MX2008013836A - Derivados de 2-piridona para el tratamiento de enfermedades o condiciones en las cuales es benefica la inhibicion de la actividad de elastasa de neutrofilos. - Google Patents
Derivados de 2-piridona para el tratamiento de enfermedades o condiciones en las cuales es benefica la inhibicion de la actividad de elastasa de neutrofilos.Info
- Publication number
- MX2008013836A MX2008013836A MX2008013836A MX2008013836A MX2008013836A MX 2008013836 A MX2008013836 A MX 2008013836A MX 2008013836 A MX2008013836 A MX 2008013836A MX 2008013836 A MX2008013836 A MX 2008013836A MX 2008013836 A MX2008013836 A MX 2008013836A
- Authority
- MX
- Mexico
- Prior art keywords
- inhibition
- neutrophil elastase
- disease
- beneficial
- treatment
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
- A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/04—Drugs for disorders of the respiratory system for throat disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/08—Bronchodilators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/16—Otologicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
Abstract
La invención proporciona los compuestos de la fórmula (I) en donde R1, R3, R4, R5, R6 R14, X y W son como se definen en la especificación y los isómeros ópticos, racematos, y tautómeros de los mismos, y las sales farmacéuticamente aceptables de los mismos; junto con los procesos para su preparación, las composiciones farmacéuticas que los contienen y su uso en terapia. Los compuestos son inhibidores de la elastasa de neutrófilos humanos.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US79878606P | 2006-05-08 | 2006-05-08 | |
PCT/SE2007/000441 WO2007129962A1 (en) | 2006-05-08 | 2007-05-07 | 2-pyridone derivatives for the treatment of disease or condition in which inhibition of neutrophil elastase activity is beneficial. |
Publications (1)
Publication Number | Publication Date |
---|---|
MX2008013836A true MX2008013836A (es) | 2008-11-10 |
Family
ID=38667997
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX2008013836A MX2008013836A (es) | 2006-05-08 | 2007-05-07 | Derivados de 2-piridona para el tratamiento de enfermedades o condiciones en las cuales es benefica la inhibicion de la actividad de elastasa de neutrofilos. |
Country Status (21)
Country | Link |
---|---|
US (1) | US7998984B2 (es) |
EP (1) | EP2018375B1 (es) |
JP (1) | JP2009536196A (es) |
KR (1) | KR20090017573A (es) |
CN (1) | CN101490033A (es) |
AR (1) | AR060875A1 (es) |
AT (1) | ATE459615T1 (es) |
AU (1) | AU2007248950B2 (es) |
BR (1) | BRPI0711357A2 (es) |
CA (1) | CA2649813A1 (es) |
CL (1) | CL2007001282A1 (es) |
DE (1) | DE602007005120D1 (es) |
ES (1) | ES2339607T3 (es) |
HK (1) | HK1127599A1 (es) |
IL (1) | IL194948A0 (es) |
MX (1) | MX2008013836A (es) |
NO (1) | NO20084872L (es) |
TW (1) | TW200808763A (es) |
UY (1) | UY30328A1 (es) |
WO (1) | WO2007129962A1 (es) |
ZA (1) | ZA200809024B (es) |
Families Citing this family (24)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
SE0302486D0 (sv) | 2003-09-18 | 2003-09-18 | Astrazeneca Ab | Novel compounds |
TW200808771A (en) * | 2006-05-08 | 2008-02-16 | Astrazeneca Ab | Novel compounds II |
TW200808763A (en) | 2006-05-08 | 2008-02-16 | Astrazeneca Ab | Novel compounds I |
AU2007297597B2 (en) * | 2006-09-21 | 2013-02-21 | Kyorin Pharmaceuticals Co., Ltd. | Serine hydrolase inhibitors |
DE102007031397A1 (de) * | 2007-07-05 | 2009-01-08 | D2O Bioscience Group Ltd. | Verwendung von Deuteriumoxid zur Behandlung von Virus-basierten Erkrankungen der Haut |
JP2011502982A (ja) | 2007-11-06 | 2011-01-27 | アストラゼネカ・アクチエボラーグ | 好中球エラスターゼの阻害剤としてのある種の2−ピラジノン誘導体およびその使用 |
ES2459198T3 (es) | 2008-04-20 | 2014-05-08 | D2 Bioscience Group Ltd | Utilización de óxido de deuterio como inhibidor de elastasa |
DE102009003942A1 (de) | 2009-01-07 | 2010-07-08 | D2O Biosience Group Ltd., Hamilton | Verwendung von Deuteriumoxid zur Behandlung Virus-basierter Erkrankungen des Auges |
TW201036957A (en) | 2009-02-20 | 2010-10-16 | Astrazeneca Ab | Novel salt 628 |
TWI546537B (zh) * | 2009-05-19 | 2016-08-21 | 維維亞生技公司 | 提供針對血液腫瘤之體外個人化藥物測試之方法 |
WO2011039528A1 (en) * | 2009-10-02 | 2011-04-07 | Astrazeneca Ab | 2-pyridone compounds used as inhibitors of neutrophil elastase |
DE102010030187A1 (de) | 2010-06-16 | 2011-12-22 | Bayer Schering Pharma Aktiengesellschaft | 4-Cyan-2-sulfonylphenyl)pyrazolyl-substituierte Pyridinone und Pyrazinone und ihre Verwendung |
JP2013177318A (ja) * | 2010-06-30 | 2013-09-09 | Dainippon Sumitomo Pharma Co Ltd | ジヒドロピリミジノン誘導体およびその医薬用途 |
CN104024241B (zh) | 2011-08-01 | 2016-01-20 | 大日本住友制药株式会社 | 尿嘧啶衍生物和其用于医学目的的用途 |
US9102624B2 (en) | 2012-08-23 | 2015-08-11 | Boehringer Ingelheim International Gmbh | Substituted 4-pyridones and their use as inhibitors of neutrophil elastase activity |
US20140057926A1 (en) | 2012-08-23 | 2014-02-27 | Boehringer Ingelheim International Gmbh | Substituted 4-pyridones and their use as inhibitors of neutrophil elastase activity |
US20140057920A1 (en) | 2012-08-23 | 2014-02-27 | Boehringer Ingelheim International Gmbh | Substituted 4-pyridones and their use as inhibitors of neutrophil elastase activity |
US9409870B2 (en) * | 2014-12-15 | 2016-08-09 | Chiesi Farmaceutici S.P.A. | Compounds |
WO2017037116A1 (en) | 2015-09-02 | 2017-03-09 | Glaxosmithkline Intellectual Property (No.2) Limited | Pyridinone dicarboxamide for use as bromodomain inhibitors |
CN106674098B (zh) * | 2016-12-23 | 2019-07-02 | 中国医科大学 | N-(3-氰基-4-烷氧基苯基)吡啶甲酰胺类化合物及其用途 |
US11666888B2 (en) | 2018-02-05 | 2023-06-06 | Bio-Rad Laboratories, Inc. | Chromatography resin having an anionic exchange-hydrophobic mixed mode ligand |
JP2023500182A (ja) | 2019-09-17 | 2023-01-05 | メレオ バイオファーマ 4 リミテッド | 移植片拒絶反応、閉塞性細気管支炎症候群、及び移植片対宿主病の治療に使用するためのアルベレスタット |
EP4252850A3 (en) | 2020-04-16 | 2023-11-15 | Mereo Biopharma 4 Limited | Methods involving neutrophil elastase inhibitor alvelestat for treating respiratory disease mediated by alpha-1 antitrypsin deficiency |
WO2023067103A1 (en) | 2021-10-20 | 2023-04-27 | Mereo Biopharma 4 Limited | Neutrophil elastase inhibitors for use in the treatment of fibrosis |
Family Cites Families (40)
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FR2358891A1 (fr) * | 1976-07-22 | 1978-02-17 | Yamanouchi Pharma Co Ltd | Composes heterocycliques contenant un azote, utilise comme agents analgesiques et anti-inflammatoires |
DE2706977A1 (de) * | 1977-02-18 | 1978-08-24 | Hoechst Ag | Benzoesaeuren und deren derivate sowie verfahren zu ihrer herstellung |
EP0008864A1 (en) | 1978-08-15 | 1980-03-19 | FISONS plc | Pyridopyrazine and quinoxaline derivatives, processes for their preparation, and pharmaceutical compositions containing them |
JPH02152966A (ja) | 1988-12-05 | 1990-06-12 | Otsuka Pharmaceut Co Ltd | 4−ヒドロキシカルボスチリル誘導体 |
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US5441960A (en) * | 1992-04-16 | 1995-08-15 | Zeneca Limited | 1-pyrimidinylacetamide human leukocyte elastate inhibitors |
HUP0001140A3 (en) | 1996-12-05 | 2002-05-28 | Amgen Inc Thousand Oaks | Substituted pyrimidinone and pyridone compounds and methods of use |
JPH1171351A (ja) * | 1997-08-29 | 1999-03-16 | Ss Pharmaceut Co Ltd | 置換キノロン誘導体及びこれを含有する医薬 |
US6949571B2 (en) | 2000-06-12 | 2005-09-27 | Eisai Co., Ltd. | 1,2-dihydropyridine compounds, process for preparation of the same and use thereof |
ATE438624T1 (de) * | 2000-12-28 | 2009-08-15 | Shionogi & Co | 2-pyridonderivate mit affinität für den cannabinoid-typ-2-rezeptor |
US20040235761A1 (en) * | 2001-08-14 | 2004-11-25 | Yousuke Furuta | Novel virus proliferaton inhibition/virucidal method and novel pyradine nucleotide/pyradine nucleoside analogue |
GB0129260D0 (en) | 2001-12-06 | 2002-01-23 | Eisai London Res Lab Ltd | Pharmaceutical compositions and their uses |
GB2383326A (en) | 2001-12-20 | 2003-06-25 | Bayer Ag | Antiinflammatory dihydropyridines |
MXPA03000145A (es) * | 2002-01-07 | 2003-07-15 | Pfizer | Compuestos de oxo u oxi-piridina como moduladores de receptores 5-ht4. |
EP2130820A1 (en) * | 2002-02-19 | 2009-12-09 | Shionogi & Co., Ltd. | Antipruritics |
ES2293077T3 (es) | 2002-08-27 | 2008-03-16 | Bayer Healthcare Ag | Derivados de dihidropiridinona como inhbidores de hne. |
GB2392910A (en) | 2002-09-10 | 2004-03-17 | Bayer Ag | 2-Oxopyrimidine derivatives and their use as human leukocyte elastase inhibitors |
TW200500341A (en) | 2002-11-12 | 2005-01-01 | Astrazeneca Ab | Novel compounds |
SE0302324D0 (sv) | 2003-08-28 | 2003-08-28 | Astrazeneca Ab | Novel compounds |
SE0302323D0 (sv) | 2003-08-28 | 2003-08-28 | Astrazeneca Ab | Novel compounds |
SE0302487D0 (sv) * | 2003-09-18 | 2003-09-18 | Astrazeneca Ab | Novel compounds |
SE0302486D0 (sv) | 2003-09-18 | 2003-09-18 | Astrazeneca Ab | Novel compounds |
JP5134248B2 (ja) | 2004-02-19 | 2013-01-30 | バイエル・ファルマ・アクチェンゲゼルシャフト | ジヒドロピリジノン誘導体 |
ES2394177T3 (es) | 2004-02-26 | 2013-01-23 | Bayer Intellectual Property Gmbh | 1,4-diaril-dihidropirimidin-2-onas y su uso como inhibidores de elastasa de neutrófilos humanos |
US20050288290A1 (en) | 2004-06-28 | 2005-12-29 | Borzilleri Robert M | Fused heterocyclic kinase inhibitors |
KR200365249Y1 (ko) * | 2004-07-28 | 2004-10-21 | 추윤정 | 전동 퍼프 |
GB0420722D0 (en) | 2004-09-17 | 2004-10-20 | Addex Pharmaceuticals Sa | Novel allosteric modulators |
GB0502258D0 (en) | 2005-02-03 | 2005-03-09 | Argenta Discovery Ltd | Compounds and their use |
TW200700392A (en) | 2005-03-16 | 2007-01-01 | Astrazeneca Ab | Novel compounds |
JO2787B1 (en) | 2005-04-27 | 2014-03-15 | امجين إنك, | Alternative amide derivatives and methods of use |
GB0512940D0 (en) | 2005-06-24 | 2005-08-03 | Argenta Discovery Ltd | Compounds and their use |
GB0605469D0 (en) | 2006-03-17 | 2006-04-26 | Argenta Discovery Ltd | Multimers of heterocyclic compounds and their use |
SI2024367T1 (sl) | 2006-05-04 | 2011-04-29 | Pulmagen Therapeutics Inflammation Ltd | Tetrahidropirolopirimidinedioni in njihova uporaba kot äśloveĺ ki neutrofil elastazni inhibitorji |
TW200808771A (en) * | 2006-05-08 | 2008-02-16 | Astrazeneca Ab | Novel compounds II |
TW200808763A (en) | 2006-05-08 | 2008-02-16 | Astrazeneca Ab | Novel compounds I |
US20110003858A1 (en) | 2006-09-04 | 2011-01-06 | Bergstroem Lena | Multimeric heterocyclic compounds useful as neutrophil elastase inhibitors |
WO2008104752A1 (en) | 2007-02-26 | 2008-09-04 | Astrazeneca Ab | Dihydropyridones as elastase inhibitors |
WO2009058076A1 (en) | 2007-11-02 | 2009-05-07 | Astrazeneca Ab | 2-pyrazinone derivatives and their use as inhibitors of neutrophile elastase |
JP2011502982A (ja) | 2007-11-06 | 2011-01-27 | アストラゼネカ・アクチエボラーグ | 好中球エラスターゼの阻害剤としてのある種の2−ピラジノン誘導体およびその使用 |
TW201036957A (en) * | 2009-02-20 | 2010-10-16 | Astrazeneca Ab | Novel salt 628 |
-
2007
- 2007-04-27 TW TW096115047A patent/TW200808763A/zh unknown
- 2007-05-07 CA CA002649813A patent/CA2649813A1/en not_active Abandoned
- 2007-05-07 MX MX2008013836A patent/MX2008013836A/es active IP Right Grant
- 2007-05-07 CL CL2007001282A patent/CL2007001282A1/es unknown
- 2007-05-07 UY UY30328A patent/UY30328A1/es not_active Application Discontinuation
- 2007-05-07 AU AU2007248950A patent/AU2007248950B2/en not_active Ceased
- 2007-05-07 EP EP07748105A patent/EP2018375B1/en active Active
- 2007-05-07 BR BRPI0711357-9A patent/BRPI0711357A2/pt not_active IP Right Cessation
- 2007-05-07 WO PCT/SE2007/000441 patent/WO2007129962A1/en active Application Filing
- 2007-05-07 JP JP2009509485A patent/JP2009536196A/ja not_active Withdrawn
- 2007-05-07 US US12/299,879 patent/US7998984B2/en not_active Expired - Fee Related
- 2007-05-07 CN CNA2007800259071A patent/CN101490033A/zh active Pending
- 2007-05-07 KR KR1020087029811A patent/KR20090017573A/ko not_active Application Discontinuation
- 2007-05-07 DE DE602007005120T patent/DE602007005120D1/de active Active
- 2007-05-07 ES ES07748105T patent/ES2339607T3/es active Active
- 2007-05-07 AT AT07748105T patent/ATE459615T1/de not_active IP Right Cessation
- 2007-05-08 AR ARP070101994A patent/AR060875A1/es unknown
-
2008
- 2008-10-21 ZA ZA200809024A patent/ZA200809024B/xx unknown
- 2008-10-27 IL IL194948A patent/IL194948A0/en unknown
- 2008-11-19 NO NO20084872A patent/NO20084872L/no not_active Application Discontinuation
-
2009
- 2009-07-22 HK HK09106680.3A patent/HK1127599A1/xx not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
US20090131486A1 (en) | 2009-05-21 |
NO20084872L (no) | 2009-02-03 |
IL194948A0 (en) | 2009-08-03 |
JP2009536196A (ja) | 2009-10-08 |
ZA200809024B (en) | 2010-03-31 |
EP2018375B1 (en) | 2010-03-03 |
KR20090017573A (ko) | 2009-02-18 |
ES2339607T3 (es) | 2010-05-21 |
BRPI0711357A2 (pt) | 2011-09-27 |
TW200808763A (en) | 2008-02-16 |
EP2018375A1 (en) | 2009-01-28 |
AU2007248950A1 (en) | 2007-11-15 |
DE602007005120D1 (de) | 2010-04-15 |
AR060875A1 (es) | 2008-07-16 |
CA2649813A1 (en) | 2007-11-15 |
WO2007129962A1 (en) | 2007-11-15 |
US7998984B2 (en) | 2011-08-16 |
CL2007001282A1 (es) | 2008-01-18 |
AU2007248950B2 (en) | 2010-11-18 |
UY30328A1 (es) | 2008-01-02 |
CN101490033A (zh) | 2009-07-22 |
HK1127599A1 (en) | 2009-10-02 |
ATE459615T1 (de) | 2010-03-15 |
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