PE20090714A1 - Imidazopiridazinas y pirrolo-pirimidinas sustituidas como inhibidores de cinasa de lipido - Google Patents

Imidazopiridazinas y pirrolo-pirimidinas sustituidas como inhibidores de cinasa de lipido

Info

Publication number
PE20090714A1
PE20090714A1 PE2008000821A PE2008000821A PE20090714A1 PE 20090714 A1 PE20090714 A1 PE 20090714A1 PE 2008000821 A PE2008000821 A PE 2008000821A PE 2008000821 A PE2008000821 A PE 2008000821A PE 20090714 A1 PE20090714 A1 PE 20090714A1
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PE
Peru
Prior art keywords
imidazopyridazines
pyrolo
kinase inhibitors
dimetoxy
imidazo
Prior art date
Application number
PE2008000821A
Other languages
English (en)
Inventor
Hans-Georg Capraro
Giorgio Caravatti
Pascal Furet
Patricia Imbach
Jiong Lan
Sabina Pecchi
Joseph Schoepfer
Original Assignee
Novartis Ag
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Filing date
Publication date
Application filed by Novartis Ag filed Critical Novartis Ag
Publication of PE20090714A1 publication Critical patent/PE20090714A1/es

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    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A61P7/06—Antianaemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/14—Vasoprotectives; Antihaemorrhoidals; Drugs for varicose therapy; Capillary stabilisers

Abstract

REFERIDA A COMPUESTOS DE FORMULA (I): DONDE X E Y SON CADA UNO N, C; R1 Y R2 SON CADA UNO ARILO SUSTITUIDO O NO, HETEROCICLILO SUSTITUIDO O NO, N-OXIDO, ENTRE OTROS. SON COMPUESTOS SELECCIONADOS: 3,6-BIS-(3,4-DIMETOXI-FENIL)-IMIDAZO-[1,2-b]-PIRIDAZINA; 4-[6-(3,4-DIMETOXI-FENIL)-IMIDAZO-[1,2-b]-PIRIDAZIN-3-IL]-BENZAMIDA; 5-[6-(3,4-DIMETOXI-FENIL)-IMIDAZO-[1,2-b]-PIRIDAZIN-3-IL]-3-TRIFLUORO-METIL-PIRIDIN-2-IL-AMINA; ENTRE OTROS. SE REFIERE TAMBIEN A UN PROCEDIMIENTO DE PREPARACION Y A UNA COMPOSICION FARMACEUTICA. DICHOS COMPUESTOS SON INHIBIDORES DE CINASA -PI3, UTILES EN EL TRATAMIENTO CONJUNTIVITIS, ANEMIA HEMOLITICA, ENGERMEDAD DE CROHN, ENTRE OTROS
PE2008000821A 2007-05-11 2008-05-09 Imidazopiridazinas y pirrolo-pirimidinas sustituidas como inhibidores de cinasa de lipido PE20090714A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US91734807P 2007-05-11 2007-05-11

Publications (1)

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PE20090714A1 true PE20090714A1 (es) 2009-07-17

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PE2008000821A PE20090714A1 (es) 2007-05-11 2008-05-09 Imidazopiridazinas y pirrolo-pirimidinas sustituidas como inhibidores de cinasa de lipido

Country Status (17)

Country Link
US (1) US20100311729A1 (es)
EP (1) EP2155202A2 (es)
JP (1) JP2010526795A (es)
KR (1) KR20100016460A (es)
CN (1) CN101678026A (es)
AR (1) AR067326A1 (es)
AU (1) AU2008250293A1 (es)
BR (1) BRPI0811600A2 (es)
CA (1) CA2686903A1 (es)
CL (1) CL2008001364A1 (es)
EA (1) EA200901505A1 (es)
MX (1) MX2009012127A (es)
PA (1) PA8780101A1 (es)
PE (1) PE20090714A1 (es)
TW (1) TW200911810A (es)
UY (1) UY31076A1 (es)
WO (1) WO2008138889A2 (es)

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