MA41949B1 - Procédé de production de gonadotrophine - Google Patents
Procédé de production de gonadotrophineInfo
- Publication number
- MA41949B1 MA41949B1 MA41949A MA41949A MA41949B1 MA 41949 B1 MA41949 B1 MA 41949B1 MA 41949 A MA41949 A MA 41949A MA 41949 A MA41949 A MA 41949A MA 41949 B1 MA41949 B1 MA 41949B1
- Authority
- MA
- Morocco
- Prior art keywords
- production process
- gonadotropin production
- host cell
- hcg
- gonadotropin
- Prior art date
Links
- 102000006771 Gonadotropins Human genes 0.000 title 1
- 108010086677 Gonadotropins Proteins 0.000 title 1
- 239000002622 gonadotropin Substances 0.000 title 1
- 238000004519 manufacturing process Methods 0.000 title 1
- 102000011022 Chorionic Gonadotropin Human genes 0.000 abstract 1
- 108010062540 Chorionic Gonadotropin Proteins 0.000 abstract 1
- 229940084986 human chorionic gonadotropin Drugs 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/59—Follicle-stimulating hormone [FSH]; Chorionic gonadotropins, e.g.hCG [human chorionic gonadotropin]; Luteinising hormone [LH]; Thyroid-stimulating hormone [TSH]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/06—Drugs for disorders of the endocrine system of the anterior pituitary hormones, e.g. TSH, ACTH, FSH, LH, PRL, GH
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/10—Transferases (2.)
- C12N9/1048—Glycosyltransferases (2.4)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/10—Transferases (2.)
- C12N9/1048—Glycosyltransferases (2.4)
- C12N9/1081—Glycosyltransferases (2.4) transferring other glycosyl groups (2.4.99)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P21/00—Preparation of peptides or proteins
- C12P21/02—Preparation of peptides or proteins having a known sequence of two or more amino acids, e.g. glutathione
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y204/00—Glycosyltransferases (2.4)
- C12Y204/99—Glycosyltransferases (2.4) transferring other glycosyl groups (2.4.99)
- C12Y204/99004—Beta-galactoside alpha-2,3-sialyltransferase (2.4.99.4)
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/10—Immunoglobulins specific features characterized by their source of isolation or production
- C07K2317/14—Specific host cells or culture conditions, e.g. components, pH or temperature
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/40—Immunoglobulins specific features characterized by post-translational modification
- C07K2317/41—Glycosylation, sialylation, or fucosylation
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2800/00—Nucleic acids vectors
- C12N2800/22—Vectors comprising a coding region that has been codon optimised for expression in a respective host
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Genetics & Genomics (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Zoology (AREA)
- General Health & Medical Sciences (AREA)
- Wood Science & Technology (AREA)
- Biochemistry (AREA)
- Medicinal Chemistry (AREA)
- General Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Endocrinology (AREA)
- Biotechnology (AREA)
- Biomedical Technology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Microbiology (AREA)
- Gastroenterology & Hepatology (AREA)
- Biophysics (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Toxicology (AREA)
- Reproductive Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Immunology (AREA)
- Diabetes (AREA)
- Epidemiology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Physics & Mathematics (AREA)
- Plant Pathology (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
Une cellule hôte caractérisée en ce qu'elle comprend, intégrée dans son génome, une séquence codant pour la chaîne de hcg, et l'utilisation de la cellule hôte pour produire une gonadotrophine chorionique humaine hcg recombinante.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP15164965 | 2015-04-24 | ||
PCT/EP2016/059006 WO2016170113A1 (fr) | 2015-04-24 | 2016-04-22 | Procédé de production de gonadotrophine |
Publications (2)
Publication Number | Publication Date |
---|---|
MA41949A MA41949A (fr) | 2018-02-28 |
MA41949B1 true MA41949B1 (fr) | 2020-12-31 |
Family
ID=53002568
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MA41949A MA41949B1 (fr) | 2015-04-24 | 2016-04-22 | Procédé de production de gonadotrophine |
Country Status (32)
Country | Link |
---|---|
US (1) | US10464984B2 (fr) |
EP (1) | EP3286209B1 (fr) |
JP (1) | JP6964519B2 (fr) |
KR (1) | KR102658666B1 (fr) |
CN (2) | CN114107315A (fr) |
AU (1) | AU2016251314B2 (fr) |
BR (1) | BR112017016895A2 (fr) |
CA (1) | CA2975449A1 (fr) |
CL (1) | CL2017002661A1 (fr) |
CO (1) | CO2017011964A2 (fr) |
DK (1) | DK3286209T3 (fr) |
EA (1) | EA034022B1 (fr) |
ES (1) | ES2837111T3 (fr) |
HK (1) | HK1246325A1 (fr) |
HR (1) | HRP20201945T1 (fr) |
HU (1) | HUE051879T2 (fr) |
IL (1) | IL253694B (fr) |
LT (1) | LT3286209T (fr) |
MA (1) | MA41949B1 (fr) |
MD (1) | MD3286209T2 (fr) |
MX (1) | MX2017010884A (fr) |
MY (1) | MY185823A (fr) |
PH (1) | PH12017501585A1 (fr) |
PT (1) | PT3286209T (fr) |
RS (1) | RS61163B1 (fr) |
SA (1) | SA517390029B1 (fr) |
SG (1) | SG11201706832PA (fr) |
SI (1) | SI3286209T1 (fr) |
TN (1) | TN2017000328A1 (fr) |
UA (1) | UA124187C2 (fr) |
WO (1) | WO2016170113A1 (fr) |
ZA (1) | ZA201707136B (fr) |
Families Citing this family (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
BR112020003379A2 (pt) | 2017-09-01 | 2020-08-25 | Ferring B.V. | usos de hormônio folículo-estimulante recombinante (fsh) para estimulação ovariana controlada |
CN108264549A (zh) * | 2018-03-29 | 2018-07-10 | 北京伟杰信生物科技有限公司 | 重组绒促性素rhCG的制备方法及应用 |
TW201945024A (zh) | 2018-04-30 | 2019-12-01 | 荷蘭商菲林公司 | 用於經控制之卵巢刺激的組成物 |
CN110812366B (zh) * | 2019-11-18 | 2023-11-17 | 珠海丽凡达生物技术有限公司 | 一种可用于激素补充的mRNA药物及其制备方法 |
CN113337562B (zh) * | 2021-05-24 | 2022-06-03 | 宁波人健药业集团股份有限公司 | 使用CHO细胞高效发酵生产rhCG的方法 |
Family Cites Families (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6855544B1 (en) | 1999-04-15 | 2005-02-15 | Crucell Holland B.V. | Recombinant protein production in a human cell |
WO2001058493A1 (fr) * | 2000-02-11 | 2001-08-16 | Maxygen Aps | Conjugates of follicle stimulating hormones |
US20030036181A1 (en) | 2000-06-30 | 2003-02-20 | Okkels Jens Sigurd | Peptide extended glycosylated polypeptides |
CN1194016C (zh) * | 2000-12-29 | 2005-03-23 | 申庆祥 | 新的人绒毛膜***-促黄体素融合蛋白及其制法和用途 |
CN101250531B (zh) * | 2006-11-27 | 2013-04-24 | 株式会社Lg生命科学 | 一核苷酸序列、包含该序列的表达载体、该载体转化的动物细胞及利用该细胞生产人fsh的方法 |
TWI604850B (zh) | 2009-10-05 | 2017-11-11 | 菲瑞茵國際中心股份有限公司 | 藥學製劑 |
US8326547B2 (en) * | 2009-10-07 | 2012-12-04 | Nanjingjinsirui Science & Technology Biology Corp. | Method of sequence optimization for improved recombinant protein expression using a particle swarm optimization algorithm |
CA2784861A1 (fr) * | 2009-12-21 | 2011-07-14 | Pharmathene, Inc. | Butyrylcholinesterases recombinantes et produits de troncature de ceux-ci |
JP2015518705A (ja) * | 2012-04-02 | 2015-07-06 | モデルナ セラピューティクス インコーポレイテッドModerna Therapeutics,Inc. | ヒト疾患に関連する生物製剤およびタンパク質の産生のための修飾ポリヌクレオチド |
DE18200782T1 (de) | 2012-04-02 | 2021-10-21 | Modernatx, Inc. | Modifizierte polynukleotide zur herstellung von proteinen im zusammenhang mit erkrankungen beim menschen |
CN103539862B (zh) * | 2013-11-01 | 2015-04-01 | 广州联康生物科技有限公司 | 一种长效重组促卵泡激素及其应用 |
-
2016
- 2016-04-22 WO PCT/EP2016/059006 patent/WO2016170113A1/fr active Application Filing
- 2016-04-22 KR KR1020177022423A patent/KR102658666B1/ko active IP Right Grant
- 2016-04-22 MX MX2017010884A patent/MX2017010884A/es unknown
- 2016-04-22 ES ES16721722T patent/ES2837111T3/es active Active
- 2016-04-22 MD MDE20180206T patent/MD3286209T2/ro unknown
- 2016-04-22 MY MYPI2017703981A patent/MY185823A/en unknown
- 2016-04-22 EA EA201791724A patent/EA034022B1/ru unknown
- 2016-04-22 PT PT167217223T patent/PT3286209T/pt unknown
- 2016-04-22 MA MA41949A patent/MA41949B1/fr unknown
- 2016-04-22 DK DK16721722.3T patent/DK3286209T3/da active
- 2016-04-22 BR BR112017016895A patent/BR112017016895A2/pt active Search and Examination
- 2016-04-22 UA UAA201711487A patent/UA124187C2/uk unknown
- 2016-04-22 US US15/566,961 patent/US10464984B2/en active Active
- 2016-04-22 JP JP2017555503A patent/JP6964519B2/ja active Active
- 2016-04-22 RS RS20201492A patent/RS61163B1/sr unknown
- 2016-04-22 AU AU2016251314A patent/AU2016251314B2/en active Active
- 2016-04-22 TN TNP/2017/000328A patent/TN2017000328A1/en unknown
- 2016-04-22 LT LTEP16721722.3T patent/LT3286209T/lt unknown
- 2016-04-22 CN CN202111399800.1A patent/CN114107315A/zh active Pending
- 2016-04-22 HU HUE16721722A patent/HUE051879T2/hu unknown
- 2016-04-22 EP EP16721722.3A patent/EP3286209B1/fr active Active
- 2016-04-22 CA CA2975449A patent/CA2975449A1/fr active Pending
- 2016-04-22 SI SI201631009T patent/SI3286209T1/sl unknown
- 2016-04-22 CN CN201680022637.8A patent/CN107532172A/zh active Pending
- 2016-04-22 SG SG11201706832PA patent/SG11201706832PA/en unknown
-
2017
- 2017-07-27 IL IL253694A patent/IL253694B/en unknown
- 2017-09-04 PH PH12017501585A patent/PH12017501585A1/en unknown
- 2017-09-26 SA SA517390029A patent/SA517390029B1/ar unknown
- 2017-10-19 CL CL2017002661A patent/CL2017002661A1/es unknown
- 2017-10-20 ZA ZA2017/07136A patent/ZA201707136B/en unknown
- 2017-11-24 CO CONC2017/0011964A patent/CO2017011964A2/es unknown
-
2018
- 2018-05-08 HK HK18105909.9A patent/HK1246325A1/zh unknown
-
2020
- 2020-12-04 HR HRP20201945TT patent/HRP20201945T1/hr unknown
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