MD20140112A2 - Analogi carba-nucleozidici 2'-substituiţi pentru tratamentul antiviral - Google Patents
Analogi carba-nucleozidici 2'-substituiţi pentru tratamentul antiviralInfo
- Publication number
- MD20140112A2 MD20140112A2 MDA20140112A MD20140112A MD20140112A2 MD 20140112 A2 MD20140112 A2 MD 20140112A2 MD A20140112 A MDA20140112 A MD A20140112A MD 20140112 A MD20140112 A MD 20140112A MD 20140112 A2 MD20140112 A2 MD 20140112A2
- Authority
- MD
- Moldova
- Prior art keywords
- nucleoside analogs
- antiviral treatment
- compounds
- substituted carba
- carba
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/23—Heterocyclic radicals containing two or more heterocyclic rings condensed among themselves or condensed with a common carbocyclic ring system, not provided for in groups C07H19/14 - C07H19/22
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
- A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
- A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/16—Antivirals for RNA viruses for influenza or rhinoviruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/12—Triazine radicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M15/00—Inhalators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2202/00—Special media to be introduced, removed or treated
- A61M2202/30—Vaccines
Abstract
Invenţia se referă la compuşi cu Formula I,,precum şi la compoziţii farmaceutice care conţin compuşii cu Formula I şi metode pentru tratarea infecţiilor cu virusul Orthomyxoviridae prin administrarea acestor compuşi.Compuşii, compoziţiile şi metodele propuse sunt utile în particular pentru tratamentul infecţiilor cu virusul gripal uman.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201261610411P | 2012-03-13 | 2012-03-13 | |
PCT/US2013/030196 WO2013138236A1 (en) | 2012-03-13 | 2013-03-11 | 2'- substituted carba-nucleoside analogs for antiviral treatment |
Publications (3)
Publication Number | Publication Date |
---|---|
MD20140112A2 true MD20140112A2 (ro) | 2015-02-28 |
MD4496B1 MD4496B1 (ro) | 2017-07-31 |
MD4496C1 MD4496C1 (ro) | 2018-02-28 |
Family
ID=47997868
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MDA20140112A MD4496C1 (ro) | 2012-03-13 | 2013-03-11 | Analogi carba-nucleozidici 2'-substituiţi pentru tratament antiviral |
Country Status (19)
Country | Link |
---|---|
US (4) | US9481704B2 (ro) |
EP (4) | EP3351552B1 (ro) |
JP (3) | JP6242378B2 (ro) |
KR (1) | KR102068856B1 (ro) |
CN (2) | CN104185638A (ro) |
AU (2) | AU2013232378B2 (ro) |
CA (1) | CA2866381C (ro) |
EA (2) | EA028928B9 (ro) |
ES (3) | ES2878087T3 (ro) |
HK (2) | HK1207083A1 (ro) |
IL (2) | IL234586A (ro) |
IN (1) | IN2014DN08505A (ro) |
MD (1) | MD4496C1 (ro) |
MX (1) | MX355267B (ro) |
NZ (1) | NZ629996A (ro) |
PL (1) | PL2834258T3 (ro) |
PT (1) | PT2834258T (ro) |
SI (1) | SI2834258T1 (ro) |
WO (1) | WO2013138236A1 (ro) |
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SG10201610936RA (en) | 2011-12-22 | 2017-02-27 | Alios Biopharma Inc | Substituted nucleosides, nucleotides and analogs thereof |
EP3351552B1 (en) | 2012-03-13 | 2021-05-19 | Gilead Sciences, Inc. | 2'-substituted carba-nucleoside analogs for antiviral treatment |
US9441007B2 (en) | 2012-03-21 | 2016-09-13 | Alios Biopharma, Inc. | Substituted nucleosides, nucleotides and analogs thereof |
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EA033866B1 (ru) * | 2014-02-06 | 2019-12-03 | Рибосайенс Ллк | 4'-дифторметилзамещенные производные нуклеозидов в качестве ингибиторов репликации рнк вируса гриппа |
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2013
- 2013-03-11 EP EP18155061.7A patent/EP3351552B1/en active Active
- 2013-03-11 PT PT137120432T patent/PT2834258T/pt unknown
- 2013-03-11 CN CN201380014318.9A patent/CN104185638A/zh active Pending
- 2013-03-11 EP EP21168626.6A patent/EP3932931A1/en active Pending
- 2013-03-11 SI SI201330567A patent/SI2834258T1/sl unknown
- 2013-03-11 MD MDA20140112A patent/MD4496C1/ro active IP Right Grant
- 2013-03-11 MX MX2014011009A patent/MX355267B/es active IP Right Grant
- 2013-03-11 NZ NZ629996A patent/NZ629996A/en unknown
- 2013-03-11 EP EP16203290.8A patent/EP3210993B1/en active Active
- 2013-03-11 ES ES18155061T patent/ES2878087T3/es active Active
- 2013-03-11 JP JP2015500493A patent/JP6242378B2/ja active Active
- 2013-03-11 ES ES16203290T patent/ES2709071T3/es active Active
- 2013-03-11 AU AU2013232378A patent/AU2013232378B2/en active Active
- 2013-03-11 ES ES13712043.2T patent/ES2621217T3/es active Active
- 2013-03-11 EA EA201491548A patent/EA028928B9/ru unknown
- 2013-03-11 CA CA2866381A patent/CA2866381C/en active Active
- 2013-03-11 PL PL13712043T patent/PL2834258T3/pl unknown
- 2013-03-11 US US13/793,557 patent/US9481704B2/en active Active
- 2013-03-11 EA EA201791916A patent/EA201791916A1/ru unknown
- 2013-03-11 WO PCT/US2013/030196 patent/WO2013138236A1/en active Application Filing
- 2013-03-11 KR KR1020147028523A patent/KR102068856B1/ko active IP Right Grant
- 2013-03-11 EP EP13712043.2A patent/EP2834258B1/en active Active
- 2013-03-11 CN CN201611121597.0A patent/CN106749272B/zh active Active
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2014
- 2014-09-11 IL IL234586A patent/IL234586A/en active IP Right Grant
- 2014-10-10 IN IN8505DEN2014 patent/IN2014DN08505A/en unknown
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2015
- 2015-08-11 HK HK15107752.6A patent/HK1207083A1/xx unknown
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2016
- 2016-09-30 US US15/282,492 patent/US20170114086A1/en not_active Abandoned
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2017
- 2017-06-21 JP JP2017121389A patent/JP6525441B2/ja active Active
- 2017-12-18 IL IL256397A patent/IL256397A/en unknown
- 2017-12-19 AU AU2017279590A patent/AU2017279590A1/en not_active Abandoned
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2018
- 2018-02-01 HK HK18115942.7A patent/HK1256856A1/zh unknown
- 2018-06-22 US US16/016,369 patent/US10941177B2/en active Active
- 2018-12-26 JP JP2018242679A patent/JP2019069986A/ja not_active Withdrawn
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2021
- 2021-01-28 US US17/161,065 patent/US11787832B2/en active Active
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FG4A | Patent for invention issued |