MX2010009092A - Nuevos derivados de 3-aminoalquil-1,3-dihidro-2h-indol-2-ona, su preparacion y su aplicacion en terapeutica. - Google Patents

Nuevos derivados de 3-aminoalquil-1,3-dihidro-2h-indol-2-ona, su preparacion y su aplicacion en terapeutica.

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Publication number
MX2010009092A
MX2010009092A MX2010009092A MX2010009092A MX2010009092A MX 2010009092 A MX2010009092 A MX 2010009092A MX 2010009092 A MX2010009092 A MX 2010009092A MX 2010009092 A MX2010009092 A MX 2010009092A MX 2010009092 A MX2010009092 A MX 2010009092A
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MX
Mexico
Prior art keywords
group
hydrogen atom
radical
alk
atom
Prior art date
Application number
MX2010009092A
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English (en)
Inventor
Claudine Serradeil-Le Gal
Loic Foulon
Gerard Valette
Laurent Goullieux
Brigitte Pouzet
Original Assignee
Sanofi Aventis
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sanofi Aventis filed Critical Sanofi Aventis
Publication of MX2010009092A publication Critical patent/MX2010009092A/es

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    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
    • C07D209/32—Oxygen atoms
    • C07D209/34—Oxygen atoms in position 2
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Abstract

La presente invención tiene por objeto los compuestos que responden a la fórmula (I) en donde: X representa un radical bivalente alquileno(C1-C5) no sustituido o sustituido; R1 representa: un grupo -NR8R9 un radical piperidin-4-ilo o un radical piperidin-3-ilo no sustituido o sustituido; R2 representa un átomo de halógeno, un grupo Alk, un grupo OAlk; R3 representa un metoxi; R4 representa un átomo de hidrógeno, un átomo de halógeno, un grupo Alk, un hidroxi, un grupo OAlk; R5 representa un átomo de hidrógeno, un átomo de halógeno, un grupo Alk, un hidroxi, un grupo OAlk, un grupo -CO2AIk, un radical -CH2OH; R6 representa un átomo de hidrógeno, un grupo Alk, un hidroxi, un grupo OAIk, un cicloalcoxi(C3-C5), un grupo -NR10CONR11R12 R7 representa un átomo de hidrógeno, un átomo de halógeno, un grupo Alk, un hidroxi, un grupo OAlk; o bien R7 está en posición -3- del fenilo y junto con R6 representan un radical trimetileno; R8 y R9 representan cada uno independientemente un átomo de hidrógeno o un alquilo(C1-C4); o bien R8 y R9 junto con el átomo de nitrógeno al que están unidos constituyen un radical heterocíclico no sustituido o sustituido; R10 representa un átomo de hidrógeno o un alquilo(C1-C4); R11 y R12 representan cada uno independientemente un átomo de hidrógeno o un alquilo(C1-C4); Alk representa un alquilo(C1-C4) no sustituido o sustituido una o varias veces con un átomo de flúor. Procedimiento de preparación y aplicación en terapéutica.
MX2010009092A 2008-02-19 2009-02-18 Nuevos derivados de 3-aminoalquil-1,3-dihidro-2h-indol-2-ona, su preparacion y su aplicacion en terapeutica. MX2010009092A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR0800866A FR2927625B1 (fr) 2008-02-19 2008-02-19 Nouveaux derives de 3-aminoalkyl-1,3-dihydro-2h-indol-2-one, leur preparation et leur application en therapeutique
PCT/FR2009/000179 WO2009115685A1 (fr) 2008-02-19 2009-02-18 Nouveaux derives de 3-aminoalkyl-1,3-dihydro-2h-indol-2-one, leur preparation et leur application en therapeutique.

Publications (1)

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MX2010009092A true MX2010009092A (es) 2011-09-21

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US (1) US8362067B2 (es)
EP (1) EP2265582B1 (es)
JP (1) JP5602639B2 (es)
KR (1) KR20100126401A (es)
CN (1) CN102015642A (es)
AR (1) AR070438A1 (es)
AT (1) ATE540023T1 (es)
AU (1) AU2009227111A1 (es)
BR (1) BRPI0907578A2 (es)
CA (1) CA2716035A1 (es)
FR (1) FR2927625B1 (es)
IL (1) IL207629A0 (es)
MX (1) MX2010009092A (es)
RU (1) RU2010138575A (es)
WO (1) WO2009115685A1 (es)

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FR2927625B1 (fr) 2008-02-19 2010-03-12 Sanofi Aventis Nouveaux derives de 3-aminoalkyl-1,3-dihydro-2h-indol-2-one, leur preparation et leur application en therapeutique
WO2012003436A1 (en) 2010-07-01 2012-01-05 Azevan Pharmaceuticals, Inc. Methods for treating post traumatic stress disorder
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AR070438A1 (es) 2010-04-07
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ATE540023T1 (de) 2012-01-15
EP2265582A1 (fr) 2010-12-29
FR2927625A1 (fr) 2009-08-21
BRPI0907578A2 (pt) 2019-09-24
JP5602639B2 (ja) 2014-10-08
JP2011512389A (ja) 2011-04-21
IL207629A0 (en) 2010-12-30
CA2716035A1 (fr) 2009-09-24
FR2927625B1 (fr) 2010-03-12
AU2009227111A1 (en) 2009-09-24
US20110059955A1 (en) 2011-03-10
RU2010138575A (ru) 2012-03-27
WO2009115685A1 (fr) 2009-09-24
KR20100126401A (ko) 2010-12-01

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