EA201692114A1 - Замещенные дигидроизохинолиноновые соединения - Google Patents
Замещенные дигидроизохинолиноновые соединенияInfo
- Publication number
- EA201692114A1 EA201692114A1 EA201692114A EA201692114A EA201692114A1 EA 201692114 A1 EA201692114 A1 EA 201692114A1 EA 201692114 A EA201692114 A EA 201692114A EA 201692114 A EA201692114 A EA 201692114A EA 201692114 A1 EA201692114 A1 EA 201692114A1
- Authority
- EA
- Eurasian Patent Office
- Prior art keywords
- compounds
- isohinoline
- substituted dihydro
- salts
- dihydro
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/472—Non-condensed isoquinolines, e.g. papaverine
- A61K31/4725—Non-condensed isoquinolines, e.g. papaverine containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B59/00—Introduction of isotopes of elements into organic compounds ; Labelled organic compounds per se
- C07B59/002—Heterocyclic compounds
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/05—Isotopically modified compounds, e.g. labelled
Abstract
Данное изобретение относится к соединениям общей формулы (I), где R, R, R, R, L, X и Z являются такими, как определено в данном описании, и их фармацевтически приемлемым солям, к фармацевтическим композициям, содержащим такие соединения и соли, и к способам применения таких соединений, солей и композиций для лечения аномального клеточного роста, в том числе рака.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201462013410P | 2014-06-17 | 2014-06-17 | |
| US201562156533P | 2015-05-04 | 2015-05-04 | |
| PCT/IB2015/054272 WO2015193765A1 (en) | 2014-06-17 | 2015-06-05 | Substituted dihydroisoquinolinone compounds |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| EA201692114A1 true EA201692114A1 (ru) | 2017-06-30 |
| EA031892B1 EA031892B1 (ru) | 2019-03-29 |
Family
ID=53434412
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| EA201692114A EA031892B1 (ru) | 2014-06-17 | 2015-06-05 | Замещенные дигидроизохинолиноновые соединения для лечения аномального клеточного роста, ассоциированного с активностью ezh2 |
Country Status (40)
| Country | Link |
|---|---|
| US (4) | US9481666B2 (ru) |
| EP (2) | EP3157915B1 (ru) |
| JP (1) | JP6152495B1 (ru) |
| KR (1) | KR101877187B1 (ru) |
| CN (1) | CN107207464B (ru) |
| AP (1) | AP2016009605A0 (ru) |
| AU (1) | AU2015275826B2 (ru) |
| BR (1) | BR112016029612B1 (ru) |
| CA (1) | CA2894298C (ru) |
| CL (1) | CL2016003246A1 (ru) |
| CR (2) | CR20160574A (ru) |
| CU (1) | CU24408B1 (ru) |
| CY (1) | CY1121706T1 (ru) |
| DK (1) | DK3157915T3 (ru) |
| EA (1) | EA031892B1 (ru) |
| ES (1) | ES2721031T3 (ru) |
| GE (1) | GEP20186933B (ru) |
| HR (1) | HRP20190604T1 (ru) |
| HU (1) | HUE042964T2 (ru) |
| IL (1) | IL248991B (ru) |
| LT (1) | LT3157915T (ru) |
| MA (1) | MA40225B1 (ru) |
| MD (1) | MD4820C1 (ru) |
| ME (1) | ME03419B (ru) |
| MX (1) | MX2016016764A (ru) |
| MY (1) | MY185765A (ru) |
| NZ (1) | NZ726108A (ru) |
| PE (1) | PE20161552A1 (ru) |
| PH (1) | PH12016502378A1 (ru) |
| PL (1) | PL3157915T3 (ru) |
| PT (1) | PT3157915T (ru) |
| RS (1) | RS58632B1 (ru) |
| SG (1) | SG11201609386YA (ru) |
| SI (1) | SI3157915T1 (ru) |
| SV (1) | SV2016005333A (ru) |
| TN (1) | TN2016000529A1 (ru) |
| TW (1) | TWI561516B (ru) |
| UA (1) | UA118380C2 (ru) |
| UY (1) | UY36170A (ru) |
| WO (1) | WO2015193765A1 (ru) |
Families Citing this family (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| UA111305C2 (uk) | 2012-12-21 | 2016-04-11 | Пфайзер Інк. | Конденсовані лактами арилу та гетероарилу |
| CR20160574A (es) | 2014-06-17 | 2017-02-23 | Pfizer | Compuestos de dihidroisoquinolinona sustituida |
| UY36758A (es) * | 2015-06-30 | 2016-12-30 | Glaxosmithkline Ip No 2 Ltd | Inhibidores del potenciador del homólogo zeste 2 |
| TW201718598A (zh) | 2015-08-27 | 2017-06-01 | 美國禮來大藥廠 | Ｅｚｈ２抑制劑 |
| US10604531B2 (en) | 2016-05-05 | 2020-03-31 | Glaxosmithkline Intellectual Property (No.2) Limited | Enhancer of zeste homolog 2 inhibitors |
| US10266542B2 (en) | 2017-03-15 | 2019-04-23 | Mirati Therapeutics, Inc. | EZH2 inhibitors |
| EP3655392A1 (en) | 2017-07-17 | 2020-05-27 | Abbvie Deutschland GmbH & Co. KG | 1,2,3,4-substituted quinoline compounds as s1p modulators |
| US11529344B2 (en) | 2017-11-14 | 2022-12-20 | Pfizer Inc. | EZH2 inhibitor combination therapies |
| DK3746446T3 (da) | 2018-01-31 | 2022-06-27 | Mirati Therapeutics Inc | PRC2-inhibitorer |
| CA3098428A1 (en) | 2018-04-18 | 2019-10-24 | Constellation Pharmaceuticals, Inc. | Modulators of methyl modifying enzymes, compositions and uses thereof |
| CA3100977A1 (en) | 2018-05-21 | 2019-11-28 | Constellation Pharmaceuticals, Inc. | Modulators of methyl modifying enzymes, compositions and uses thereof |
| JP2021531340A (ja) | 2018-07-09 | 2021-11-18 | フォンダシヨン、アジール、デ、アブグルスFondation Asile Des Aveugles | 眼障害を治療するためのｐｒｃ２サブユニットの阻害 |
| US20230012362A1 (en) * | 2018-10-24 | 2023-01-12 | Vanderbilt University | Wdr5 inhibitors and modulators |
| KR20200101219A (ko) * | 2019-02-19 | 2020-08-27 | 한미약품 주식회사 | 신규한 헤테로트리시클릭 유도체 화합물 및 이의 용도 |
| WO2022018594A1 (en) | 2020-07-20 | 2022-01-27 | Pfizer Inc. | Synthesis of novel intermediates for substituted 3,4-dihydroisoquinolinones |
| EP4261211A1 (en) * | 2020-12-11 | 2023-10-18 | Etern Biopharma (Shanghai) Co., Ltd. | Dihydroisoquinolinone derivative and application thereof |
| WO2023098880A1 (zh) * | 2021-12-02 | 2023-06-08 | 上海翰森生物医药科技有限公司 | 稠环类衍生物调节剂、其制备方法和应用 |
| WO2023111810A1 (en) | 2021-12-14 | 2023-06-22 | Pfizer Inc. | Combination therapies and uses for treating cancer |
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| US5376645A (en) | 1990-01-23 | 1994-12-27 | University Of Kansas | Derivatives of cyclodextrins exhibiting enhanced aqueous solubility and the use thereof |
| KR0166088B1 (ko) | 1990-01-23 | 1999-01-15 | . | 수용해도가 증가된 시클로덱스트린 유도체 및 이의 용도 |
| GB9518953D0 (en) | 1995-09-15 | 1995-11-15 | Pfizer Ltd | Pharmaceutical formulations |
| WO2000035298A1 (en) | 1996-11-27 | 2000-06-22 | Wm. Wrigley Jr. Company | Chewing gum containing medicament active agents |
| GB9711643D0 (en) | 1997-06-05 | 1997-07-30 | Janssen Pharmaceutica Nv | Glass thermoplastic systems |
| FR2889526B1 (fr) | 2005-08-04 | 2012-02-17 | Aventis Pharma Sa | 7-aza-indazoles substitues, compositions les contenant, procede de fabrication et utilisation |
| WO2007022280A1 (en) | 2005-08-16 | 2007-02-22 | Memory Pharmaceuticals Corporation | Phosphodiesterase 10 inhibitors |
| BRPI0620151A2 (pt) * | 2005-12-22 | 2010-06-29 | Wyeth Corp | composto; composição farmacêutica; método de tratar ou inibir o crescimento de células tumorais cancerosas em um mamìfero que deste necessita; método; e processo |
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| UA111305C2 (uk) | 2012-12-21 | 2016-04-11 | Пфайзер Інк. | Конденсовані лактами арилу та гетероарилу |
| US9216996B2 (en) | 2012-12-21 | 2015-12-22 | Gilead Sciences, Inc. | Substituted 2,3,4,5,7,9,13,13a-octahydropyrido[1′,2′:4,5]pyrazino[2,1-b][1,3]oxazepines and methods for treating viral infections |
| PL2935248T3 (pl) | 2012-12-21 | 2018-07-31 | Plexxikon Inc | Związki i sposoby modulacji kinaz i wskazania dla nich |
| FR3000065A1 (fr) | 2012-12-21 | 2014-06-27 | Univ Lille Ii Droit & Sante | Composes bicycliques ayant une activite potentialisatrice de l'activite d'un antibiotique actif contre les mycobacteries-composition et produit pharmaceutiques comprenant de tels composes |
| FR3000059A1 (fr) | 2012-12-21 | 2014-06-27 | Saint Gobain Placo | Composition pour plaques de platre et produits obtenus |
| KR102168621B1 (ko) | 2012-12-21 | 2020-10-22 | 얀센 바이오파마, 인코퍼레이트. | 치환된 뉴클레오사이드, 뉴클레오타이드 및 그것의 유사체 |
| WO2014096150A1 (en) | 2012-12-21 | 2014-06-26 | Sanofi | Dual glp1/gip or trigonal glp1/gip/glucagon agonists |
| LT2935312T (lt) | 2012-12-21 | 2018-10-25 | F. Hoffmann-La Roche Ag | Peptidai, kaip oksitocino agonistai |
| CR20160574A (es) | 2014-06-17 | 2017-02-23 | Pfizer | Compuestos de dihidroisoquinolinona sustituida |
-
2015
- 2015-06-05 CR CR20160574A patent/CR20160574A/es unknown
- 2015-06-05 MD MDA20160136A patent/MD4820C1/ru active IP Right Grant
- 2015-06-05 MA MA40225A patent/MA40225B1/fr unknown
- 2015-06-05 AU AU2015275826A patent/AU2015275826B2/en active Active
- 2015-06-05 HU HUE15730290A patent/HUE042964T2/hu unknown
- 2015-06-05 AP AP2016009605A patent/AP2016009605A0/en unknown
- 2015-06-05 EP EP15730290.2A patent/EP3157915B1/en active Active
- 2015-06-05 EP EP19159058.7A patent/EP3521285A1/en not_active Withdrawn
- 2015-06-05 PT PT15730290T patent/PT3157915T/pt unknown
- 2015-06-05 MY MYPI2016704453A patent/MY185765A/en unknown
- 2015-06-05 NZ NZ726108A patent/NZ726108A/en unknown
- 2015-06-05 SI SI201530698T patent/SI3157915T1/sl unknown
- 2015-06-05 GE GEAP201514347A patent/GEP20186933B/en unknown
- 2015-06-05 KR KR1020177001230A patent/KR101877187B1/ko active IP Right Grant
- 2015-06-05 BR BR112016029612-5A patent/BR112016029612B1/pt active IP Right Grant
- 2015-06-05 RS RS20190512A patent/RS58632B1/sr unknown
- 2015-06-05 CN CN201580032058.7A patent/CN107207464B/zh active Active
- 2015-06-05 LT LTEP15730290.2T patent/LT3157915T/lt unknown
- 2015-06-05 ES ES15730290T patent/ES2721031T3/es active Active
- 2015-06-05 PL PL15730290T patent/PL3157915T3/pl unknown
- 2015-06-05 EA EA201692114A patent/EA031892B1/ru unknown
- 2015-06-05 SG SG11201609386YA patent/SG11201609386YA/en unknown
- 2015-06-05 TN TN2016000529A patent/TN2016000529A1/en unknown
- 2015-06-05 UA UAA201611695A patent/UA118380C2/uk unknown
- 2015-06-05 CU CU2016000180A patent/CU24408B1/es unknown
- 2015-06-05 MX MX2016016764A patent/MX2016016764A/es active IP Right Grant
- 2015-06-05 WO PCT/IB2015/054272 patent/WO2015193765A1/en active Application Filing
- 2015-06-05 CR CR20200484A patent/CR20200484A/es unknown
- 2015-06-05 DK DK15730290.2T patent/DK3157915T3/en active
- 2015-06-05 ME MEP-2019-85A patent/ME03419B/me unknown
- 2015-06-05 JP JP2016573051A patent/JP6152495B1/ja active Active
- 2015-06-05 PE PE2016002737A patent/PE20161552A1/es unknown
- 2015-06-15 TW TW104119287A patent/TWI561516B/zh active
- 2015-06-16 CA CA2894298A patent/CA2894298C/en active Active
- 2015-06-16 UY UY0001036170A patent/UY36170A/es not_active Application Discontinuation
- 2015-06-16 US US14/740,439 patent/US9481666B2/en active Active
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2016
- 2016-09-12 US US15/262,230 patent/US20160376254A1/en not_active Abandoned
- 2016-11-15 IL IL248991A patent/IL248991B/en active IP Right Grant
- 2016-11-29 PH PH12016502378A patent/PH12016502378A1/en unknown
- 2016-12-05 SV SV2016005333A patent/SV2016005333A/es unknown
- 2016-12-19 CL CL2016003246A patent/CL2016003246A1/es unknown
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2017
- 2017-06-28 US US15/635,648 patent/US20170298048A1/en not_active Abandoned
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2018
- 2018-10-10 US US16/156,304 patent/US10570121B2/en active Active
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2019
- 2019-03-28 HR HRP20190604TT patent/HRP20190604T1/hr unknown
- 2019-04-05 CY CY20191100381T patent/CY1121706T1/el unknown
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