UA96304C2 - 2-METHYLMORPHOLINE PYRIDO-, PYRAZO- AND PYRIMIDO-PYRIMIDINE DERIVATIVES AS mTOR INHIBITORS - Google Patents
2-METHYLMORPHOLINE PYRIDO-, PYRAZO- AND PYRIMIDO-PYRIMIDINE DERIVATIVES AS mTOR INHIBITORSInfo
- Publication number
- UA96304C2 UA96304C2 UAA200902219A UAA200902219A UA96304C2 UA 96304 C2 UA96304 C2 UA 96304C2 UA A200902219 A UAA200902219 A UA A200902219A UA A200902219 A UAA200902219 A UA A200902219A UA 96304 C2 UA96304 C2 UA 96304C2
- Authority
- UA
- Ukraine
- Prior art keywords
- pyrazo
- pyrimido
- pyrido
- methylmorpholine
- pyrimidine derivatives
- Prior art date
Links
Abstract
There is provided a compound of Formula (I), or a pharmaceutically acceptable salt thereof. There are also provided processes for the manufacture of a compound of Formula (1), and the use of a compound of Formula (1) as a medicament and in the treatment of cancer.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US82331106P | 2006-08-23 | 2006-08-23 |
Publications (1)
Publication Number | Publication Date |
---|---|
UA96304C2 true UA96304C2 (en) | 2011-10-25 |
Family
ID=41175600
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
UAA200902219A UA96304C2 (en) | 2006-08-23 | 2007-08-21 | 2-METHYLMORPHOLINE PYRIDO-, PYRAZO- AND PYRIMIDO-PYRIMIDINE DERIVATIVES AS mTOR INHIBITORS |
Country Status (3)
Country | Link |
---|---|
CN (1) | CN101558067B (en) |
UA (1) | UA96304C2 (en) |
ZA (1) | ZA200900992B (en) |
Families Citing this family (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN102887895B (en) * | 2011-07-22 | 2016-08-24 | 山东轩竹医药科技有限公司 | Pyridopyrimidine class mTOR inhibitors |
CN103588792B (en) * | 2013-03-04 | 2016-03-23 | 中国科学院上海药物研究所 | Pyridopyrimidine or pyrimido-pyrimidine compounds, its preparation method, medical composition and its use |
CN104557913B (en) * | 2013-10-28 | 2017-02-08 | 上海汇伦生命科技有限公司 | Pyridopyrimidine compounds as well as preparation method and application thereof |
CN103908452A (en) * | 2014-02-18 | 2014-07-09 | 广州金域医学检验中心有限公司 | Composite drug and medicinal preparation for inhibiting lung cancer cell metastasis and detection method for lung cancer cell metastasis |
CN106008559B (en) * | 2015-03-25 | 2020-10-16 | 中国科学院上海药物研究所 | Synthesis process of substituted pyridopyrimidine compounds |
CN111315750B (en) * | 2017-11-06 | 2022-12-23 | 南京明德新药研发有限公司 | Pyridopyrimidines as mTORC1/2 dikinase inhibitors |
CN110407833B (en) * | 2018-04-28 | 2021-03-09 | 海创药业股份有限公司 | Deuterated Vissturtib compound and application thereof |
CN113286594B (en) * | 2019-01-18 | 2023-12-15 | 南京明德新药研发有限公司 | Application of pyridopyrimidine compounds in preparation of medicines for treating nasopharyngeal carcinoma |
WO2020224585A1 (en) * | 2019-05-06 | 2020-11-12 | 南京明德新药研发有限公司 | Salt and crystal form of mtorc1/2 dual kinase activity inhibitor and preparation method therefor |
CN111892529A (en) * | 2020-08-19 | 2020-11-06 | 南通大学 | 6-chloro-5-hydroxyisoindole-1-one and synthesis method thereof |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5990117A (en) * | 1998-04-15 | 1999-11-23 | Cell Pathways, Inc. | Method for inhibiting neoplastic cells and related conditions by exposure to quinazoline derivatives |
DE60144322D1 (en) * | 2000-04-27 | 2011-05-12 | Astellas Pharma Inc | CONDENSED HETEROARYL DERIVATIVES |
KR101464384B1 (en) * | 2005-11-22 | 2014-11-21 | 쿠도스 파마슈티칼스 리미티드 | PYRIDO-, PYRAZO- AND PYRIMIDO-PYRIMIDINE DERIVATIVES AS mTOR INHIBITORS |
-
2007
- 2007-08-21 CN CN200780038974.7A patent/CN101558067B/en active Active
- 2007-08-21 UA UAA200902219A patent/UA96304C2/en unknown
-
2009
- 2009-02-11 ZA ZA200900992A patent/ZA200900992B/en unknown
Also Published As
Publication number | Publication date |
---|---|
CN101558067A (en) | 2009-10-14 |
ZA200900992B (en) | 2010-07-28 |
CN101558067B (en) | 2014-05-28 |
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