MD1560G2 - Compuşi ciclici, compoziţii farmaceutice pe baza lor şi metode de tratament al infecţiilor sau bolilor provocate de retrovirusuri - Google Patents

Compuşi ciclici, compoziţii farmaceutice pe baza lor şi metode de tratament al infecţiilor sau bolilor provocate de retrovirusuri

Info

Publication number
MD1560G2
MD1560G2 MD96-0172A MD960172A MD1560G2 MD 1560 G2 MD1560 G2 MD 1560G2 MD 960172 A MD960172 A MD 960172A MD 1560 G2 MD1560 G2 MD 1560G2
Authority
MD
Moldova
Prior art keywords
retroviruses
infections
treatment
methods
pharmaceutical compositions
Prior art date
Application number
MD96-0172A
Other languages
English (en)
Russian (ru)
Other versions
MD960172A (ro
Inventor
Edmund Lee Ellsworth
Элизабет Энн ЛУННЕЙ
Bradley Dean Tait
Original Assignee
Parke, Davis & Company
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US08/319,821 external-priority patent/US5789440A/en
Application filed by Parke, Davis & Company filed Critical Parke, Davis & Company
Publication of MD960172A publication Critical patent/MD960172A/ro
Publication of MD1560G2 publication Critical patent/MD1560G2/ro

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C321/00—Thiols, sulfides, hydropolysulfides or polysulfides
    • C07C321/24—Thiols, sulfides, hydropolysulfides, or polysulfides having thio groups bound to carbon atoms of six-membered aromatic rings
    • C07C321/26—Thiols
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
    • C07C323/10—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and singly-bound oxygen atoms bound to the same carbon skeleton
    • C07C323/18—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and singly-bound oxygen atoms bound to the same carbon skeleton having the sulfur atom of at least one of the thio groups bound to a carbon atom of a six-membered aromatic ring of the carbon skeleton
    • C07C323/20—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and singly-bound oxygen atoms bound to the same carbon skeleton having the sulfur atom of at least one of the thio groups bound to a carbon atom of a six-membered aromatic ring of the carbon skeleton with singly-bound oxygen atoms bound to carbon atoms of the same non-condensed six-membered aromatic ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
    • C07C323/22—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and doubly-bound oxygen atoms bound to the same carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/80—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D211/84—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen directly attached to ring carbon atoms
    • C07D211/86—Oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
    • C07D309/32—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/96—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings spiro-condensed with carbocyclic rings or ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D407/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00
    • C07D407/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings
    • C07D407/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D407/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00
    • C07D407/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings
    • C07D407/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/06—Systems containing only non-condensed rings with a five-membered ring
    • C07C2601/08—Systems containing only non-condensed rings with a five-membered ring the ring being saturated
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/06—Systems containing only non-condensed rings with a five-membered ring
    • C07C2601/10—Systems containing only non-condensed rings with a five-membered ring the ring being unsaturated
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
    • C07C2601/14—The ring being saturated
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
    • C07C2601/16—Systems containing only non-condensed rings with a six-membered ring the ring being unsaturated

Abstract

Invenţia se referă la sinteza compuşilor ciclici cu formula generală I, în special la derivaţii ai 5,6-dihidropironei şi sărurile lor, dihidropiperidine, derivaţi ai ciclohexanonelor. Invenţia se referă de asemenea la compoziţii farmaceutice şi metode de tratament al infecţiilor sau bolilor provocate de retrovirusuri.
MD96-0172A 1993-11-19 1994-10-26 Compuşi ciclici, compoziţii farmaceutice pe baza lor şi metode de tratament al infecţiilor sau bolilor provocate de retrovirusuri MD1560G2 (ro)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US15544393A 1993-11-19 1993-11-19
US08/319,821 US5789440A (en) 1993-11-19 1994-10-12 5,6-dihydropyrone derivatives as protease inhibitors and antiviral agents
PCT/US1994/012234 WO1995014011A2 (en) 1993-11-19 1994-10-26 5,6-dihydropyrone derivatives as protease inhibitors and antiviral agents

Publications (2)

Publication Number Publication Date
MD960172A MD960172A (ro) 1999-01-31
MD1560G2 true MD1560G2 (ro) 2001-07-31

Family

ID=26852339

Family Applications (2)

Application Number Title Priority Date Filing Date
MD96-0172A MD1560G2 (ro) 1993-11-19 1994-10-26 Compuşi ciclici, compoziţii farmaceutice pe baza lor şi metode de tratament al infecţiilor sau bolilor provocate de retrovirusuri
MD96-0172D MD1560F2 (ro) 1993-11-19 1994-10-26 Compusi ciclici, compozitii farmaceutice pe baza lor si metode de tratament al infectiilor sau bolilor provocate de retrovirusuri

Family Applications After (1)

Application Number Title Priority Date Filing Date
MD96-0172D MD1560F2 (ro) 1993-11-19 1994-10-26 Compusi ciclici, compozitii farmaceutice pe baza lor si metode de tratament al infectiilor sau bolilor provocate de retrovirusuri

Country Status (27)

Country Link
US (1) US5936128A (ro)
EP (1) EP0729463B1 (ro)
JP (1) JP3698435B2 (ro)
AT (1) ATE217871T1 (ro)
AU (1) AU680064B2 (ro)
BG (1) BG63012B1 (ro)
CA (1) CA2176041A1 (ro)
CZ (1) CZ291856B6 (ro)
DE (1) DE69430671T2 (ro)
DK (1) DK0729463T3 (ro)
EE (1) EE9600045A (ro)
ES (1) ES2176263T3 (ro)
FI (1) FI962021A (ro)
HR (1) HRP940936B1 (ro)
HU (1) HUT75225A (ro)
IL (1) IL111673A (ro)
MD (2) MD1560G2 (ro)
NO (1) NO315117B1 (ro)
NZ (1) NZ275318A (ro)
PL (1) PL180634B1 (ro)
PT (1) PT729463E (ro)
RO (1) RO117850B1 (ro)
RU (1) RU2160733C2 (ro)
SI (1) SI0729463T1 (ro)
SK (1) SK283240B6 (ro)
TJ (1) TJ320B (ro)
WO (1) WO1995014011A2 (ro)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2002515730A (ja) * 1995-10-16 2002-05-28 カイロン コーポレイション 遺伝子発現を変調する因子のスクリーニング方法
DK0861085T3 (da) 1995-11-13 2005-11-21 Vitaleech Bioscience N V Antivirale isolater opnået fra igler
US5834506A (en) * 1996-11-01 1998-11-10 Warner-Lambert Company Dihydropyrones with improved antiviral activity
US6087455A (en) * 1997-12-19 2000-07-11 Shell Oil Company Process for hydrogenation of macromolecular organic substrates
WO2000015634A2 (en) 1998-09-11 2000-03-23 Warner-Lambert Company Hiv protease inhibitors
DE10030094A1 (de) 2000-06-19 2001-12-20 Bayer Ag Phenylsubstituierte 5,6-Dihydro-pyron-Derivate
DE10100175A1 (de) * 2001-01-04 2002-07-11 Bayer Ag Hetarylsubstituierte Homotetram-und Homotetronsäuren
DOP2003000641A (es) 2002-05-10 2003-11-15 Pfizer Inhibidores de las arn polimerasa dependiente de arn del virus de las hepatitis c y composiciones y tratamiento que los usan
US7148226B2 (en) 2003-02-21 2006-12-12 Agouron Pharmaceuticals, Inc. Inhibitors of hepatitis C virus RNA-dependent RNA polymerase, and compositions and treatments using the same
RS51794B (en) 2004-08-18 2011-12-31 Pfizer Inc. RNA SUBSTITUTE RNA POLYMERASE INHIBITORS OF HEPATITIS C VIRUS AND COMPOSITIONS AND TREATMENTS USING THEM
WO2009126305A1 (en) * 2008-04-11 2009-10-15 The Trustees Of Columbia University Glucose metabolism modulating compounds
EP3068416A4 (en) 2013-11-11 2017-08-09 Kuality Herbceutics LLC Kava derived therapeutic compounds and methods of use thereof
CN108026084A (zh) * 2015-05-07 2018-05-11 夸利蒂赫布丘蒂克斯公司 治疗化合物及其使用方法
CN109641843B (zh) * 2016-06-14 2022-07-19 百时美施贵宝公司 作为apj激动剂的4-羟基-3-磺酰基吡啶-2(1h)-酮
RU2019114964A (ru) 2016-10-17 2020-11-17 Дженентек, Инк. Терапевтические средства и способы их применения
GB201707856D0 (en) 2017-05-16 2017-06-28 Arctic Pharma As Compounds

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3206276A (en) * 1961-09-28 1965-09-14 Minerals Engineering Company Process for recovery of pure v2o5 from vanadium bearing materials
US3818046A (en) * 1972-12-18 1974-06-18 Dow Chemical Co Sulfur-containing hydroxy pyrones and alkali metal salts thereof
US3931235A (en) * 1972-12-18 1976-01-06 The Dow Chemical Company Process for preparing sulfur-containing hydroxy pyrones
EP0278742A2 (en) * 1987-02-11 1988-08-17 May & Baker Limited Cyclic diones

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3206476A (en) * 1962-06-04 1965-09-14 Sterling Drug Inc 3-substituted-4-hydroxy-6-aryl-2-pyrones and preparation
WO1989007939A2 (en) * 1988-03-01 1989-09-08 The Upjohn Company Coumarins to inhibit reverse transcriptase in humans
JPH03227923A (ja) * 1990-01-30 1991-10-08 Sawai Seiyaku Kk ひと免疫不全ウイルス疾患処置剤
EP0614599A4 (en) * 1991-11-18 1995-01-04 Motorola Inc User selectable noise reduction for a portable microphone.
ZA938019B (en) * 1992-11-13 1995-04-28 Upjohn Co Pyran-2-ones and 5,6-dihydropyran-2-ones useful for treating HIV and other retroviruses
IL108459A0 (en) * 1993-02-05 1994-04-12 Opjohn Company 4-Hydroxy-benzopyran-2-ones and 4-hydroxy-cycloalkyl [B] pyran-2-ones useful for treating infections due to hiv and other retroviruses

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3206276A (en) * 1961-09-28 1965-09-14 Minerals Engineering Company Process for recovery of pure v2o5 from vanadium bearing materials
US3818046A (en) * 1972-12-18 1974-06-18 Dow Chemical Co Sulfur-containing hydroxy pyrones and alkali metal salts thereof
US3931235A (en) * 1972-12-18 1976-01-06 The Dow Chemical Company Process for preparing sulfur-containing hydroxy pyrones
EP0278742A2 (en) * 1987-02-11 1988-08-17 May & Baker Limited Cyclic diones

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
Biochem. Biophys, Ress.Comm., 188, 1992, p. 631-637. *

Also Published As

Publication number Publication date
IL111673A (en) 1999-04-11
EE9600045A (et) 1996-10-15
PL180634B1 (pl) 2001-03-30
SK64696A3 (en) 1997-03-05
EP0729463B1 (en) 2002-05-22
AU680064B2 (en) 1997-07-17
HRP940936B1 (en) 2003-12-31
RU2160733C2 (ru) 2000-12-20
HU9601349D0 (en) 1996-07-29
FI962021A (fi) 1996-07-12
AU8090094A (en) 1995-06-06
PL314483A1 (en) 1996-09-16
NZ275318A (en) 1999-06-29
WO1995014011A3 (en) 1995-06-29
ATE217871T1 (de) 2002-06-15
MD960172A (ro) 1999-01-31
IL111673A0 (en) 1995-01-24
TJ320B (en) 2001-10-22
NO962018L (no) 1996-07-04
CZ136896A3 (en) 1997-12-17
HRP940936A2 (en) 1997-08-31
HUT75225A (en) 1997-04-28
WO1995014011A2 (en) 1995-05-26
SK283240B6 (sk) 2003-04-01
US5936128A (en) 1999-08-10
EP0729463A1 (en) 1996-09-04
RO117850B1 (ro) 2002-08-30
CA2176041A1 (en) 1995-05-26
NO315117B1 (no) 2003-07-14
BG63012B1 (bg) 2001-01-31
ES2176263T3 (es) 2002-12-01
MD1560F2 (ro) 2000-11-30
JPH09505292A (ja) 1997-05-27
DE69430671D1 (de) 2002-06-27
FI962021A0 (fi) 1996-05-13
NO962018D0 (no) 1996-05-15
DE69430671T2 (de) 2002-11-21
JP3698435B2 (ja) 2005-09-21
DK0729463T3 (da) 2002-09-09
CZ291856B6 (cs) 2003-06-18
PT729463E (pt) 2002-10-31
BG100563A (bg) 1996-12-31
SI0729463T1 (en) 2002-08-31

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Legal Events

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PD99 Pending application
MM4A Patent for invention definitely lapsed due to non-payment of fees