NO20092737L - Substituerte pyrazolo-kinazolinderivater, fremgangsmate for deres fremstilling og deres anvendelse som kinase-inhibitorer - Google Patents

Substituerte pyrazolo-kinazolinderivater, fremgangsmate for deres fremstilling og deres anvendelse som kinase-inhibitorer

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Publication number
NO20092737L
NO20092737L NO20092737A NO20092737A NO20092737L NO 20092737 L NO20092737 L NO 20092737L NO 20092737 A NO20092737 A NO 20092737A NO 20092737 A NO20092737 A NO 20092737A NO 20092737 L NO20092737 L NO 20092737L
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Norway
Prior art keywords
preparation
substituted
kinase inhibitors
pyrazoloquinazoline
derivatives
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NO20092737A
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English (en)
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NO342675B1 (no
Inventor
Michele Caruso
Italo Beria
Maria Gabriella Brasca
Ron Ferguson
Helena Posteri
Barbara Valsasina
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Nerviano Medical Sciences Srl
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Application filed by Nerviano Medical Sciences Srl filed Critical Nerviano Medical Sciences Srl
Publication of NO20092737L publication Critical patent/NO20092737L/no
Publication of NO342675B1 publication Critical patent/NO342675B1/no

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    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
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    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/12—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms
    • C07D295/135—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms with the ring nitrogen atoms and the substituent nitrogen atoms separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings
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    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/14—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D295/155—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with the ring nitrogen atoms and the carbon atoms with three bonds to hetero atoms separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings
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    • C40B50/14—Solid phase synthesis, i.e. wherein one or more library building blocks are bound to a solid support during library creation; Particular methods of cleavage from the solid support

Abstract

Pyrazolo-quinazolinderivater ifølge Formel (I) som definert i spesifikasjonen, og farmasøytisk akseptable salter derav, prosess for deres fremstilling og farmasøytiske sammensetninger omfattende dem er vist; forbindelsene ifølge oppfinnelsen kan være nyttige i terapi, i behandlingen av sykdommer assosiert med en feilregulert proteinkinase-aktivitet, som kreft.
NO20092737A 2006-12-21 2009-07-21 Substituerte pyrazolo-quinazolinderivater med kinaseinhibitorisk effekt egnet til behandling av kreft samt fremgangsmåter for fremstilling derav NO342675B1 (no)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP06126902 2006-12-21
EP07118039 2007-10-08
PCT/EP2007/064096 WO2008074788A1 (en) 2006-12-21 2007-12-17 Substituted pyrazolo-quinazoline derivatives, process for their preparation and their use as kinase inhibitors

Publications (2)

Publication Number Publication Date
NO20092737L true NO20092737L (no) 2009-09-18
NO342675B1 NO342675B1 (no) 2018-06-25

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NO20092737A NO342675B1 (no) 2006-12-21 2009-07-21 Substituerte pyrazolo-quinazolinderivater med kinaseinhibitorisk effekt egnet til behandling av kreft samt fremgangsmåter for fremstilling derav

Country Status (24)

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US (1) US8614220B2 (no)
EP (1) EP2125822B1 (no)
JP (1) JP5498796B2 (no)
KR (1) KR101512284B1 (no)
AR (1) AR064608A1 (no)
AU (1) AU2007336281B2 (no)
BR (1) BRPI0720588B8 (no)
CA (1) CA2673451C (no)
CL (1) CL2007003756A1 (no)
DK (1) DK2125822T3 (no)
EA (1) EA017769B1 (no)
ES (1) ES2527696T3 (no)
HK (1) HK1136292A1 (no)
HU (1) HUE024105T2 (no)
IL (1) IL199323A (no)
MX (1) MX2009006613A (no)
NO (1) NO342675B1 (no)
NZ (1) NZ578417A (no)
PL (1) PL2125822T3 (no)
PT (1) PT2125822E (no)
SG (1) SG177911A1 (no)
SI (1) SI2125822T1 (no)
TW (1) TWI418560B (no)
WO (1) WO2008074788A1 (no)

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HUE024105T2 (hu) 2016-02-29
WO2008074788A1 (en) 2008-06-26
IL199323A (en) 2015-08-31
US8614220B2 (en) 2013-12-24
US20100216808A1 (en) 2010-08-26
JP2010513389A (ja) 2010-04-30
KR101512284B1 (ko) 2015-04-15
CA2673451C (en) 2016-02-09
PL2125822T3 (pl) 2015-04-30
AU2007336281A2 (en) 2009-09-03
JP5498796B2 (ja) 2014-05-21
AU2007336281B2 (en) 2013-05-30
AU2007336281A1 (en) 2008-06-26
KR20090101942A (ko) 2009-09-29
PT2125822E (pt) 2015-01-30
AR064608A1 (es) 2009-04-15
NZ578417A (en) 2012-05-25
EA200970611A1 (ru) 2009-12-30
DK2125822T3 (en) 2015-01-12
NO342675B1 (no) 2018-06-25
HK1136292A1 (en) 2010-06-25
CA2673451A1 (en) 2008-06-26
SI2125822T1 (sl) 2015-01-30
EP2125822A1 (en) 2009-12-02
BRPI0720588A2 (pt) 2014-02-25
ES2527696T3 (es) 2015-01-28
TW200833693A (en) 2008-08-16
EA017769B1 (ru) 2013-03-29
BRPI0720588B1 (pt) 2020-03-10
TWI418560B (zh) 2013-12-11
MX2009006613A (es) 2009-07-02
SG177911A1 (en) 2012-02-28
BRPI0720588B8 (pt) 2021-05-25
EP2125822B1 (en) 2014-11-19
CL2007003756A1 (es) 2008-08-22

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