MX2009007006A - Pirimidinas 5,6-sustituidas inhibidoras del virus de inmunodeficiencia humana. - Google Patents

Pirimidinas 5,6-sustituidas inhibidoras del virus de inmunodeficiencia humana.

Info

Publication number
MX2009007006A
MX2009007006A MX2009007006A MX2009007006A MX2009007006A MX 2009007006 A MX2009007006 A MX 2009007006A MX 2009007006 A MX2009007006 A MX 2009007006A MX 2009007006 A MX2009007006 A MX 2009007006A MX 2009007006 A MX2009007006 A MX 2009007006A
Authority
MX
Mexico
Prior art keywords
6alkyl
6alkyloxy
cyano
polyhaloc1
amino
Prior art date
Application number
MX2009007006A
Other languages
English (en)
Inventor
Jerome Emile Georges Guillemont
Celine Isabelle Mordant
Benoit Antoine Schmitt
Original Assignee
Tibotec Pharm Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Tibotec Pharm Ltd filed Critical Tibotec Pharm Ltd
Publication of MX2009007006A publication Critical patent/MX2009007006A/es

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
    • C07D239/48—Two nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms

Abstract

Se describen inhibidores de la duplicación del VIH de la fórmula: (ver fórmula (I)) R1 es hidrógeno; arilo; formilo; alquil(C1-6)carbonilo, alquilo de C1-6; alquil(C1-6)oxicarbonilo; R2 R3, R7 y R8 son hidrógeno; hidroxi; halógeno; cicloalquilo de C3-7; alquiloxi de C1-6; carboxilo; alquil(C1-6)oxicarbonilo; ciano; nitro; amino; mono- o di-alquil(C1-6)amino; polihalo-alquilo de C1-6; polihalo-alquiloxi de C1-6;-C(=O)R10; alquilo de C1-6 sustituido opcionalmente con halógeno, ciano o -C(=O)R10; alquilo de C1-6 sustituido opcionalmente, alquenilo de C2-6, o alquinilo de C2-6; R4 y R9 son hidroxi; halógeno; cilcoalquilo de C3-7; alquiloxi de C1-6; carboxilo; alquil(1-6)oxicarbonilo; formilo; ciano; nitro; amino; mono- o di-alquil(C1-6)amino; polihalo-alquilo de C1-6; polihalo-alquiloxi de C1-6; -C(=O)R10, ciano; -S(=O)rR10; -NH-S(=O)2R10; -NHC(=O)H; -C(=O)NHNH2; -NHC(=O)R10; -Het; -Y-Het; alquilo de C1-6 sustituido opcionalmente, alquenilo de C2-6 o alquinilo de C2-6; R5 es alquenilo de C2-6; o alquinilo de C2-6, ambos sustituidos con ciano; aminocarbonilo, mono- y di-alquil(C1-6)aminocarbonilo, arilo, piridilo, tienilo, furanilo, o con uno o dos grupos alquiloxi de C1-6; Het; -C(=O)NR5aR5b; -CH(OR5c)R5d; X es -NR1-, -O-, -CH2-, o -S-; composiciones farmacéuticas que contienen estos compuestos como ingredientes activos, y procedimientos de preparación de dichos compuestos y composiciones.
MX2009007006A 2006-12-29 2007-12-28 Pirimidinas 5,6-sustituidas inhibidoras del virus de inmunodeficiencia humana. MX2009007006A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP06127328 2006-12-29
PCT/EP2007/064606 WO2008080965A2 (en) 2006-12-29 2007-12-28 Hiv inhibiting 5,6-substituted pyrimidines

Publications (1)

Publication Number Publication Date
MX2009007006A true MX2009007006A (es) 2009-07-09

Family

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Family Applications (1)

Application Number Title Priority Date Filing Date
MX2009007006A MX2009007006A (es) 2006-12-29 2007-12-28 Pirimidinas 5,6-sustituidas inhibidoras del virus de inmunodeficiencia humana.

Country Status (12)

Country Link
US (1) US8318736B2 (es)
EP (2) EP2114902B1 (es)
JP (1) JP5283633B2 (es)
KR (1) KR20090094084A (es)
CN (2) CN106045965A (es)
AU (1) AU2007341228B2 (es)
BR (1) BRPI0722079B8 (es)
CA (2) CA2674185C (es)
EA (1) EA020749B1 (es)
ES (2) ES2523863T3 (es)
MX (1) MX2009007006A (es)
WO (1) WO2008080965A2 (es)

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WO2008080965A2 (en) 2008-07-10
ES2523863T3 (es) 2014-12-02
US8318736B2 (en) 2012-11-27
BRPI0722079A2 (pt) 2014-04-08
AU2007341228B2 (en) 2013-04-18
EA200970656A1 (ru) 2009-12-30
BRPI0722079B8 (pt) 2021-05-25
CA2674185C (en) 2017-02-28
AU2007341228A1 (en) 2008-07-10
EP2114902B1 (en) 2014-09-17
KR20090094084A (ko) 2009-09-03
WO2008080965A3 (en) 2008-09-04
EP2114902A2 (en) 2009-11-11
CN106045965A (zh) 2016-10-26
EA020749B1 (ru) 2015-01-30
US20100261722A1 (en) 2010-10-14
CA2923637A1 (en) 2008-07-10
BRPI0722079B1 (pt) 2020-01-14
ES2618057T3 (es) 2017-06-20
CA2674185A1 (en) 2008-07-10
CN101573342A (zh) 2009-11-04
JP2010514736A (ja) 2010-05-06
JP5283633B2 (ja) 2013-09-04
EP2781510A1 (en) 2014-09-24
EP2781510B1 (en) 2016-12-14
CA2923637C (en) 2018-10-02

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