MA51673A - Composés destinés au traitement de troubles dépendant de la kinase - Google Patents
Composés destinés au traitement de troubles dépendant de la kinaseInfo
- Publication number
- MA51673A MA51673A MA051673A MA51673A MA51673A MA 51673 A MA51673 A MA 51673A MA 051673 A MA051673 A MA 051673A MA 51673 A MA51673 A MA 51673A MA 51673 A MA51673 A MA 51673A
- Authority
- MA
- Morocco
- Prior art keywords
- kinase
- treatment
- compounds intended
- dependent disorders
- disorders
- Prior art date
Links
- 150000001875 compounds Chemical class 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/48—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/20—Oxygen atoms
- C07D215/22—Oxygen atoms attached in position 2 or 4
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/4709—Non-condensed quinolines and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D498/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/553—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having one nitrogen atom as the only ring hetero atom
- C07F9/576—Six-membered rings
- C07F9/60—Quinoline or hydrogenated quinoline ring systems
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Hematology (AREA)
- Oncology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Color Electrophotography (AREA)
- Peptides Or Proteins (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Quinoline Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201862622702P | 2018-01-26 | 2018-01-26 | |
US201862758321P | 2018-11-09 | 2018-11-09 |
Publications (1)
Publication Number | Publication Date |
---|---|
MA51673A true MA51673A (fr) | 2020-12-02 |
Family
ID=65409544
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MA051673A MA51673A (fr) | 2018-01-26 | 2019-01-25 | Composés destinés au traitement de troubles dépendant de la kinase |
Country Status (18)
Country | Link |
---|---|
US (2) | US11542259B2 (fr) |
EP (1) | EP3743070A1 (fr) |
JP (2) | JP7321165B2 (fr) |
KR (1) | KR20200115582A (fr) |
CN (5) | CN117402114A (fr) |
AU (1) | AU2019212801A1 (fr) |
BR (1) | BR112020015201A2 (fr) |
CA (1) | CA3088200A1 (fr) |
CL (1) | CL2020001931A1 (fr) |
CO (1) | CO2020010465A2 (fr) |
CR (2) | CR20230287A (fr) |
IL (2) | IL300824A (fr) |
MA (1) | MA51673A (fr) |
MX (2) | MX2020007765A (fr) |
PE (1) | PE20211203A1 (fr) |
PH (1) | PH12020551208A1 (fr) |
SG (1) | SG11202006921PA (fr) |
WO (1) | WO2019148044A1 (fr) |
Families Citing this family (19)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP7480048B2 (ja) | 2018-01-26 | 2024-05-09 | エグゼリクシス, インコーポレイテッド | キナーゼ依存的障害を処置するための化合物 |
CA3088200A1 (fr) * | 2018-01-26 | 2019-08-01 | Exelixis, Inc. | Composes destines au traitement de troubles dependant de la kinase |
CN113302175A (zh) | 2018-11-09 | 2021-08-24 | 维瓦斯治疗公司 | 双环化合物 |
KR20210102381A (ko) * | 2018-12-13 | 2021-08-19 | 엑셀리시스, 인코포레이티드 | 키나아제 억제제의 결정질 형태 및 염 형태 |
CN113710322A (zh) * | 2019-01-25 | 2021-11-26 | 埃克塞里艾克西斯公司 | 用于治疗激酶依赖性病症的化合物 |
CN109761899B (zh) * | 2019-02-14 | 2022-11-15 | 广州六顺生物科技股份有限公司 | 喹啉衍生物、其药学上可接受的盐或其溶剂合物、其应用、药物及药物组合物 |
SG11202111404XA (en) * | 2019-04-16 | 2021-11-29 | Vivace Therapeutics Inc | Bicyclic compounds |
CR20210616A (es) * | 2019-06-03 | 2022-03-22 | Exelixis Inc | Formas de sales cristalinas de un inhibidor de cinasas |
AR119069A1 (es) * | 2019-06-04 | 2021-11-24 | Exelixis Inc | Compuestos para el tratamiento de trastornos dependientes de quinasas |
CN110845406B (zh) * | 2019-12-04 | 2021-07-20 | 广州安岩仁医药科技有限公司 | 喹啉类化合物的制备方法 |
EP4103188A4 (fr) * | 2020-02-10 | 2024-04-10 | Stemsynergy Therapeutics Inc | Inhibiteurs de myc et leurs utilisations |
WO2021222673A1 (fr) * | 2020-04-30 | 2021-11-04 | Exelixis, Inc. | Procédé de préparation d'un inhibiteur de kinase |
PE20231369A1 (es) * | 2020-07-31 | 2023-09-07 | Exelixis Inc | Combinaciones para el tratamiento del cancer |
IL302485A (en) | 2020-11-05 | 2023-06-01 | Exelixis Inc | Kinase inhibitor pharmaceutical preparations |
TW202241862A (zh) * | 2021-02-01 | 2022-11-01 | 大陸商江蘇恆瑞醫藥股份有限公司 | 二甲醯胺類化合物、其製備方法及其在醫藥上的應用 |
CN113582924A (zh) * | 2021-09-09 | 2021-11-02 | 四川国康药业有限公司 | 一种多靶点酪氨酸激酶抑制剂及其制备方法和用途 |
TW202334090A (zh) * | 2021-11-03 | 2023-09-01 | 美商艾克塞里克斯公司 | 用於治療激酶依賴性病症之化合物 |
WO2023122739A1 (fr) | 2021-12-22 | 2023-06-29 | Exelixis, Inc. | Formes cristallines et formes salines d'un inhibiteur de kinase |
CN114573553B (zh) * | 2022-01-27 | 2023-11-10 | 广州六顺生物科技有限公司 | 杂芳环类衍生物及其制备方法和应用 |
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DK0817775T3 (da) | 1995-03-30 | 2001-11-19 | Pfizer | Quinazolinderivater |
GB9508538D0 (en) | 1995-04-27 | 1995-06-14 | Zeneca Ltd | Quinazoline derivatives |
GB9508565D0 (en) | 1995-04-27 | 1995-06-14 | Zeneca Ltd | Quiazoline derivative |
SI0892789T2 (sl) | 1996-04-12 | 2010-03-31 | Warner Lambert Co | Ireverzibilni inhibitorji tirozin kinaz |
UA73073C2 (uk) | 1997-04-03 | 2005-06-15 | Уайт Холдінгз Корпорейшн | Заміщені 3-ціанохіноліни, спосіб їх одержання та фармацевтична композиція |
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EP2213686A1 (fr) | 2009-01-28 | 2010-08-04 | Externautics S.p.A. | Marqueurs de tumeur et procédés d'utilisation correspondants |
EP2214019A1 (fr) | 2009-01-28 | 2010-08-04 | Externautics S.p.A. | Marqueurs de tumeurs et leurs utilisations |
UA108618C2 (uk) | 2009-08-07 | 2015-05-25 | Застосування c-met-модуляторів в комбінації з темозоломідом та/або променевою терапією для лікування раку | |
EP2494361B2 (fr) | 2009-10-26 | 2019-01-09 | Externautics S.p.A. | Marqueurs de tumeurs des ovaires et leurs méthodes d'utilisation |
EP2493916B1 (fr) | 2009-10-26 | 2016-06-08 | Externautics S.p.A. | Marqueurs associés avec des tumeurs pulmonaires et leur utilisation |
EP3345920A1 (fr) | 2009-10-26 | 2018-07-11 | Externautics S.p.A. | Marqueurs de tumeur du sein et procédés d'utilisation correspondants |
EP2494351B1 (fr) | 2009-10-26 | 2016-06-08 | Externautics S.p.A. | Marqueurs de tumeurs du rectum et du côlon, et leurs méthodes d'utilisation |
WO2011051271A2 (fr) | 2009-10-26 | 2011-05-05 | Externautics S.P.A. | Marqueurs de tumeur de la prostate et méthodes d'utilisation |
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EP2383578A1 (fr) | 2010-04-30 | 2011-11-02 | Externautics S.p.A. | Marqueur de tumeur et procédés d'utilisation correspondants |
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2019
- 2019-01-25 CA CA3088200A patent/CA3088200A1/fr active Pending
- 2019-01-25 CN CN202311157242.7A patent/CN117402114A/zh active Pending
- 2019-01-25 CN CN201980015066.9A patent/CN111757735B/zh active Active
- 2019-01-25 PE PE2020001121A patent/PE20211203A1/es unknown
- 2019-01-25 BR BR112020015201-3A patent/BR112020015201A2/pt unknown
- 2019-01-25 JP JP2020540751A patent/JP7321165B2/ja active Active
- 2019-01-25 CN CN202311131715.6A patent/CN117603138A/zh active Pending
- 2019-01-25 US US16/964,330 patent/US11542259B2/en active Active
- 2019-01-25 MX MX2020007765A patent/MX2020007765A/es unknown
- 2019-01-25 KR KR1020207024581A patent/KR20200115582A/ko not_active Application Discontinuation
- 2019-01-25 WO PCT/US2019/015297 patent/WO2019148044A1/fr active Application Filing
- 2019-01-25 CR CR20230287A patent/CR20230287A/es unknown
- 2019-01-25 AU AU2019212801A patent/AU2019212801A1/en active Pending
- 2019-01-25 MA MA051673A patent/MA51673A/fr unknown
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- 2019-01-25 IL IL300824A patent/IL300824A/en unknown
- 2019-01-25 CN CN202311123887.9A patent/CN117820226A/zh active Pending
- 2019-01-25 CN CN202311144729.1A patent/CN117624045A/zh active Pending
- 2019-01-25 EP EP19704970.3A patent/EP3743070A1/fr active Pending
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2020
- 2020-07-13 IL IL276032A patent/IL276032A/en unknown
- 2020-07-22 MX MX2022016051A patent/MX2022016051A/es unknown
- 2020-07-23 CL CL2020001931A patent/CL2020001931A1/es unknown
- 2020-08-07 PH PH12020551208A patent/PH12020551208A1/en unknown
- 2020-08-25 CO CONC2020/0010465A patent/CO2020010465A2/es unknown
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2022
- 2022-11-17 US US17/989,393 patent/US20240043414A1/en active Pending
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Publication number | Publication date |
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EP3743070A1 (fr) | 2020-12-02 |
JP2021511360A (ja) | 2021-05-06 |
JP7321165B2 (ja) | 2023-08-04 |
CN117402114A (zh) | 2024-01-16 |
IL300824A (en) | 2023-04-01 |
US20240043414A1 (en) | 2024-02-08 |
CL2020001931A1 (es) | 2020-12-11 |
JP2023103446A (ja) | 2023-07-26 |
CN111757735B (zh) | 2023-09-22 |
IL276032A (en) | 2020-08-31 |
CN111757735A (zh) | 2020-10-09 |
AU2019212801A1 (en) | 2020-08-20 |
MX2022016051A (es) | 2023-02-01 |
KR20200115582A (ko) | 2020-10-07 |
CO2020010465A2 (es) | 2020-10-30 |
WO2019148044A1 (fr) | 2019-08-01 |
CA3088200A1 (fr) | 2019-08-01 |
SG11202006921PA (en) | 2020-08-28 |
US11542259B2 (en) | 2023-01-03 |
CN117603138A (zh) | 2024-02-27 |
BR112020015201A2 (pt) | 2020-12-29 |
CN117624045A (zh) | 2024-03-01 |
CR20200358A (es) | 2021-02-22 |
CN117820226A (zh) | 2024-04-05 |
MX2020007765A (es) | 2020-09-25 |
PH12020551208A1 (en) | 2021-05-17 |
PE20211203A1 (es) | 2021-07-05 |
CR20230287A (es) | 2023-07-26 |
US20210040076A1 (en) | 2021-02-11 |
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