibodies |
US4424279A (en) | 1982-08-12 | 1984-01-03 | Quidel | Rapid plunger immunoassay method and apparatus |
US4816567A (en) | 1983-04-08 | 1989-03-28 | Genentech, Inc. | Recombinant immunoglobin preparations |
US4676980A (en) | 1985-09-23 | 1987-06-30 | The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services | Target specific cross-linked heteroantibodies |
US6548640B1 (en) | 1986-03-27 | 2003-04-15 | Btg International Limited | Altered antibodies |
IL85035A0 (en) | 1987-01-08 | 1988-06-30 | Int Genetic Eng | Polynucleotide molecule,a chimeric antibody with specificity for human b cell surface antigen,a process for the preparation and methods utilizing the same |
US5283187A (en) | 1987-11-17 | 1994-02-01 | Brown University Research Foundation | Cell culture-containing tubular capsule produced by co-extrusion |
US4892538A (en) | 1987-11-17 | 1990-01-09 | Brown University Research Foundation | In vivo delivery of neurotransmitters by implanted, encapsulated cells |
WO1989006692A1 (en) | 1988-01-12 | 1989-07-27 | Genentech, Inc. | Method of treating tumor cells by inhibiting growth factor receptor function |
GB8823869D0 (en) | 1988-10-12 | 1988-11-16 | Medical Res Council | Production of antibodies |
DE3920358A1 (de) | 1989-06-22 | 1991-01-17 | Behringwerke Ag | Bispezifische und oligospezifische, mono- und oligovalente antikoerperkonstrukte, ihre herstellung und verwendung |
DE69120146T2 (de) | 1990-01-12 | 1996-12-12 | Cell Genesys Inc | Erzeugung xenogener antikörper |
US6075181A (en) | 1990-01-12 | 2000-06-13 | Abgenix, Inc. | Human antibodies derived from immunized xenomice |
US6150584A (en) | 1990-01-12 | 2000-11-21 | Abgenix, Inc. | Human antibodies derived from immunized xenomice |
ES2246502T3 (es) | 1990-08-29 | 2006-02-16 | Genpharm International, Inc. | Animales no humanos transgenicos capaces de producir anticuerpos heterologos. |
US5545806A (en) | 1990-08-29 | 1996-08-13 | Genpharm International, Inc. | Ransgenic non-human animals for producing heterologous antibodies |
US5625126A (en) | 1990-08-29 | 1997-04-29 | Genpharm International, Inc. | Transgenic non-human animals for producing heterologous antibodies |
US5661016A (en) | 1990-08-29 | 1997-08-26 | Genpharm International Inc. | Transgenic non-human animals capable of producing heterologous antibodies of various isotypes |
US5633425A (en) | 1990-08-29 | 1997-05-27 | Genpharm International, Inc. | Transgenic non-human animals capable of producing heterologous antibodies |
US6582959B2 (en) | 1991-03-29 | 2003-06-24 | Genentech, Inc. | Antibodies to vascular endothelial cell growth factor |
US20030206899A1 (en) | 1991-03-29 | 2003-11-06 | Genentech, Inc. | Vascular endothelial cell growth factor antagonists |
WO1994004679A1 (en) | 1991-06-14 | 1994-03-03 | Genentech, Inc. | Method for making humanized antibodies |
GB9114948D0 (en) | 1991-07-11 | 1991-08-28 | Pfizer Ltd | Process for preparing sertraline intermediates |
WO1993008829A1 (en) | 1991-11-04 | 1993-05-13 | The Regents Of The University Of California | Compositions that mediate killing of hiv-infected cells |
IL105914A0 (en) | 1992-06-04 | 1993-10-20 | Univ California | Methods and compositions for in vivo gene therapy |
CA2145985C (en) | 1992-10-28 | 2003-09-16 | Napoleone Ferrara | Vascular endothelial cell growth factor antagonists |
US6177401B1 (en) | 1992-11-13 | 2001-01-23 | Max-Planck-Gesellschaft Zur Forderung Der Wissenschaften | Use of organic compounds for the inhibition of Flk-1 mediated vasculogenesis and angiogenesis |
US5635388A (en) | 1994-04-04 | 1997-06-03 | Genentech, Inc. | Agonist antibodies against the flk2/flt3 receptor and uses thereof |
US5910486A (en) | 1994-09-06 | 1999-06-08 | Uab Research Foundation | Methods for modulating protein function in cells using, intracellular antibody homologues |
US5731168A (en) | 1995-03-01 | 1998-03-24 | Genentech, Inc. | Method for making heteromultimeric polypeptides |
IL117645A (en) | 1995-03-30 | 2005-08-31 | Genentech Inc | Vascular endothelial cell growth factor antagonists for use as medicaments in the treatment of age-related macular degeneration |
ES2304786T3 (es) | 1995-04-27 | 2008-10-16 | Amgen Fremont Inc. | Anticuerpos anti-il-8 humanos, derivados a partir de xenoratones inmunizados. |
EP0823941A4 (en) | 1995-04-28 | 2001-09-19 | Abgenix Inc | HUMAN ANTIBODIES DERIVED FROM IMMUNIZED XENO MOUSES |
US5880141A (en) | 1995-06-07 | 1999-03-09 | Sugen, Inc. | Benzylidene-Z-indoline compounds for the treatment of disease |
US6267958B1 (en) | 1995-07-27 | 2001-07-31 | Genentech, Inc. | Protein formulation |
GB9624482D0 (en) | 1995-12-18 | 1997-01-15 | Zeneca Phaema S A | Chemical compounds |
JP4464466B2 (ja) | 1996-03-05 | 2010-05-19 | アストラゼネカ・ユーケイ・リミテッド | 4―アニリノキナゾリン誘導体 |
US6100071A (en) | 1996-05-07 | 2000-08-08 | Genentech, Inc. | Receptors as novel inhibitors of vascular endothelial growth factor activity and processes for their production |
TR199900048T2 (xx) | 1996-07-13 | 1999-04-21 | Glaxo Group Limited | Protein tirozin kinaz inhibit�rleri olarak bisiklik heteroaromatik bile�ikler |
HRP970371A2 (en) | 1996-07-13 | 1998-08-31 | Kathryn Jane Smith | Heterocyclic compounds |
DK1500329T3 (da) | 1996-12-03 | 2012-07-09 | Amgen Fremont Inc | Humane antistoffer, der specifikt binder TNF-alfa |
US20020032315A1 (en) | 1997-08-06 | 2002-03-14 | Manuel Baca | Anti-vegf antibodies |
US6884879B1 (en) | 1997-04-07 | 2005-04-26 | Genentech, Inc. | Anti-VEGF antibodies |
EP0973804B1 (en) | 1997-04-07 | 2006-12-27 | Genentech, Inc. | Anti-vegf antibodies |
EP3260468A1 (en) | 1997-04-07 | 2017-12-27 | Genentech, Inc. | Anti-vegf antibodies |
CA2289102A1 (en) | 1997-05-07 | 1998-11-12 | Sugen, Inc. | 2-indolinone derivatives as modulators of protein kinase activity |
JP2002501532A (ja) | 1997-05-30 | 2002-01-15 | メルク エンド カンパニー インコーポレーテッド | 新規血管形成阻害薬 |
ATE368665T1 (de) | 1997-08-22 | 2007-08-15 | Astrazeneca Ab | Oxindolylchinazolinderivate als angiogenesehemmer |
EP1017682A4 (en) | 1997-09-26 | 2000-11-08 | Merck & Co Inc | NEW ANGIOGENESIS INHIBITORS |
CN1280580A (zh) | 1997-11-11 | 2001-01-17 | 辉瑞产品公司 | 用作抗癌药的噻吩并嘧啶和噻吩并吡啶衍生物 |
ATE531812T1 (de) | 1997-12-05 | 2011-11-15 | Scripps Research Inst | Humanisierung von nager-antikörpern |
JP3591264B2 (ja) * | 1997-12-24 | 2004-11-17 | 富士レビオ株式会社 | Vegf121特異的モノクローナル抗体及び測定方法 |
DE19806989A1 (de) | 1998-02-19 | 1999-08-26 | Roche Diagnostics Gmbh | Erzeugung räumlich scharf begrenzter Festphasen für Bindungsassays |
HUP0103617A2 (hu) | 1998-05-29 | 2002-02-28 | Sugen, Inc. | Protein kinázt gátló, pirrolilcsoporttal helyettesített 2-indolszármazékok, e vegyületeket tartalmazó gyógyászati készítmények, valamint e vegyületek alkalmazása |
US6387663B1 (en) * | 1998-07-31 | 2002-05-14 | University Of Southern California | Targeting pharmaceutical agents to injured tissues |
HUP0104865A3 (en) | 1999-01-15 | 2004-07-28 | Genentech Inc | Polypeptide variants with altered effector function |
US6703020B1 (en) | 1999-04-28 | 2004-03-09 | Board Of Regents, The University Of Texas System | Antibody conjugate methods for selectively inhibiting VEGF |
US6949245B1 (en) | 1999-06-25 | 2005-09-27 | Genentech, Inc. | Humanized anti-ErbB2 antibodies and treatment with anti-ErbB2 antibodies |
TWI262914B (en) | 1999-07-02 | 2006-10-01 | Agouron Pharma | Compounds and pharmaceutical compositions for inhibiting protein kinases |
JP4620312B2 (ja) | 1999-11-16 | 2011-01-26 | ジェネンテック, インコーポレイテッド | Vegfに対するエライザ |
ES2528794T3 (es) | 2000-04-11 | 2015-02-12 | Genentech, Inc. | Anticuerpos multivalentes y usos de los mismos |
KR20030074693A (ko) | 2000-12-28 | 2003-09-19 | 알투스 바이올로직스 인코포레이티드 | 전항체 및 이의 단편의 결정과 이의 제조 및 사용 방법 |
AR042586A1 (es) | 2001-02-15 | 2005-06-29 | Sugen Inc | 3-(4-amidopirrol-2-ilmetiliden)-2-indolinona como inhibidores de la protein quinasa; sus composiciones farmaceuticas; un metodo para la modulacion de la actividad catalitica de la proteinquinasa; un metodo para tratar o prevenir una afeccion relacionada con la proteinquinasa |
US7217797B2 (en) | 2002-10-15 | 2007-05-15 | Pdl Biopharma, Inc. | Alteration of FcRn binding affinities or serum half-lives of antibodies by mutagenesis |
MXPA05012723A (es) | 2003-05-30 | 2006-02-08 | Genentech Inc | Tratamiento con anticuerpos anti-vgf. |
US20050009110A1 (en) * | 2003-07-08 | 2005-01-13 | Xiao-Jia Chang | Methods of producing antibodies for diagnostics and therapeutics |
US20050106667A1 (en) | 2003-08-01 | 2005-05-19 | Genentech, Inc | Binding polypeptides with restricted diversity sequences |
US7758859B2 (en) | 2003-08-01 | 2010-07-20 | Genentech, Inc. | Anti-VEGF antibodies |
WO2005044853A2 (en) | 2003-11-01 | 2005-05-19 | Genentech, Inc. | Anti-vegf antibodies |
US20050282233A1 (en) | 2004-03-05 | 2005-12-22 | Ludwig Institute For Cancer Research | Multivalent antibody materials and methods for VEGF/PDGF family of growth factors |
UA88294C2 (ru) * | 2004-03-24 | 2009-10-12 | Фейсит Биотек Корпорейшен | ПРИМЕНЕНИЕ АНТИ-α5β1 АНТИТЕЛ ДЛЯ УГНЕТЕНИЯ ПРОЛИФЕРАЦИИ РАКОВЫХ КЛЕТОК |
DE102004029909A1 (de) | 2004-06-21 | 2006-01-19 | Roche Diagnostics Gmbh | Verfahren und Vorrichtung zur Herstellung von bindungsfähigen Reagenzträgern |
US20060009360A1 (en) | 2004-06-25 | 2006-01-12 | Robert Pifer | New adjuvant composition |
KR20090019890A (ko) * | 2006-06-05 | 2009-02-25 | 제넨테크, 인크. | Egf 또는 tgf-알파 수준이 상승된 암 환자의 생존 연장 |
EP2471816A1 (en) | 2006-08-30 | 2012-07-04 | Genentech, Inc. | Multispecific antibodies |
RS53387B (en) * | 2006-10-04 | 2014-10-31 | Genentech, Inc. | ELISA FOR VEGF |
RU2010123381A (ru) * | 2007-11-09 | 2011-12-20 | Дженентек, Инк. (Us) | Способ и композиции для диагностического применения у раковых пациентов |
US8227577B2 (en) | 2007-12-21 | 2012-07-24 | Hoffman-La Roche Inc. | Bivalent, bispecific antibodies |
US9266967B2 (en) | 2007-12-21 | 2016-02-23 | Hoffmann-La Roche, Inc. | Bivalent, bispecific antibodies |
US20090162359A1 (en) | 2007-12-21 | 2009-06-25 | Christian Klein | Bivalent, bispecific antibodies |
US8242247B2 (en) | 2007-12-21 | 2012-08-14 | Hoffmann-La Roche Inc. | Bivalent, bispecific antibodies |
PT2235064E (pt) | 2008-01-07 | 2016-03-01 | Amgen Inc | Método de preparação de moléculas heterodiméricas de fc de anticorpos utilizando efeitos de indução eletrostática |
DK2274008T3 (da) * | 2008-03-27 | 2014-05-12 | Zymogenetics Inc | Sammensætninger og fremgangsmåder til hæmning af PDGFRBETA og VEGF-A |
US20100029491A1 (en) * | 2008-07-11 | 2010-02-04 | Maike Schmidt | Methods and compositions for diagnostic use for tumor treatment |
US8268314B2 (en) | 2008-10-08 | 2012-09-18 | Hoffmann-La Roche Inc. | Bispecific anti-VEGF/anti-ANG-2 antibodies |
KR101596539B1 (ko) * | 2008-12-23 | 2016-02-22 | 제넨테크, 인크. | 암 환자에서의 진단 목적용 방법 및 조성물 |
CA2756244A1 (en) | 2009-04-02 | 2010-10-07 | Roche Glycart Ag | Multispecific antibodies comprising full length antibodies and single chain fab fragments |
EP2417156B1 (en) | 2009-04-07 | 2015-02-11 | Roche Glycart AG | Trivalent, bispecific antibodies |
WO2010136172A1 (en) | 2009-05-27 | 2010-12-02 | F. Hoffmann-La Roche Ag | Tri- or tetraspecific antibodies |
US9676845B2 (en) | 2009-06-16 | 2017-06-13 | Hoffmann-La Roche, Inc. | Bispecific antigen binding proteins |
US8703132B2 (en) | 2009-06-18 | 2014-04-22 | Hoffmann-La Roche, Inc. | Bispecific, tetravalent antigen binding proteins |
UY32920A (es) | 2009-10-02 | 2011-04-29 | Boehringer Ingelheim Int | Moleculas de unión biespecíficas para la terapia anti-angiogénesis |
-
2011
- 2011-07-18 SG SG2013002035A patent/SG187018A1/en unknown
- 2011-07-18 KR KR1020137004039A patent/KR20130126588A/ko not_active Application Discontinuation
- 2011-07-18 SG SG10201505601RA patent/SG10201505601RA/en unknown
- 2011-07-18 WO PCT/EP2011/062230 patent/WO2012010550A1/en active Application Filing
- 2011-07-18 AU AU2011281701A patent/AU2011281701A1/en not_active Abandoned
- 2011-07-18 SG SG10201505595WA patent/SG10201505595WA/en unknown
- 2011-07-18 WO PCT/EP2011/062231 patent/WO2012010551A1/en active Application Filing
- 2011-07-18 EP EP14188048.4A patent/EP2848939A1/en not_active Withdrawn
- 2011-07-18 CN CN201410775889.0A patent/CN104634971A/zh active Pending
- 2011-07-18 AU AU2011281705A patent/AU2011281705A1/en not_active Abandoned
- 2011-07-18 KR KR1020157001119A patent/KR20150013949A/ko not_active Application Discontinuation
- 2011-07-18 EP EP11732485.5A patent/EP2596359A1/en not_active Withdrawn
- 2011-07-18 BR BR112013001433A patent/BR112013001433A2/pt not_active IP Right Cessation
- 2011-07-18 AU AU2011281704A patent/AU2011281704A1/en not_active Abandoned
- 2011-07-18 SG SG2013003868A patent/SG187119A1/en unknown
- 2011-07-18 SG SG2013003884A patent/SG187120A1/en unknown
- 2011-07-18 BR BR112013001431A patent/BR112013001431A2/pt not_active IP Right Cessation
- 2011-07-18 CN CN2011800449797A patent/CN103180736A/zh active Pending
- 2011-07-18 RU RU2013104300/15A patent/RU2013104300A/ru not_active Application Discontinuation
- 2011-07-18 CA CA2805708A patent/CA2805708A1/en not_active Abandoned
- 2011-07-18 JP JP2013520101A patent/JP2013534305A/ja active Pending
- 2011-07-18 EP EP11735862.2A patent/EP2596361A1/en not_active Withdrawn
- 2011-07-18 KR KR1020137004034A patent/KR20130126587A/ko not_active Application Discontinuation
- 2011-07-18 CN CN201410791040.2A patent/CN104614525A/zh active Pending
- 2011-07-18 KR KR1020137004030A patent/KR20130091745A/ko not_active Application Discontinuation
- 2011-07-18 BR BR112013001429A patent/BR112013001429A2/pt not_active IP Right Cessation
- 2011-07-18 SG SG2013003892A patent/SG187121A1/en unknown
- 2011-07-18 WO PCT/EP2011/062227 patent/WO2012010547A1/en active Application Filing
- 2011-07-18 MX MX2013000674A patent/MX2013000674A/es not_active Application Discontinuation
- 2011-07-18 CN CN2011800450690A patent/CN103270418A/zh active Pending
- 2011-07-18 MX MX2013000672A patent/MX2013000672A/es not_active Application Discontinuation
- 2011-07-18 MX MX2013000675A patent/MX2013000675A/es not_active Application Discontinuation
- 2011-07-18 RU RU2013104299/15A patent/RU2013104299A/ru not_active Application Discontinuation
- 2011-07-18 KR KR1020137004044A patent/KR20130055647A/ko not_active Application Discontinuation
- 2011-07-18 CA CA2805618A patent/CA2805618A1/en not_active Abandoned
- 2011-07-18 MX MX2013000676A patent/MX2013000676A/es not_active Application Discontinuation
- 2011-07-18 CN CN201510105182.3A patent/CN104730243A/zh active Pending
- 2011-07-18 CA CA2805623A patent/CA2805623A1/en not_active Abandoned
- 2011-07-18 SG SG10201505593VA patent/SG10201505593VA/en unknown
- 2011-07-18 RU RU2013104302/15A patent/RU2013104302A/ru not_active Application Discontinuation
- 2011-07-18 CN CN2011800449994A patent/CN103180738A/zh active Pending
- 2011-07-18 JP JP2013520105A patent/JP2013534307A/ja active Pending
- 2011-07-18 CN CN201510296857.7A patent/CN104965084B/zh not_active Expired - Fee Related
- 2011-07-18 EP EP14188054.2A patent/EP2824457A1/en not_active Withdrawn
- 2011-07-18 EP EP14170386.8A patent/EP2801826A1/en not_active Withdrawn
- 2011-07-18 SG SG10201505414XA patent/SG10201505414XA/en unknown
- 2011-07-18 WO PCT/EP2011/062228 patent/WO2012010548A1/en active Application Filing
- 2011-07-18 CN CN201180044980XA patent/CN103180737A/zh active Pending
- 2011-07-18 JP JP2013520102A patent/JP2013537522A/ja not_active Withdrawn
- 2011-07-18 RU RU2013104301/15A patent/RU2013104301A/ru not_active Application Discontinuation
- 2011-07-18 JP JP2013520104A patent/JP2013534306A/ja active Pending
- 2011-07-18 EP EP11732484.8A patent/EP2596358A1/en not_active Withdrawn
- 2011-07-18 EP EP20140188047 patent/EP2866032A1/en not_active Withdrawn
- 2011-07-18 EP EP11732486.3A patent/EP2596360A1/en not_active Withdrawn
- 2011-07-18 CA CA2805709A patent/CA2805709A1/en not_active Abandoned
- 2011-07-18 AU AU2011281702A patent/AU2011281702A1/en not_active Abandoned
-
2013
- 2013-01-11 ZA ZA2013/00305A patent/ZA201300305B/en unknown
- 2013-01-14 ZA ZA2013/00345A patent/ZA201300345B/en unknown
- 2013-01-16 ZA ZA2013/00440A patent/ZA201300440B/en unknown
- 2013-01-17 US US13/744,135 patent/US20130171135A1/en not_active Abandoned
- 2013-01-17 US US13/744,131 patent/US20130336960A1/en not_active Abandoned
- 2013-01-17 US US13/744,140 patent/US20130344059A1/en not_active Abandoned
- 2013-01-17 US US13/744,014 patent/US20130336959A1/en not_active Abandoned
- 2013-03-13 US US13/802,333 patent/US20140193397A1/en not_active Abandoned
- 2013-03-13 US US13/802,303 patent/US20140056875A1/en not_active Abandoned
- 2013-03-13 US US13/802,356 patent/US20140017231A1/en not_active Abandoned
- 2013-03-13 US US13/801,404 patent/US20130183300A1/en not_active Abandoned
- 2013-03-13 US US13/802,282 patent/US20140056874A1/en not_active Abandoned
- 2013-03-13 US US13/802,394 patent/US20140017232A1/en not_active Abandoned
- 2013-03-13 US US13/802,379 patent/US20140023639A1/en not_active Abandoned
- 2013-03-13 US US13/801,360 patent/US20130243758A1/en not_active Abandoned
- 2013-10-22 HK HK16103925.6A patent/HK1216039A1/zh unknown
-
2015
- 2015-04-24 JP JP2015089690A patent/JP2015206795A/ja active Pending
- 2015-05-01 JP JP2015094412A patent/JP2015180879A/ja active Pending
- 2015-07-22 JP JP2015144659A patent/JP2016014670A/ja active Pending
- 2015-08-21 JP JP2015163347A patent/JP2016026290A/ja active Pending
Also Published As
Similar Documents
Publication | Publication Date | Title |
---|---|---|
MX2013000674A (es) | Metodo para identificar a un paciente con incrementada probabilidad de responder a una terapia anticancer. | |
MX2012001716A (es) | Marcadores biologicos para monitorizar la respuesta del paciente a los antagonistas vegf. | |
MX356802B (es) | Marcadores biologicos para identificar pacientes para tratamiento con antagonistas de vegf. | |
MY188365A (en) | Diagnosis and treatments relating to th2 inhibition | |
MX2016002423A (es) | Composiciones y metodos de diagnostico para el tratamiento de glioblastoma. | |
HK1246646A1 (zh) | 用於治療糖尿病性視網膜病及其他眼科疾病的方法 | |
IL222252A0 (en) | Methods, system and apparatus for the detection, diagnosis and treatment of biological rhythm disorders | |
MX2021010672A (es) | Uso de un anticuerpo que tiene la capacidad para ligarse a clnd6 en el tratamiento o prevención de cáncer. | |
IL238432B (en) | Methods and devices for the treatment of eye diseases in humans | |
MX2015007714A (es) | Agente terapeutico de direccionamiento a glipicano 3 (gpc3) que es administrado a pacientes para quienes la terapia con agentes terapeuticos de direccionamiento a gpc3 es eficaz. | |
SG194471A1 (en) | Method of treating vision disorders | |
MX2017011486A (es) | Métodos de detección y cuantificación de il-13 y sus usos en el diagnóstico y tratamiento de enfermedades asociadas a th2. | |
IN2015DN00450A (es) | ||
IN2012DN06309A (es) | ||
WO2012145535A3 (en) | Animal model of human cancer and methods of use | |
SG179070A1 (en) | Method to identify a patient with an increased likelihood of responding to an anti-cancer agent | |
BR112012026224A2 (pt) | métodos para tratar mal de alzheimer e para avaliar a eficácia de uma terapia | |
WO2012109233A3 (en) | Methods for predicting recurrence risk in breast cancer patients | |
MX2013010367A (es) | Composiciones y metodos para la terapia y diagnostico de influenza. | |
HK1203190A1 (en) | Compounds for use in imaging, diagnosing and or treatment of diseases of the central nervous system | |
MX351945B (es) | Mutantes c-raf que confieren resistencia a inhibidores raf. | |
MX2011010920A (es) | Biomarcador para monitorear pacientes. | |
MX2011010061A (es) | Biomarcador para monitorear pacientes. | |
MX351765B (es) | Uso de sales de 3-carboxi-n-etil-n,n-dimetilpropan-1-aminio en el tratamiento de enfermedades cardiovasculares. | |
EP2850437A4 (en) | METHODS OF IDENTIFYING IFN INDUCED EXPRESSION PATTERNS AND USE IN DIAGNOSIS, MONITORING AND THERAPY |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
FA | Abandonment or withdrawal |