MA40225B1 - Composés dihydroisoquinolinone substitués - Google Patents
Composés dihydroisoquinolinone substituésInfo
- Publication number
- MA40225B1 MA40225B1 MA40225A MA40225A MA40225B1 MA 40225 B1 MA40225 B1 MA 40225B1 MA 40225 A MA40225 A MA 40225A MA 40225 A MA40225 A MA 40225A MA 40225 B1 MA40225 B1 MA 40225B1
- Authority
- MA
- Morocco
- Prior art keywords
- compounds
- salts
- substituted
- substituted dihydroisoquinolinone
- dihydroisoquinolinone compounds
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/472—Non-condensed isoquinolines, e.g. papaverine
- A61K31/4725—Non-condensed isoquinolines, e.g. papaverine containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B59/00—Introduction of isotopes of elements into organic compounds ; Labelled organic compounds per se
- C07B59/002—Heterocyclic compounds
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/05—Isotopically modified compounds, e.g. labelled
Abstract
La présente invention concerne des composés de formule générale (i) dans laquelle r1, r2, r3, r4, l, x et z sont tels que définis ici, ainsi que leurs sels pharmaceutiquement acceptables, des compositions pharmaceutiques comprenant ces composés et sels, ainsi que des procédés d'utiliser de tels composés, sels et compositions pour le traitement de la croissance cellulaire anormale, y compris le cancer.
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201462013410P | 2014-06-17 | 2014-06-17 | |
US201562156533P | 2015-05-04 | 2015-05-04 | |
EP15730290.2A EP3157915B1 (fr) | 2014-06-17 | 2015-06-05 | Composés dihydroisoquinolinone substitués |
PCT/IB2015/054272 WO2015193765A1 (fr) | 2014-06-17 | 2015-06-05 | Composés dihydroisoquinolinone substitués |
Publications (2)
Publication Number | Publication Date |
---|---|
MA40225A MA40225A (fr) | 2019-02-27 |
MA40225B1 true MA40225B1 (fr) | 2019-05-31 |
Family
ID=53434412
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MA40225A MA40225B1 (fr) | 2014-06-17 | 2015-06-05 | Composés dihydroisoquinolinone substitués |
Country Status (40)
Country | Link |
---|---|
US (4) | US9481666B2 (fr) |
EP (2) | EP3521285A1 (fr) |
JP (1) | JP6152495B1 (fr) |
KR (1) | KR101877187B1 (fr) |
CN (1) | CN107207464B (fr) |
AP (1) | AP2016009605A0 (fr) |
AU (1) | AU2015275826B2 (fr) |
BR (1) | BR112016029612B1 (fr) |
CA (1) | CA2894298C (fr) |
CL (1) | CL2016003246A1 (fr) |
CR (2) | CR20200484A (fr) |
CU (1) | CU24408B1 (fr) |
CY (1) | CY1121706T1 (fr) |
DK (1) | DK3157915T3 (fr) |
EA (1) | EA031892B1 (fr) |
ES (1) | ES2721031T3 (fr) |
GE (1) | GEP20186933B (fr) |
HR (1) | HRP20190604T1 (fr) |
HU (1) | HUE042964T2 (fr) |
IL (1) | IL248991B (fr) |
LT (1) | LT3157915T (fr) |
MA (1) | MA40225B1 (fr) |
MD (1) | MD4820C1 (fr) |
ME (1) | ME03419B (fr) |
MX (1) | MX2016016764A (fr) |
MY (1) | MY185765A (fr) |
NZ (1) | NZ726108A (fr) |
PE (1) | PE20161552A1 (fr) |
PH (1) | PH12016502378A1 (fr) |
PL (1) | PL3157915T3 (fr) |
PT (1) | PT3157915T (fr) |
RS (1) | RS58632B1 (fr) |
SG (1) | SG11201609386YA (fr) |
SI (1) | SI3157915T1 (fr) |
SV (1) | SV2016005333A (fr) |
TN (1) | TN2016000529A1 (fr) |
TW (1) | TWI561516B (fr) |
UA (1) | UA118380C2 (fr) |
UY (1) | UY36170A (fr) |
WO (1) | WO2015193765A1 (fr) |
Families Citing this family (18)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
UA111305C2 (uk) | 2012-12-21 | 2016-04-11 | Пфайзер Інк. | Конденсовані лактами арилу та гетероарилу |
MA40225B1 (fr) | 2014-06-17 | 2019-05-31 | Pfizer | Composés dihydroisoquinolinone substitués |
TW201708210A (zh) * | 2015-06-30 | 2017-03-01 | 葛蘭素史克智慧財產(第二)有限公司 | Zeste同源物2增強子之抑制劑 |
TW201718598A (zh) | 2015-08-27 | 2017-06-01 | 美國禮來大藥廠 | Ezh2抑制劑 |
PE20190106A1 (es) | 2016-05-05 | 2019-01-15 | Glaxosmithkline Ip No 2 Ltd | Inhibidores del potenciador del homologo zeste 2 |
US10266542B2 (en) | 2017-03-15 | 2019-04-23 | Mirati Therapeutics, Inc. | EZH2 inhibitors |
US20210147381A1 (en) | 2017-07-17 | 2021-05-20 | AbbVie Deutschland GmbH & Co. KG | 1,2,3,4-substituted quinoline compounds as sip modulators |
JP7201400B2 (ja) * | 2017-11-14 | 2023-01-10 | ファイザー・インク | Ezh2阻害剤組合せ療法 |
CN112004816B (zh) | 2018-01-31 | 2024-01-05 | 米拉蒂医疗股份有限公司 | Prc2抑制剂 |
CA3098428A1 (fr) | 2018-04-18 | 2019-10-24 | Constellation Pharmaceuticals, Inc. | Modulateurs d'enzymes de modification de methyle, compositions et utilisations de ceux-ci |
WO2019226491A1 (fr) * | 2018-05-21 | 2019-11-28 | Constellation Pharmaceuticals, Inc. | Modulateurs d'enzymes de modification de méthyle, compositions et utilisations de ceux-ci |
CA3104209A1 (fr) | 2018-07-09 | 2020-01-16 | Fondation Asile Des Aveugles | Inhibition de sous-unites de prc2 permettant de traiter des troubles oculaires |
EP3870173A4 (fr) * | 2018-10-24 | 2022-06-22 | Vanderbilt University | Modulateurs et inhibiteurs de wdr5 |
KR20200101219A (ko) * | 2019-02-19 | 2020-08-27 | 한미약품 주식회사 | 신규한 헤테로트리시클릭 유도체 화합물 및 이의 용도 |
WO2022018594A1 (fr) | 2020-07-20 | 2022-01-27 | Pfizer Inc. | Synthèse de nouveaux intermédiaires pour 3,4-dihydroisoquinolinones substituées |
CN116783188A (zh) * | 2020-12-11 | 2023-09-19 | 上海奕拓医药科技有限责任公司 | 一种二氢异喹啉酮衍生物及其应用 |
WO2023098880A1 (fr) * | 2021-12-02 | 2023-06-08 | 上海翰森生物医药科技有限公司 | Dérivé de cycle fusionné, son procédé de préparation et son application |
WO2023111810A1 (fr) | 2021-12-14 | 2023-06-22 | Pfizer Inc. | Polythérapies et leurs utilisations pour le traitement du cancer |
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US3846412A (en) | 1971-03-18 | 1974-11-05 | Lepetit Spa | Dihydro-2-amino-isoquinolines and their derivatives |
KR0166088B1 (ko) | 1990-01-23 | 1999-01-15 | . | 수용해도가 증가된 시클로덱스트린 유도체 및 이의 용도 |
US5376645A (en) | 1990-01-23 | 1994-12-27 | University Of Kansas | Derivatives of cyclodextrins exhibiting enhanced aqueous solubility and the use thereof |
GB9518953D0 (en) | 1995-09-15 | 1995-11-15 | Pfizer Ltd | Pharmaceutical formulations |
WO2000035296A1 (fr) | 1996-11-27 | 2000-06-22 | Wm. Wrigley Jr. Company | Liberation amelioree d'agents medicamenteux actifs par un enrobage de chewing-gum |
GB9711643D0 (en) | 1997-06-05 | 1997-07-30 | Janssen Pharmaceutica Nv | Glass thermoplastic systems |
FR2889526B1 (fr) | 2005-08-04 | 2012-02-17 | Aventis Pharma Sa | 7-aza-indazoles substitues, compositions les contenant, procede de fabrication et utilisation |
US20070093515A1 (en) | 2005-08-16 | 2007-04-26 | Arrington Mark P | Phosphodiesterase 10 inhibitors |
CA2631777A1 (fr) * | 2005-12-22 | 2007-07-05 | Wyeth | Isoquinoline-1,3(2h,4h)-diones, 1-thioxo-1,4-dihydro-2h-isoquinoline-3-ones et 1,4-dihydro-3(2h)-isoquinolones et procedes d'utilisation correspondant |
US20100113415A1 (en) | 2008-05-29 | 2010-05-06 | Rajapakse Hemaka A | Epha4 rtk inhibitors for treatment of neurological and neurodegenerative disorders and cancer |
MX2010014057A (es) * | 2008-06-17 | 2011-03-21 | Astrazeneca Ab | Compuestos de piridina. |
US8440693B2 (en) * | 2009-12-22 | 2013-05-14 | Novartis Ag | Substituted isoquinolinones and quinazolinones |
US20110251216A1 (en) | 2010-02-19 | 2011-10-13 | The Regents Of The University Of Michigan | Compositions and methods for inhibiting ezh2 |
US8637509B2 (en) | 2010-05-07 | 2014-01-28 | Glaxosmithkline Llc | Azaindazoles |
ES2534804T3 (es) | 2010-05-07 | 2015-04-28 | Glaxosmithkline Llc | Indazoles |
JP5864545B2 (ja) | 2010-05-07 | 2016-02-17 | グラクソスミスクライン・リミテッド・ライアビリティ・カンパニーGlaxoSmithKline LLC | インドール |
KR102061353B1 (ko) | 2010-09-10 | 2020-01-02 | 에피자임, 인코포레이티드 | 인간 ezh2의 억제제 및 이의 사용 방법 |
WO2012035078A1 (fr) | 2010-09-16 | 2012-03-22 | Novartis Ag | Inhibiteurs de la 17α-hydroxylase/c17,20-lyase |
WO2012068589A2 (fr) | 2010-11-19 | 2012-05-24 | Constellation Pharmaceuticals | Modulateurs d'enzymes de modification par méthylation, compositions et utilisations associées |
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FR3000059A1 (fr) | 2012-12-21 | 2014-06-27 | Saint Gobain Placo | Composition pour plaques de platre et produits obtenus |
UA111305C2 (uk) * | 2012-12-21 | 2016-04-11 | Пфайзер Інк. | Конденсовані лактами арилу та гетероарилу |
HUE039848T2 (hu) | 2012-12-21 | 2019-02-28 | Hoffmann La Roche | Peptidek oxitocin agonistákként |
US9604930B2 (en) | 2012-12-21 | 2017-03-28 | Epizyme, Inc. | Tetrahydro- and dihydro-isoquinoline PRMT5 inhibitors and uses thereof |
FR3000065A1 (fr) | 2012-12-21 | 2014-06-27 | Univ Lille Ii Droit & Sante | Composes bicycliques ayant une activite potentialisatrice de l'activite d'un antibiotique actif contre les mycobacteries-composition et produit pharmaceutiques comprenant de tels composes |
AU2013366691A1 (en) | 2012-12-21 | 2015-07-09 | Sanofi | Exendin-4 derivatives |
US9233974B2 (en) | 2012-12-21 | 2016-01-12 | Gilead Sciences, Inc. | Antiviral compounds |
SI2822954T1 (sl) | 2012-12-21 | 2016-07-29 | Gilead Sciences, Inc. | Policiklične karbamoilpiridonske spojine in njihova farmacevtska uporaba |
CA2895239C (fr) | 2012-12-21 | 2020-10-27 | Plexxikon Inc. | Composes et procedes pour la modulation de kinase, et indications associees |
KR102168621B1 (ko) | 2012-12-21 | 2020-10-22 | 얀센 바이오파마, 인코퍼레이트. | 치환된 뉴클레오사이드, 뉴클레오타이드 및 그것의 유사체 |
MA40225B1 (fr) | 2014-06-17 | 2019-05-31 | Pfizer | Composés dihydroisoquinolinone substitués |
-
2015
- 2015-06-05 MA MA40225A patent/MA40225B1/fr unknown
- 2015-06-05 DK DK15730290.2T patent/DK3157915T3/en active
- 2015-06-05 JP JP2016573051A patent/JP6152495B1/ja active Active
- 2015-06-05 LT LTEP15730290.2T patent/LT3157915T/lt unknown
- 2015-06-05 KR KR1020177001230A patent/KR101877187B1/ko active IP Right Grant
- 2015-06-05 EP EP19159058.7A patent/EP3521285A1/fr not_active Withdrawn
- 2015-06-05 MX MX2016016764A patent/MX2016016764A/es active IP Right Grant
- 2015-06-05 PE PE2016002737A patent/PE20161552A1/es unknown
- 2015-06-05 CN CN201580032058.7A patent/CN107207464B/zh active Active
- 2015-06-05 MY MYPI2016704453A patent/MY185765A/en unknown
- 2015-06-05 EP EP15730290.2A patent/EP3157915B1/fr active Active
- 2015-06-05 SG SG11201609386YA patent/SG11201609386YA/en unknown
- 2015-06-05 CR CR20200484A patent/CR20200484A/es unknown
- 2015-06-05 GE GEAP201514347A patent/GEP20186933B/en unknown
- 2015-06-05 TN TN2016000529A patent/TN2016000529A1/en unknown
- 2015-06-05 BR BR112016029612-5A patent/BR112016029612B1/pt active IP Right Grant
- 2015-06-05 ME MEP-2019-85A patent/ME03419B/fr unknown
- 2015-06-05 WO PCT/IB2015/054272 patent/WO2015193765A1/fr active Application Filing
- 2015-06-05 PT PT15730290T patent/PT3157915T/pt unknown
- 2015-06-05 UA UAA201611695A patent/UA118380C2/uk unknown
- 2015-06-05 AP AP2016009605A patent/AP2016009605A0/en unknown
- 2015-06-05 ES ES15730290T patent/ES2721031T3/es active Active
- 2015-06-05 RS RS20190512A patent/RS58632B1/sr unknown
- 2015-06-05 NZ NZ726108A patent/NZ726108A/en unknown
- 2015-06-05 CU CU2016000180A patent/CU24408B1/es unknown
- 2015-06-05 HU HUE15730290A patent/HUE042964T2/hu unknown
- 2015-06-05 PL PL15730290T patent/PL3157915T3/pl unknown
- 2015-06-05 SI SI201530698T patent/SI3157915T1/sl unknown
- 2015-06-05 CR CR20160574A patent/CR20160574A/es unknown
- 2015-06-05 MD MDA20160136A patent/MD4820C1/ro active IP Right Grant
- 2015-06-05 AU AU2015275826A patent/AU2015275826B2/en active Active
- 2015-06-05 EA EA201692114A patent/EA031892B1/ru unknown
- 2015-06-15 TW TW104119287A patent/TWI561516B/zh active
- 2015-06-16 UY UY0001036170A patent/UY36170A/es not_active Application Discontinuation
- 2015-06-16 US US14/740,439 patent/US9481666B2/en active Active
- 2015-06-16 CA CA2894298A patent/CA2894298C/fr active Active
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2016
- 2016-09-12 US US15/262,230 patent/US20160376254A1/en not_active Abandoned
- 2016-11-15 IL IL248991A patent/IL248991B/en active IP Right Grant
- 2016-11-29 PH PH12016502378A patent/PH12016502378A1/en unknown
- 2016-12-05 SV SV2016005333A patent/SV2016005333A/es unknown
- 2016-12-19 CL CL2016003246A patent/CL2016003246A1/es unknown
-
2017
- 2017-06-28 US US15/635,648 patent/US20170298048A1/en not_active Abandoned
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2018
- 2018-10-10 US US16/156,304 patent/US10570121B2/en active Active
-
2019
- 2019-03-28 HR HRP20190604TT patent/HRP20190604T1/hr unknown
- 2019-04-05 CY CY20191100381T patent/CY1121706T1/el unknown
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